IRIS
COSTANTINO, Gabriele
 Distribuzione geografica
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Continente #
NA - Nord America 3.337
EU - Europa 3.110
AS - Asia 1.330
AF - Africa 13
Continente sconosciuto - Info sul continente non disponibili 6
OC - Oceania 4
SA - Sud America 1
Totale 7.801
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Nazione #
US - Stati Uniti d'America 3.259
CN - Cina 1.029
IE - Irlanda 638
SE - Svezia 616
IT - Italia 525
FI - Finlandia 395
UA - Ucraina 384
DE - Germania 333
TR - Turchia 200
CA - Canada 74
AT - Austria 44
SG - Singapore 36
GB - Regno Unito 33
IN - India 29
FR - Francia 27
NL - Olanda 24
BE - Belgio 23
CZ - Repubblica Ceca 13
RO - Romania 7
ES - Italia 6
EU - Europa 6
LU - Lussemburgo 6
RU - Federazione Russa 6
EG - Egitto 5
IR - Iran 5
BG - Bulgaria 4
JP - Giappone 4
PK - Pakistan 4
RS - Serbia 4
SK - Slovacchia (Repubblica Slovacca) 4
CH - Svizzera 3
HK - Hong Kong 3
HR - Croazia 3
IL - Israele 3
KR - Corea 3
NZ - Nuova Zelanda 3
PA - Panama 3
SI - Slovenia 3
EE - Estonia 2
GH - Ghana 2
LB - Libano 2
PL - Polonia 2
PT - Portogallo 2
SA - Arabia Saudita 2
SD - Sudan 2
VN - Vietnam 2
AE - Emirati Arabi Uniti 1
AU - Australia 1
AZ - Azerbaigian 1
BN - Brunei Darussalam 1
BR - Brasile 1
CM - Camerun 1
CY - Cipro 1
GR - Grecia 1
ID - Indonesia 1
LT - Lituania 1
MX - Messico 1
MY - Malesia 1
NO - Norvegia 1
NP - Nepal 1
RW - Ruanda 1
SC - Seychelles 1
TW - Taiwan 1
ZA - Sudafrica 1
Totale 7.801
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Città #
Chandler 652
Dublin 636
Jacksonville 490
Parma 270
Beijing 255
Ann Arbor 225
Ashburn 212
Nanjing 186
Izmir 170
Princeton 154
Dearborn 146
Wilmington 110
San Mateo 100
Helsinki 82
Nanchang 67
Bremen 66
Shanghai 60
Toronto 58
Shenyang 51
Hefei 47
Hebei 44
Jinan 39
Jiaxing 38
Kunming 38
Vienna 36
Des Moines 33
Guangzhou 29
New York 27
Norwalk 25
Changsha 24
Kocaeli 24
Milan 24
Houston 23
Brussels 20
Falls Church 20
Tianjin 20
Seattle 18
Los Angeles 17
Woodbridge 14
Zhengzhou 14
Boardman 12
Hangzhou 11
Bengaluru 10
Bologna 10
Borås 10
Haikou 10
Modena 10
Fremont 9
Ningbo 8
West Jordan 8
Brooklyn 7
Frankfurt am Main 7
Pavia 7
Pune 7
Sassari 7
Boston 6
Grafing 6
Istanbul 6
Luxembourg 6
San Giuliano Milanese 6
Wenzhou 6
Birmingham 5
Chongqing 5
Edinburgh 5
Fairfield 5
Formigine 5
Lanzhou 5
Perugia 5
Redwood City 5
Rockville 5
Timisoara 5
Amritsar 4
Düsseldorf 4
Fuzhou 4
London 4
Lyon 4
Mestre 4
New Brunswick 4
Sissa 4
Sofia 4
Taiyuan 4
Taizhou 4
Tulsa 4
Wuhan 4
Amstelveen 3
Bratislava 3
Cairo 3
Chengdu 3
Florence 3
Gonzaga 3
Leicester 3
Lucca 3
Ottawa 3
Panama City 3
Philadelphia 3
Quattro Castella 3
Reggio Emilia 3
Rome 3
Tabriz 3
Turin 3
Totale 4.883
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Nome #
1,4-Benzothiazine and 1,4-benzoxazine imidazole derivatives with antifungal activity: a docking study 159
The in silico drug discovery toolbox: applications in lead discovery and optimization 157
Discovery of Substituted (2-Aminooxazol-4-yl)Isoxazole-3-carboxylic Acids as Inhibitors of Bacterial Serine Acetyltransferase in the Quest for Novel Potential Antibacterial Adjuvants 136
Nuovi composti antimicrobici 131
Irreversible Inhibition of Epidermal Growth Factor Receptor Activity by 3-Aminopropanamides. 99
Investigational Studies on a Hit Compound Cyclopropane-Carboxylic Acid Derivative Targeting O-Acetylserine Sulfhydrylase as a Colistin Adjuvant 96
Scaffold Morphing Approach To Expand the Toolbox of Broad-Spectrum Antivirals Blocking Dengue/Zika Replication 92
Integration of Enhanced Sampling Methods with Saturation Transfer Difference Experiments to Identify Protein Druggable Pockets 84
Discovering a new class of antifungal agents that selectively inhibits microbial carbonic anhydrases 83
Probing the Reactivity of 2,4-Dichlorofuro[3,4-d ]pyrimidin-7-one: A Versatile and Underexploited Scaffold to Generate Substituted or Fused Pyrimidine Derivatives 82
