IRIS
COSTANTINO, Gabriele
 Distribuzione geografica
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Continente #
NA - Nord America 8.159
AS - Asia 6.548
EU - Europa 4.428
SA - Sud America 959
AF - Africa 325
Continente sconosciuto - Info sul continente non disponibili 10
OC - Oceania 10
Totale 20.439
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Nazione #
US - Stati Uniti d'America 7.957
SG - Singapore 2.310
CN - Cina 1.789
VN - Vietnam 1.066
IT - Italia 815
BR - Brasile 745
IE - Irlanda 643
SE - Svezia 631
HK - Hong Kong 513
DE - Germania 512
FI - Finlandia 451
UA - Ucraina 403
TR - Turchia 233
FR - Francia 218
NL - Olanda 218
ZA - Sudafrica 198
BD - Bangladesh 130
CA - Canada 124
RU - Federazione Russa 115
IN - India 112
GB - Regno Unito 102
AR - Argentina 74
AT - Austria 58
IQ - Iraq 55
ES - Italia 50
MX - Messico 46
PL - Polonia 45
CI - Costa d'Avorio 43
EC - Ecuador 43
JP - Giappone 36
ID - Indonesia 34
BE - Belgio 33
PK - Pakistan 32
CZ - Repubblica Ceca 30
PH - Filippine 30
KR - Corea 29
TH - Thailandia 22
VE - Venezuela 22
CO - Colombia 20
SA - Arabia Saudita 19
UZ - Uzbekistan 19
PY - Paraguay 18
EG - Egitto 15
LT - Lituania 14
RO - Romania 14
IR - Iran 13
LU - Lussemburgo 13
TW - Taiwan 12
IL - Israele 11
MA - Marocco 11
AE - Emirati Arabi Uniti 10
PE - Perù 10
TN - Tunisia 10
BO - Bolivia 9
DZ - Algeria 9
KE - Kenya 9
MY - Malesia 9
RS - Serbia 9
UY - Uruguay 9
PA - Panama 8
CL - Cile 7
KG - Kirghizistan 7
KZ - Kazakistan 7
EU - Europa 6
JO - Giordania 6
SN - Senegal 6
AL - Albania 5
AU - Australia 5
AZ - Azerbaigian 5
BG - Bulgaria 5
CH - Svizzera 5
HN - Honduras 5
HR - Croazia 5
NP - Nepal 5
OM - Oman 5
PS - Palestinian Territory 5
TT - Trinidad e Tobago 5
CR - Costa Rica 4
KW - Kuwait 4
LV - Lettonia 4
MD - Moldavia 4
NZ - Nuova Zelanda 4
PT - Portogallo 4
RW - Ruanda 4
SK - Slovacchia (Repubblica Slovacca) 4
XK - ???statistics.table.value.countryCode.XK??? 4
BA - Bosnia-Erzegovina 3
CM - Camerun 3
EE - Estonia 3
GR - Grecia 3
JM - Giamaica 3
LB - Libano 3
SD - Sudan 3
SI - Slovenia 3
AM - Armenia 2
AO - Angola 2
BH - Bahrain 2
BN - Brunei Darussalam 2
CY - Cipro 2
DO - Repubblica Dominicana 2
Totale 20.404
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Città #
Dallas 1.727
Singapore 1.178
Ashburn 803
Chandler 644
Dublin 639
San Jose 599
Jacksonville 490
Hong Kong 489
Beijing 475
Santa Clara 362
Parma 348
Ho Chi Minh City 305
Hanoi 260
Ann Arbor 225
Boardman 209
Nanjing 189
Johannesburg 180
Izmir 170
Lauterbourg 156
Princeton 154
Dearborn 146
Los Angeles 144
Munich 114
Wilmington 110
Shanghai 102
San Mateo 100
Hefei 96
Helsinki 94
New York 91
Toronto 72
Buffalo 68
Nanchang 67
Bremen 65
São Paulo 61
Columbus 58
Moscow 58
Haiphong 56
Da Nang 54
Shenyang 53
Council Bluffs 48
Frankfurt am Main 48
Chicago 45
Hebei 44
Turku 44
Abidjan 43
Jinan 43
Jiaxing 41
Kunming 40
Warsaw 40
Guangzhou 39
Houston 39
Vienna 37
The Dalles 36
Des Moines 35
Milan 35
Brooklyn 34
Hillsboro 32
Atlanta 31
Tianjin 31
Changsha 29
Bologna 27
London 27
Jakarta 26
Orem 26
Tokyo 26
Brussels 25
Norwalk 25
Baghdad 24
Kocaeli 24
Seattle 24
Chennai 23
Falls Church 20
Boston 19
Curitiba 19
Istanbul 19
Seoul 19
Biên Hòa 18
Montreal 18
Quito 18
Rio de Janeiro 18
Belo Horizonte 17
Denver 17
Nuremberg 17
San Francisco 17
Amsterdam 16
Bengaluru 16
Brno 16
Zhengzhou 16
Stockholm 15
Dhaka 14
Tashkent 14
