IRIS
RADI, Marco
 Distribuzione geografica
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Continente #
NA - Nord America 4.080
AS - Asia 3.564
EU - Europa 2.506
SA - Sud America 557
AF - Africa 244
Continente sconosciuto - Info sul continente non disponibili 4
OC - Oceania 2
Totale 10.957
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Nazione #
US - Stati Uniti d'America 3.963
SG - Singapore 1.362
CN - Cina 1.220
SE - Svezia 483
IE - Irlanda 479
BR - Brasile 450
IT - Italia 450
DE - Germania 289
HK - Hong Kong 285
FI - Finlandia 222
TR - Turchia 197
VN - Vietnam 180
NL - Olanda 127
UA - Ucraina 127
ZA - Sudafrica 117
CI - Costa d'Avorio 98
RU - Federazione Russa 88
IN - India 82
KR - Corea 82
CA - Canada 80
GB - Regno Unito 59
FR - Francia 58
AR - Argentina 52
ID - Indonesia 27
JP - Giappone 26
ES - Italia 25
BE - Belgio 20
MX - Messico 20
BD - Bangladesh 18
PL - Polonia 18
EC - Ecuador 15
IQ - Iraq 14
AT - Austria 13
CZ - Repubblica Ceca 13
CO - Colombia 10
CL - Cile 9
PK - Pakistan 9
NP - Nepal 8
LT - Lituania 7
SA - Arabia Saudita 7
AE - Emirati Arabi Uniti 6
EG - Egitto 6
NG - Nigeria 6
RS - Serbia 6
UZ - Uzbekistan 6
VE - Venezuela 6
JM - Giamaica 5
PY - Paraguay 5
SK - Slovacchia (Repubblica Slovacca) 5
EU - Europa 4
KZ - Kazakistan 4
MA - Marocco 4
PE - Perù 4
AM - Armenia 3
BO - Bolivia 3
DK - Danimarca 3
DZ - Algeria 3
GR - Grecia 3
GT - Guatemala 3
LB - Libano 3
OM - Oman 3
TN - Tunisia 3
AO - Angola 2
AZ - Azerbaigian 2
GE - Georgia 2
HN - Honduras 2
IL - Israele 2
JO - Giordania 2
KG - Kirghizistan 2
KW - Kuwait 2
PA - Panama 2
PS - Palestinian Territory 2
SD - Sudan 2
SY - Repubblica araba siriana 2
TT - Trinidad e Tobago 2
UY - Uruguay 2
AD - Andorra 1
AF - Afghanistan, Repubblica islamica di 1
AU - Australia 1
BG - Bulgaria 1
BN - Brunei Darussalam 1
BY - Bielorussia 1
CH - Svizzera 1
CR - Costa Rica 1
DO - Repubblica Dominicana 1
GA - Gabon 1
GI - Gibilterra 1
GY - Guiana 1
IR - Iran 1
KE - Kenya 1
KH - Cambogia 1
LU - Lussemburgo 1
LV - Lettonia 1
MD - Moldavia 1
NI - Nicaragua 1
NO - Norvegia 1
NZ - Nuova Zelanda 1
PH - Filippine 1
RO - Romania 1
RW - Ruanda 1
Totale 10.955
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Città #
Singapore 660
Chandler 488
Dublin 477
Ashburn 462
Santa Clara 303
Jacksonville 285
Hong Kong 279
Beijing 270
Dallas 242
Dearborn 174
Izmir 171
Boardman 147
Ann Arbor 140
Nanjing 138
Parma 135
Johannesburg 109
Abidjan 98
Princeton 88
Hefei 87
Ho Chi Minh City 86
Chicago 79
Seoul 71
Columbus 69
Wilmington 63
Shenyang 62
Los Angeles 59
Jinan 57
New York 57
Grafing 56
Bengaluru 50
The Dalles 49
San Mateo 48
Toronto 48
Helsinki 45
Moscow 43
Munich 41
Nanchang 41
São Paulo 41
Council Bluffs 37
Hanoi 37
Hebei 36
Tianjin 36
Woodbridge 36
Kunming 34
Shanghai 32
Changsha 31
Seattle 31
Jiaxing 29
Des Moines 28
Guangzhou 28
Brooklyn 27
Bologna 25
Hangzhou 24
Milan 21
Tokyo 21
Turku 19
Falls Church 18
Zhengzhou 18
Montreal 17
Warsaw 17
Jakarta 16
London 16
Buffalo 15
Haikou 15
Houston 15
Brussels 14
Fuzhou 13
Lanzhou 13
Rio de Janeiro 13
Taiyuan 13
Nuremberg 12
Bremen 11
Düsseldorf 11
Orem 11
Amsterdam 10
Atlanta 10
Belo Horizonte 10
Hải Dương 10
Kocaeli 10
Ningbo 10
Taizhou 10
Campinas 9
Frankfurt am Main 9
Fremont 9
Stockholm 9
Brasília 8
Caxias do Sul 8
Charlotte 8
Curitiba 8
Phoenix 8
Buenos Aires 7
Chennai 7
Denver 7
Istanbul 7
Norwalk 7
Pavia 7
Porto Alegre 7
Salvador 7
Vienna 7
Barcelona 6
Totale 6.823
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Nome #
The in silico drug discovery toolbox: applications in lead discovery and optimization 213
Identification of 4-amino-2-Pyridones as new potent PCSK9 inhibitors: From phenotypic hit discovery to in vivo tolerability 181
Bithiazole Inhibitors of Phosphatidylinositol 4-Kinase (PI4KIIIβ) as Broad-Spectrum Antivirals Blocking the Replication of SARS-CoV-2, Zika Virus, and Human Rhinoviruses 170
ATP-Competitive Inhibitors of mTOR: An Update 168