Refining the structure−activity relationships of 2-phenylcyclopropane carboxylic acids as inhibitors of O-acetylserine sulfhydrylase isoforms 81
Antifungal properties of newly designed carbonic anhydrases inhibitors selective for microbial enzymes 80
1-Aminoindane-1,5-dicarboxylic Acid: a Novel Antagonist at Phospholipase C Linked Metabotropic Glutamate Receptors 77
Rational Design, Synthesis and Preliminary Structure-Activity Relationships of α-Substituted-2-Phenylcyclopropane Carboxylic Acids as Inhibitors of Salmonella Typhimurium O-Acetylserine Sulfhydrylase 77
Discovery of antitubercular 2,4-diphenyl-1H-imidazoles from chemical library repositioning and rational design 76
Molecular dynamics simulations and docking studies on 3D models of the heterodimeric and homodimeric 5-HT(2A) receptor subtype. 72
Inhibitors of the sulfur assimilation pathway in bacterial pathogens as enhancers of antibiotic therapy 70
Inhibition of Nonessential Bacterial Targets: Discovery of a Novel Serine O-Acetyltransferase Inhibitor 69
Aspergillus fumigatus tryptophan metabolic route differently affects host immunity 66
6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity. 65
Dirhodium(II)-tetraacetate-Mediated Decomposition of Ethyldiazo- acetate and Ethyldiazomalonate in the Presence of Fullerene. A New Procedure for the Selective Synthesis of [6-6]-Closed Methanofullerenes 65
Autocorrelation as a tool for a congruent description of molecules in 3D-QSAR studies 64
Design and synthesis of trans-2-substituted-cyclopropane-1-carboxylic acids as the first non-natural small molecule inhibitors of O-acetylserine sulfhydrylase 64
A competitive o‐acetylserine sulfhydrylase inhibitor modulates the formation of cysteine synthase complex 64
Discovery and characterization of novel potent PARP-1 inhibitors endowed with neuroprotective properties: From TIQ-A to HYDAMTIQ 64
Cyclopropane derivatives as potential human serine racemase inhibitors: unveiling novel insights into a difficult target 64
Asymmetric Synthesis of Enantiomerically Pure (2S,1'S,2'S,3'R)-phenylcarboxycyclopropylglycine (PCCG-4): A Potent and Selective Ligand at Group II Metabotropic Glutamate Receptors 63
Blocking cysteine biosynthesis in Salmonella typhimurium: the moonlighting enzyme CysK as a potential antibiotic target 62
Modulation of bacterial metabolism by the microenvironment controls MAIT cell stimulation 62
Unveiling hidden features of orphan nuclear receptors: the case of the small heterodimer partner (SHP). 60
The aryl hydrocarbon receptor (AhR) mediates the counter-regulatory effects of pelargonidins in models of inflammation and metabolic dysfunctions 60
A High Performance Workflow for Chemistry Driven de Novo Design 59
alfa-Diazocarbonyl Chemistry - Target Driven Applications 59
Synthesis of 6,6-Dicarboxy-3,4-methano-L-proline, a New Constrained Glutamate Analog Endowed with Neuroprotective Properties 57
Cyclopropane-1,2-dicarboxylic acids as new tools for the biophysical investigation of O-acetylserine sulfhydrylases by fluorimetric methods and saturation transfer difference (STD) NMR 56
Synthesis and Biological Evaluation of 6-Carboxy-3,4-methanoprolines, New Rigid Glutamate Analogs 55
Design, Synthesis and Investigation onthe Structure–Activity Relationships of N-Substituted 2-Aminothiazole Derivatives as Antitubercular Agents 55
Accepting the Invitation to Open Innovation in Malaria Drug Discovery: Synthesis, Biological Evaluation, and Investigation on the Structure-Activity Relationships of Benzo[b]thiophene-2-carboxamides as Antimalarial Agents 55
S-(+)-2-(3'-Carboxy-bicyclo[1.1.1]pentyl)glycine, a Structurally New Group I Metabotropic Glutamate Receptor Antagonist 54
Computational Insights into the mechanism of inhibition of OASS-A by a small molecule inhibitor 54
Discovery of Multitarget Agents Active as Broad-Spectrum Antivirals and Correctors of Cystic Fibrosis Transmembrane Conductance Regulator for Associated Pulmonary Diseases 54