Woodbridge 14
Hải Dương 13
Modena 13
Rome 13
Manchester 12
Poplar 12
Thái Bình 12
Brasília 11
Hangzhou 11
Totale 12.756
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Nome #
1,4-Benzothiazine and 1,4-benzoxazine imidazole derivatives with antifungal activity: a docking study 1.605
Discovery of Substituted (2-Aminooxazol-4-yl)Isoxazole-3-carboxylic Acids as Inhibitors of Bacterial Serine Acetyltransferase in the Quest for Novel Potential Antibacterial Adjuvants 264
Antibacterial and antibiofilm activity of Eucalyptus globulus leaf extract, asiatic acid and ursolic acid against bacteria isolated from bovine mastitis 254
The in silico drug discovery toolbox: applications in lead discovery and optimization 236
Investigational Studies on a Hit Compound Cyclopropane-Carboxylic Acid Derivative Targeting O-Acetylserine Sulfhydrylase as a Colistin Adjuvant 219
Irreversible Inhibition of Epidermal Growth Factor Receptor Activity by 3-Aminopropanamides. 214
Exploring the chemical space around N-(5-nitrothiazol-2-yl)-1,2,3-thiadiazole-4-carboxamide, a hit compound with serine acetyltransferase (SAT) inhibitory properties 201
Refining the structure−activity relationships of 2-phenylcyclopropane carboxylic acids as inhibitors of O-acetylserine sulfhydrylase isoforms 198
Nuovi composti antimicrobici 193
Inhibitors of O-Acetylserine Sulfhydrylase with a Cyclopropane-Carboxylic Acid Scaffold Are Effective Colistin Adjuvants in Gram Negative Bacteria 190
A competitive o‐acetylserine sulfhydrylase inhibitor modulates the formation of cysteine synthase complex 190
Antifungal properties of newly designed carbonic anhydrases inhibitors selective for microbial enzymes 189
Aspergillus fumigatus tryptophan metabolic route differently affects host immunity 183
Design and synthesis of trans-2-substituted-cyclopropane-1-carboxylic acids as the first non-natural small molecule inhibitors of O-acetylserine sulfhydrylase 179
Rational Design, Synthesis and Preliminary Structure-Activity Relationships of α-Substituted-2-Phenylcyclopropane Carboxylic Acids as Inhibitors of Salmonella Typhimurium O-Acetylserine Sulfhydrylase 179
Integration of Enhanced Sampling Methods with Saturation Transfer Difference Experiments to Identify Protein Druggable Pockets 178
Chemical Probes to Investigate Central Nervous System Disorders: Design, Synthesis and Mechanism of Action of a Potent Human Serine Racemase Inhibitor 176
Probing the Reactivity of 2,4-Dichlorofuro[3,4-d ]pyrimidin-7-one: A Versatile and Underexploited Scaffold to Generate Substituted or Fused Pyrimidine Derivatives 174
Inhibition of Nonessential Bacterial Targets: Discovery of a Novel Serine O-Acetyltransferase Inhibitor 174
Preliminary structure−activity relationships analysis on N-(3,5-dichlorophenyl)-4,5-dihydronaphtho[1,2-d]thiazol-2-amine, a disruptor of mycobacterial energetics 171
ANTIMICROBIAL AND ANTIBIOFILM ACTIVITY OF EUCALYPTUS GLOBULUS LEAVES EXTRACT AND ITS MAIN COMPOUNDS ON MASTITIS PATHOGENS OF DAIRY COWS. 170
Extraction and Quantification of Azelaic Acid from Different Wheat Samples (Triticum durum Desf.) and Evaluation of Their Antimicrobial and Antioxidant Activities 170
2-Aminooxazole as a Novel Privileged Scaffold in Antitubercular Medicinal Chemistry 166
