A small family of S-DABO cytosine analogs (S-DABOCs) has been synthesized and biologically evaluated as HIV-1 inhibitor both on wild type (wt) and drug-resistant mutants leading to the identification of an interesting compound (5d). Molecular modeling studies have been finally performed in order to rationalize the results.
Towards novel S-DABOC inhibitors: Synthesis, biological investigation, and molecular modeling studies / Radi, Marco; Lucilla, Angeli; Luigi, Franchi; Lorenzo, Contemori; Giovanni, Maga; Alberta, Samuele; Samantha, Zanoli; Mercedes Armand, Ugon; Emmanuel, Gonzalez; Anuska, Llano; Jose A., Esté; Maurizio, Botta. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - 18:(2008), pp. 5777-5780. [10.1016/j.bmcl.2008.09.070]
Towards novel S-DABOC inhibitors: Synthesis, biological investigation, and molecular modeling studies
RADI, Marco;
2008-01-01
Abstract
A small family of S-DABO cytosine analogs (S-DABOCs) has been synthesized and biologically evaluated as HIV-1 inhibitor both on wild type (wt) and drug-resistant mutants leading to the identification of an interesting compound (5d). Molecular modeling studies have been finally performed in order to rationalize the results.| File | Dimensione | Formato | |
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