IRIS
RIVARA, Silvia
 Distribuzione geografica
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Continente #
EU - Europa 3.577
NA - Nord America 3.449
AS - Asia 1.175
SA - Sud America 6
AF - Africa 3
Continente sconosciuto - Info sul continente non disponibili 1
OC - Oceania 1
Totale 8.212
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Nazione #
US - Stati Uniti d'America 3.401
CN - Cina 952
FI - Finlandia 719
IE - Irlanda 683
IT - Italia 632
SE - Svezia 632
UA - Ucraina 319
DE - Germania 301
TR - Turchia 145
GB - Regno Unito 67
AT - Austria 60
BE - Belgio 52
FR - Francia 51
CA - Canada 46
IN - India 29
NL - Olanda 18
SG - Singapore 18
VN - Vietnam 15
CZ - Repubblica Ceca 10
ES - Italia 7
RU - Federazione Russa 6
HK - Hong Kong 5
RO - Romania 5
BR - Brasile 3
CL - Cile 3
HR - Croazia 3
EG - Egitto 2
JP - Giappone 2
KR - Corea 2
LU - Lussemburgo 2
PK - Pakistan 2
PL - Polonia 2
RS - Serbia 2
CH - Svizzera 1
EE - Estonia 1
EU - Europa 1
HU - Ungheria 1
ID - Indonesia 1
IL - Israele 1
IQ - Iraq 1
IR - Iran 1
JO - Giordania 1
LT - Lituania 1
MX - Messico 1
NG - Nigeria 1
NO - Norvegia 1
NZ - Nuova Zelanda 1
PA - Panama 1
PT - Portogallo 1
Totale 8.212
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Città #
Chandler 711
Dublin 681
Jacksonville 382
Ann Arbor 350
Dearborn 270
Parma 233
Ashburn 208
Beijing 202
Nanjing 181
Izmir 135
Princeton 135
Wilmington 103
New York 90
San Mateo 86
Bremen 69
Shanghai 69
Vienna 57
Shenyang 53
Brussels 48
Hebei 48
Helsinki 48
Nanchang 45
Jinan 44
Kunming 44
Toronto 43
Boardman 39
Hefei 39
Düsseldorf 34
Los Angeles 31
Woodbridge 31
Des Moines 29
Jiaxing 29
Guangzhou 28
Changsha 26
Seattle 24
Pune 23
Fremont 19
Milan 19
Brescia 17
Tianjin 17
Bologna 16
Norwalk 16
Houston 15
Dong Ket 14
Hangzhou 14
Modena 14
Zhengzhou 14
Auburn Hills 13
Paris 12
Fuzhou 10
Grafing 10
Piacenza 9
Ankara 8
Falls Church 7
Taizhou 7
Ascoli Piceno 6
Borås 6
Brno 6
Follonica 6
Lanzhou 6
London 6
Ningbo 6
Prata Di Pordenone 6
Redmond 6
Belluno 5
Chengdu 5
Montegaldella 5
Redwood City 5
Rome 5
Solignano 5
Trento 5
Urbino 5
Xian 5
Acqui Terme 4
Ardea 4
Fairfield 4
Haikou 4
Huizen 4
Leuven 4
Naples 4
Palermo 4
Soliera 4
Alessandria 3
Atlanta 3
Baotou 3
Chongqing 3
Dueville 3
Edinburgh 3
Fano 3
Ferrara 3
Fiorano Modenese 3
Montreal 3
Padova 3
Reggio Emilia 3
Rockville 3
Washington 3
Wenzhou 3
Wuhan 3
Zagreb 3
Amsterdam 2
Totale 5.107
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Nome #
Balancing reactivity and antitumor activity: heteroarylthioacetamide derivatives as potent and time-dependent inhibitors of EGFR 193
UniPR129 is a competitive small molecule Eph-ephrin antagonist blocking in vitro angiogenesis at low micromolar concentrations. 131
Benzisothiazolinone Derivatives as Potent Allosteric Monoacylglycerol Lipase Inhibitors That Functionally Mimic Sulfenylation of Regulatory Cysteines 129
New Antimicrobials Targeting Bacterial RNA Polymerase Holoenzyme Assembly Identified with an in Vivo BRET-Based Discovery Platform 123
Analysis of Structure-Activity Relationships for MT2 Selective Antagonists by Melatonin MT1 and MT2 Receptor Models 112
2-Aminobenzimidazoles as new potent H3-antagonists 110
Dibasic biphenyl H(3) receptor antagonists: Steric tolerance for a lipophilic side chain. 104
Irreversible Inhibition of Epidermal Growth Factor Receptor Activity by 3-Aminopropanamides. 98
Application of 3D-QSAR in the Rational Design of Receptor Ligands and Enzyme Inhibitors 95
Combining ligand- and structure-based approaches for the discovery of new inhibitors of the EPHA2-ephrin-A1 interaction 94
Amino acid derivatives as palmitoylethanolamide prodrugs: Synthesis, in vitro metabolism and in vivo plasma profile in rats 92
