Dengue is a mosquito-borne viral disease caused by four antigenically distinct serotypes of Dengue Virus (DENV), namely DENV1-4 and is currently considered the most important arthropod-born viral disease in the world. An effective antiviral therapy to treat Dengue Virus infection is still missing and a number of replicative cycle inhibitors are currently under study. Considering the rapid spreading of DENV and the common timeframe required for bringing a new drug on the market, the repurposing of approved drugs used for different diseases to identify novel inhibitors of this pathogen represents an attractive approach for a rapid therapeutic intervention. Herein, we will describe the most recent drug repurposing approaches to fight DENV infection and their implications in antiviral drug-discovery.

Drug repurposing approaches to fight Dengue virus infection and related diseases / Botta, Lorenzo; Rivara, Mirko; Zuliani, Valentina; Radi, Marco. - In: FRONTIERS IN BIOSCIENCE. - ISSN 1093-4715. - 23:(2018), pp. 997-1019.

Drug repurposing approaches to fight Dengue virus infection and related diseases

Rivara, Mirko;Zuliani, Valentina;Radi, Marco
2018

Abstract

Dengue is a mosquito-borne viral disease caused by four antigenically distinct serotypes of Dengue Virus (DENV), namely DENV1-4 and is currently considered the most important arthropod-born viral disease in the world. An effective antiviral therapy to treat Dengue Virus infection is still missing and a number of replicative cycle inhibitors are currently under study. Considering the rapid spreading of DENV and the common timeframe required for bringing a new drug on the market, the repurposing of approved drugs used for different diseases to identify novel inhibitors of this pathogen represents an attractive approach for a rapid therapeutic intervention. Herein, we will describe the most recent drug repurposing approaches to fight DENV infection and their implications in antiviral drug-discovery.
Drug repurposing approaches to fight Dengue virus infection and related diseases / Botta, Lorenzo; Rivara, Mirko; Zuliani, Valentina; Radi, Marco. - In: FRONTIERS IN BIOSCIENCE. - ISSN 1093-4715. - 23:(2018), pp. 997-1019.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2840450
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