IRIS
COSTANTINO, Gabriele
 Distribuzione geografica
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Continente #
NA - Nord America 8.544
AS - Asia 6.582
EU - Europa 4.499
SA - Sud America 967
AF - Africa 326
Continente sconosciuto - Info sul continente non disponibili 158
OC - Oceania 10
Totale 21.086
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Nazione #
US - Stati Uniti d'America 8.328
SG - Singapore 2.322
CN - Cina 1.799
VN - Vietnam 1.066
IT - Italia 851
BR - Brasile 750
SE - Svezia 652
IE - Irlanda 643
DE - Germania 516
HK - Hong Kong 515
FI - Finlandia 451
UA - Ucraina 403
TR - Turchia 233
FR - Francia 219
NL - Olanda 218
ZA - Sudafrica 198
BD - Bangladesh 137
CA - Canada 127
RU - Federazione Russa 115
IN - India 112
GB - Regno Unito 103
AR - Argentina 75
AT - Austria 58
IQ - Iraq 56
ES - Italia 52
MX - Messico 46
PL - Polonia 45
CI - Costa d'Avorio 43
EC - Ecuador 43
JP - Giappone 37
ID - Indonesia 34
BE - Belgio 33
PK - Pakistan 32
CZ - Repubblica Ceca 30
PH - Filippine 30
KR - Corea 29
TH - Thailandia 22
VE - Venezuela 22
CO - Colombia 21
SA - Arabia Saudita 19
UZ - Uzbekistan 19
PY - Paraguay 18
EG - Egitto 15
RO - Romania 15
LT - Lituania 14
LU - Lussemburgo 14
IR - Iran 13
MA - Marocco 12
TW - Taiwan 12
IL - Israele 11
PE - Perù 11
AE - Emirati Arabi Uniti 10
MY - Malesia 10
TN - Tunisia 10
BO - Bolivia 9
DZ - Algeria 9
KE - Kenya 9
RS - Serbia 9
UY - Uruguay 9
PA - Panama 8
CL - Cile 7
JM - Giamaica 7
KG - Kirghizistan 7
KZ - Kazakistan 7
AL - Albania 6
CR - Costa Rica 6
EU - Europa 6
JO - Giordania 6
PT - Portogallo 6
SN - Senegal 6
AU - Australia 5
AZ - Azerbaigian 5
BG - Bulgaria 5
CH - Svizzera 5
HN - Honduras 5
HR - Croazia 5
NP - Nepal 5
OM - Oman 5
PS - Palestinian Territory 5
TT - Trinidad e Tobago 5
KW - Kuwait 4
LV - Lettonia 4
MD - Moldavia 4
NZ - Nuova Zelanda 4
RW - Ruanda 4
SK - Slovacchia (Repubblica Slovacca) 4
XK - ???statistics.table.value.countryCode.XK??? 4
BA - Bosnia-Erzegovina 3
CM - Camerun 3
EE - Estonia 3
GR - Grecia 3
GT - Guatemala 3
LB - Libano 3
NI - Nicaragua 3
SD - Sudan 3
SI - Slovenia 3
AM - Armenia 2
AO - Angola 2
BB - Barbados 2
BH - Bahrain 2
Totale 20.899
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Città #
Dallas 1.727
Singapore 1.181
Ashburn 818
Chandler 644
Dublin 639
San Jose 633
Hong Kong 491
Jacksonville 490
Beijing 478
Santa Clara 376
Parma 349
Ho Chi Minh City 305
Council Bluffs 282
Hanoi 260
Ann Arbor 225
Boardman 209
Nanjing 189
Johannesburg 180
Izmir 170
Lauterbourg 156
Princeton 154
Dearborn 146
Los Angeles 145
Munich 114
Wilmington 110
Shanghai 107
San Mateo 100
Hefei 96
Helsinki 94
New York 91
Toronto 72
Buffalo 68
Nanchang 67
Bremen 65
São Paulo 62
Moscow 59
Columbus 58
Haiphong 56
Da Nang 54
Shenyang 53
Frankfurt am Main 52
Milan 48
Chicago 45
Hebei 44
Turku 44
Abidjan 43
Jinan 43
Jiaxing 41
Kunming 40
Warsaw 40
Guangzhou 39
Houston 39
Vienna 37
Brooklyn 36
The Dalles 36
Des Moines 35
Atlanta 32
Hillsboro 32
Tianjin 31
Bologna 30
Changsha 29
London 27
Tokyo 27
Jakarta 26
Orem 26
Baghdad 25
Brussels 25
Norwalk 25
Kocaeli 24
Seattle 24
Chennai 23
Falls Church 20
Boston 19
Curitiba 19
Istanbul 19
Seoul 19
Biên Hòa 18
Montreal 18
Quito 18
Rio de Janeiro 18
Rome 18
Belo Horizonte 17
Denver 17
Nuremberg 17
San Francisco 17
Amsterdam 16
Bengaluru 16
Brno 16
Zhengzhou 16
Stockholm 15
Dhaka 14
Modena 14
Tashkent 14
Woodbridge 14
Hải Dương 13
Phoenix 13
Manchester 12
Poplar 12
Thái Bình 12
Brasília 11
Totale 13.103
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Nome #
1,4-Benzothiazine and 1,4-benzoxazine imidazole derivatives with antifungal activity: a docking study 1.625
Antibacterial and antibiofilm activity of Eucalyptus globulus leaf extract, asiatic acid and ursolic acid against bacteria isolated from bovine mastitis 275
Discovery of Substituted (2-Aminooxazol-4-yl)Isoxazole-3-carboxylic Acids as Inhibitors of Bacterial Serine Acetyltransferase in the Quest for Novel Potential Antibacterial Adjuvants 267
The in silico drug discovery toolbox: applications in lead discovery and optimization 238
Investigational Studies on a Hit Compound Cyclopropane-Carboxylic Acid Derivative Targeting O-Acetylserine Sulfhydrylase as a Colistin Adjuvant 219
Irreversible Inhibition of Epidermal Growth Factor Receptor Activity by 3-Aminopropanamides. 217
Exploring the chemical space around N-(5-nitrothiazol-2-yl)-1,2,3-thiadiazole-4-carboxamide, a hit compound with serine acetyltransferase (SAT) inhibitory properties 207
