A convergent strategy for the synthesis of ara-neplanocin A analogues has been developed. Microwave assisted Mitsunobu reaction proved to be an essential tool both for the 2' - hydroxy inversion and for the coupling reaction with the heterocyclic bases. The exploitation of the present approach allowed generating a family of ara-neplanocins which biological potential is still unexplored.
A Convergent Approach for the Synthesis of Ara-Neplanocin a Analogues Under Subzero Microwave Assisted Conditions / Marco Radi;Jagadeeshwar R. Rao;Ashok K. Jha;Chung K. Chu. - In: NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS. - ISSN 1525-7770. - 28(2009), pp. 504-518. [10.1080/15257770903044143]