IRIS
RADI, Marco
 Distribuzione geografica
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Continente #
NA - Nord America 4.996
AS - Asia 4.708
EU - Europa 2.822
SA - Sud America 618
AF - Africa 280
Continente sconosciuto - Info sul continente non disponibili 4
OC - Oceania 2
Totale 13.430
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Nazione #
US - Stati Uniti d'America 4.850
SG - Singapore 1.583
CN - Cina 1.333
VN - Vietnam 700
IT - Italia 601
SE - Svezia 483
BR - Brasile 480
IE - Irlanda 476
HK - Hong Kong 347
DE - Germania 294
FI - Finlandia 220
TR - Turchia 199
FR - Francia 160
NL - Olanda 135
ZA - Sudafrica 134
UA - Ucraina 131
BD - Bangladesh 114
IN - India 107
CI - Costa d'Avorio 97
CA - Canada 92
RU - Federazione Russa 92
KR - Corea 91
GB - Regno Unito 78
AR - Argentina 60
ES - Italia 38
JP - Giappone 36
ID - Indonesia 32
IQ - Iraq 29
MX - Messico 27
PL - Polonia 25
EC - Ecuador 23
BE - Belgio 22
CO - Colombia 17
AT - Austria 14
TH - Thailandia 14
CZ - Repubblica Ceca 13
PH - Filippine 13
SA - Arabia Saudita 13
PK - Pakistan 12
TW - Taiwan 11
UZ - Uzbekistan 10
VE - Venezuela 10
CL - Cile 9
LT - Lituania 8
NP - Nepal 8
OM - Oman 8
EG - Egitto 7
MA - Marocco 7
AE - Emirati Arabi Uniti 6
JM - Giamaica 6
NG - Nigeria 6
PE - Perù 6
PY - Paraguay 6
RS - Serbia 6
TN - Tunisia 6
DZ - Algeria 5
SK - Slovacchia (Repubblica Slovacca) 5
ET - Etiopia 4
EU - Europa 4
KE - Kenya 4
KZ - Kazakistan 4
LB - Libano 4
AM - Armenia 3
AO - Angola 3
AZ - Azerbaigian 3
BO - Bolivia 3
DK - Danimarca 3
GR - Grecia 3
GT - Guatemala 3
HN - Honduras 3
PA - Panama 3
PS - Palestinian Territory 3
SY - Repubblica araba siriana 3
TT - Trinidad e Tobago 3
AL - Albania 2
BN - Brunei Darussalam 2
CR - Costa Rica 2
GE - Georgia 2
GY - Guiana 2
IL - Israele 2
JO - Giordania 2
KG - Kirghizistan 2
KH - Cambogia 2
KW - Kuwait 2
LV - Lettonia 2
MY - Malesia 2
NI - Nicaragua 2
QA - Qatar 2
SD - Sudan 2
UY - Uruguay 2
AD - Andorra 1
AF - Afghanistan, Repubblica islamica di 1
AU - Australia 1
BG - Bulgaria 1
BY - Bielorussia 1
BZ - Belize 1
CH - Svizzera 1
CY - Cipro 1
DO - Repubblica Dominicana 1
GA - Gabon 1
Totale 13.413
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Città #
Singapore 780
Ashburn 562
Chandler 479
Dublin 473
San Jose 455
Hong Kong 323
Santa Clara 314
Jacksonville 281
Beijing 280
Dallas 247
Ho Chi Minh City 243
Boardman 188
Dearborn 170
Izmir 168
Parma 157
Ann Arbor 140
Hanoi 139
Nanjing 136
Johannesburg 125
Abidjan 97
Lauterbourg 95
Chicago 93
New York 89
Princeton 87
Hefei 86
Los Angeles 80
Columbus 69
Seoul 69
Shenyang 62
Wilmington 62
Jinan 57
Grafing 54
Toronto 53
Council Bluffs 52
The Dalles 50
Bengaluru 49
São Paulo 48
San Mateo 47
Helsinki 45
Moscow 44
Nanchang 40
Munich 38
Hebei 36
Tianjin 36
Woodbridge 36
Kunming 34
Shanghai 34
Milan 32
Seattle 32
Changsha 31
Bologna 30
Brooklyn 29
Des Moines 29
Buffalo 28
Guangzhou 28
Jiaxing 28
Tokyo 27
Hillsboro 26
Haiphong 24
Hangzhou 24
Orem 23
Da Nang 22
Warsaw 21
Montreal 20
Turku 19
Falls Church 18
London 18
Zhengzhou 17
Brussels 16
Houston 16
Jakarta 16
Haikou 15
Nuremberg 15
Frankfurt am Main 14
Hải Dương 14
Rio de Janeiro 14
Amsterdam 13
Atlanta 13
Fuzhou 13
Taiyuan 13
Chennai 12
Denver 12
Lanzhou 12
Rome 12
Biên Hòa 11
Bremen 11
Curitiba 11
Düsseldorf 11
Stockholm 11
Belo Horizonte 10
Kocaeli 10
Mexico City 10
Taizhou 10
Bắc Ninh 9
Campinas 9
Caxias do Sul 9
Charlotte 9
Fremont 9
Istanbul 9
Manchester 9
Totale 8.206
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Nome #
The in silico drug discovery toolbox: applications in lead discovery and optimization 236
Identification of 4-amino-2-Pyridones as new potent PCSK9 inhibitors: From phenotypic hit discovery to in vivo tolerability 234
Bithiazole Inhibitors of Phosphatidylinositol 4-Kinase (PI4KIIIβ) as Broad-Spectrum Antivirals Blocking the Replication of SARS-CoV-2, Zika Virus, and Human Rhinoviruses 199
ATP-Competitive Inhibitors of mTOR: An Update 198