Accepting the Invitation to Open Innovation in Malaria Drug Discovery: Synthesis, Biological Evaluation, and Investigation on the Structure-Activity Relationships of Benzo[b]thiophene-2-carboxamides as Antimalarial Agents 165
Inhibitors of the sulfur assimilation pathway in bacterial pathogens as enhancers of antibiotic therapy 164
Discovering a new class of antifungal agents that selectively inhibits microbial carbonic anhydrases 163
Cyclopropane-1,2-dicarboxylic acids as new tools for the biophysical investigation of O-acetylserine sulfhydrylases by fluorimetric methods and saturation transfer difference (STD) NMR 160
Metabolite Profiling and Bioactivities of Leaves, Stems, and Flowers of Rumex usambarensis (Dammer) Dammer, a Traditional African Medicinal Plant 157
1-Aminoindane-1,5-dicarboxylic Acid: a Novel Antagonist at Phospholipase C Linked Metabotropic Glutamate Receptors 157
Cycloserine enantiomers are reversible inhibitors of human alanine:glyoxylate aminotransferase: Implications for Primary Hyperoxaluria type 1 157
Scaffold Morphing Approach To Expand the Toolbox of Broad-Spectrum Antivirals Blocking Dengue/Zika Replication 152
Aminonicotinic acid 1-oxides are chemically stable inhibitors of quinolinic acid synthesis in the mammalian brain: a step towards new anti-excitotoxic agents 146
Blocking cysteine biosynthesis in Salmonella typhimurium: the moonlighting enzyme CysK as a potential antibiotic target 144
Substituted N-Phenyl-5-(2-(phenylamino)thiazol-4-yl)isoxazole-3-carboxamides Are Valuable Antitubercular Candidates that Evade Innate Efflux Machinery 143
Modulation of bacterial metabolism by the microenvironment controls MAIT cell stimulation 143
Expanding the knowledge around antitubercular 5-(2-aminothiazol-4-yl)isoxazole-3-carboxamides: Hit–to–lead optimization and release of a novel antitubercular chemotype via scaffold derivatization 142
Adjuvant therapies against tuberculosis: discovery of a 2-aminothiazole targeting Mycobacterium tuberculosis energetics 142
Cyclopropane derivatives as potential human serine racemase inhibitors: unveiling novel insights into a difficult target 142
Chemical Markers in Italian Propolis: Chrysin, Galangin and CAPE as Indicators of Geographic Origin 142
A High Performance Workflow for Chemistry Driven de Novo Design 141
Further insights into the SAR of α-substituted cyclopropylamine derivatives as inhibitors of histone demethylase KDM1A 141
Discovery of novel fragments inhibiting O-acetylserine sulphhydrylase by combining scaffold hopping and ligand–based drug design 141
The aryl hydrocarbon receptor (AhR) mediates the counter-regulatory effects of pelargonidins in models of inflammation and metabolic dysfunctions 141
A one-pot two-step microwave-assisted synthesis of N1-substituted 5,6-ring-fused 2-pyridones 138
A combined ligand- and structure-based approach for the identification of rilmenidine-derived compounds which synergize the antitumor effects of doxorubicin 138
Molecular dynamics simulations and docking studies on 3D models of the heterodimeric and homodimeric 5-HT(2A) receptor subtype. 136
QSAR and Molecular Modeling Studies of Baclofen Analogs as GABAB Agonists. Insights into the Role of the Aromatic Moiety in GABAB Binding and Activation. 136
A multicomponent pharmacophore fragment-decoration approach to identify selective LRRK2-targeting probes 136
Inhibition of O-acetylserine sulfhydrylase by fluoroalanine derivatives 134