Multi-Target CFTR Modulators Endowed with Multiple Beneficial Side Effects for Cystic Fibrosis Patients: Toward a Simplified Therapeutic Approach 162
A cascade screening approach for the identification of Bcr-Abl myristate pocket binders active against wild type and T315I mutant 147
Probing the Reactivity of 2,4-Dichlorofuro[3,4-d ]pyrimidin-7-one: A Versatile and Underexploited Scaffold to Generate Substituted or Fused Pyrimidine Derivatives 145
Probing the effects of MR120 in preclinical chronic colitis: A first-in-class anti-IBD agent targeting the CCL20/CCR6 axis 142
System-Oriented Optimization of Multi-target 2,6-Diaminopurine Derivatives: Easily Accessible Broad-Spectrum Antivirals Active Against Flaviviruses, Influenza Virus and SARS-CoV-2 141
Discovery and SAR of 1,3,4-thiadiazole derivatives as potent Abl tyrosine kinase inhibitors and cytodifferentiating agents 140
Scaffold Morphing Approach To Expand the Toolbox of Broad-Spectrum Antivirals Blocking Dengue/Zika Replication 137
Microwave-enhanced Sonogashira coupling reaction of substituted pyrimidinones and pyrimidine nucleosides 129
A one-pot, two-step microwave-assisted synthesis of highly functionalized benzoxazoles using solid-supported reagents (SSRs) 128
Synthesis, biological evaluation, and SAR study of novel pyrazole analogues as inhibitors of Mycobacterium tuberculosis: Part 2. Synthesis of rigid pyrazolones 128
Multicomponent Synthesis of Purines and Pyrimidines: From the Origin of Life to New Sustainable Approaches for Drug-Discovery Applications 126
Discovery of small-molecule targeting the CCL20/CCR6 axis as first-in-class inhibitors for inflammatory bowel diseases 123
Towards new methodologies for the synthesis of biologically interesting 6-substituted pyrimidines and 4(3H)-pyrimidinones 123
6-Vinyl pyrimidine and pyrimidinone derivatives and the use thereof 122
New insights into small-molecule inhibitors of Bcr-Abl 120
Troxacitabine Prodrugs for Pancreatic Cancer 120
A Versatile Route to C-6 Arylmethyl-FunctionalizedS-DABO and Related Analogues 119
Targeting the Human DEAD-Box Polypeptide 3 (DDX3) RNA Helicase as a Novel Strategy to Inhibit Viral Replication 118
Allosteric Inhibitors of Bcr-Abl: Towards Novel Myristate-Pocket Binders 117
Synthesis, biological evaluation and SAR study of novel pyrazole analogues as inhibitors of Mycobacterium tuberculosis 117
Drug repurposing approaches to fight Dengue virus infection and related diseases 117
Biologically Driven Synthesis of Pyrazolo[3,4-d]pyrimidines As Protein Kinase Inhibitors: An Old Scaffold As a New Tool for Medicinal Chemistry and Chemical Biology Studies 117
Exploring the chemical space around the privileged pyrazolo[3,4-d] pyrimidine scaffold: Toward novel allosteric inhibitors of T315I-mutated Abl 115
4-Amino-Substituted Pyrazolo[3,4-d]Pyrimidines: Synthesis and Biological Properties 115
Synthesis of novel non-nucleoside and nucleoside derivatives as potential HIV-1 inhibitors 115
Synthesis of an Original Oxygenated Taxuspine X Analogue: a Versatile “Non-Natural” Natural Product with Remarkable P-gp Modulating Activity 115
A multicomponent pharmacophore fragment-decoration approach to identify selective LRRK2-targeting probes 113
A Multidisciplinary Approach for the Identification of Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: S-DABOCs and DAVPs 112
A one-pot two-step microwave-assisted synthesis of N1-substituted 5,6-ring-fused 2-pyridones 112
Src Kinase Inhibitors: An Update on Patented Compounds 112
Synthesis of enantiomerically pure α-[4-(1-substituted)-1,2,3-triazol-4-yl]-benzylacetamides via microwave-assisted click chemistry: towards new potential antimicrobial agents 111
A Convergent Approach for the Synthesis of Ara-Neplanocin a Analogues Under Subzero Microwave Assisted Conditions 110
Discovery of Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase Competing with the Nucleotide Substrate 109
Dual Src and Abl inhibitors target wild type Abl and the AblT315I Imatinib-resistant mutant with different mechanisms 108
