IRIS
RADI, Marco
 Distribuzione geografica
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Continente #
NA - Nord America 2.887
EU - Europa 1.994
AS - Asia 1.525
AF - Africa 113
SA - Sud America 36
Continente sconosciuto - Info sul continente non disponibili 4
Totale 6.559
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Nazione #
US - Stati Uniti d'America 2.837
CN - Cina 885
IE - Irlanda 477
SE - Svezia 475
SG - Singapore 399
IT - Italia 358
DE - Germania 224
FI - Finlandia 200
TR - Turchia 188
UA - Ucraina 122
CI - Costa d'Avorio 97
CA - Canada 48
BR - Brasile 31
GB - Regno Unito 29
FR - Francia 24
BE - Belgio 17
KR - Corea 16
NL - Olanda 15
IN - India 13
CZ - Repubblica Ceca 12
ES - Italia 12
RU - Federazione Russa 7
NG - Nigeria 5
RS - Serbia 5
SK - Slovacchia (Repubblica Slovacca) 5
EU - Europa 4
HK - Hong Kong 4
NP - Nepal 4
ZA - Sudafrica 4
AR - Argentina 3
EG - Egitto 3
GR - Grecia 3
JP - Giappone 3
PK - Pakistan 3
AT - Austria 2
IQ - Iraq 2
SD - Sudan 2
UZ - Uzbekistan 2
BD - Bangladesh 1
BY - Bielorussia 1
CH - Svizzera 1
CL - Cile 1
DO - Repubblica Dominicana 1
DZ - Algeria 1
ID - Indonesia 1
JM - Giamaica 1
LB - Libano 1
LT - Lituania 1
LU - Lussemburgo 1
LV - Lettonia 1
NO - Norvegia 1
PE - Perù 1
PH - Filippine 1
RW - Ruanda 1
SA - Arabia Saudita 1
SI - Slovenia 1
VN - Vietnam 1
Totale 6.559
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Città #
Chandler 488
Dublin 475
Singapore 288
Jacksonville 285
Santa Clara 277
Beijing 192
Ashburn 177
Dearborn 174
Izmir 171
Boardman 142
Ann Arbor 140
Nanjing 137
Parma 102
Abidjan 97
Princeton 88
Chicago 69
Wilmington 63
Shenyang 62
Grafing 56
Jinan 56
San Mateo 48
Helsinki 42
Nanchang 40
Toronto 40
Hebei 36
Woodbridge 36
Kunming 33
New York 30
Jiaxing 29
Seattle 29
Shanghai 29
Changsha 28
Des Moines 28
Tianjin 28
Guangzhou 24
Hangzhou 22
Hefei 22
Falls Church 18
Milan 16
Zhengzhou 16
Bologna 15
Haikou 15
Brussels 14
Fuzhou 13
Lanzhou 13
Bremen 11
Taiyuan 11
Brooklyn 10
Düsseldorf 10
Houston 10
Kocaeli 10
Taizhou 10
Ningbo 9
Fremont 8
London 8
Istanbul 7
Norwalk 7
Pavia 7
Cagliari 6
Redwood City 6
Solaro 6
Amsterdam 5
Barcelona 5
Bratislava 5
Brno 5
Lagos 5
Modena 5
Munich 5
Rovato 5
Seongnam 5
Seoul 5
Tulsa 5
Altidona 4
Amritsar 4
Chengdu 4
Chongqing 4
Dallas 4
Lyon 4
Madrid 4
Marseille 4
Redmond 4
Aulla 3
Brescia 3
Casalgrande 3
Compiano 3
Edinburgh 3
Finale Emilia 3
Frontone 3
Hong Kong 3
Kottayam 3
Los Angeles 3
Montreal 3
Moscow 3
Neviano degli Arduini 3
Piacenza 3
Pisa 3
Quattro Castella 3
Rome 3
Siena 3
Spineda 3
Totale 4.487
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Nome #
The in silico drug discovery toolbox: applications in lead discovery and optimization 173
Bithiazole Inhibitors of Phosphatidylinositol 4-Kinase (PI4KIIIβ) as Broad-Spectrum Antivirals Blocking the Replication of SARS-CoV-2, Zika Virus, and Human Rhinoviruses 122
A cascade screening approach for the identification of Bcr-Abl myristate pocket binders active against wild type and T315I mutant 112
Multi-Target CFTR Modulators Endowed with Multiple Beneficial Side Effects for Cystic Fibrosis Patients: Toward a Simplified Therapeutic Approach 112
Scaffold Morphing Approach To Expand the Toolbox of Broad-Spectrum Antivirals Blocking Dengue/Zika Replication 101
ATP-Competitive Inhibitors of mTOR: An Update 96
Probing the Reactivity of 2,4-Dichlorofuro[3,4-d ]pyrimidin-7-one: A Versatile and Underexploited Scaffold to Generate Substituted or Fused Pyrimidine Derivatives 94
Biologically Driven Synthesis of Pyrazolo[3,4-d]pyrimidines As Protein Kinase Inhibitors: An Old Scaffold As a New Tool for Medicinal Chemistry and Chemical Biology Studies 94
Microwave-enhanced Sonogashira coupling reaction of substituted pyrimidinones and pyrimidine nucleosides 91
