A series of novel enantiomerically pure azole derivatives was synthesized. The new compounds, bearing both an imidazole as well as a triazole moiety, were evaluated as antimycobacterial agents. One of them proved to have activity against Mycobaterium tuberculosis comparable to those of the classical antibacterial/antifungal drugs Econazole and Clotrimazole.
Synthesis and biological evaluation of new enantiomerically pure azole derivatives as inhibitors of Mycobacterium tuberculosis / Daniele Castagnolo;Marco Radi;Filippo Dessì;Fabrizio Manetti;Manuela Saddi;Rita Meleddu;Alessandro De Logu;Maurizio Botta. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - 19(2009), pp. 2203-2205. [10.1016/j.bmcl.2009.02.101]