IRIS
RIVARA, Silvia
 Distribuzione geografica
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Continente #
NA - Nord America 6.203
AS - Asia 4.875
EU - Europa 4.813
SA - Sud America 805
AF - Africa 252
OC - Oceania 4
Continente sconosciuto - Info sul continente non disponibili 2
Totale 16.954
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Nazione #
US - Stati Uniti d'America 6.028
SG - Singapore 2.039
CN - Cina 1.619
IT - Italia 1.002
FI - Finlandia 784
IE - Irlanda 687
SE - Svezia 654
BR - Brasile 650
DE - Germania 498
HK - Hong Kong 411
UA - Ucraina 332
VN - Vietnam 302
NL - Olanda 204
ZA - Sudafrica 166
TR - Turchia 162
GB - Regno Unito 151
CA - Canada 113
RU - Federazione Russa 109
FR - Francia 89
AT - Austria 79
IN - India 79
BE - Belgio 63
AR - Argentina 62
CI - Costa d'Avorio 51
PL - Polonia 42
MX - Messico 40
BD - Bangladesh 38
JP - Giappone 38
ID - Indonesia 37
ES - Italia 33
KR - Corea 30
CZ - Repubblica Ceca 26
EC - Ecuador 24
IQ - Iraq 22
PK - Pakistan 20
VE - Venezuela 17
CO - Colombia 13
JO - Giordania 13
MA - Marocco 11
PY - Paraguay 10
LT - Lituania 9
CL - Cile 8
EG - Egitto 8
PE - Perù 8
UZ - Uzbekistan 8
RO - Romania 7
KE - Kenya 6
UY - Uruguay 6
AE - Emirati Arabi Uniti 5
AZ - Azerbaigian 5
BO - Bolivia 5
DO - Repubblica Dominicana 5
HN - Honduras 5
IL - Israele 5
NP - Nepal 5
SA - Arabia Saudita 5
AL - Albania 4
EE - Estonia 4
PS - Palestinian Territory 4
RS - Serbia 4
TH - Thailandia 4
BY - Bielorussia 3
CY - Cipro 3
HR - Croazia 3
HU - Ungheria 3
LB - Libano 3
MD - Moldavia 3
NI - Nicaragua 3
SI - Slovenia 3
SK - Slovacchia (Repubblica Slovacca) 3
TN - Tunisia 3
AM - Armenia 2
BG - Bulgaria 2
BH - Bahrain 2
CR - Costa Rica 2
ET - Etiopia 2
GY - Guiana 2
JM - Giamaica 2
KG - Kirghizistan 2
KZ - Kazakistan 2
LU - Lussemburgo 2
LV - Lettonia 2
NO - Norvegia 2
OM - Oman 2
PA - Panama 2
PH - Filippine 2
PT - Portogallo 2
SY - Repubblica araba siriana 2
AO - Angola 1
BB - Barbados 1
BW - Botswana 1
CH - Svizzera 1
DK - Danimarca 1
DZ - Algeria 1
EU - Europa 1
GR - Grecia 1
IR - Iran 1
MK - Macedonia 1
MY - Malesia 1
NG - Nigeria 1
Totale 16.944
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Città #
Singapore 1.011
Chandler 711
Ashburn 710
Dublin 685
Dallas 592
Santa Clara 415
Beijing 411
Hong Kong 408
Jacksonville 383
Ann Arbor 350
Parma 332
Dearborn 270
Boardman 235
Nanjing 182
Johannesburg 153
Los Angeles 138
New York 138
Izmir 135
Princeton 135
Munich 134
Shanghai 125
Ho Chi Minh City 112
Hefei 109
Wilmington 103
San Mateo 86
Helsinki 71
Bremen 69
Columbus 68
Hanoi 67
Vienna 65
Toronto 62
Brussels 59
Shenyang 55
São Paulo 55
Moscow 54
Abidjan 51
Hebei 48
Bologna 47
Kunming 47
Nanchang 46
Jinan 45
Buffalo 43
The Dalles 41
Turku 41
Düsseldorf 40
Milan 38
Tokyo 38
Council Bluffs 37
Guangzhou 35
London 34
Changsha 31
Warsaw 31
Woodbridge 31
Frankfurt am Main 30
Modena 30
Seattle 30
Des Moines 29
Jiaxing 29
Jakarta 28
Seoul 28
Brescia 27
Houston 25
Chennai 23
Montreal 23
Pune 23
Phoenix 22
Stockholm 22
Tianjin 22
Brooklyn 20
Fremont 20
Rio de Janeiro 20
Belo Horizonte 19
Nuremberg 19
Ankara 18
Amsterdam 17
Zhengzhou 17
Norwalk 16
Chicago 15
Hangzhou 15
Da Nang 14
Denver 14
Dong Ket 14
Paris 14
Atlanta 13
Auburn Hills 13
Brno 13
Haiphong 13
Amman 12
San Francisco 12
Brasília 11
Boston 10
Campinas 10
Fuzhou 10
Grafing 10
Mexico City 10
Naples 10
Ottawa 10
Poplar 10
Redondo Beach 10
Trieste 10
Totale 10.242
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Nome #
Balancing reactivity and antitumor activity: heteroarylthioacetamide derivatives as potent and time-dependent inhibitors of EGFR 311
Benzisothiazolinone Derivatives as Potent Allosteric Monoacylglycerol Lipase Inhibitors That Functionally Mimic Sulfenylation of Regulatory Cysteines 237
Antidepressant-like activity and cardioprotective effects of fatty acid amide hydrolase inhibitor URB694 in socially stressed Wistar Kyoto rats 203
Discovery of a new 1-(phenylsulfonyl)-1H-indole derivative targeting the EphA2 receptor with antiproliferative activity on U251 glioblastoma cell line 196