Targeting the Human DEAD-Box Polypeptide 3 (DDX3) RNA Helicase as a Novel Strategy to Inhibit Viral Replication 89
Synthesis, biological evaluation, and SAR study of novel pyrazole analogues as inhibitors of Mycobacterium tuberculosis: Part 2. Synthesis of rigid pyrazolones 87
Src Kinase Inhibitors: An Update on Patented Compounds 87
Exploring the chemical space around the privileged pyrazolo[3,4-d] pyrimidine scaffold: Toward novel allosteric inhibitors of T315I-mutated Abl 84
Towards new methodologies for the synthesis of biologically interesting 6-substituted pyrimidines and 4(3H)-pyrimidinones 84
Drug repurposing approaches to fight Dengue virus infection and related diseases 83
Discovery and SAR of 1,3,4-thiadiazole derivatives as potent Abl tyrosine kinase inhibitors and cytodifferentiating agents 81
Identification of 4-amino-2-Pyridones as new potent PCSK9 inhibitors: From phenotypic hit discovery to in vivo tolerability 80
6-Vinyl pyrimidine and pyrimidinone derivatives and the use thereof 80
Design and Synthesis of Thiadiazoles and Thiazoles Targeting the Bcr-Abl T315I Mutant: from Docking False Positives to ATP-Noncompetitive Inhibitors 78
4-Amino-Substituted Pyrazolo[3,4-d]Pyrimidines: Synthesis and Biological Properties 78
A one-pot, two-step microwave-assisted synthesis of highly functionalized benzoxazoles using solid-supported reagents (SSRs) 78
New insights into small-molecule inhibitors of Bcr-Abl 78
Synthesis of novel non-nucleoside and nucleoside derivatives as potential HIV-1 inhibitors 78
Synthesis of an Original Oxygenated Taxuspine X Analogue: a Versatile “Non-Natural” Natural Product with Remarkable P-gp Modulating Activity 76
Synthesis, biological evaluation and SAR study of novel pyrazole analogues as inhibitors of Mycobacterium tuberculosis 75
Troxacitabine Prodrugs for Pancreatic Cancer 74
Probing the effects of MR120 in preclinical chronic colitis: A first-in-class anti-IBD agent targeting the CCL20/CCR6 axis 73
Allosteric Inhibitors of Bcr-Abl: Towards Novel Myristate-Pocket Binders 72
Solid-phase synthesis (SPS) of substituted uracils via Oxone® cleavage methodology 72
Synthesis of enantiomerically pure α-[4-(1-substituted)-1,2,3-triazol-4-yl]-benzylacetamides via microwave-assisted click chemistry: towards new potential antimicrobial agents 72
Dual Src and Abl inhibitors target wild type Abl and the AblT315I Imatinib-resistant mutant with different mechanisms 71
In Vitro Optimization of Non-Small Cell Lung Cancer Activity with Troxacitabine,l-1,3-Dioxolane-cytidine, Prodrugs 71
Microwave-assisted organocatalytic multicomponent Knoevenagel/hetero Diels–Alder reaction for the synthesis of 2,3-dihydropyran[2,3-c]pyrazoles 70
A Convergent Approach for the Synthesis of Ara-Neplanocin a Analogues Under Subzero Microwave Assisted Conditions 70
System-Oriented Optimization of Multi-target 2,6-Diaminopurine Derivatives: Easily Accessible Broad-Spectrum Antivirals Active Against Flaviviruses, Influenza Virus and SARS-CoV-2 70
Deciphering Imidazoline Off-targets by Fishing in the Class A of GPCR field 69
Computational techniques are valuable tools for the discovery of protein–protein interaction inhibitors: The 14-3-3σ case 69
Crystal Structure of HIV-1 Reverse Transcriptase Bound to a Non-Nucleoside Inhibitor with a Novel Mechanism of Action 69
Design, Synthesis, Biological Activity, and ADME Properties of Pyrazolo[3,4-d]pyrimidines Active in Hypoxic Human Leukemia Cells: A Lead Optimization Study 68
Compounds with DDX3 inhibitory activity and uses thereof 68
Discovery of small-molecule targeting the CCL20/CCR6 axis as first-in-class inhibitors for inflammatory bowel diseases 67
Discovery of Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase Competing with the Nucleotide Substrate 67
