CINECA IRIS Institutional Research Information System

Increased dose of dolutegravir as a potential rescue therapy in multi-experienced patients.

BACKGROUND: The pilot Phase IIb VIKING study suggested that dolutegravir (DTG), an HIV integrase inhibitor (INI), is efficacious in INI-resistant patients at the 50 mg twice-daily dose. However, DTG response was most reduced in subjects carrying resistance-associated mutations at pos...

Quality of life in idiopathic pulmonary fibrosis: The impact of sleep disordered breathing

Purpose: the study aims at describing the role of sleep disordered breathing (SDB) on daytime symptoms, quality of sleep and quality of life (QoL) in patients with moderate-severe IPF. Methods: we enrolled 34 consecutive room air breathing IPF outpatients who received a full-night ...

Reactive slow waves in sleep underlying several physiological and pathological NREM conditions.Comments on Flamand, et al. Sleep 2018;41(10). doi:10.1093/sleep/zsy139

Larix decidua δ18O tree-ring cellulose mainly reflects the isotopic signature of winter snow in a high-altitude glacial valley of the European Alps

We analyzed the chronologies of cellulose stable isotopes (δ13C and δ18O) and tree-ring widths from European larch (Larix decidua) in a high-altitude site (2190�m�a.s.l.) at the bottom of a glacial valley in the Italian Alps, and investigated their dependence on monthly meteorological v...