IRIS
COSTANTINO, Gabriele
 Distribuzione geografica
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Continente #
NA - Nord America 3.651
EU - Europa 3.224
AS - Asia 1.953
AF - Africa 60
SA - Sud America 9
Continente sconosciuto - Info sul continente non disponibili 6
OC - Oceania 4
Totale 8.907
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Nazione #
US - Stati Uniti d'America 3.566
CN - Cina 1.096
IE - Irlanda 634
SE - Svezia 615
IT - Italia 588
SG - Singapore 575
FI - Finlandia 397
UA - Ucraina 385
DE - Germania 350
TR - Turchia 207
CA - Canada 78
AT - Austria 44
CI - Costa d'Avorio 41
FR - Francia 34
GB - Regno Unito 34
IN - India 31
CZ - Repubblica Ceca 27
BE - Belgio 25
NL - Olanda 25
LU - Lussemburgo 10
ES - Italia 8
BR - Brasile 7
RO - Romania 7
RU - Federazione Russa 7
EU - Europa 6
PA - Panama 6
PK - Pakistan 6
EG - Egitto 5
IR - Iran 5
BG - Bulgaria 4
JP - Giappone 4
RS - Serbia 4
RW - Ruanda 4
SK - Slovacchia (Repubblica Slovacca) 4
TW - Taiwan 4
CH - Svizzera 3
CM - Camerun 3
HK - Hong Kong 3
HR - Croazia 3
IL - Israele 3
KR - Corea 3
LT - Lituania 3
NZ - Nuova Zelanda 3
PL - Polonia 3
SI - Slovenia 3
VN - Vietnam 3
AR - Argentina 2
AZ - Azerbaigian 2
EE - Estonia 2
GH - Ghana 2
LB - Libano 2
MY - Malesia 2
PT - Portogallo 2
SA - Arabia Saudita 2
SD - Sudan 2
AE - Emirati Arabi Uniti 1
AU - Australia 1
BN - Brunei Darussalam 1
CY - Cipro 1
GR - Grecia 1
ID - Indonesia 1
IS - Islanda 1
MX - Messico 1
NG - Nigeria 1
NO - Norvegia 1
NP - Nepal 1
SC - Seychelles 1
ZA - Sudafrica 1
Totale 8.907
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Città #
Chandler 644
Dublin 632
Jacksonville 490
Singapore 402
Parma 285
Beijing 259
Ann Arbor 225
Ashburn 222
Nanjing 186
Boardman 182
Izmir 170
Princeton 154
Dearborn 146
Wilmington 110
San Mateo 100
Shanghai 95
Helsinki 84
Nanchang 67
Bremen 65
Toronto 60
Shenyang 51
Hefei 47
Hebei 44
Abidjan 41
Jiaxing 39
Jinan 39
Kunming 38
Vienna 36
Santa Clara 35
Des Moines 33
Guangzhou 30
Chicago 28
New York 28
Milan 26
Norwalk 25
Changsha 24
Kocaeli 24
Houston 23
Brussels 22
Falls Church 20
Tianjin 20
Los Angeles 18
Seattle 18
Brno 16
Munich 16
Woodbridge 14
Zhengzhou 14
Istanbul 13
Bologna 12
Hangzhou 11
Bengaluru 10
Borås 10
Haikou 10
Modena 10
Dallas 9
Fremont 9
Frankfurt am Main 8
Ningbo 8
West Jordan 8
Brooklyn 7
Dalmine 7
Pavia 7
Pune 7
Sassari 7
Boston 6
Grafing 6
Luxembourg 6
San Giuliano Milanese 6
Wenzhou 6
Birmingham 5
Chongqing 5
Edinburgh 5
Fairfield 5
Formigine 5
Gambara 5
Lanzhou 5
Ottawa 5
Perugia 5
Redwood City 5
Rockville 5
Timisoara 5
Turin 5
Verona 5
Amritsar 4
Düsseldorf 4
Fuzhou 4
London 4
Lyon 4
Mestre 4
New Brunswick 4
Sissa 4
Sofia 4
Taiyuan 4
Taizhou 4
Tulsa 4
Uppsala 4
Wuhan 4
Amstelveen 3
Bratislava 3
Brescia 3
Totale 5.665
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Nome #
1,4-Benzothiazine and 1,4-benzoxazine imidazole derivatives with antifungal activity: a docking study 193
The in silico drug discovery toolbox: applications in lead discovery and optimization 169
Discovery of Substituted (2-Aminooxazol-4-yl)Isoxazole-3-carboxylic Acids as Inhibitors of Bacterial Serine Acetyltransferase in the Quest for Novel Potential Antibacterial Adjuvants 147
Nuovi composti antimicrobici 143
Irreversible Inhibition of Epidermal Growth Factor Receptor Activity by 3-Aminopropanamides. 121
Investigational Studies on a Hit Compound Cyclopropane-Carboxylic Acid Derivative Targeting O-Acetylserine Sulfhydrylase as a Colistin Adjuvant 109
Refining the structure−activity relationships of 2-phenylcyclopropane carboxylic acids as inhibitors of O-acetylserine sulfhydrylase isoforms 99
Scaffold Morphing Approach To Expand the Toolbox of Broad-Spectrum Antivirals Blocking Dengue/Zika Replication 98
Discovering a new class of antifungal agents that selectively inhibits microbial carbonic anhydrases 91
Integration of Enhanced Sampling Methods with Saturation Transfer Difference Experiments to Identify Protein Druggable Pockets 91