In Vitro Optimization of Non-Small Cell Lung Cancer Activity with Troxacitabine,l-1,3-Dioxolane-cytidine, Prodrugs 108
Towards Innovative Antibacterial Correctors for Cystic Fibrosis Targeting the Lung Microbiome with a Multifunctional Effect 107
Arylation of 2-Furyl 4-Fluorophenyl Ketone: An Extension of Heck Chemistry towards Novel Integrase Inhibitors 107
Microwave-assisted organocatalytic multicomponent Knoevenagel/hetero Diels–Alder reaction for the synthesis of 2,3-dihydropyran[2,3-c]pyrazoles 107
Benzofuran-2-Carboxamide Derivatives as Immunomodulatory Agents Blocking the CCL20-Induced Chemotaxis and Colon Cancer Growth 106
C6-Unsubstituted Pyrazolo[3,4-d]pyrimidines Are Dual Src/Abl Inhibitors Effective against Imatinib Mesylate Resistant Chronic Myeloid Leukemia Cell Lines 106
Design and Synthesis of Thiadiazoles and Thiazoles Targeting the Bcr-Abl T315I Mutant: from Docking False Positives to ATP-Noncompetitive Inhibitors 105
Solid-phase synthesis (SPS) of substituted uracils via Oxone® cleavage methodology 105
A Domino Microwave-Assisted Protocol for the Synthesis of 2,6-Disubstituted Pyrimidinones 105
A microwave-assisted multicomponent protocol for the synthesis of benzofuran-2-carboxamides 105
A combined ligand- and structure-based approach for the identification of rilmenidine-derived compounds which synergize the antitumor effects of doxorubicin 104
Identification of Breast Cancer Inhibitors Specific for G Protein-Coupled Estrogen Receptor (GPER)-Expressing Cells 104
Derivati 1,3,4-tiadiazolici metodi di preparazione e uso di essi 103
Discovery of Multitarget Agents Active as Broad-Spectrum Antivirals and Correctors of Cystic Fibrosis Transmembrane Conductance Regulator for Associated Pulmonary Diseases 103
Discovery of Multitarget Antivirals Acting on Both the Dengue Virus NS5-NS3 Interaction and the Host Src/Fyn Kinases 103
Design, Synthesis, Biological Activity, and ADME Properties of Pyrazolo[3,4-d]pyrimidines Active in Hypoxic Human Leukemia Cells: A Lead Optimization Study 102
Parallel Solution-Phase Synthesis of 4-Dialkylamino-2-methylsulfonyl-6-vinylpyrimidines 101
Deciphering Imidazoline Off-targets by Fishing in the Class A of GPCR field 99
An alternative synthetic approach for the synthesis of biologically relevant 1,4-disubstituted pyrazolo[3,4-d]pyrimidines 99
Crystal structure of HIV-1 reverse transcriptase bound to a nucleotide-competitive reverse transcriptase inhibitor and the use thereof 98
Compounds with DDX3 inhibitory activity and uses thereof 98
Identification of Broad-Spectrum Dengue/Zika Virus Replication Inhibitors by Functionalization of Quinoline and 2,6-Diaminopurine Scaffolds 98
A combined targeted/phenotypic approach for the identification of new antiangiogenics agents active on a zebrafish model: From in silico screening to cyclodextrin formulation 97
Toward the Discovery of Novel Anti-HIV Drugs. Second-Generation Inhibitors of the Cellular ATPase DDX3 with Improved Anti-HIV Activity: Synthesis, Structure-Activity Relationship Analysis, Cytotoxicity Studies, and Target Validation 97
Microwave-Assisted Acylation of Amines, Alcohols, and Phenols by the Use of Solid-Supported Reagents (SSRs) 97
Computational techniques are valuable tools for the discovery of protein–protein interaction inhibitors: The 14-3-3σ case 96
Crystal Structure of HIV-1 Reverse Transcriptase Bound to a Non-Nucleoside Inhibitor with a Novel Mechanism of Action 96
Bithiazole inhibitors of PI4KB show broad-spectrum antiviral activity against different viral families 95
New 4-substituted derivatives of pyrazolo[3,4-d]pyrimidines and pyrrolo[2,3-d]pyrimidines and uses thereof 95
Vascular Endothelial Growth Factor (VEGF) receptors: drugs and new inhibitors 94
Synthesis, Biological Activity, and ADME Properties of Novel S-DABOs/N-DABOs as HIV Reverse Transcriptase Inhibitors 94
Molecular Characterization of c-Abl/c-Src Kinase Inhibitors Targeted against Murine Tumour Progenitor Cells that Express Stem Cell Markers 93
