IRIS
COSTANTINO, Gabriele
 Distribuzione geografica
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Continente #
NA - Nord America 4.044
EU - Europa 3.609
AS - Asia 2.322
SA - Sud America 247
AF - Africa 74
Continente sconosciuto - Info sul continente non disponibili 7
OC - Oceania 5
Totale 10.308
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Nazione #
US - Stati Uniti d'America 3.949
CN - Cina 1.125
SG - Singapore 843
IT - Italia 645
IE - Irlanda 636
SE - Svezia 615
FI - Finlandia 405
UA - Ucraina 388
DE - Germania 373
BR - Brasile 218
TR - Turchia 213
NL - Olanda 198
CA - Canada 81
RU - Federazione Russa 73
AT - Austria 52
FR - Francia 43
GB - Regno Unito 43
CI - Costa d'Avorio 41
IN - India 33
BE - Belgio 32
CZ - Repubblica Ceca 27
ID - Indonesia 14
LU - Lussemburgo 13
RO - Romania 12
HK - Hong Kong 11
PK - Pakistan 11
ES - Italia 9
AR - Argentina 8
UZ - Uzbekistan 8
BD - Bangladesh 7
EG - Egitto 7
IQ - Iraq 7
PA - Panama 7
EC - Ecuador 6
EU - Europa 6
LT - Lituania 6
UY - Uruguay 6
IR - Iran 5
JP - Giappone 5
MX - Messico 5
ZA - Sudafrica 5
BG - Bulgaria 4
BO - Bolivia 4
RS - Serbia 4
RW - Ruanda 4
SK - Slovacchia (Repubblica Slovacca) 4
TW - Taiwan 4
VN - Vietnam 4
AZ - Azerbaigian 3
CH - Svizzera 3
CM - Camerun 3
EE - Estonia 3
HR - Croazia 3
IL - Israele 3
KR - Corea 3
LB - Libano 3
NZ - Nuova Zelanda 3
PL - Polonia 3
PT - Portogallo 3
SI - Slovenia 3
VE - Venezuela 3
AE - Emirati Arabi Uniti 2
AU - Australia 2
BH - Bahrain 2
BN - Brunei Darussalam 2
GH - Ghana 2
GR - Grecia 2
JO - Giordania 2
KG - Kirghizistan 2
LV - Lettonia 2
MA - Marocco 2
MY - Malesia 2
NO - Norvegia 2
SA - Arabia Saudita 2
SD - Sudan 2
AM - Armenia 1
AO - Angola 1
CO - Colombia 1
CY - Cipro 1
DK - Danimarca 1
DZ - Algeria 1
HU - Ungheria 1
IS - Islanda 1
JM - Giamaica 1
KE - Kenya 1
MN - Mongolia 1
NG - Nigeria 1
NP - Nepal 1
PE - Perù 1
PH - Filippine 1
PS - Palestinian Territory 1
SC - Seychelles 1
SN - Senegal 1
TG - Togo 1
TN - Tunisia 1
TT - Trinidad e Tobago 1
XK - ???statistics.table.value.countryCode.XK??? 1
Totale 10.308
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Città #
Chandler 644
Dublin 633
Jacksonville 490
Singapore 485
Santa Clara 323
Parma 306
Beijing 261
Ashburn 237
Ann Arbor 225
Nanjing 186
Boardman 182
Izmir 170
Princeton 154
Dearborn 146
Wilmington 110
San Mateo 100
Shanghai 98
Helsinki 92
Nanchang 67
Bremen 65
Toronto 61
Moscow 55
Shenyang 51
Hefei 47
Hebei 44
Abidjan 41
Jinan 40
Jiaxing 39
Kunming 39
Vienna 37
Des Moines 34
Guangzhou 31
Milan 30
New York 29
Chicago 28
Norwalk 25
Brussels 24
Changsha 24
Kocaeli 24
Council Bluffs 23
Houston 23
Los Angeles 22
Falls Church 20
Tianjin 20
Bologna 18
Seattle 18
São Paulo 17
Brno 16
Munich 16
Frankfurt am Main 15
Nuremberg 15
Istanbul 14
Woodbridge 14
Zhengzhou 14
Jakarta 13
Hangzhou 11
Bengaluru 10
Borås 10
Haikou 10
Hong Kong 10
Modena 10
Dallas 9
Fremont 9
London 9
Luxembourg 9
Ningbo 8
West Jordan 8
Brooklyn 7
Dalmine 7
Ottawa 7
Pavia 7
Pune 7
Sassari 7
Baghdad 6
Belo Horizonte 6
Boston 6
Curitiba 6
Grafing 6
San Giuliano Milanese 6
Tashkent 6
Turin 6
Wenzhou 6
Angers 5
Birmingham 5
Cairo 5
Campinas 5
Charleroi 5
Chongqing 5
Edinburgh 5
Fairfield 5
Florence 5
Formigine 5
Fuzhou 5
Gambara 5
Lanzhou 5
Montevideo 5
Perugia 5
Redwood City 5
Reggio Emilia 5
Ribeirão Preto 5
Totale 6.254
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Nome #
1,4-Benzothiazine and 1,4-benzoxazine imidazole derivatives with antifungal activity: a docking study 212
The in silico drug discovery toolbox: applications in lead discovery and optimization 177
Discovery of Substituted (2-Aminooxazol-4-yl)Isoxazole-3-carboxylic Acids as Inhibitors of Bacterial Serine Acetyltransferase in the Quest for Novel Potential Antibacterial Adjuvants 160
Irreversible Inhibition of Epidermal Growth Factor Receptor Activity by 3-Aminopropanamides. 152
Nuovi composti antimicrobici 150
Refining the structure−activity relationships of 2-phenylcyclopropane carboxylic acids as inhibitors of O-acetylserine sulfhydrylase isoforms 132
Investigational Studies on a Hit Compound Cyclopropane-Carboxylic Acid Derivative Targeting O-Acetylserine Sulfhydrylase as a Colistin Adjuvant 130