Parallel Solution-Phase Synthesis of 4-Dialkylamino-2-methylsulfonyl-6-vinylpyrimidines 67
Derivati 1,3,4-tiadiazolici metodi di preparazione e uso di essi 67
Arylation of 2-Furyl 4-Fluorophenyl Ketone: An Extension of Heck Chemistry towards Novel Integrase Inhibitors 66
C6-Unsubstituted Pyrazolo[3,4-d]pyrimidines Are Dual Src/Abl Inhibitors Effective against Imatinib Mesylate Resistant Chronic Myeloid Leukemia Cell Lines 66
A Versatile Route to C-6 Arylmethyl-FunctionalizedS-DABO and Related Analogues 66
Discovery of Multitarget Agents Active as Broad-Spectrum Antivirals and Correctors of Cystic Fibrosis Transmembrane Conductance Regulator for Associated Pulmonary Diseases 66
A Multidisciplinary Approach for the Identification of Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: S-DABOCs and DAVPs 65
Synthesis, Biological Activity, and ADME Properties of Novel S-DABOs/N-DABOs as HIV Reverse Transcriptase Inhibitors 65
Exploring the synthesis of masked phosphoramido 6-vinylcytidine derivatives as building blocks for cross-linking oligonucleotides 65
Pyazolopyrimidines: old molecules, new targets 65
Discovery of Multitarget Antivirals Acting on Both the Dengue Virus NS5-NS3 Interaction and the Host Src/Fyn Kinases 65
Stereoselective synthesis of N1-6-methyluridine and related 2-substituted analogues 64
Crystal structure of HIV-1 reverse transcriptase bound to a nucleotide-competitive reverse transcriptase inhibitor and the use thereof 64
Toward the Discovery of Novel Anti-HIV Drugs. Second-Generation Inhibitors of the Cellular ATPase DDX3 with Improved Anti-HIV Activity: Synthesis, Structure-Activity Relationship Analysis, Cytotoxicity Studies, and Target Validation 64
Vascular Endothelial Growth Factor (VEGF) receptors: drugs and new inhibitors 63
A Domino Microwave-Assisted Protocol for the Synthesis of 2,6-Disubstituted Pyrimidinones 63
Microwave-Assisted Acylation of Amines, Alcohols, and Phenols by the Use of Solid-Supported Reagents (SSRs) 63
Molecular Characterization of c-Abl/c-Src Kinase Inhibitors Targeted against Murine Tumour Progenitor Cells that Express Stem Cell Markers 62
New 4-substituted derivatives of pyrazolo[3,4-d]pyrimidines and pyrrolo[2,3-d]pyrimidines and uses thereof 61
Studies on the ATP Binding Site of Fyn Kinase for the Identification of New Inhibitors and Their Evaluation as Potential Agents against Tauopathies and Tumors 61
Synthesis of reactive cytidine derivatives as building blocks for cross-linking oligonucleotides 60
Identification of Breast Cancer Inhibitors Specific for G Protein-Coupled Estrogen Receptor (GPER)-Expressing Cells 60
Towards Innovative Antibacterial Correctors for Cystic Fibrosis Targeting the Lung Microbiome with a Multifunctional Effect 59
Combining X-ray crystallography and molecular modeling toward the optimization of pyrazolo[3,4-d ]pyrimidines as potent c-Src inhibitors active in vivo against neuroblastoma 59
Unconventional plasticity of hiv-1 reverse transcriptase: How inhibitors could open a connection "gate" between allosteric and catalytic sites 59
A multicomponent pharmacophore fragment-decoration approach to identify selective LRRK2-targeting probes 59
Identification of Broad-Spectrum Dengue/Zika Virus Replication Inhibitors by Functionalization of Quinoline and 2,6-Diaminopurine Scaffolds 59
Pyrazolo[3,4-d]pyrimidine Prodrugs: Strategic Optimization of the Aqueous Solubility of Dual Src/Abl Inhibitors 57
Recent highlights in the synthesis of highly functionalized pyrimidines 57
The fight against AIDS: new avenues for inhibiting reverse transcriptase (RT), an old target 57
Homology Modeling, Validation and Dynamics of the G Protein-coupled Estrogen Receptor 1 (GPER-1) 57
