A new class of non-nucleoside reverse transcriptase inhibitors with a 6-vinylpyrimidine scaffold (1) has been found to inhibit HIV-1 reverse transcriptase (RT) by competition with the nucleotide substrate after binding to the non-nucleoside inhibitor binding pocket of the enzyme. Molecular modeling studies have been performed to elucidate their peculiar behavior.

Discovery of Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase Competing with the Nucleotide Substrate / Giovanni, Maga; Radi, Marco; Samantha, Zanoli; Fabrizio, Manetti; Reynel, Cancio; Ulrich, Hübscher; Silvio, Spadari; Chiara, Falciani; Montserrat, Terrazas; Jaume, Vilarrasa; Maurizio, Botta. - In: ANGEWANDTE CHEMIE. INTERNATIONAL EDITION. - ISSN 1433-7851. - 46:(2007), pp. 1810-1813. [10.1002/anie.200604165]

Discovery of Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase Competing with the Nucleotide Substrate

RADI, Marco;
2007-01-01

Abstract

A new class of non-nucleoside reverse transcriptase inhibitors with a 6-vinylpyrimidine scaffold (1) has been found to inhibit HIV-1 reverse transcriptase (RT) by competition with the nucleotide substrate after binding to the non-nucleoside inhibitor binding pocket of the enzyme. Molecular modeling studies have been performed to elucidate their peculiar behavior.
2007
Discovery of Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase Competing with the Nucleotide Substrate / Giovanni, Maga; Radi, Marco; Samantha, Zanoli; Fabrizio, Manetti; Reynel, Cancio; Ulrich, Hübscher; Silvio, Spadari; Chiara, Falciani; Montserrat, Terrazas; Jaume, Vilarrasa; Maurizio, Botta. - In: ANGEWANDTE CHEMIE. INTERNATIONAL EDITION. - ISSN 1433-7851. - 46:(2007), pp. 1810-1813. [10.1002/anie.200604165]
File in questo prodotto:
File Dimensione Formato  
2007_Angew.pdf

non disponibili

Tipologia: Documento in Post-print
Licenza: NON PUBBLICO - Accesso privato/ristretto
Dimensione 433.43 kB
Formato Adobe PDF
433.43 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2432279
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 20
  • ???jsp.display-item.citation.isi??? 19
social impact