The Role of HB-Donor Groups in the Heterocyclic Polar Fragment of H3-Antagonists. I. Synthesis and Biological Assays 92
Antidepressant-like activity and cardioprotective effects of fatty acid amide hydrolase inhibitor URB694 in socially stressed Wistar Kyoto rats 91
Synthesis and 3D-QSAR Analysis of H3 Receptor Antagonists Containing a Neutral Heterocyclic Polar Group 90
2-N-Acylaminoalkylindoles: Design and Quantitative Structure-Activity Relationship Studies Leading to MT2-Selective Melatonin Antagonists 90
Antidepressant-like effects of pharmacological inhibition of FAAH activity in socially isolated female rats 90
QSAR study of 2-aminobenzimidazole derivatives as H3 antagonists 88
Novel Irreversible Epidermal Growth Factor Receptor Inhibitors by Chemical Modulation of the Cysteine-Trap Portion 85
Biphenyl-3-yl alkylcarbamates as fatty acid amide hydrolase (FAAH) inhibitors: steric effects of N-alkyl chain on rat plasma and liver stability 84
Aminobenzimidazoles as new potent H3-antagonists 84
Cardioprotective effects of fatty acid amide hydrolase inhibitor URB694, in a rodent model of trait anxiety 84
Chiral Recognition of Flexible Melatonin Receptor Ligands Induced by Conformational Equilibria 83
Synthesis and biological assays of new H3-antagonists with imidazole and imidazoline polar groups 83
Design and structure-activity relationship of amino acid derivatives of lithocholic acid as novel EphA2 antagonists 83
Free-Energy Simulations Support a Lipophilic Binding Route for Melatonin Receptors 80
Validation of a histamine H3 receptor model through structure–activity relationships for classical H3 antagonists 80
Alchilammidi tricicliche: ligandi selettivi dei recettori melatoninergici MT1 e MT2 76
Plasma concentration and brain penetration of the H3-receptor antagonist Thioperamide in rats 75
Toward the Definition of Stereochemical Requirements for MT(2)-Selective Antagonists and Partial Agonists by Studying 4-Phenyl-2-propionamidotetralin Derivatives. 75
Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor. 75
Chapter 9: Natural and Synthetic Agents That Target Intracellular Monoacylglycerol Lipase (MGL) Activity 74
Tricyclic Alkylamides as Melatonin Receptor Ligands with Antagonist or Inverse Agonist Activity 74
Dibasic non-imidazole histamine H3 receptor antagonists with a rigid byphenyl scaffold. 73
Cyclohexylcarbamic Acid 3'- or 4'-Substituted Biphenyl-3-yl Esters of as Fatty Acid Amide Hydrolase Inhibitors: Synthesis, Quantitative Structure-Activity Relationships and Molecular Modelling Studies 72
Synthesis, biological activity, QSAR and QSPR study of 2/aminobenzimidazole derivatives as potent H3-antagonists 72
Metadynamics for perspective drug design: Computationally driven synthesis of new protein-protein interaction inhibitors targeting the EphA2 receptor 72
Synthesis and structure-activity relationships for biphenyl H3 receptor antagonists with moderate anti-cholinesterase activity. 71
Development of a GPCR model for SAR interpretation of classical and new H3 antagonists 70
Design and structure-activity relationships of amino acid derivatives of lithocholic acid as novel EphA2 receptor antagonists. 69
N-(Anilinoethyl)amides: design and synthesis of metabolically stable, selective melatonin receptor ligands 68
N-(2-Oxo-3-oxetanyl)carbamic Acid Esters as N-Acylethanolamine Acid Amidase Inhibitors: Synthesis, Structure–Activity and Structure–Property Relationships. 68
Comparative Analysis of Virtual Screening Approaches in the Search for Novel EphA2 Receptor Antagonists 67
A sulfonyl fluoride derivative inhibits EGFR L858R/T790M/C797S by covalent modification of the catalytic lysine 67
Synthesis, Pharmacological Evaluation and Structure-Activity Relationships of Benzopyran Derivatives with Potent SERM Activity 66