Discovery of Multitarget Antivirals Acting on Both the Dengue Virus NS5-NS3 Interaction and the Host Src/Fyn Kinases 54
Nuova composizione 54
(2R,1'S,2'R,3'S)-2-(2'-Carboxy-3'-phenylcyclopropyl)glycine (PCCG-13), the first potent and selective competitive antagonist of phospholipase D-coupled metabotropic glutamate receptors: asymmetric synthesis and preliminary biological properties 53
QSAR and Molecular Modeling Studies of Baclofen Analogs as GABAB Agonists. Insights into the Role of the Aromatic Moiety in GABAB Binding and Activation. 52
Predictive ability of regression models. Part II: Selection of the best predictive PLS model 52
Membrane-Sensitive Conformational States of Helix 8 in the Metabotropic Glu2 Receptor, a Class C GPCR 52
Substituted N-Phenyl-5-(2-(phenylamino)thiazol-4-yl)isoxazole-3-carboxamides Are Valuable Antitubercular Candidates that Evade Innate Efflux Machinery 52
Back door modulation of the farnesoid X receptor: design, synthesis, and biological evaluation of a series of side chain modified chenodeoxycholic acid derivatives. 52
Metabotropic glutamate receptors: new ligads and molecular modelling studies 51
Aminonicotinic acid 1-oxides are chemically stable inhibitors of quinolinic acid synthesis in the mammalian brain: a step towards new anti-excitotoxic agents 51
Adjuvant therapies against tuberculosis: discovery of a 2-aminothiazole targeting Mycobacterium tuberculosis energetics 51
Generating optimal linear PLS estimation (GOLPE). An advanced chemometric tool for handling 3D-QSAR problems 51
Binding modes of noncompetitive AMPA antagonists: a computational approach 50
Kynurenine-3-hydroxylase and its Selective Inhibitors: Molecular Modelling Studies 50
Inhibition of O-acetylserine sulfhydrylase by fluoroalanine derivatives 50
A multicomponent pharmacophore fragment-decoration approach to identify selective LRRK2-targeting probes 50
On the way to selective PARP-2 inhibitors. Design, synthesis, and preliminary evaluation of a series of isoquinolinone derivatives 49
Derivatives of Nicotinic Acid N-Oxide, their preparation and their use as inhibitors of enzyme 3-hydroxyanthranilate-3,4-dioxygenase 49
Heterocyclic modulators of the NMDA Receptor 49
Further insights into the SAR of α-substituted cyclopropylamine derivatives as inhibitors of histone demethylase KDM1A 49
Discovery of novel fragments inhibiting O-acetylserine sulphhydrylase by combining scaffold hopping and ligand–based drug design 49
Exploring the chemical space around N-(5-nitrothiazol-2-yl)-1,2,3-thiadiazole-4-carboxamide, a hit compound with serine acetyltransferase (SAT) inhibitory properties 48
Life or death decisions: the cast of poly(ADP-ribose)polymerase (PARP) as a therapeutic target for brain ischaemia. 48
Bile acid derivatives as ligands of the farnesoid X receptor. Synthesis, evaluation, and structure-activity relationship of a series of body and side chain modified analogues of chenodeoxycholic acid. 48
Predictive binding of .beta.-carboline inverse agonists and antagonists via the CoMFA/GOLPE approach 48
In vitro digestion of zingiber officinale extract and evaluation of stability as a first step to determine its bioaccesibility 48
Cycloserine enantiomers are reversible inhibitors of human alanine:glyoxylate aminotransferase: Implications for Primary Hyperoxaluria type 1 48
Insights into phenylalanine derivatives recognition of VLA-4 integrin: from a pharmacophoric study to 3D-QSAR and molecular docking analyses 47
QSAR study of anticonvulsant negative allosteric modulators of the AMPA receptor. 47
Disjoint Principal Properties of Organic Substituents 47
The pseudoactive site as a tool for indirect drug design. Application to inhibitors of kynurenine-3-hydroxylase 47
A one-pot two-step microwave-assisted synthesis of N1-substituted 5,6-ring-fused 2-pyridones 47
Addressing the Conformational Flexibility of Serine Racemase by Combining Targeted Molecular Dynamics, Conformational Sampling and Docking Studies 47
Series Design 47
