IRIS
RADI, Marco
 Distribuzione geografica
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Continente #
NA - Nord America 3.172
EU - Europa 2.311
AS - Asia 2.073
SA - Sud America 259
AF - Africa 118
Continente sconosciuto - Info sul continente non disponibili 4
Totale 7.937
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Nazione #
US - Stati Uniti d'America 3.097
CN - Cina 926
SG - Singapore 579
IE - Irlanda 477
SE - Svezia 477
IT - Italia 397
DE - Germania 258
BR - Brasile 240
HK - Hong Kong 230
FI - Finlandia 215
TR - Turchia 192
UA - Ucraina 126
NL - Olanda 122
CI - Costa d'Avorio 97
IN - India 67
RU - Federazione Russa 65
CA - Canada 58
FR - Francia 51
GB - Regno Unito 38
BE - Belgio 17
ES - Italia 17
KR - Corea 16
AT - Austria 12
CZ - Repubblica Ceca 12
ID - Indonesia 10
AR - Argentina 8
MX - Messico 8
JP - Giappone 7
ZA - Sudafrica 7
BD - Bangladesh 6
IQ - Iraq 6
PK - Pakistan 6
NG - Nigeria 5
NP - Nepal 5
RS - Serbia 5
SK - Slovacchia (Repubblica Slovacca) 5
CO - Colombia 4
EU - Europa 4
JM - Giamaica 4
VN - Vietnam 4
DK - Danimarca 3
EG - Egitto 3
GR - Grecia 3
LB - Libano 3
PL - Polonia 3
SA - Arabia Saudita 3
UZ - Uzbekistan 3
AE - Emirati Arabi Uniti 2
EC - Ecuador 2
HN - Honduras 2
MA - Marocco 2
OM - Oman 2
PE - Perù 2
SD - Sudan 2
VE - Venezuela 2
AM - Armenia 1
BY - Bielorussia 1
CH - Svizzera 1
CL - Cile 1
CR - Costa Rica 1
DO - Repubblica Dominicana 1
DZ - Algeria 1
KG - Kirghizistan 1
KH - Cambogia 1
KW - Kuwait 1
KZ - Kazakistan 1
LT - Lituania 1
LU - Lussemburgo 1
LV - Lettonia 1
MD - Moldavia 1
NO - Norvegia 1
PA - Panama 1
PH - Filippine 1
RW - Ruanda 1
SI - Slovenia 1
Totale 7.937
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Città #
Chandler 488
Dublin 475
Singapore 341
Jacksonville 285
Santa Clara 279
Hong Kong 229
Ashburn 205
Beijing 201
Dearborn 174
Izmir 171
Boardman 142
Ann Arbor 140
Nanjing 137
Parma 127
Abidjan 97
Princeton 88
Chicago 70
Wilmington 63
Shenyang 62
Grafing 56
Jinan 56
Hefei 52
Bengaluru 50
San Mateo 48
The Dalles 48
Helsinki 44
Moscow 43
Toronto 42
Nanchang 40
New York 38
Council Bluffs 37
Hebei 36
Woodbridge 36
Kunming 33
Seattle 30
Jiaxing 29
Shanghai 29
Tianjin 29
Changsha 28
Des Moines 28
Bologna 24
Guangzhou 24
Hangzhou 22
Columbus 21
Munich 20
Falls Church 18
Milan 18
Zhengzhou 16
Brooklyn 15
Haikou 15
Brussels 14
Fuzhou 13
Lanzhou 13
Turku 13
Dallas 12
São Paulo 12
Bremen 11
Düsseldorf 11
London 11
Los Angeles 11
Nuremberg 11
Taiyuan 11
Houston 10
Kocaeli 10
Montreal 10
Taizhou 10
Ningbo 9
Fremont 8
Amsterdam 7
Belo Horizonte 7
Istanbul 7
Jakarta 7
Norwalk 7
Pavia 7
Barcelona 6
Cagliari 6
Frankfurt am Main 6
Redwood City 6
Solaro 6
Vienna 6
Brasília 5
Bratislava 5
Brno 5
Curitiba 5
Franca 5
Lagos 5
Modena 5
Rio de Janeiro 5
Rovato 5
Seongnam 5
Seoul 5
Tulsa 5
Altidona 4
Amritsar 4
Campinas 4
Caxias do Sul 4
Charlotte 4
Chengdu 4
Chongqing 4
Goiânia 4
Totale 5.169
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Nome #
The in silico drug discovery toolbox: applications in lead discovery and optimization 185
Bithiazole Inhibitors of Phosphatidylinositol 4-Kinase (PI4KIIIβ) as Broad-Spectrum Antivirals Blocking the Replication of SARS-CoV-2, Zika Virus, and Human Rhinoviruses 136
Multi-Target CFTR Modulators Endowed with Multiple Beneficial Side Effects for Cystic Fibrosis Patients: Toward a Simplified Therapeutic Approach 129
A cascade screening approach for the identification of Bcr-Abl myristate pocket binders active against wild type and T315I mutant 117
ATP-Competitive Inhibitors of mTOR: An Update 116
Probing the Reactivity of 2,4-Dichlorofuro[3,4-d ]pyrimidin-7-one: A Versatile and Underexploited Scaffold to Generate Substituted or Fused Pyrimidine Derivatives 115
Scaffold Morphing Approach To Expand the Toolbox of Broad-Spectrum Antivirals Blocking Dengue/Zika Replication 112