Probing the Reactivity of 2,4-Dichlorofuro[3,4-d ]pyrimidin-7-one: A Versatile and Underexploited Scaffold to Generate Substituted or Fused Pyrimidine Derivatives 90
Antifungal properties of newly designed carbonic anhydrases inhibitors selective for microbial enzymes 88
1-Aminoindane-1,5-dicarboxylic Acid: a Novel Antagonist at Phospholipase C Linked Metabotropic Glutamate Receptors 86
Rational Design, Synthesis and Preliminary Structure-Activity Relationships of α-Substituted-2-Phenylcyclopropane Carboxylic Acids as Inhibitors of Salmonella Typhimurium O-Acetylserine Sulfhydrylase 86
Discovery of antitubercular 2,4-diphenyl-1H-imidazoles from chemical library repositioning and rational design 82
Inhibition of Nonessential Bacterial Targets: Discovery of a Novel Serine O-Acetyltransferase Inhibitor 79
Molecular dynamics simulations and docking studies on 3D models of the heterodimeric and homodimeric 5-HT(2A) receptor subtype. 77
A competitive o‐acetylserine sulfhydrylase inhibitor modulates the formation of cysteine synthase complex 77
Exploring the chemical space around N-(5-nitrothiazol-2-yl)-1,2,3-thiadiazole-4-carboxamide, a hit compound with serine acetyltransferase (SAT) inhibitory properties 76
Inhibitors of the sulfur assimilation pathway in bacterial pathogens as enhancers of antibiotic therapy 76
Design and synthesis of trans-2-substituted-cyclopropane-1-carboxylic acids as the first non-natural small molecule inhibitors of O-acetylserine sulfhydrylase 74
Aspergillus fumigatus tryptophan metabolic route differently affects host immunity 73
Cyclopropane derivatives as potential human serine racemase inhibitors: unveiling novel insights into a difficult target 72
Autocorrelation as a tool for a congruent description of molecules in 3D-QSAR studies 71
Dirhodium(II)-tetraacetate-Mediated Decomposition of Ethyldiazo- acetate and Ethyldiazomalonate in the Presence of Fullerene. A New Procedure for the Selective Synthesis of [6-6]-Closed Methanofullerenes 71
Discovery and characterization of novel potent PARP-1 inhibitors endowed with neuroprotective properties: From TIQ-A to HYDAMTIQ 71
6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity. 70
QSAR and Molecular Modeling Studies of Baclofen Analogs as GABAB Agonists. Insights into the Role of the Aromatic Moiety in GABAB Binding and Activation. 70
Blocking cysteine biosynthesis in Salmonella typhimurium: the moonlighting enzyme CysK as a potential antibiotic target 70
Asymmetric Synthesis of Enantiomerically Pure (2S,1'S,2'S,3'R)-phenylcarboxycyclopropylglycine (PCCG-4): A Potent and Selective Ligand at Group II Metabotropic Glutamate Receptors 70
Inhibitors of O-Acetylserine Sulfhydrylase with a Cyclopropane-Carboxylic Acid Scaffold Are Effective Colistin Adjuvants in Gram Negative Bacteria 68
The aryl hydrocarbon receptor (AhR) mediates the counter-regulatory effects of pelargonidins in models of inflammation and metabolic dysfunctions 68
Cycloserine enantiomers are reversible inhibitors of human alanine:glyoxylate aminotransferase: Implications for Primary Hyperoxaluria type 1 68
Modulation of bacterial metabolism by the microenvironment controls MAIT cell stimulation 68
A High Performance Workflow for Chemistry Driven de Novo Design 67
alfa-Diazocarbonyl Chemistry - Target Driven Applications 65
Unveiling hidden features of orphan nuclear receptors: the case of the small heterodimer partner (SHP). 64
Cyclopropane-1,2-dicarboxylic acids as new tools for the biophysical investigation of O-acetylserine sulfhydrylases by fluorimetric methods and saturation transfer difference (STD) NMR 64
Design, Synthesis and Investigation onthe Structure–Activity Relationships of N-Substituted 2-Aminothiazole Derivatives as Antitubercular Agents 63
Synthesis of 6,6-Dicarboxy-3,4-methano-L-proline, a New Constrained Glutamate Analog Endowed with Neuroprotective Properties 62
Accepting the Invitation to Open Innovation in Malaria Drug Discovery: Synthesis, Biological Evaluation, and Investigation on the Structure-Activity Relationships of Benzo[b]thiophene-2-carboxamides as Antimalarial Agents 62
