A new class of non-nucleoside reverse transcriptase inhibitors with a 6-vinylpyrimidine scaffold (1) has been found to inhibit HIV-1 reverse transcriptase (RT) by competition with the nucleotide substrate after binding to the non-nucleoside inhibitor binding pocket of the enzyme. Molecular modeling studies have been performed to elucidate their peculiar behavior.

Discovery of Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase Competing with the Nucleotide Substrate / Giovanni Maga;Marco Radi;Samantha Zanoli;Fabrizio Manetti;Reynel Cancio;Ulrich Hübscher;Silvio Spadari;Chiara Falciani;Montserrat Terrazas;Jaume Vilarrasa;Maurizio Botta. - In: ANGEWANDTE CHEMIE. INTERNATIONAL EDITION. - ISSN 1433-7851. - 46:(2007), pp. 1810-1813. [10.1002/anie.200604165]

Discovery of Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase Competing with the Nucleotide Substrate

RADI, Marco;
2007

Abstract

A new class of non-nucleoside reverse transcriptase inhibitors with a 6-vinylpyrimidine scaffold (1) has been found to inhibit HIV-1 reverse transcriptase (RT) by competition with the nucleotide substrate after binding to the non-nucleoside inhibitor binding pocket of the enzyme. Molecular modeling studies have been performed to elucidate their peculiar behavior.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11381/2432279
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