Identification of 4-amino-2-Pyridones as new potent PCSK9 inhibitors: From phenotypic hit discovery to in vivo tolerability 110
Probing the effects of MR120 in preclinical chronic colitis: A first-in-class anti-IBD agent targeting the CCL20/CCR6 axis 109
Discovery and SAR of 1,3,4-thiadiazole derivatives as potent Abl tyrosine kinase inhibitors and cytodifferentiating agents 107
Biologically Driven Synthesis of Pyrazolo[3,4-d]pyrimidines As Protein Kinase Inhibitors: An Old Scaffold As a New Tool for Medicinal Chemistry and Chemical Biology Studies 107
Microwave-enhanced Sonogashira coupling reaction of substituted pyrimidinones and pyrimidine nucleosides 106
System-Oriented Optimization of Multi-target 2,6-Diaminopurine Derivatives: Easily Accessible Broad-Spectrum Antivirals Active Against Flaviviruses, Influenza Virus and SARS-CoV-2 103
Towards new methodologies for the synthesis of biologically interesting 6-substituted pyrimidines and 4(3H)-pyrimidinones 102
Exploring the chemical space around the privileged pyrazolo[3,4-d] pyrimidine scaffold: Toward novel allosteric inhibitors of T315I-mutated Abl 101
Synthesis, biological evaluation, and SAR study of novel pyrazole analogues as inhibitors of Mycobacterium tuberculosis: Part 2. Synthesis of rigid pyrazolones 101
Targeting the Human DEAD-Box Polypeptide 3 (DDX3) RNA Helicase as a Novel Strategy to Inhibit Viral Replication 99
Src Kinase Inhibitors: An Update on Patented Compounds 98
Drug repurposing approaches to fight Dengue virus infection and related diseases 97
6-Vinyl pyrimidine and pyrimidinone derivatives and the use thereof 94
Discovery of small-molecule targeting the CCL20/CCR6 axis as first-in-class inhibitors for inflammatory bowel diseases 93
A one-pot, two-step microwave-assisted synthesis of highly functionalized benzoxazoles using solid-supported reagents (SSRs) 93
New insights into small-molecule inhibitors of Bcr-Abl 93
Troxacitabine Prodrugs for Pancreatic Cancer 93
Synthesis, biological evaluation and SAR study of novel pyrazole analogues as inhibitors of Mycobacterium tuberculosis 92
Synthesis of novel non-nucleoside and nucleoside derivatives as potential HIV-1 inhibitors 91
Synthesis of an Original Oxygenated Taxuspine X Analogue: a Versatile “Non-Natural” Natural Product with Remarkable P-gp Modulating Activity 90
Design and Synthesis of Thiadiazoles and Thiazoles Targeting the Bcr-Abl T315I Mutant: from Docking False Positives to ATP-Noncompetitive Inhibitors 88
4-Amino-Substituted Pyrazolo[3,4-d]Pyrimidines: Synthesis and Biological Properties 87
Solid-phase synthesis (SPS) of substituted uracils via Oxone® cleavage methodology 87
C6-Unsubstituted Pyrazolo[3,4-d]pyrimidines Are Dual Src/Abl Inhibitors Effective against Imatinib Mesylate Resistant Chronic Myeloid Leukemia Cell Lines 86
In Vitro Optimization of Non-Small Cell Lung Cancer Activity with Troxacitabine,l-1,3-Dioxolane-cytidine, Prodrugs 86
Microwave-assisted organocatalytic multicomponent Knoevenagel/hetero Diels–Alder reaction for the synthesis of 2,3-dihydropyran[2,3-c]pyrazoles 85
Dual Src and Abl inhibitors target wild type Abl and the AblT315I Imatinib-resistant mutant with different mechanisms 83
Derivati 1,3,4-tiadiazolici metodi di preparazione e uso di essi 83
Synthesis of enantiomerically pure α-[4-(1-substituted)-1,2,3-triazol-4-yl]-benzylacetamides via microwave-assisted click chemistry: towards new potential antimicrobial agents 83
A Multidisciplinary Approach for the Identification of Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: S-DABOCs and DAVPs 82
Allosteric Inhibitors of Bcr-Abl: Towards Novel Myristate-Pocket Binders 80
A Convergent Approach for the Synthesis of Ara-Neplanocin a Analogues Under Subzero Microwave Assisted Conditions 80
Deciphering Imidazoline Off-targets by Fishing in the Class A of GPCR field 80
