A fast and efficient protocol for the generation of substituted 5-arylidene rhodanines in a sequential one-pot two-step process combining the "Holmberg method" and the Knoevenagel condensation under microwaveassisted conditions has been developed. The final compounds 11a-k have been obtained in high yield and purity after a simple precipitation from, methanol, making this procedure facile, practical, and rapid to execute.
Practical One-Pot Two-Step Protocol for the Microwave-Assisted Synthesis of Highly Functionalized Rhodanine Derivatives / Marco Radi;Lorenzo Botta;Gianni Casaluce;Martina Bernardini;Maurizio Botta. - In: JOURNAL OF COMBINATORIAL CHEMISTRY. - ISSN 1520-4766. - 12(2010), pp. 200-205. [10.1021/cc9001789]