2-Aminobenzimidazoles as new potent H3-antagonists 195
New Antimicrobials Targeting Bacterial RNA Polymerase Holoenzyme Assembly Identified with an in Vivo BRET-Based Discovery Platform 194
Analysis of Structure-Activity Relationships for MT2 Selective Antagonists by Melatonin MT1 and MT2 Receptor Models 193
Antidepressant-like effects of pharmacological inhibition of FAAH activity in socially isolated female rats 191
Social stress-induced depressive-like symptoms and changes in gut microbial and lipidomic profiles are prevented by pharmacological inhibition of FAAH activity in male rats 189
Irreversible Inhibition of Epidermal Growth Factor Receptor Activity by 3-Aminopropanamides. 189
Dibasic biphenyl H(3) receptor antagonists: Steric tolerance for a lipophilic side chain. 186
Chemical modification of NSC12 leads to a specific FGF-trap with antitumor activity in multiple myeloma 185
UniPR129 is a competitive small molecule Eph-ephrin antagonist blocking in vitro angiogenesis at low micromolar concentrations. 178
2-N-Acylaminoalkylindoles: Design and Quantitative Structure-Activity Relationship Studies Leading to MT2-Selective Melatonin Antagonists 176
Amino acid derivatives as palmitoylethanolamide prodrugs: Synthesis, in vitro metabolism and in vivo plasma profile in rats 170
Aminobenzimidazoles as new potent H3-antagonists 168
Combining ligand- and structure-based approaches for the discovery of new inhibitors of the EPHA2-ephrin-A1 interaction 166
Application of 3D-QSAR in the Rational Design of Receptor Ligands and Enzyme Inhibitors 164
Cardioprotective effects of fatty acid amide hydrolase inhibitor URB694, in a rodent model of trait anxiety 162
Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor. 161
Synthesis, biological activity, QSAR and QSPR study of 2/aminobenzimidazole derivatives as potent H3-antagonists 160
Novel Irreversible Epidermal Growth Factor Receptor Inhibitors by Chemical Modulation of the Cysteine-Trap Portion 158
Alchilammidi tricicliche: ligandi selettivi dei recettori melatoninergici MT1 e MT2 157
A sulfonyl fluoride derivative inhibits EGFR L858R/T790M/C797S by covalent modification of the catalytic lysine 157
Free-Energy Simulations Support a Lipophilic Binding Route for Melatonin Receptors 154
Chiral Recognition of Flexible Melatonin Receptor Ligands Induced by Conformational Equilibria 153
Biphenyl-3-yl alkylcarbamates as fatty acid amide hydrolase (FAAH) inhibitors: steric effects of N-alkyl chain on rat plasma and liver stability 152
The Role of HB-Donor Groups in the Heterocyclic Polar Fragment of H3-Antagonists. I. Synthesis and Biological Assays 150
N-Acylethanolamine Acid Amidase (NAAA): Mechanism of Palmitoylethanolamide Hydrolysis Revealed by Mechanistic Simulations 148
Validation of a histamine H3 receptor model through structure–activity relationships for classical H3 antagonists 146
Design and structure-activity relationship of amino acid derivatives of lithocholic acid as novel EphA2 antagonists 146
Synthesis, Structural Elucidation, and Biological Evaluation of NSC12, an Orally Available Fibroblast Growth Factor (FGF) Ligand Trap for the Treatment of FGF-Dependent Lung Tumors 144
Atropisomerism and Conformational Equilibria: Impact on PI3Kδ Inhibition of 2-((6-Amino-9H-purin-9-yl)methyl)-5-methyl-3-(o-tolyl)quinazolin-4(3H)-one (IC87114) and Its Conformationally Restricted Analogs 143
Discovery of novel FGF trap small molecules endowed with anti-myeloma activity 139
Dibasic non-imidazole histamine H3 receptor antagonists with a rigid byphenyl scaffold. 139
Chapter 9: Natural and Synthetic Agents That Target Intracellular Monoacylglycerol Lipase (MGL) Activity 138
Small molecules targeting the eubacterial β-sliding clamp discovered by combined in silico and in vitro screening approaches 137
Synthesis and 3D-QSAR Analysis of H3 Receptor Antagonists Containing a Neutral Heterocyclic Polar Group 135
QSAR study of 2-aminobenzimidazole derivatives as H3 antagonists 135