Compounds with DDX3 inhibitory activity and uses thereof 79
Discovery of Multitarget Antivirals Acting on Both the Dengue Virus NS5-NS3 Interaction and the Host Src/Fyn Kinases 79
Computational techniques are valuable tools for the discovery of protein–protein interaction inhibitors: The 14-3-3σ case 78
Design, Synthesis, Biological Activity, and ADME Properties of Pyrazolo[3,4-d]pyrimidines Active in Hypoxic Human Leukemia Cells: A Lead Optimization Study 77
Discovery of Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase Competing with the Nucleotide Substrate 77
Parallel Solution-Phase Synthesis of 4-Dialkylamino-2-methylsulfonyl-6-vinylpyrimidines 77
A Versatile Route to C-6 Arylmethyl-FunctionalizedS-DABO and Related Analogues 77
Discovery of Multitarget Agents Active as Broad-Spectrum Antivirals and Correctors of Cystic Fibrosis Transmembrane Conductance Regulator for Associated Pulmonary Diseases 77
Stereoselective synthesis of N1-6-methyluridine and related 2-substituted analogues 76
Crystal structure of HIV-1 reverse transcriptase bound to a nucleotide-competitive reverse transcriptase inhibitor and the use thereof 76
Crystal Structure of HIV-1 Reverse Transcriptase Bound to a Non-Nucleoside Inhibitor with a Novel Mechanism of Action 76
Pyazolopyrimidines: old molecules, new targets 75
Towards Innovative Antibacterial Correctors for Cystic Fibrosis Targeting the Lung Microbiome with a Multifunctional Effect 74
Arylation of 2-Furyl 4-Fluorophenyl Ketone: An Extension of Heck Chemistry towards Novel Integrase Inhibitors 74
New 4-substituted derivatives of pyrazolo[3,4-d]pyrimidines and pyrrolo[2,3-d]pyrimidines and uses thereof 74
A one-pot two-step microwave-assisted synthesis of N1-substituted 5,6-ring-fused 2-pyridones 74
Toward the Discovery of Novel Anti-HIV Drugs. Second-Generation Inhibitors of the Cellular ATPase DDX3 with Improved Anti-HIV Activity: Synthesis, Structure-Activity Relationship Analysis, Cytotoxicity Studies, and Target Validation 74
Microwave-Assisted Acylation of Amines, Alcohols, and Phenols by the Use of Solid-Supported Reagents (SSRs) 74
Exploring the synthesis of masked phosphoramido 6-vinylcytidine derivatives as building blocks for cross-linking oligonucleotides 74
Vascular Endothelial Growth Factor (VEGF) receptors: drugs and new inhibitors 73
Molecular Characterization of c-Abl/c-Src Kinase Inhibitors Targeted against Murine Tumour Progenitor Cells that Express Stem Cell Markers 73
A multicomponent pharmacophore fragment-decoration approach to identify selective LRRK2-targeting probes 73
Synthesis of reactive cytidine derivatives as building blocks for cross-linking oligonucleotides 71
Synthesis, Biological Activity, and ADME Properties of Novel S-DABOs/N-DABOs as HIV Reverse Transcriptase Inhibitors 71
Identification of Broad-Spectrum Dengue/Zika Virus Replication Inhibitors by Functionalization of Quinoline and 2,6-Diaminopurine Scaffolds 70
Identification of Breast Cancer Inhibitors Specific for G Protein-Coupled Estrogen Receptor (GPER)-Expressing Cells 70
Studies on the ATP Binding Site of Fyn Kinase for the Identification of New Inhibitors and Their Evaluation as Potential Agents against Tauopathies and Tumors 69
A Domino Microwave-Assisted Protocol for the Synthesis of 2,6-Disubstituted Pyrimidinones 69
Combining X-ray crystallography and molecular modeling toward the optimization of pyrazolo[3,4-d ]pyrimidines as potent c-Src inhibitors active in vivo against neuroblastoma 68
The fight against AIDS: new avenues for inhibiting reverse transcriptase (RT), an old target 67
Synthesis and biological evaluation of new enantiomerically pure azole derivatives as inhibitors of Mycobacterium tuberculosis 66
Towards novel S-DABOC inhibitors: Synthesis, biological investigation, and molecular modeling studies 66