Exploring the synthesis of masked phosphoramido 6-vinylcytidine derivatives as building blocks for cross-linking oligonucleotides 92
Stereoselective synthesis of N1-6-methyluridine and related 2-substituted analogues 91
Nucleoside Derivatives of 2,6-Diaminopurine Antivirals: Base-Modified Nucleosides with Broad-Spectrum Antimicrobial Properties 90
Identification of Potent c-Src Inhibitors Strongly Affecting the Proliferation of Human Neuroblastoma Cells 89
A Combination Strategy to Inhibit Pim-1: Synergism between Noncompetitive and ATP-Competitive Inhibitors 89
Synthesis and biological evaluation of new enantiomerically pure azole derivatives as inhibitors of Mycobacterium tuberculosis 89
Towards novel S-DABOC inhibitors: Synthesis, biological investigation, and molecular modeling studies 89
Pyazolopyrimidines: old molecules, new targets 89
Combining X-ray crystallography and molecular modeling toward the optimization of pyrazolo[3,4-d ]pyrimidines as potent c-Src inhibitors active in vivo against neuroblastoma 88
Discovery of Chiral Cyclopropyl Dihydro-Alkylthio-Benzyl-Oxopyrimidine (S-DABO) Derivatives as Potent HIV-1 Reverse Transcriptase Inhibitors with High Activity Against Clinically Relevant Mutants 88
Synthesis of reactive cytidine derivatives as building blocks for cross-linking oligonucleotides 87
Homology Modeling, Validation and Dynamics of the G Protein-coupled Estrogen Receptor 1 (GPER-1) 84
Su1816–Protection by Ccr6 Blockade in a Murine Model of Crohn’s Disease 83
Pyrazolo[3,4-d]pyrimidine Prodrugs: Strategic Optimization of the Aqueous Solubility of Dual Src/Abl Inhibitors 83
Practical One-Pot Two-Step Protocol for the Microwave-Assisted Synthesis of Highly Functionalized Rhodanine Derivatives 83
Recent highlights in the synthesis of highly functionalized pyrimidines 83
Preclinical discovery and development of maraviroc for the treatment of HIV 82
The fight against AIDS: new avenues for inhibiting reverse transcriptase (RT), an old target 82
Studies on the ATP Binding Site of Fyn Kinase for the Identification of New Inhibitors and Their Evaluation as Potential Agents against Tauopathies and Tumors 81
Unconventional plasticity of hiv-1 reverse transcriptase: How inhibitors could open a connection "gate" between allosteric and catalytic sites 81
Design, Synthesis, and Biological Evaluation of Pyrazolo[3,4-d]pyrimidines Active in Vivo on the Bcr-Abl T315I Mutant 79
Targeting PI4KB and Src/Abl host kinases as broad-spectrum antiviral strategy: Myth or real opportunity? 77
Rethinking the old antiviral drug moroxydine: Discovery of novel analogues as anti-hepatitis C virus (HCV) agents 76
4-Trifluoromethyl bithiazoles as broad-spectrum antimicrobial agents for virus-related bacterial infections or co-infections 74
CYP-dependent metabolism of antitumor pyrazolo[3,4-d]pyrimidine derivatives is characterized by an oxidative dechlorination reaction 74
Insight into the allosteric inhibition of Abl kinase 73
HIV-1 RT Inhibitors with a Novel Mechanism of Action: NNRTIs that Compete with the Nucleotide Substrate 71
Microwave assisted domino reactions of propargylamines with isothiocyanates: selective synthesis of 2-aminothiazoles and 2-amino-4-methylenethiazolines 67
A Microwave‐Assisted One‐Pot Three‐Step Metal‐Free [4+2] Annulation for the Sustainable Synthesis of Highly Substituted 1,2,4‐Triazines 67
Effects of CCL20/CCR6 modulators in a T cell adoptive transfer model of colitis 66
Totale 10.591
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Categoria #
all - tutte 39.810
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 39.810
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021332 0 0 0 0 0 15 43 52 121 21 73 7
2021/2022539 7 14 15 36 39 72 48 91 28 18 13 158
2022/20231.840 192 186 130 136 140 219 34 123 587 9 58 26
2023/2024680 44 79 26 26 59 132 41 65 15 25 47 121
2024/20252.489 137 114 194 124 273 212 116 145 223 210 301 440
2025/20262.974 471 465 804 408 751 75 0 0 0 0 0 0
Totale 11.074