N-Acylphosphatidylethanolamine phospholipase D (NAPE-PLD) is a membrane-associated zinc enzyme that catalyzes the hydrolysis of N-acylphosphatidylethanolamines (NAPEs) into fatty acid ethanolamides (FAEs). Here, we describe the identification of the first small-molecule NAPE-PLD inhibitor, the quinazoline sulfonamide derivative 2,4-dioxo-N-[4-(4-pyridyl)phenyl]-1H-quinazoline-6-sulfonamide, ARN19874.

Synthesis and characterization of the first inhibitor of: N -acylphosphatidylethanolamine phospholipase D (NAPE-PLD) / Castellani, Beatrice; Diamanti, Eleonora; Pizzirani, Daniela; Tardia, Piero; Maccesi, Martina; Realini, Natalia; Magotti, Paola; Garau, Gianpiero; Bakkum, Thomas; Rivara, Silvia; Mor, Marco; Piomelli, Daniele. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - 53:95(2017), pp. 12814-12817. [10.1039/c7cc07582k]

Synthesis and characterization of the first inhibitor of: N -acylphosphatidylethanolamine phospholipase D (NAPE-PLD)

Rivara, Silvia;Mor, Marco;PIOMELLI, DANIELE
2017

Abstract

N-Acylphosphatidylethanolamine phospholipase D (NAPE-PLD) is a membrane-associated zinc enzyme that catalyzes the hydrolysis of N-acylphosphatidylethanolamines (NAPEs) into fatty acid ethanolamides (FAEs). Here, we describe the identification of the first small-molecule NAPE-PLD inhibitor, the quinazoline sulfonamide derivative 2,4-dioxo-N-[4-(4-pyridyl)phenyl]-1H-quinazoline-6-sulfonamide, ARN19874.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11381/2839818
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