Experimental and Theoretical Analysis of the Interaction of (±)-cis-Ketoconazole with b-Cyclodextrin in the presence of (+)-L-Tartaric Acid 66
Structure-Property Relationships on Histamine H3-Antagonists: Binding of Phenyl-substituted Alkylthioimidazole Derivatives to Rat Plasma Proteins 66
MT2 selective melatonin receptor antagonists: design and structure-activity relationships 66
Synthesis, Structural Elucidation, and Biological Evaluation of NSC12, an Orally Available Fibroblast Growth Factor (FGF) Ligand Trap for the Treatment of FGF-Dependent Lung Tumors 66
Tetrahydroquinoline Ring as a Versatile Bioisostere of Tetralin for Melatonin Receptor Ligands 66
Imidazole H3-antagonists: Relationship between Structure and Ex-vivo binding to Rat Brain H3-Receptors 65
Atropisomerism and Conformational Equilibria: Impact on PI3Kδ Inhibition of 2-((6-Amino-9H-purin-9-yl)methyl)-5-methyl-3-(o-tolyl)quinazolin-4(3H)-one (IC87114) and Its Conformationally Restricted Analogs 64
N-Acylethanolamine Acid Amidase (NAAA): Mechanism of Palmitoylethanolamide Hydrolysis Revealed by Mechanistic Simulations 63
Ligands for the histamine H3-receptor: new potent antagonists of the 2-thioimidazole type 62
Epidermal Growth Factor Receptor Irreversible Inhibitors: Chemical Exploration of the Cysteine-Trap Portion 62
Three-Dimensional Quantitative Structure-Activity Relationship Studies on Selected MT1 and MT2 Melatonin Receptor Ligands: Requirements for Subtype Selectivity and Intrinsic Activity Modulation 61
Synthesis and biological evaluation of new non-imidazole H(3)-receptor antagonists of the 2-aminobenzimidazole series 61
In vitro characterization of potency, affinity and selectivity of H3-antagonists: from thioperamide to thioperamide unrelated derivatives 61
Δ5-Cholenoyl-amino acids as selective and orally available antagonists of the Eph-ephrin system 61
Novel melatonin ligands having antidepressant activity as well as sleep-inducing properties 60
H3-receptor antagonists: Synthesis and structure relationships of para- and meta-substituted 4(5)-phenyl-2-((2-(4(5)-imidazolyl)ethyl)thio)imidazoles 60
Metadynamics Simulations Distinguish Short- and Long-Residence-Time Inhibitors of Cyclin-Dependent Kinase 8. 59
N-(Anilinoethyl)amide Melatonergic Ligands with Improved Water Solubility and Metabolic Stability 59
Design, synthesis and SAR of alkylcarbamic acid aryl esters, a new class of fatty acid amide hydrolase inhibitors 58
Histamine H3-antagonists: the basicity of the polar group in quantitative structure-activity and structure-property relationship 58
Pharmacokinetics, pharmacodynamics and safety studies on URB937, a peripherally restricted fatty acid amide hydrolase inhibitor, in rats 58
Design and synthesis of N-(3,3-diphenylpropenyl)alkanamides as a novel class of high-affinity MT2-selective melatonin receptor ligands. 57
APPLICATION OF COMPUTATIONAL METHODSTO THE DESIGN OF FATTY ACID AMIDE HYDROLASE(FAAH) INHIBITORS BASED ON A CARBAMICTEMPLATE STRUCTURE 57
Identification of bivalent ligands with melatonin receptor agonist and fatty acid amide hydrolase (FAAH) inhibitory activity that exhibit ocular hypotensive effect in the rabbit 57
Exploiting Free-Energy Minima to Design Novel EphA2 Protein-Protein Antagonists: From Simulation to Experiment and Return 57
Synthesis, Enantiomeric Resolution, and Structure-Activity Relationship Study of a Series of 10,11-Dihydro-5H-Dibenzo[a,d]cycloheptene MT(2) Receptor Antagonists. 55
Anxiolytic effects of the melatonin MT2 receptor partial agonist UCM765: Comparison with melatonin and diazepam. 55
Understanding the role of carbamate reactivity in fatty acid amide hydrolase inhibition by QM/MM mechanistic modelling. 53
