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Biomimetic ceramic-based hybrid coatings for controlling mammalian cell and bacterial adhesion

Surface wettability and surface energy are important factors influencing the interaction between cells and surfaces. These properties determine the behavior of cells, including their adhesion, proliferation and differentiation on various materials, which is essential in designing biomaterials for tissue engineering or medical implants. In particular, the surface energy dictates the extent of cell-surface contact, while surface wettability affects the distribution of proteins and other biologi...

Target fishing in the “kinome”: integrated in silico/in vitro discovery of novel kinase inhibitory activities of alternariol

Alternariol (AOH), an emerging mycotoxin produced by Alternaria species, is a frequent contaminant of plant-derived foods and a major contributor to chronic dietary exposure to Alternaria toxins. Despite evidence of its cytotoxic, genotoxic, endocrine-disrupting, and immunomodulatory effects, its molecular mechanisms of toxicity remain incompletely understood, limiting mechanistically informed risk assessment. As evidence suggests that AOH acts as a multi-kinase inhibitor, this study aimed to...

Mechanical and Environmental Performance of Circular Concrete with Recycled Aggregates from Composite Material Waste

The construction sector has a significant environmental footprint, primarily due to its extensive use of natural resources. In the context of ongoing efforts to promote resource efficiency and reduce the consumption of nonrenewable materials, this study explores the physical, mechanical, and environmental performance of a circular concrete incorporating recycled aggregates derived from sink manufacturing waste consisting of a composite material that would otherwise be disposed of in landfills...

Porcine intestinal barrier adaptive responses to hyperosmolarity differ in relation to the in vitro environment and epithelial cell differentiation

Background The gastrointestinal tract is crucial for absorption and defence against pathogens due to a dynamic epithelium. During weaning, the pig intestine is sensitive to environmental, infectious, and osmotic stressors, which alter tight junctions (TJ), thus increasing epithelial permeability and the risk of dysfunction. The objective of the study was to investigate the intestinal epithelial barrier (IEB) response in the porcine IPEC-J2 cell line under two conditions: (1) non-stabilized m...

Integrated transcriptomic profiling reveals oncogenic pathways and chimeric transcripts in equine sarcoid lesions with predominant BPV1 detection

Sarcoids are the most common cutaneous tumors in horses, representing up to 90% (35%-90%) of skin neoplasms. Mostly caused by Bovine Papillomavirus (BPVs) infections, sarcoids are highly resistant to therapy and prone to recurring, posing a significant threat to equine health. The aim of this study is to explore molecular pathogenetic mechanisms underlying the development of equine sarcoids, by applying transcriptomic approach. After testing samples for viral DNA, both mRNA and small RNA expr...

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