Multi-Target CFTR Modulators Endowed with Multiple Beneficial Side Effects for Cystic Fibrosis Patients: Toward a Simplified Therapeutic Approach 185
Discovery and SAR of 1,3,4-thiadiazole derivatives as potent Abl tyrosine kinase inhibitors and cytodifferentiating agents 174
Probing the Reactivity of 2,4-Dichlorofuro[3,4-d ]pyrimidin-7-one: A Versatile and Underexploited Scaffold to Generate Substituted or Fused Pyrimidine Derivatives 174
A cascade screening approach for the identification of Bcr-Abl myristate pocket binders active against wild type and T315I mutant 171
Probing the effects of MR120 in preclinical chronic colitis: A first-in-class anti-IBD agent targeting the CCL20/CCR6 axis 166
System-Oriented Optimization of Multi-target 2,6-Diaminopurine Derivatives: Easily Accessible Broad-Spectrum Antivirals Active Against Flaviviruses, Influenza Virus and SARS-CoV-2 164
Discovery of small-molecule targeting the CCL20/CCR6 axis as first-in-class inhibitors for inflammatory bowel diseases 161
Multicomponent Synthesis of Purines and Pyrimidines: From the Origin of Life to New Sustainable Approaches for Drug-Discovery Applications 160
A Multidisciplinary Approach for the Identification of Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: S-DABOCs and DAVPs 155
Synthesis, biological evaluation, and SAR study of novel pyrazole analogues as inhibitors of Mycobacterium tuberculosis: Part 2. Synthesis of rigid pyrazolones 155
6-Vinyl pyrimidine and pyrimidinone derivatives and the use thereof 153
Scaffold Morphing Approach To Expand the Toolbox of Broad-Spectrum Antivirals Blocking Dengue/Zika Replication 152
A one-pot, two-step microwave-assisted synthesis of highly functionalized benzoxazoles using solid-supported reagents (SSRs) 149
Benzofuran-2-Carboxamide Derivatives as Immunomodulatory Agents Blocking the CCL20-Induced Chemotaxis and Colon Cancer Growth 148
Synthesis, biological evaluation and SAR study of novel pyrazole analogues as inhibitors of Mycobacterium tuberculosis 147
A Versatile Route to C-6 Arylmethyl-FunctionalizedS-DABO and Related Analogues 147
4-Amino-Substituted Pyrazolo[3,4-d]Pyrimidines: Synthesis and Biological Properties 144
Allosteric Inhibitors of Bcr-Abl: Towards Novel Myristate-Pocket Binders 140
A one-pot two-step microwave-assisted synthesis of N1-substituted 5,6-ring-fused 2-pyridones 139
A Domino Microwave-Assisted Protocol for the Synthesis of 2,6-Disubstituted Pyrimidinones 139
A combined ligand- and structure-based approach for the identification of rilmenidine-derived compounds which synergize the antitumor effects of doxorubicin 139
Towards new methodologies for the synthesis of biologically interesting 6-substituted pyrimidines and 4(3H)-pyrimidinones 138
A Convergent Approach for the Synthesis of Ara-Neplanocin a Analogues Under Subzero Microwave Assisted Conditions 137
Microwave-enhanced Sonogashira coupling reaction of substituted pyrimidinones and pyrimidine nucleosides 137
A multicomponent pharmacophore fragment-decoration approach to identify selective LRRK2-targeting probes 137
New insights into small-molecule inhibitors of Bcr-Abl 136
Biologically Driven Synthesis of Pyrazolo[3,4-d]pyrimidines As Protein Kinase Inhibitors: An Old Scaffold As a New Tool for Medicinal Chemistry and Chemical Biology Studies 134
Towards Innovative Antibacterial Correctors for Cystic Fibrosis Targeting the Lung Microbiome with a Multifunctional Effect 133
Troxacitabine Prodrugs for Pancreatic Cancer 132
A microwave-assisted multicomponent protocol for the synthesis of benzofuran-2-carboxamides 131
Arylation of 2-Furyl 4-Fluorophenyl Ketone: An Extension of Heck Chemistry towards Novel Integrase Inhibitors 130
A combined targeted/phenotypic approach for the identification of new antiangiogenics agents active on a zebrafish model: From in silico screening to cyclodextrin formulation 129
Synthesis of an Original Oxygenated Taxuspine X Analogue: a Versatile “Non-Natural” Natural Product with Remarkable P-gp Modulating Activity 129
