A fast and efficient protocol for the generation of substituted 5-arylidene rhodanines in a sequential one-pot two-step process combining the "Holmberg method" and the Knoevenagel condensation under microwaveassisted conditions has been developed. The final compounds 11a-k have been obtained in high yield and purity after a simple precipitation from, methanol, making this procedure facile, practical, and rapid to execute.

Practical One-Pot Two-Step Protocol for the Microwave-Assisted Synthesis of Highly Functionalized Rhodanine Derivatives / Radi, Marco; Lorenzo, Botta; Gianni, Casaluce; Martina, Bernardini; Maurizio, Botta. - In: JOURNAL OF COMBINATORIAL CHEMISTRY. - ISSN 1520-4766. - 12:(2010), pp. 200-205. [10.1021/cc9001789]

Practical One-Pot Two-Step Protocol for the Microwave-Assisted Synthesis of Highly Functionalized Rhodanine Derivatives

RADI, Marco;
2010-01-01

Abstract

A fast and efficient protocol for the generation of substituted 5-arylidene rhodanines in a sequential one-pot two-step process combining the "Holmberg method" and the Knoevenagel condensation under microwaveassisted conditions has been developed. The final compounds 11a-k have been obtained in high yield and purity after a simple precipitation from, methanol, making this procedure facile, practical, and rapid to execute.
2010
Practical One-Pot Two-Step Protocol for the Microwave-Assisted Synthesis of Highly Functionalized Rhodanine Derivatives / Radi, Marco; Lorenzo, Botta; Gianni, Casaluce; Martina, Bernardini; Maurizio, Botta. - In: JOURNAL OF COMBINATORIAL CHEMISTRY. - ISSN 1520-4766. - 12:(2010), pp. 200-205. [10.1021/cc9001789]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2432262
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