Cyclohexylcarbamic Acid 3'- or 4'-Substituted Biphenyl-3-yl Esters of as Fatty Acid Amide Hydrolase Inhibitors: Synthesis, Quantitative Structure-Activity Relationships and Molecular Modelling Studies 130
Design and structure-activity relationships of amino acid derivatives of lithocholic acid as novel EphA2 receptor antagonists. 130
N-(Anilinoethyl)amide Melatonergic Ligands with Improved Water Solubility and Metabolic Stability 130
Toward the Definition of Stereochemical Requirements for MT(2)-Selective Antagonists and Partial Agonists by Studying 4-Phenyl-2-propionamidotetralin Derivatives. 129
Epidermal Growth Factor Receptor Irreversible Inhibitors: Chemical Exploration of the Cysteine-Trap Portion 128
Δ5-Cholenoyl-amino acids as selective and orally available antagonists of the Eph-ephrin system 128
Comparative Analysis of Virtual Screening Approaches in the Search for Novel EphA2 Receptor Antagonists 126
Development of a GPCR model for SAR interpretation of classical and new H3 antagonists 126
Experimental and Theoretical Analysis of the Interaction of (±)-cis-Ketoconazole with b-Cyclodextrin in the presence of (+)-L-Tartaric Acid 122
APPLICATION OF COMPUTATIONAL METHODSTO THE DESIGN OF FATTY ACID AMIDE HYDROLASE(FAAH) INHIBITORS BASED ON A CARBAMICTEMPLATE STRUCTURE 122
2-Arylmelatonin analogues: Probing the 2-phenyl binding pocket of melatonin MT1 and MT2 receptors 121
N-(Anilinoethyl)amides: design and synthesis of metabolically stable, selective melatonin receptor ligands 120
Synthesis and biological assays of new H3-antagonists with imidazole and imidazoline polar groups 120
MT2 selective melatonin receptor antagonists: design and structure-activity relationships 119
Exploiting Free-Energy Minima to Design Novel EphA2 Protein-Protein Antagonists: From Simulation to Experiment and Return 119
Molecular Determinants of EphA2 and EphB2 Antagonism Enable the Design of Ligands with Improved Selectivity 118
Pharmacokinetics, pharmacodynamics and safety studies on URB937, a peripherally restricted fatty acid amide hydrolase inhibitor, in rats 117
Synthesis and structure-activity relationships for biphenyl H3 receptor antagonists with moderate anti-cholinesterase activity. 116
N-(2-Oxo-3-oxetanyl)carbamic Acid Esters as N-Acylethanolamine Acid Amidase Inhibitors: Synthesis, Structure–Activity and Structure–Property Relationships. 116
Anxiolytic effects of the melatonin MT2 receptor partial agonist UCM765: Comparison with melatonin and diazepam. 116
Metadynamics for perspective drug design: Computationally driven synthesis of new protein-protein interaction inhibitors targeting the EphA2 receptor 116
Synthesis, Enantiomeric Resolution, and Structure-Activity Relationship Study of a Series of 10,11-Dihydro-5H-Dibenzo[a,d]cycloheptene MT(2) Receptor Antagonists. 115
Design and synthesis of N-(3,3-diphenylpropenyl)alkanamides as a novel class of high-affinity MT2-selective melatonin receptor ligands. 114
Social stress contagion in rats: Behavioural, autonomic and neuroendocrine correlates 113
Tricyclic Alkylamides as Melatonin Receptor Ligands with Antagonist or Inverse Agonist Activity 113
Fatty Acid Amide Hydrolase (FAAH), Acetylcholinesterase (AChE), and Butyrylcholinesterase (BuChE): Networked Targets for the Development of Carbamates as Potential Anti-Alzheimer's Disease Agents 113
Metadynamics Simulations Distinguish Short- and Long-Residence-Time Inhibitors of Cyclin-Dependent Kinase 8. 113
An Optimized Workflow for the Discovery of New Antimicrobial Compounds Targeting Bacterial RNA Polymerase Complex Formation 112
Identification of bivalent ligands with melatonin receptor agonist and fatty acid amide hydrolase (FAAH) inhibitory activity that exhibit ocular hypotensive effect in the rabbit 112
Long-lasting inhibition of EGFR autophosphorylation in A549 tumor cells by intracellular accumulation of non-covalent inhibitors 112
JAK3 Inhibitors: Covalent and Noncovalent Interactions of a Cyanamide Group Investigated by Multiscale Free-Energy Simulations 111
Free-energy studies reveal a possible mechanism for oxidation-dependent inhibition of MGL 110