Bivalent ligand approach on N-{2-[(3 -methoxyphenyl)methylamino]ethyl}acetamide: Synthesis, binding affinity and intrinsic activity for MT1 and MT2 melatonin receptors. 53
Quantum mechanics/molecular mechanics modeling of covalent addition between EGFR-cysteine 797 and N -(4-Anilinoquinazolin-6-yl) acrylamide 52
Chemical modification of NSC12 leads to a specific FGF-trap with antitumor activity in multiple myeloma 52
N-(Substituted-anilinoethyl)amides: Design, Synthesis and Pharmacological Characterization of a New Class of Melatonin Receptor Ligands. 52
2-[N-Acylamino(C1-C3)alkyl]indoles as MT1 Melatonin Receptor Partial Agonists, Antagonists, and Putative Inverse Agonists. 52
Synthesis and Structure-Activity Relationships of Amino Acid Conjugates of Cholanic Acid as Antagonists of the EphA2 Receptor. 51
Identification of productive inhibitor binding orientation in fatty acid amide hydrolase (FAAH) by QM/MM mechanistic modelling. 49
Structure-property relationships of a class of carbamate-based fatty acid amide hydrolase (FAAH) inhibitors: chemical and biological stability 49
Long-lasting inhibition of EGFR autophosphorylation in A549 tumor cells by intracellular accumulation of non-covalent inhibitors 49
Fatty Acid Amide Hydrolase (FAAH), Acetylcholinesterase (AChE), and Butyrylcholinesterase (BuChE): Networked Targets for the Development of Carbamates as Potential Anti-Alzheimer's Disease Agents 49
Recent advances in the development of melatonin MT(1) and MT(2) receptor agonists. 48
Promotion of non-rapid eye movement sleep and activation of reticular thalamic neurons by a novel MT2 melatonin receptor ligand. 48
Novel Benzazole Derivatives Endowed with Potent Antiheparanase Activity 48
Free-energy studies reveal a possible mechanism for oxidation-dependent inhibition of MGL 48
Synthesis and Quantitative Structure-Activity Relationship of Fatty Acid Amide Hydrolase Inhibitors: Modulation at the N-Portion of Biphenyl-3-yl Alkylcarbamates. 48
ST7612AA1, a thioacetate-ω(γ-lactam carboxamide) derivative selected from a novel generation of oral HDAC inhibitors 48
Synthesis and characterization of the first inhibitor of: N -acylphosphatidylethanolamine phospholipase D (NAPE-PLD) 48
Computer-Aided Design of Novel Antagonists of the EphA2 Receptor 47
Design and SAR Analysis of Covalent Inhibitors Driven by Hybrid QM/MM Simulations 47
Correlation between energetics of collisionally activated decompositions, interaction energy and biological potency of carbamate FAAH inhibitors. 46
The collisional behavior of ESI-generated protonated molecules of some carbamate FAAH inhibitors isosteres and its relationships with biological activity. 46
Highly Potent and Selective MT2 Melatonin Receptor Full Agonists from Conformational Analysis of 1-Benzyl-2-acylaminomethyl-tetrahydroquinolines 46
Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus 46
Strategies leading to MT2 selective melatonin receptor antagonists. 46
Social stress contagion in rats: Behavioural, autonomic and neuroendocrine correlates 45
The Control of Heparanase Through the Use of Small Molecules 45
New coumarin-based fluorescent melatonin ligands. Design, synthesis and pharmacological characterization 44
Synthesis and characterization of new bivalent agents as melatonin- and histamine h3-ligands. 44
Totale 6.891
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Categoria #
all - tutte 27.520
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 27.520
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/2019195 0 0 0 0 0 0 0 0 0 14 180 1
2019/20201.642 266 226 86 28 142 213 231 39 177 87 48 99
2020/2021949 17 92 93 46 111 42 139 35 200 34 97 43
2021/2022759 22 25 13 87 51 19 70 98 51 59 56 208
2022/20232.764 303 265 170 212 275 333 29 157 848 38 92 42
2023/2024788 58 72 29 37 77 249 74 90 57 45 0 0
Totale 8.429