Scaffold Morphing Approach To Expand the Toolbox of Broad-Spectrum Antivirals Blocking Dengue/Zika Replication 105
Probing the Reactivity of 2,4-Dichlorofuro[3,4-d ]pyrimidin-7-one: A Versatile and Underexploited Scaffold to Generate Substituted or Fused Pyrimidine Derivatives 105
Integration of Enhanced Sampling Methods with Saturation Transfer Difference Experiments to Identify Protein Druggable Pockets 105
Rational Design, Synthesis and Preliminary Structure-Activity Relationships of α-Substituted-2-Phenylcyclopropane Carboxylic Acids as Inhibitors of Salmonella Typhimurium O-Acetylserine Sulfhydrylase 99
Inhibition of Nonessential Bacterial Targets: Discovery of a Novel Serine O-Acetyltransferase Inhibitor 98
QSAR and Molecular Modeling Studies of Baclofen Analogs as GABAB Agonists. Insights into the Role of the Aromatic Moiety in GABAB Binding and Activation. 97
Discovering a new class of antifungal agents that selectively inhibits microbial carbonic anhydrases 97
Antifungal properties of newly designed carbonic anhydrases inhibitors selective for microbial enzymes 97
Inhibitors of the sulfur assimilation pathway in bacterial pathogens as enhancers of antibiotic therapy 96
1-Aminoindane-1,5-dicarboxylic Acid: a Novel Antagonist at Phospholipase C Linked Metabotropic Glutamate Receptors 94
Cycloserine enantiomers are reversible inhibitors of human alanine:glyoxylate aminotransferase: Implications for Primary Hyperoxaluria type 1 92
A competitive o‐acetylserine sulfhydrylase inhibitor modulates the formation of cysteine synthase complex 91
Exploring the chemical space around N-(5-nitrothiazol-2-yl)-1,2,3-thiadiazole-4-carboxamide, a hit compound with serine acetyltransferase (SAT) inhibitory properties 90
Discovery of antitubercular 2,4-diphenyl-1H-imidazoles from chemical library repositioning and rational design 90
Inhibitors of O-Acetylserine Sulfhydrylase with a Cyclopropane-Carboxylic Acid Scaffold Are Effective Colistin Adjuvants in Gram Negative Bacteria 89
Aspergillus fumigatus tryptophan metabolic route differently affects host immunity 89
Dirhodium(II)-tetraacetate-Mediated Decomposition of Ethyldiazo- acetate and Ethyldiazomalonate in the Presence of Fullerene. A New Procedure for the Selective Synthesis of [6-6]-Closed Methanofullerenes 84
Molecular dynamics simulations and docking studies on 3D models of the heterodimeric and homodimeric 5-HT(2A) receptor subtype. 83
Design and synthesis of trans-2-substituted-cyclopropane-1-carboxylic acids as the first non-natural small molecule inhibitors of O-acetylserine sulfhydrylase 83
Asymmetric Synthesis of Enantiomerically Pure (2S,1'S,2'S,3'R)-phenylcarboxycyclopropylglycine (PCCG-4): A Potent and Selective Ligand at Group II Metabotropic Glutamate Receptors 80
Cyclopropane derivatives as potential human serine racemase inhibitors: unveiling novel insights into a difficult target 80
Blocking cysteine biosynthesis in Salmonella typhimurium: the moonlighting enzyme CysK as a potential antibiotic target 78
Modulation of bacterial metabolism by the microenvironment controls MAIT cell stimulation 78
Autocorrelation as a tool for a congruent description of molecules in 3D-QSAR studies 77
Cyclopropane-1,2-dicarboxylic acids as new tools for the biophysical investigation of O-acetylserine sulfhydrylases by fluorimetric methods and saturation transfer difference (STD) NMR 77
Discovery and characterization of novel potent PARP-1 inhibitors endowed with neuroprotective properties: From TIQ-A to HYDAMTIQ 76
The aryl hydrocarbon receptor (AhR) mediates the counter-regulatory effects of pelargonidins in models of inflammation and metabolic dysfunctions 76
6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity. 75
Metabolite Profiling and Bioactivities of Leaves, Stems, and Flowers of Rumex usambarensis (Dammer) Dammer, a Traditional African Medicinal Plant 74
Unveiling hidden features of orphan nuclear receptors: the case of the small heterodimer partner (SHP). 74
A High Performance Workflow for Chemistry Driven de Novo Design 74