Homology model of the closed, functionally active, form of the amino terminal domain of mGlur1. 46
Use of Experimental Design To Optimize Docking Performance: The Case of LiGenDock, the Docking Module of Ligen, a New De Novo Design Program 46
Identification of Breast Cancer Inhibitors Specific for G Protein-Coupled Estrogen Receptor (GPER)-Expressing Cells 45
In silico approaches towards the understanding of the structure-function relationships in metabotropic glutamate receptors (mGluRs) and other family C GPRCs. 44
Synthesis and biological evaluation of (2S)- and (2R)-2-(3'-phosphonobicyclo[1.1.1]pentyl)glycines as novel group III selective metabotropic glutamate receptor ligands. 44
Modulation of glutamate receptor pathways in the search for new neuroprotective agents. 44
Synthesis and preliminary biological evaluation at the glycineB site of (+) and (-)-oxetanylglycine, a novel non proteinogenic aminoacid 43
Binding mode of 6ECDCA, a potent bile acid agonist of the farnesoid X receptor (FXR). 43
Nongenomic actions of bile acids. Synthesis and preliminary characterization of 23- and 6,23-alkyl-substituted bile acid derivatives as selective modulators for the G-protein coupled receptor TGR5 43
Design, Synthesis and Preliminary Evaluation of Novel 3’-Substituted Carboxycyclopropylglycines as Antagonists at Group 2 Metabotropic Glutamate Receptors 43
A combined ligand- and structure-based approach for the identification of rilmenidine-derived compounds which synergize the antitumor effects of doxorubicin 43
Sodium channel blockers for neuropathic pain. 42
Conformational requirements for interaction of L-Glutamic acid with metabotropic EEA receptors 42
Homology Modeling of Metabotropic Glutamate Receptors (mGluRs). Structural Motifs Affecting Binding Modes and Pharmacological Profile of mGluR1 Agonists and Competitive Antagonists 42
Homology Modeling, Validation and Dynamics of the G Protein-coupled Estrogen Receptor 1 (GPER-1) 42
Identification of Broad-Spectrum Dengue/Zika Virus Replication Inhibitors by Functionalization of Quinoline and 2,6-Diaminopurine Scaffolds 42
Modeling of poly(ADP-ribose)polymerase (PARP) inhibitors. Docking of ligands and quantitative structure-activity relationship analysis 41
Modeling of amino-terminal domains of group I metabotropic glutamate receptors: structural motifs affecting ligand selectivity 41
Modulators of the kynurenine pathway of tryptophan metabolism: synthesis and preliminary biological evaluation of (S)-4-(ethylsulfonyl)benzoylalanine, a potent and selective kynurenine aminotransferase II (KAT II) inhibitor. 41
Molecular dynamics simulation of the heterodimeric mGluR2/5HT(2A) complex. An atomistic resolution study of a potential new target in psychiatric conditions. 41
Molecular Dynamic Simulation of the ligand binding domain of mGluR1 in response to agonist and antagonist binding 41
Poly(ADP-ribose)-polymerase-catalyzed hydrolysis of NAD+: QM/MM simulation of the enzyme reaction. 41
Pharmacophore models of group I and group II metabotropic glutamate receptor agonists. Analysis of conformational, steric, and topological parameters affecting potency and selectivity 41
Modulation of the Kynurenine Pathway in Search for New Neuroprotective Agents. Synthesis and Preliminary Evaluation of (m-Nitrobenzoyl)alanine, a Potent Inhibitor of Kynurenine-3-hydroxylase 41
A microwave-assisted multicomponent protocol for the synthesis of benzofuran-2-carboxamides 41
Totale 5.852
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Categoria #
all - tutte 29.073
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 29.073
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/2019236 0 0 0 0 0 0 0 0 0 14 215 7
2019/20201.679 315 266 106 16 180 128 197 38 121 167 30 115
2020/2021931 6 107 74 17 131 24 97 50 219 48 137 21
2021/2022796 19 35 20 41 28 37 88 111 47 50 67 253
2022/20232.652 341 293 144 178 251 310 34 164 797 20 79 41
2023/2024692 60 79 27 48 96 149 87 68 31 47 0 0
Totale 7.930