A versatile approach for the synthesis of 1,4-disubstituted pyrazolo[3,4-d]pyrimidines has been developed. Starting from commercially available allopurinol, TBAF mediated N1-functionalization and subsequent C4 nucleophilic substitution, under microwave assisted- or standard heating conditions, granted access to highly functionalized pyrazolo[3,4-d]pyrimidines of potential biological interest.
An alternative synthetic approach for the synthesis of biologically relevant 1,4-disubstituted pyrazolo[3,4-d]pyrimidines / Radi, Marco; Vincenzo, Bernardo; Giulia, Vignaroli; Annalaura, Brai; Mariangela, Biava; Silvia, Schenone; Maurizio, Botta. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - 54:(2013), pp. 5204-5206. [10.1016/j.tetlet.2013.07.069]
An alternative synthetic approach for the synthesis of biologically relevant 1,4-disubstituted pyrazolo[3,4-d]pyrimidines
RADI, Marco;
2013-01-01
Abstract
A versatile approach for the synthesis of 1,4-disubstituted pyrazolo[3,4-d]pyrimidines has been developed. Starting from commercially available allopurinol, TBAF mediated N1-functionalization and subsequent C4 nucleophilic substitution, under microwave assisted- or standard heating conditions, granted access to highly functionalized pyrazolo[3,4-d]pyrimidines of potential biological interest.| File | Dimensione | Formato | |
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