alfa-Diazocarbonyl Chemistry - Target Driven Applications 74
Discovery of novel fragments inhibiting O-acetylserine sulphhydrylase by combining scaffold hopping and ligand–based drug design 74
Substituted N-Phenyl-5-(2-(phenylamino)thiazol-4-yl)isoxazole-3-carboxamides Are Valuable Antitubercular Candidates that Evade Innate Efflux Machinery 73
Discovery of Multitarget Antivirals Acting on Both the Dengue Virus NS5-NS3 Interaction and the Host Src/Fyn Kinases 72
Aminonicotinic acid 1-oxides are chemically stable inhibitors of quinolinic acid synthesis in the mammalian brain: a step towards new anti-excitotoxic agents 71
Generating optimal linear PLS estimation (GOLPE). An advanced chemometric tool for handling 3D-QSAR problems 71
Accepting the Invitation to Open Innovation in Malaria Drug Discovery: Synthesis, Biological Evaluation, and Investigation on the Structure-Activity Relationships of Benzo[b]thiophene-2-carboxamides as Antimalarial Agents 71
Inhibition of O-acetylserine sulfhydrylase by fluoroalanine derivatives 70
Discovery of Multitarget Agents Active as Broad-Spectrum Antivirals and Correctors of Cystic Fibrosis Transmembrane Conductance Regulator for Associated Pulmonary Diseases 69
Synthesis of 6,6-Dicarboxy-3,4-methano-L-proline, a New Constrained Glutamate Analog Endowed with Neuroprotective Properties 67
Design, Synthesis and Investigation onthe Structure–Activity Relationships of N-Substituted 2-Aminothiazole Derivatives as Antitubercular Agents 67
Further insights into the SAR of α-substituted cyclopropylamine derivatives as inhibitors of histone demethylase KDM1A 67
Nuova composizione 67
Synthesis and Biological Evaluation of 6-Carboxy-3,4-methanoprolines, New Rigid Glutamate Analogs 66
Identification of Breast Cancer Inhibitors Specific for G Protein-Coupled Estrogen Receptor (GPER)-Expressing Cells 66
2-Aminooxazole as a Novel Privileged Scaffold in Antitubercular Medicinal Chemistry 66
In vitro digestion of zingiber officinale extract and evaluation of stability as a first step to determine its bioaccesibility 65
A multicomponent pharmacophore fragment-decoration approach to identify selective LRRK2-targeting probes 65
S-(+)-2-(3'-Carboxy-bicyclo[1.1.1]pentyl)glycine, a Structurally New Group I Metabotropic Glutamate Receptor Antagonist 64
Computational Insights into the mechanism of inhibition of OASS-A by a small molecule inhibitor 64
Use of Experimental Design To Optimize Docking Performance: The Case of LiGenDock, the Docking Module of Ligen, a New De Novo Design Program 64
Adjuvant therapies against tuberculosis: discovery of a 2-aminothiazole targeting Mycobacterium tuberculosis energetics 64
Membrane-Sensitive Conformational States of Helix 8 in the Metabotropic Glu2 Receptor, a Class C GPCR 63
Identification of Broad-Spectrum Dengue/Zika Virus Replication Inhibitors by Functionalization of Quinoline and 2,6-Diaminopurine Scaffolds 63
Binding modes of noncompetitive AMPA antagonists: a computational approach 62
Life or death decisions: the cast of poly(ADP-ribose)polymerase (PARP) as a therapeutic target for brain ischaemia. 62
Kynurenine-3-hydroxylase and its Selective Inhibitors: Molecular Modelling Studies 62
Predictive ability of regression models. Part II: Selection of the best predictive PLS model 62
(2R,1'S,2'R,3'S)-2-(2'-Carboxy-3'-phenylcyclopropyl)glycine (PCCG-13), the first potent and selective competitive antagonist of phospholipase D-coupled metabotropic glutamate receptors: asymmetric synthesis and preliminary biological properties 62
Derivatives of Nicotinic Acid N-Oxide, their preparation and their use as inhibitors of enzyme 3-hydroxyanthranilate-3,4-dioxygenase 62
Metabotropic glutamate receptors: new ligads and molecular modelling studies 61
Back door modulation of the farnesoid X receptor: design, synthesis, and biological evaluation of a series of side chain modified chenodeoxycholic acid derivatives. 61
Expanding the knowledge around antitubercular 5-(2-aminothiazol-4-yl)isoxazole-3-carboxamides: Hit–to–lead optimization and release of a novel antitubercular chemotype via scaffold derivatization 60
