A practical microwave-assisted protocol for the synthesis of 2,6-disubstituted pyrimidinones has been developed. This approach is based on a domino Michael addition-cyclocondensation reaction between substituted thioureas/guanidines and acetylenecarboxylates. The application of such protocol for the synthesis of not easily accessible N-DABO derivatives as potential antiviral agents is also reported.
A Domino Microwave-Assisted Protocol for the Synthesis of 2,6-Disubstituted Pyrimidinones / Marco Radi; Gianni Casaluce; Maurizio Botta. - In: SYNLETT. - ISSN 0936-5214. - 2011(2011), pp. 1997-2000. [10.1055/s-0030-1261174]
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