A fast and efficient protocol for the generation of substituted 5-arylidene rhodanines in a sequential one-pot two-step process combining the "Holmberg method" and the Knoevenagel condensation under microwaveassisted conditions has been developed. The final compounds 11a-k have been obtained in high yield and purity after a simple precipitation from, methanol, making this procedure facile, practical, and rapid to execute.
Practical One-Pot Two-Step Protocol for the Microwave-Assisted Synthesis of Highly Functionalized Rhodanine Derivatives / Radi, Marco; Lorenzo, Botta; Gianni, Casaluce; Martina, Bernardini; Maurizio, Botta. - In: JOURNAL OF COMBINATORIAL CHEMISTRY. - ISSN 1520-4766. - 12:(2010), pp. 200-205. [10.1021/cc9001789]
Practical One-Pot Two-Step Protocol for the Microwave-Assisted Synthesis of Highly Functionalized Rhodanine Derivatives
RADI, Marco;
2010-01-01
Abstract
A fast and efficient protocol for the generation of substituted 5-arylidene rhodanines in a sequential one-pot two-step process combining the "Holmberg method" and the Knoevenagel condensation under microwaveassisted conditions has been developed. The final compounds 11a-k have been obtained in high yield and purity after a simple precipitation from, methanol, making this procedure facile, practical, and rapid to execute.File | Dimensione | Formato | |
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