A small family of S-DABO cytosine analogs (S-DABOCs) has been synthesized and biologically evaluated as HIV-1 inhibitor both on wild type (wt) and drug-resistant mutants leading to the identification of an interesting compound (5d). Molecular modeling studies have been finally performed in order to rationalize the results.
Towards novel S-DABOC inhibitors: Synthesis, biological investigation, and molecular modeling studies / Marco Radi;Lucilla Angeli;Luigi Franchi;Lorenzo Contemori;Giovanni Maga;Alberta Samuele;Samantha Zanoli;Mercedes Armand-Ugon;Emmanuel Gonzalez;Anuska Llano;Jose A. Esté;Maurizio Botta. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - 18(2008), pp. 5777-5780. [10.1016/j.bmcl.2008.09.070]