An efficient synthetic strategy has been developed to prepare an oxygenated analog of Taxuspine X. Macrocycle formation through Yamaguchi macrolactonization approach gave access to an original compound (18) showing remarkable P-gp modulating activity. Further functionalization of this versatile scaffold could lead to potential anticancer and/or MDR reversing agents.
Synthesis of an Original Oxygenated Taxuspine X Analogue: a Versatile “Non-Natural” Natural Product with Remarkable P-gp Modulating Activity / Avramova, S. t. a. n. i. s. l. a. v. a. . I.; Elena, Galletti; Renzulli, M. i. c. h. e. l. a. . L.; Gianluca, Giorgi; Gianpietro, Sgaragli; Daniela, Alderighi; Chiara, Ghiron; Federico, Corelli; Radi, Marco; Maurizio, Botta. - In: CHEMMEDCHEM. - ISSN 1860-7179. - 3:(2008), pp. 745-748. [10.1002/cmdc.200700337]
Synthesis of an Original Oxygenated Taxuspine X Analogue: a Versatile “Non-Natural” Natural Product with Remarkable P-gp Modulating Activity
RADI, Marco;
2008-01-01
Abstract
An efficient synthetic strategy has been developed to prepare an oxygenated analog of Taxuspine X. Macrocycle formation through Yamaguchi macrolactonization approach gave access to an original compound (18) showing remarkable P-gp modulating activity. Further functionalization of this versatile scaffold could lead to potential anticancer and/or MDR reversing agents.| File | Dimensione | Formato | |
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