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Epigenetic profiles of tissue informative CpGs inform ALS disease status and progression

Background: Cell-free DNA (cfDNA), derived from dying cells, has demonstrated utility across multiple clinical applications. However, its potential in neurodegenerative diseases remains underexplored, with most existing cfDNA technologies tailored to specific disease contexts like cancer or non-invasive prenatal screening. Methods: To address this gap, we developed a novel approach to characterize epigenetic cfDNA profiles by identifying key regions of DNA methylation that reveal the tissues ...

Sex differences in congenital hereditary endothelial dystrophy (CHED) and Slc4a11−/− mouse model of CHED

Background: Sex differences have been described in several corneal diseases such as Fuchs endothelial corneal dystrophy and keratoconus, with estrogens implicated in the induction of these differences. Here, we report the identification of sex differences in a cohort of 177 individuals with Corneal Hereditary Endothelial Dystrophy (CHED), a rare corneal endothelial dystrophy associated with biallelic SLC4A11 gene mutations, and in a Slc4a11−/− mouse model of CHED. Methods: Central corneal thi...

Dysregulated DNA Methylation in Abca4-/- Retinal Pigment Epithelium: Insights into Early Stage of Stargardt Disease

Stargardt disease (STGD1), the most common inherited juvenile macular degeneration, is caused by biallelic mutations in the ABCA4 gene. Currently, there is no approved treatment. In this study, we investigated early-stage epigenomic changes in the retinal pigment epithelium (RPE) of Abca4-/- mice, a well-established model of STGD1. Reduced representation bisulfite sequencing (RRBS) revealed hypermethylation of gene regions associated with disease-related pathways, implicating methyl-CpG-bindi...

Whole genome sequence of the syntrophic fatty acid-degrading bacterium Syntrophomonas curvata GB8-1T

The syntrophic fatty acid-degrading bacterium Syntrophomonas curvata strain GB8-1T, isolated from anaerobic granular sludge, metabolizes C4-C18 fatty acids when grown with a suitable hydrogenotrophic partner. The complete genome sequence data provide insight into syntrophic fatty acid compound degradation under thermodynamically limiting conditions when exogenous electron acceptors are absent.

∂∂¯-lemma and Bott–Chern cohomology of twistor spaces

In the paper we study the Bott-Chern and Aeppli cohomologies of the twistor space of a compact self-dual 4-manifold and we characterize the validity of the 88-lemma. We also compute explicitly the Dolbeault cohomology of the twistor space Z of the flat 4-dimensional torus, which is known to not satisfy the 88 lemma. (c) 2026 The Author(s). Published by Elsevier GmbH. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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