Exploring the chemical space around the privileged pyrazolo[3,4-d] pyrimidine scaffold: Toward novel allosteric inhibitors of T315I-mutated Abl 128
Dual Src and Abl inhibitors target wild type Abl and the AblT315I Imatinib-resistant mutant with different mechanisms 128
Design, Synthesis, Biological Activity, and ADME Properties of Pyrazolo[3,4-d]pyrimidines Active in Hypoxic Human Leukemia Cells: A Lead Optimization Study 127
Drug repurposing approaches to fight Dengue virus infection and related diseases 127
Synthesis of enantiomerically pure α-[4-(1-substituted)-1,2,3-triazol-4-yl]-benzylacetamides via microwave-assisted click chemistry: towards new potential antimicrobial agents 126
Targeting PI4KB and Src/Abl host kinases as broad-spectrum antiviral strategy: Myth or real opportunity? 125
An alternative synthetic approach for the synthesis of biologically relevant 1,4-disubstituted pyrazolo[3,4-d]pyrimidines 125
Src Kinase Inhibitors: An Update on Patented Compounds 125
Targeting the Human DEAD-Box Polypeptide 3 (DDX3) RNA Helicase as a Novel Strategy to Inhibit Viral Replication 124
Identification of Breast Cancer Inhibitors Specific for G Protein-Coupled Estrogen Receptor (GPER)-Expressing Cells 124
Bithiazole inhibitors of PI4KB show broad-spectrum antiviral activity against different viral families 123
C6-Unsubstituted Pyrazolo[3,4-d]pyrimidines Are Dual Src/Abl Inhibitors Effective against Imatinib Mesylate Resistant Chronic Myeloid Leukemia Cell Lines 123
In Vitro Optimization of Non-Small Cell Lung Cancer Activity with Troxacitabine,l-1,3-Dioxolane-cytidine, Prodrugs 121
Solid-phase synthesis (SPS) of substituted uracils via Oxone® cleavage methodology 121
Effects of CCL20/CCR6 modulators in a T cell adoptive transfer model of colitis 120
Discovery of Multitarget Antivirals Acting on Both the Dengue Virus NS5-NS3 Interaction and the Host Src/Fyn Kinases 120
Nucleoside Derivatives of 2,6-Diaminopurine Antivirals: Base-Modified Nucleosides with Broad-Spectrum Antimicrobial Properties 118
Derivati 1,3,4-tiadiazolici metodi di preparazione e uso di essi 118
Microwave-Assisted Acylation of Amines, Alcohols, and Phenols by the Use of Solid-Supported Reagents (SSRs) 118
Discovery of Multitarget Agents Active as Broad-Spectrum Antivirals and Correctors of Cystic Fibrosis Transmembrane Conductance Regulator for Associated Pulmonary Diseases 118
eHydrogenation: Hydrogen-free Electrochemical Hydrogenation 117
Discovery of Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase Competing with the Nucleotide Substrate 117
Homology Modeling, Validation and Dynamics of the G Protein-coupled Estrogen Receptor 1 (GPER-1) 117
Design and Synthesis of Thiadiazoles and Thiazoles Targeting the Bcr-Abl T315I Mutant: from Docking False Positives to ATP-Noncompetitive Inhibitors 116
Deciphering Imidazoline Off-targets by Fishing in the Class A of GPCR field 116
Synthesis, Biological Activity, and ADME Properties of Novel S-DABOs/N-DABOs as HIV Reverse Transcriptase Inhibitors 115
Identification of Broad-Spectrum Dengue/Zika Virus Replication Inhibitors by Functionalization of Quinoline and 2,6-Diaminopurine Scaffolds 115
Computational techniques are valuable tools for the discovery of protein–protein interaction inhibitors: The 14-3-3σ case 113
Toward the Discovery of Novel Anti-HIV Drugs. Second-Generation Inhibitors of the Cellular ATPase DDX3 with Improved Anti-HIV Activity: Synthesis, Structure-Activity Relationship Analysis, Cytotoxicity Studies, and Target Validation 113
4-Trifluoromethyl bithiazoles as broad-spectrum antimicrobial agents for virus-related bacterial infections or co-infections 112
Microwave-assisted organocatalytic multicomponent Knoevenagel/hetero Diels–Alder reaction for the synthesis of 2,3-dihydropyran[2,3-c]pyrazoles 112
Parallel Solution-Phase Synthesis of 4-Dialkylamino-2-methylsulfonyl-6-vinylpyrimidines 112
Stereoselective synthesis of N1-6-methyluridine and related 2-substituted analogues 111