Design and SAR Analysis of Covalent Inhibitors Driven by Hybrid QM/MM Simulations 110
Tetrahydroquinoline Ring as a Versatile Bioisostere of Tetralin for Melatonin Receptor Ligands 110
Mechanistic Modeling of Monoglyceride Lipase Covalent Modification Elucidates the Role of Leaving Group Expulsion and Discriminates Inhibitors with High and Low Potency 109
2-[N-Acylamino(C1-C3)alkyl]indoles as MT1 Melatonin Receptor Partial Agonists, Antagonists, and Putative Inverse Agonists. 108
Histamine H3-antagonists: the basicity of the polar group in quantitative structure-activity and structure-property relationship 108
Synthesis, Pharmacological Evaluation and Structure-Activity Relationships of Benzopyran Derivatives with Potent SERM Activity 106
Plasma concentration and brain penetration of the H3-receptor antagonist Thioperamide in rats 106
Synthesis and biological evaluation of new non-imidazole H(3)-receptor antagonists of the 2-aminobenzimidazole series 106
Three-Dimensional Quantitative Structure-Activity Relationship Studies on Selected MT1 and MT2 Melatonin Receptor Ligands: Requirements for Subtype Selectivity and Intrinsic Activity Modulation 105
Structure-property relationships of a class of carbamate-based fatty acid amide hydrolase (FAAH) inhibitors: chemical and biological stability 104
New classes of potent heparanase inhibitors from ligand-based virtual screening 104
Synthesis and characterization of the first inhibitor of: N -acylphosphatidylethanolamine phospholipase D (NAPE-PLD) 103
Design, synthesis and SAR of alkylcarbamic acid aryl esters, a new class of fatty acid amide hydrolase inhibitors 101
Highly Potent and Selective MT2 Melatonin Receptor Full Agonists from Conformational Analysis of 1-Benzyl-2-acylaminomethyl-tetrahydroquinolines 101
Homology models of melatonin receptors: challenges and recent advances. 100
Computer-Aided Design of Novel Antagonists of the EphA2 Receptor 100
Synthesis and Structure-Activity Relationships of Amino Acid Conjugates of Cholanic Acid as Antagonists of the EphA2 Receptor. 99
H3-receptor antagonists: Synthesis and structure relationships of para- and meta-substituted 4(5)-phenyl-2-((2-(4(5)-imidazolyl)ethyl)thio)imidazoles 99
Ligands for the histamine H3-receptor: new potent antagonists of the 2-thioimidazole type 98
In vitro characterization of potency, affinity and selectivity of H3-antagonists: from thioperamide to thioperamide unrelated derivatives 98
Structure-Property Relationships on Histamine H3-Antagonists: Binding of Phenyl-substituted Alkylthioimidazole Derivatives to Rat Plasma Proteins 97
Antiproliferative and pro-apoptotic activity of melatonin analogues on melanoma and breast cancer cells 97
Imidazole H3-antagonists: Relationship between Structure and Ex-vivo binding to Rat Brain H3-Receptors 95
ST7612AA1, a thioacetate-ω(γ-lactam carboxamide) derivative selected from a novel generation of oral HDAC inhibitors 95
Synthesis and Structure-Activity Relationships of FAAH Inhibitors: Cyclohexylcarbamic Acid Biphenyl Esters with Chemical Modulation at the Proximal Phenyl Ring 94
Pharmacological inhibition of FAAH activity in rodents: A promising pharmacological approach for psychological-cardiac comorbidity? 93
Novel melatonin ligands having antidepressant activity as well as sleep-inducing properties 92
Synthesis and characterization of new bivalent agents as melatonin- and histamine h3-ligands. 92
N-(Substituted-anilinoethyl)amides: Design, Synthesis and Pharmacological Characterization of a New Class of Melatonin Receptor Ligands. 92
Totale 13.334
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Categoria #
all - tutte 61.438
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 61.438
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021590 0 0 0 0 0 42 139 35 200 34 97 43
2021/2022759 22 25 13 87 51 19 70 98 51 59 56 208
2022/20232.764 303 265 170 212 275 333 29 157 848 38 92 42
2023/20241.050 58 72 29 37 77 249 74 90 57 76 94 137
2024/20253.696 82 190 244 221 317 384 186 214 491 382 347 638
2025/20264.811 703 922 1.102 806 1.075 203 0 0 0 0 0 0
Totale 17.198