A combined targeted/phenotypic approach for the identification of new antiangiogenics agents active on a zebrafish model: From in silico screening to cyclodextrin formulation 56
Synthesis and biological evaluation of new enantiomerically pure azole derivatives as inhibitors of Mycobacterium tuberculosis 56
Towards novel S-DABOC inhibitors: Synthesis, biological investigation, and molecular modeling studies 56
A one-pot two-step microwave-assisted synthesis of N1-substituted 5,6-ring-fused 2-pyridones 55
Identification of Potent c-Src Inhibitors Strongly Affecting the Proliferation of Human Neuroblastoma Cells 54
A Combination Strategy to Inhibit Pim-1: Synergism between Noncompetitive and ATP-Competitive Inhibitors 53
Design, Synthesis, and Biological Evaluation of Pyrazolo[3,4-d]pyrimidines Active in Vivo on the Bcr-Abl T315I Mutant 53
Insight into the allosteric inhibition of Abl kinase 53
Practical One-Pot Two-Step Protocol for the Microwave-Assisted Synthesis of Highly Functionalized Rhodanine Derivatives 52
Rethinking the old antiviral drug moroxydine: Discovery of novel analogues as anti-hepatitis C virus (HCV) agents 52
Discovery of Chiral Cyclopropyl Dihydro-Alkylthio-Benzyl-Oxopyrimidine (S-DABO) Derivatives as Potent HIV-1 Reverse Transcriptase Inhibitors with High Activity Against Clinically Relevant Mutants 52
A combined ligand- and structure-based approach for the identification of rilmenidine-derived compounds which synergize the antitumor effects of doxorubicin 52
Preclinical discovery and development of maraviroc for the treatment of HIV 51
A microwave-assisted multicomponent protocol for the synthesis of benzofuran-2-carboxamides 51
Nucleoside Derivatives of 2,6-Diaminopurine Antivirals: Base-Modified Nucleosides with Broad-Spectrum Antimicrobial Properties 49
An alternative synthetic approach for the synthesis of biologically relevant 1,4-disubstituted pyrazolo[3,4-d]pyrimidines 49
Microwave assisted domino reactions of propargylamines with isothiocyanates: selective synthesis of 2-aminothiazoles and 2-amino-4-methylenethiazolines 48
Multicomponent Synthesis of Purines and Pyrimidines: From the Origin of Life to New Sustainable Approaches for Drug-Discovery Applications 45
HIV-1 RT Inhibitors with a Novel Mechanism of Action: NNRTIs that Compete with the Nucleotide Substrate 45
CYP-dependent metabolism of antitumor pyrazolo[3,4-d]pyrimidine derivatives is characterized by an oxidative dechlorination reaction 44
Discovery of the first small molecule inhibitor of human DDX3 specifically designed to target the RNA binding site: Towards the next generation HIV-1 inhibitors 41
Su1816–Protection by Ccr6 Blockade in a Murine Model of Crohn’s Disease 37
Benzofuran-2-Carboxamide Derivatives as Immunomodulatory Agents Blocking the CCL20-Induced Chemotaxis and Colon Cancer Growth 33
Identification of a new class of small molecule proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors 20
Bithiazole inhibitors of PI4KB show broad-spectrum antiviral activity against different viral families 18
Small Chemical Entities Targeting Pcsk9: Synergistic Effect With Simvastatin On Ldl Cholesterol Uptake By Hepg2 Cells 18
eHydrogenation: Hydrogen-free Electrochemical Hydrogenation 15
Totale 6.622
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Categoria #
all - tutte 25.164
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 25.164
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020791 0 0 0 0 0 143 127 34 65 323 24 75
2020/2021524 5 63 12 14 98 15 43 52 121 21 73 7
2021/2022539 7 14 15 36 39 72 48 91 28 18 13 158
2022/20231.840 192 186 130 136 140 219 34 123 587 9 58 26
2023/2024680 44 79 26 26 59 132 41 65 15 25 47 121
2024/20251.043 137 114 194 124 273 201 0 0 0 0 0 0
Totale 6.654