alfa-Diazocarbonyl Chemistry - Target Driven Applications 133
Discovery of antitubercular 2,4-diphenyl-1H-imidazoles from chemical library repositioning and rational design 132
Identification of Human Alanine-Glyoxylate Aminotransferase Ligands as Pharmacological Chaperones for Variants Associated with Primary Hyperoxaluria Type 1 130
In vitro digestion of zingiber officinale extract and evaluation of stability as a first step to determine its bioaccesibility 130
A microwave-assisted multicomponent protocol for the synthesis of benzofuran-2-carboxamides 130
Dirhodium(II)-tetraacetate-Mediated Decomposition of Ethyldiazo- acetate and Ethyldiazomalonate in the Presence of Fullerene. A New Procedure for the Selective Synthesis of [6-6]-Closed Methanofullerenes 126
6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity. 125
Discovery of New Potential Anti-Infective Compounds Based on Carbonic Anhydrase Inhibitors by Rational Target-Focused Repurposing Approaches 125
Identification of Breast Cancer Inhibitors Specific for G Protein-Coupled Estrogen Receptor (GPER)-Expressing Cells 124
Nuova composizione 123
S-(+)-2-(3'-Carboxy-bicyclo[1.1.1]pentyl)glycine, a Structurally New Group I Metabotropic Glutamate Receptor Antagonist 119
Design, Synthesis and Investigation onthe Structure–Activity Relationships of N-Substituted 2-Aminothiazole Derivatives as Antitubercular Agents 119
Discovery of Multitarget Antivirals Acting on Both the Dengue Virus NS5-NS3 Interaction and the Host Src/Fyn Kinases 119
In silico approaches towards the understanding of the structure-function relationships in metabotropic glutamate receptors (mGluRs) and other family C GPRCs. 118
Discovery of Multitarget Agents Active as Broad-Spectrum Antivirals and Correctors of Cystic Fibrosis Transmembrane Conductance Regulator for Associated Pulmonary Diseases 118
Use of Experimental Design To Optimize Docking Performance: The Case of LiGenDock, the Docking Module of Ligen, a New De Novo Design Program 117
Rational Design and Synthesis of Thioridazine Analogues as Enhancers of the Antituberculosis Therapy 117
Antimicrobial peptides (AMPs): a patent review (2015-2020) 116
Predictive binding of .beta.-carboline inverse agonists and antagonists via the CoMFA/GOLPE approach 116
Homology Modeling, Validation and Dynamics of the G Protein-coupled Estrogen Receptor 1 (GPER-1) 116
Autocorrelation as a tool for a congruent description of molecules in 3D-QSAR studies 115
Derivatives of Nicotinic Acid N-Oxide, their preparation and their use as inhibitors of enzyme 3-hydroxyanthranilate-3,4-dioxygenase 115
Identification of Broad-Spectrum Dengue/Zika Virus Replication Inhibitors by Functionalization of Quinoline and 2,6-Diaminopurine Scaffolds 115
Discovery and characterization of novel potent PARP-1 inhibitors endowed with neuroprotective properties: From TIQ-A to HYDAMTIQ 114
Asymmetric Synthesis of Enantiomerically Pure (2S,1'S,2'S,3'R)-phenylcarboxycyclopropylglycine (PCCG-4): A Potent and Selective Ligand at Group II Metabotropic Glutamate Receptors 114
Design, Synthesis and Preliminary Evaluation of Novel 3’-Substituted Carboxycyclopropylglycines as Antagonists at Group 2 Metabotropic Glutamate Receptors 114
Computational Insights into the mechanism of inhibition of OASS-A by a small molecule inhibitor 113