Identification of Human Alanine-Glyoxylate Aminotransferase Ligands as Pharmacological Chaperones for Variants Associated with Primary Hyperoxaluria Type 1 60
Bile acid derivatives as ligands of the farnesoid X receptor. Synthesis, evaluation, and structure-activity relationship of a series of body and side chain modified analogues of chenodeoxycholic acid. 60
Heterocyclic modulators of the NMDA Receptor 60
Predictive ability of regression models. Part I: Standard Deviation of Prediction Errors (SDEP) 60
Insights into phenylalanine derivatives recognition of VLA-4 integrin: from a pharmacophoric study to 3D-QSAR and molecular docking analyses 59
Modulation of glutamate receptor pathways in the search for new neuroprotective agents. 59
On the way to selective PARP-2 inhibitors. Design, synthesis, and preliminary evaluation of a series of isoquinolinone derivatives 59
Disjoint Principal Properties of Organic Substituents 59
Predictive binding of .beta.-carboline inverse agonists and antagonists via the CoMFA/GOLPE approach 59
A one-pot two-step microwave-assisted synthesis of N1-substituted 5,6-ring-fused 2-pyridones 59
Homology Modeling, Validation and Dynamics of the G Protein-coupled Estrogen Receptor 1 (GPER-1) 59
QSAR study of anticonvulsant negative allosteric modulators of the AMPA receptor. 58
The pseudoactive site as a tool for indirect drug design. Application to inhibitors of kynurenine-3-hydroxylase 58
Discovery of New Potential Anti-Infective Compounds Based on Carbonic Anhydrase Inhibitors by Rational Target-Focused Repurposing Approaches 58
Addressing the Conformational Flexibility of Serine Racemase by Combining Targeted Molecular Dynamics, Conformational Sampling and Docking Studies 58
Series Design 58
A microwave-assisted multicomponent protocol for the synthesis of benzofuran-2-carboxamides 58
A combined ligand- and structure-based approach for the identification of rilmenidine-derived compounds which synergize the antitumor effects of doxorubicin 58
Homology model of the closed, functionally active, form of the amino terminal domain of mGlur1. 57
Synthesis and preliminary biological evaluation at the glycineB site of (+) and (-)-oxetanylglycine, a novel non proteinogenic aminoacid 57
In silico approaches towards the understanding of the structure-function relationships in metabotropic glutamate receptors (mGluRs) and other family C GPRCs. 56
Sodium channel blockers for neuropathic pain. 56
Homology Modeling of Metabotropic Glutamate Receptors (mGluRs). Structural Motifs Affecting Binding Modes and Pharmacological Profile of mGluR1 Agonists and Competitive Antagonists 56
Modulation of bacterial metabolism by the microenvironment controls MAIT cell stimulation article 55
Chemical Markers in Italian Propolis: Chrysin, Galangin and CAPE as Indicators of Geographic Origin 55
Synthesis, molecular modeling and preliminary biological evaluation of 1-amino-3-phosphono-3-cyclopentene-1-carboxylic acid and 1-amino-3-phosphono-2-cyclopentene-1-carboxylic acid, two novel agonists of metabotropic glutamate receptors of group III. 54
Nongenomic actions of bile acids. Synthesis and preliminary characterization of 23- and 6,23-alkyl-substituted bile acid derivatives as selective modulators for the G-protein coupled receptor TGR5 53
Design, Synthesis and Preliminary Evaluation of Novel 3’-Substituted Carboxycyclopropylglycines as Antagonists at Group 2 Metabotropic Glutamate Receptors 53
Synthesis and biological evaluation of (2S)- and (2R)-2-(3'-phosphonobicyclo[1.1.1]pentyl)glycines as novel group III selective metabotropic glutamate receptor ligands. 52
Totale 7.656
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Categoria #
all - tutte 46.290
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 46.290
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020312 0 0 0 0 0 0 0 0 0 167 30 115
2020/2021931 6 107 74 17 131 24 97 50 219 48 137 21
2021/2022796 19 35 20 41 28 37 88 111 47 50 67 253
2022/20232.630 338 289 143 177 248 309 34 161 791 20 79 41
2023/2024940 59 79 27 48 96 148 87 68 31 57 100 140
2024/20252.292 96 203 278 169 315 343 145 149 374 220 0 0
Totale 10.448