Compounds with DDX3 inhibitory activity and uses thereof 111
Vascular Endothelial Growth Factor (VEGF) receptors: drugs and new inhibitors 110
A Combination Strategy to Inhibit Pim-1: Synergism between Noncompetitive and ATP-Competitive Inhibitors 110
Combining X-ray crystallography and molecular modeling toward the optimization of pyrazolo[3,4-d ]pyrimidines as potent c-Src inhibitors active in vivo against neuroblastoma 110
Molecular Characterization of c-Abl/c-Src Kinase Inhibitors Targeted against Murine Tumour Progenitor Cells that Express Stem Cell Markers 110
A Microwave‐Assisted One‐Pot Three‐Step Metal‐Free [4+2] Annulation for the Sustainable Synthesis of Highly Substituted 1,2,4‐Triazines 110
Crystal structure of HIV-1 reverse transcriptase bound to a nucleotide-competitive reverse transcriptase inhibitor and the use thereof 109
Design, Synthesis, and Biological Evaluation of Pyrazolo[3,4-d]pyrimidines Active in Vivo on the Bcr-Abl T315I Mutant 109
New 4-substituted derivatives of pyrazolo[3,4-d]pyrimidines and pyrrolo[2,3-d]pyrimidines and uses thereof 108
Crystal Structure of HIV-1 Reverse Transcriptase Bound to a Non-Nucleoside Inhibitor with a Novel Mechanism of Action 108
Exploring the synthesis of masked phosphoramido 6-vinylcytidine derivatives as building blocks for cross-linking oligonucleotides 107
Su1816–Protection by Ccr6 Blockade in a Murine Model of Crohn’s Disease 105
Towards novel S-DABOC inhibitors: Synthesis, biological investigation, and molecular modeling studies 105
Identification of Potent c-Src Inhibitors Strongly Affecting the Proliferation of Human Neuroblastoma Cells 104
Synthesis and biological evaluation of new enantiomerically pure azole derivatives as inhibitors of Mycobacterium tuberculosis 104
Discovery of Chiral Cyclopropyl Dihydro-Alkylthio-Benzyl-Oxopyrimidine (S-DABO) Derivatives as Potent HIV-1 Reverse Transcriptase Inhibitors with High Activity Against Clinically Relevant Mutants 103
Pyrazolo[3,4-d]pyrimidine Prodrugs: Strategic Optimization of the Aqueous Solubility of Dual Src/Abl Inhibitors 102
Pyazolopyrimidines: old molecules, new targets 102
Preclinical discovery and development of maraviroc for the treatment of HIV 101
Recent highlights in the synthesis of highly functionalized pyrimidines 99
“Investigating PCSK9 inhibition as potential strategy in Alzheimer’s disease” 95
Exploring the druggability of the UEV domain of human TSG101 in search for broad-spectrum antivirals 95
Practical One-Pot Two-Step Protocol for the Microwave-Assisted Synthesis of Highly Functionalized Rhodanine Derivatives 95
Synthesis of reactive cytidine derivatives as building blocks for cross-linking oligonucleotides 95
The fight against AIDS: new avenues for inhibiting reverse transcriptase (RT), an old target 95
Unconventional plasticity of hiv-1 reverse transcriptase: How inhibitors could open a connection "gate" between allosteric and catalytic sites 94
Studies on the ATP Binding Site of Fyn Kinase for the Identification of New Inhibitors and Their Evaluation as Potential Agents against Tauopathies and Tumors 89
CYP-dependent metabolism of antitumor pyrazolo[3,4-d]pyrimidine derivatives is characterized by an oxidative dechlorination reaction 89
Discovery of p-Trifluoromethylbenzohydrazide Derivatives as Potent Antiviral Agents against Monkeypox Virus 88
Insight into the allosteric inhibition of Abl kinase 87
Totale 12.726
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Categoria #
all - tutte 46.656
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 46.656
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022532 7 14 15 35 39 70 47 90 27 18 13 157
2022/20231.816 189 184 129 133 140 215 34 120 580 8 58 26
2023/2024672 44 79 26 26 58 130 41 61 15 25 47 120
2024/20252.466 136 113 192 121 272 211 116 144 223 209 296 433
2025/20265.530 468 458 799 405 746 382 603 215 709 352 246 147
2026/202711 11 0 0 0 0 0 0 0 0 0 0 0
Totale 13.549