Nucleoside Derivatives of 2,6-Diaminopurine Antivirals: Base-Modified Nucleosides with Broad-Spectrum Antimicrobial Properties 65
Pyrazolo[3,4-d]pyrimidine Prodrugs: Strategic Optimization of the Aqueous Solubility of Dual Src/Abl Inhibitors 65
A combined targeted/phenotypic approach for the identification of new antiangiogenics agents active on a zebrafish model: From in silico screening to cyclodextrin formulation 64
A Combination Strategy to Inhibit Pim-1: Synergism between Noncompetitive and ATP-Competitive Inhibitors 64
Unconventional plasticity of hiv-1 reverse transcriptase: How inhibitors could open a connection "gate" between allosteric and catalytic sites 64
A combined ligand- and structure-based approach for the identification of rilmenidine-derived compounds which synergize the antitumor effects of doxorubicin 64
Homology Modeling, Validation and Dynamics of the G Protein-coupled Estrogen Receptor 1 (GPER-1) 64
Identification of Potent c-Src Inhibitors Strongly Affecting the Proliferation of Human Neuroblastoma Cells 63
Insight into the allosteric inhibition of Abl kinase 63
Discovery of Chiral Cyclopropyl Dihydro-Alkylthio-Benzyl-Oxopyrimidine (S-DABO) Derivatives as Potent HIV-1 Reverse Transcriptase Inhibitors with High Activity Against Clinically Relevant Mutants 63
Recent highlights in the synthesis of highly functionalized pyrimidines 63
A microwave-assisted multicomponent protocol for the synthesis of benzofuran-2-carboxamides 63
Benzofuran-2-Carboxamide Derivatives as Immunomodulatory Agents Blocking the CCL20-Induced Chemotaxis and Colon Cancer Growth 62
Multicomponent Synthesis of Purines and Pyrimidines: From the Origin of Life to New Sustainable Approaches for Drug-Discovery Applications 62
Rethinking the old antiviral drug moroxydine: Discovery of novel analogues as anti-hepatitis C virus (HCV) agents 62
An alternative synthetic approach for the synthesis of biologically relevant 1,4-disubstituted pyrazolo[3,4-d]pyrimidines 62
Design, Synthesis, and Biological Evaluation of Pyrazolo[3,4-d]pyrimidines Active in Vivo on the Bcr-Abl T315I Mutant 61
Practical One-Pot Two-Step Protocol for the Microwave-Assisted Synthesis of Highly Functionalized Rhodanine Derivatives 61
Preclinical discovery and development of maraviroc for the treatment of HIV 59
CYP-dependent metabolism of antitumor pyrazolo[3,4-d]pyrimidine derivatives is characterized by an oxidative dechlorination reaction 56
HIV-1 RT Inhibitors with a Novel Mechanism of Action: NNRTIs that Compete with the Nucleotide Substrate 55
Microwave assisted domino reactions of propargylamines with isothiocyanates: selective synthesis of 2-aminothiazoles and 2-amino-4-methylenethiazolines 55
Discovery of the first small molecule inhibitor of human DDX3 specifically designed to target the RNA binding site: Towards the next generation HIV-1 inhibitors 54
eHydrogenation: Hydrogen-free Electrochemical Hydrogenation 48
Su1816–Protection by Ccr6 Blockade in a Murine Model of Crohn’s Disease 46
Bithiazole inhibitors of PI4KB show broad-spectrum antiviral activity against different viral families 40
4-Trifluoromethyl bithiazoles as broad-spectrum antimicrobial agents for virus-related bacterial infections or co-infections 40
Late-stage functionalization of the 4-amino-2-pyridone chemotype using electrochemical and MCR approaches 33
Totale 7.948
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Categoria #
all - tutte 30.897
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 30.897
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/202075 0 0 0 0 0 0 0 0 0 0 0 75
2020/2021524 5 63 12 14 98 15 43 52 121 21 73 7
2021/2022539 7 14 15 36 39 72 48 91 28 18 13 158
2022/20231.840 192 186 130 136 140 219 34 123 587 9 58 26
2023/2024680 44 79 26 26 59 132 41 65 15 25 47 121
2024/20252.430 137 114 194 124 273 212 116 145 223 210 301 381
Totale 8.041