Discovery of Multitarget Agents Active as Broad-Spectrum Antivirals and Correctors of Cystic Fibrosis Transmembrane Conductance Regulator for Associated Pulmonary Diseases 62
Discovery of Multitarget Antivirals Acting on Both the Dengue Virus NS5-NS3 Interaction and the Host Src/Fyn Kinases 62
Aminonicotinic acid 1-oxides are chemically stable inhibitors of quinolinic acid synthesis in the mammalian brain: a step towards new anti-excitotoxic agents 60
Generating optimal linear PLS estimation (GOLPE). An advanced chemometric tool for handling 3D-QSAR problems 60
Discovery of novel fragments inhibiting O-acetylserine sulphhydrylase by combining scaffold hopping and ligand–based drug design 60
S-(+)-2-(3'-Carboxy-bicyclo[1.1.1]pentyl)glycine, a Structurally New Group I Metabotropic Glutamate Receptor Antagonist 59
Synthesis and Biological Evaluation of 6-Carboxy-3,4-methanoprolines, New Rigid Glutamate Analogs 59
Computational Insights into the mechanism of inhibition of OASS-A by a small molecule inhibitor 59
Substituted N-Phenyl-5-(2-(phenylamino)thiazol-4-yl)isoxazole-3-carboxamides Are Valuable Antitubercular Candidates that Evade Innate Efflux Machinery 59
Nuova composizione 59
Adjuvant therapies against tuberculosis: discovery of a 2-aminothiazole targeting Mycobacterium tuberculosis energetics 58
(2R,1'S,2'R,3'S)-2-(2'-Carboxy-3'-phenylcyclopropyl)glycine (PCCG-13), the first potent and selective competitive antagonist of phospholipase D-coupled metabotropic glutamate receptors: asymmetric synthesis and preliminary biological properties 58
Predictive ability of regression models. Part II: Selection of the best predictive PLS model 57
In vitro digestion of zingiber officinale extract and evaluation of stability as a first step to determine its bioaccesibility 57
Further insights into the SAR of α-substituted cyclopropylamine derivatives as inhibitors of histone demethylase KDM1A 57
Metabolite Profiling and Bioactivities of Leaves, Stems, and Flowers of Rumex usambarensis (Dammer) Dammer, a Traditional African Medicinal Plant 56
Metabotropic glutamate receptors: new ligads and molecular modelling studies 56
Kynurenine-3-hydroxylase and its Selective Inhibitors: Molecular Modelling Studies 56
Membrane-Sensitive Conformational States of Helix 8 in the Metabotropic Glu2 Receptor, a Class C GPCR 56
Use of Experimental Design To Optimize Docking Performance: The Case of LiGenDock, the Docking Module of Ligen, a New De Novo Design Program 56
Back door modulation of the farnesoid X receptor: design, synthesis, and biological evaluation of a series of side chain modified chenodeoxycholic acid derivatives. 56
A multicomponent pharmacophore fragment-decoration approach to identify selective LRRK2-targeting probes 56
Binding modes of noncompetitive AMPA antagonists: a computational approach 55
Predictive binding of .beta.-carboline inverse agonists and antagonists via the CoMFA/GOLPE approach 55
Derivatives of Nicotinic Acid N-Oxide, their preparation and their use as inhibitors of enzyme 3-hydroxyanthranilate-3,4-dioxygenase 55
Heterocyclic modulators of the NMDA Receptor 55
Life or death decisions: the cast of poly(ADP-ribose)polymerase (PARP) as a therapeutic target for brain ischaemia. 54
Bile acid derivatives as ligands of the farnesoid X receptor. Synthesis, evaluation, and structure-activity relationship of a series of body and side chain modified analogues of chenodeoxycholic acid. 54
On the way to selective PARP-2 inhibitors. Design, synthesis, and preliminary evaluation of a series of isoquinolinone derivatives 54
Inhibition of O-acetylserine sulfhydrylase by fluoroalanine derivatives 54
Identification of Breast Cancer Inhibitors Specific for G Protein-Coupled Estrogen Receptor (GPER)-Expressing Cells 54
Disjoint Principal Properties of Organic Substituents 53
Series Design 53
Homology Modeling, Validation and Dynamics of the G Protein-coupled Estrogen Receptor 1 (GPER-1) 53
