A new class of non-nucleoside reverse transcriptase inhibitors with a 6-vinylpyrimidine scaffold (1) has been found to inhibit HIV-1 reverse transcriptase (RT) by competition with the nucleotide substrate after binding to the non-nucleoside inhibitor binding pocket of the enzyme. Molecular modeling studies have been performed to elucidate their peculiar behavior.
Discovery of Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase Competing with the Nucleotide Substrate / Giovanni Maga;Marco Radi;Samantha Zanoli;Fabrizio Manetti;Reynel Cancio;Ulrich Hübscher;Silvio Spadari;Chiara Falciani;Montserrat Terrazas;Jaume Vilarrasa;Maurizio Botta. - In: ANGEWANDTE CHEMIE. INTERNATIONAL EDITION. - ISSN 1433-7851. - 46(2007), pp. 1810-1813. [10.1002/anie.200604165]