Addressing the Conformational Flexibility of Serine Racemase by Combining Targeted Molecular Dynamics, Conformational Sampling and Docking Studies 113
Synthesis and Biological Evaluation of 6-Carboxy-3,4-methanoprolines, New Rigid Glutamate Analogs 112
(2R,1'S,2'R,3'S)-2-(2'-Carboxy-3'-phenylcyclopropyl)glycine (PCCG-13), the first potent and selective competitive antagonist of phospholipase D-coupled metabotropic glutamate receptors: asymmetric synthesis and preliminary biological properties 112
Modulation of bacterial metabolism by the microenvironment controls MAIT cell stimulation article 111
Generating optimal linear PLS estimation (GOLPE). An advanced chemometric tool for handling 3D-QSAR problems 109
Heterocyclic modulators of the NMDA Receptor 109
Formulazione topica a base di estratto di Eucalyptus Globus L. e antibiotici convenzionali per il trattamento dell'uomo e nell'animale delle infezioni della pelle e del cavo orale 104
Sodium channel blockers for neuropathic pain. 104
Synthesis of 6,6-Dicarboxy-3,4-methano-L-proline, a New Constrained Glutamate Analog Endowed with Neuroprotective Properties 103
Predictive ability of regression models. Part II: Selection of the best predictive PLS model 102
Back door modulation of the farnesoid X receptor: design, synthesis, and biological evaluation of a series of side chain modified chenodeoxycholic acid derivatives. 102
Kynurenine-3-hydroxylase and its Selective Inhibitors: Molecular Modelling Studies 101
Membrane-Sensitive Conformational States of Helix 8 in the Metabotropic Glu2 Receptor, a Class C GPCR 101
Series Design 100
Homology Modeling of Metabotropic Glutamate Receptors (mGluRs). Structural Motifs Affecting Binding Modes and Pharmacological Profile of mGluR1 Agonists and Competitive Antagonists 99
Homology model of the closed, functionally active, form of the amino terminal domain of mGlur1. 98
Synthesis and biological evaluation of (2S)- and (2R)-2-(3'-phosphonobicyclo[1.1.1]pentyl)glycines as novel group III selective metabotropic glutamate receptor ligands. 98
Life or death decisions: the cast of poly(ADP-ribose)polymerase (PARP) as a therapeutic target for brain ischaemia. 98
Unveiling hidden features of orphan nuclear receptors: the case of the small heterodimer partner (SHP). 97
Molecular dynamics simulation of the heterodimeric mGluR2/5HT(2A) complex. An atomistic resolution study of a potential new target in psychiatric conditions. 96
Metabotropic glutamate receptors: new ligads and molecular modelling studies 95
Predictive ability of regression models. Part I: Standard Deviation of Prediction Errors (SDEP) 94
Conformational requirements for interaction of L-Glutamic acid with metabotropic EEA receptors 93
Target flexibility: an emerging consideration in drug discovery and design 93
Totale 15.371
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Categoria #
all - tutte 72.329
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 72.329
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/202121 0 0 0 0 0 0 0 0 0 0 0 21
2021/2022796 19 35 20 41 28 37 88 111 47 50 67 253
2022/20232.630 338 289 143 177 248 309 34 161 791 20 79 41
2023/2024940 59 79 27 48 96 148 87 68 31 57 100 140
2024/20253.544 96 205 292 172 316 352 151 151 378 320 377 734
2025/20268.887 749 1.056 1.924 727 1.056 396 898 265 921 504 218 173
Totale 20.587