Insights into phenylalanine derivatives recognition of VLA-4 integrin: from a pharmacophoric study to 3D-QSAR and molecular docking analyses 52
QSAR study of anticonvulsant negative allosteric modulators of the AMPA receptor. 52
A one-pot two-step microwave-assisted synthesis of N1-substituted 5,6-ring-fused 2-pyridones 52
The pseudoactive site as a tool for indirect drug design. Application to inhibitors of kynurenine-3-hydroxylase 51
Addressing the Conformational Flexibility of Serine Racemase by Combining Targeted Molecular Dynamics, Conformational Sampling and Docking Studies 51
Homology model of the closed, functionally active, form of the amino terminal domain of mGlur1. 50
Modulation of glutamate receptor pathways in the search for new neuroprotective agents. 50
A combined ligand- and structure-based approach for the identification of rilmenidine-derived compounds which synergize the antitumor effects of doxorubicin 49
2-Aminooxazole as a Novel Privileged Scaffold in Antitubercular Medicinal Chemistry 49
Synthesis and biological evaluation of (2S)- and (2R)-2-(3'-phosphonobicyclo[1.1.1]pentyl)glycines as novel group III selective metabotropic glutamate receptor ligands. 48
Sodium channel blockers for neuropathic pain. 48
Nongenomic actions of bile acids. Synthesis and preliminary characterization of 23- and 6,23-alkyl-substituted bile acid derivatives as selective modulators for the G-protein coupled receptor TGR5 48
Homology Modeling of Metabotropic Glutamate Receptors (mGluRs). Structural Motifs Affecting Binding Modes and Pharmacological Profile of mGluR1 Agonists and Competitive Antagonists 48
Design, Synthesis and Preliminary Evaluation of Novel 3’-Substituted Carboxycyclopropylglycines as Antagonists at Group 2 Metabotropic Glutamate Receptors 48
In silico approaches towards the understanding of the structure-function relationships in metabotropic glutamate receptors (mGluRs) and other family C GPRCs. 47
Conformational requirements for interaction of L-Glutamic acid with metabotropic EEA receptors 47
Binding mode of 6ECDCA, a potent bile acid agonist of the farnesoid X receptor (FXR). 47
A microwave-assisted multicomponent protocol for the synthesis of benzofuran-2-carboxamides 47
Modulators of the kynurenine pathway of tryptophan metabolism: synthesis and preliminary biological evaluation of (S)-4-(ethylsulfonyl)benzoylalanine, a potent and selective kynurenine aminotransferase II (KAT II) inhibitor. 46
Discovery of New Potential Anti-Infective Compounds Based on Carbonic Anhydrase Inhibitors by Rational Target-Focused Repurposing Approaches 46
Synthesis and preliminary biological evaluation at the glycineB site of (+) and (-)-oxetanylglycine, a novel non proteinogenic aminoacid 46
Modulation of the Kynurenine Pathway in Search for New Neuroprotective Agents. Synthesis and Preliminary Evaluation of (m-Nitrobenzoyl)alanine, a Potent Inhibitor of Kynurenine-3-hydroxylase 46
Identification of Broad-Spectrum Dengue/Zika Virus Replication Inhibitors by Functionalization of Quinoline and 2,6-Diaminopurine Scaffolds 46
Synthesis, molecular modeling and preliminary biological evaluation of 1-amino-3-phosphono-3-cyclopentene-1-carboxylic acid and 1-amino-3-phosphono-2-cyclopentene-1-carboxylic acid, two novel agonists of metabotropic glutamate receptors of group III. 45
Molecular dynamics simulation of the heterodimeric mGluR2/5HT(2A) complex. An atomistic resolution study of a potential new target in psychiatric conditions. 45
Totale 6.640
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Categoria #
all - tutte 38.445
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 38.445
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020976 0 0 0 0 180 128 197 38 121 167 30 115
2020/2021931 6 107 74 17 131 24 97 50 219 48 137 21
2021/2022796 19 35 20 41 28 37 88 111 47 50 67 253
2022/20232.630 338 289 143 177 248 309 34 161 791 20 79 41
2023/2024940 59 79 27 48 96 148 87 68 31 57 100 140
2024/2025885 96 203 278 169 139 0 0 0 0 0 0 0
Totale 9.041