Refining the structure−activity relationships of 2-phenylcyclopropane carboxylic acids as inhibitors of O-acetylserine sulfhydrylase isoforms 199
A competitive o‐acetylserine sulfhydrylase inhibitor modulates the formation of cysteine synthase complex 195
Nuovi composti antimicrobici 195
ANTIMICROBIAL AND ANTIBIOFILM ACTIVITY OF EUCALYPTUS GLOBULUS LEAVES EXTRACT AND ITS MAIN COMPOUNDS ON MASTITIS PATHOGENS OF DAIRY COWS. 194
Antifungal properties of newly designed carbonic anhydrases inhibitors selective for microbial enzymes 194
Inhibitors of O-Acetylserine Sulfhydrylase with a Cyclopropane-Carboxylic Acid Scaffold Are Effective Colistin Adjuvants in Gram Negative Bacteria 192
Aspergillus fumigatus tryptophan metabolic route differently affects host immunity 184
Design and synthesis of trans-2-substituted-cyclopropane-1-carboxylic acids as the first non-natural small molecule inhibitors of O-acetylserine sulfhydrylase 183
Rational Design, Synthesis and Preliminary Structure-Activity Relationships of α-Substituted-2-Phenylcyclopropane Carboxylic Acids as Inhibitors of Salmonella Typhimurium O-Acetylserine Sulfhydrylase 182
Chemical Probes to Investigate Central Nervous System Disorders: Design, Synthesis and Mechanism of Action of a Potent Human Serine Racemase Inhibitor 181
Inhibition of Nonessential Bacterial Targets: Discovery of a Novel Serine O-Acetyltransferase Inhibitor 178
Integration of Enhanced Sampling Methods with Saturation Transfer Difference Experiments to Identify Protein Druggable Pockets 178
Preliminary structure−activity relationships analysis on N-(3,5-dichlorophenyl)-4,5-dihydronaphtho[1,2-d]thiazol-2-amine, a disruptor of mycobacterial energetics 177
Extraction and Quantification of Azelaic Acid from Different Wheat Samples (Triticum durum Desf.) and Evaluation of Their Antimicrobial and Antioxidant Activities 176
Probing the Reactivity of 2,4-Dichlorofuro[3,4-d ]pyrimidin-7-one: A Versatile and Underexploited Scaffold to Generate Substituted or Fused Pyrimidine Derivatives 174
Inhibitors of the sulfur assimilation pathway in bacterial pathogens as enhancers of antibiotic therapy 169
2-Aminooxazole as a Novel Privileged Scaffold in Antitubercular Medicinal Chemistry 168
Accepting the Invitation to Open Innovation in Malaria Drug Discovery: Synthesis, Biological Evaluation, and Investigation on the Structure-Activity Relationships of Benzo[b]thiophene-2-carboxamides as Antimalarial Agents 167
Metabolite Profiling and Bioactivities of Leaves, Stems, and Flowers of Rumex usambarensis (Dammer) Dammer, a Traditional African Medicinal Plant 164
Discovering a new class of antifungal agents that selectively inhibits microbial carbonic anhydrases 164
Cyclopropane-1,2-dicarboxylic acids as new tools for the biophysical investigation of O-acetylserine sulfhydrylases by fluorimetric methods and saturation transfer difference (STD) NMR 163
1-Aminoindane-1,5-dicarboxylic Acid: a Novel Antagonist at Phospholipase C Linked Metabotropic Glutamate Receptors 159
Cycloserine enantiomers are reversible inhibitors of human alanine:glyoxylate aminotransferase: Implications for Primary Hyperoxaluria type 1 159
Blocking cysteine biosynthesis in Salmonella typhimurium: the moonlighting enzyme CysK as a potential antibiotic target 156
Scaffold Morphing Approach To Expand the Toolbox of Broad-Spectrum Antivirals Blocking Dengue/Zika Replication 152
Aminonicotinic acid 1-oxides are chemically stable inhibitors of quinolinic acid synthesis in the mammalian brain: a step towards new anti-excitotoxic agents 148
Chemical Markers in Italian Propolis: Chrysin, Galangin and CAPE as Indicators of Geographic Origin 146
Substituted N-Phenyl-5-(2-(phenylamino)thiazol-4-yl)isoxazole-3-carboxamides Are Valuable Antitubercular Candidates that Evade Innate Efflux Machinery 145
A High Performance Workflow for Chemistry Driven de Novo Design 144
Cyclopropane derivatives as potential human serine racemase inhibitors: unveiling novel insights into a difficult target 144
Further insights into the SAR of α-substituted cyclopropylamine derivatives as inhibitors of histone demethylase KDM1A 144
Modulation of bacterial metabolism by the microenvironment controls MAIT cell stimulation 144
Expanding the knowledge around antitubercular 5-(2-aminothiazol-4-yl)isoxazole-3-carboxamides: Hit–to–lead optimization and release of a novel antitubercular chemotype via scaffold derivatization 143
A one-pot two-step microwave-assisted synthesis of N1-substituted 5,6-ring-fused 2-pyridones 143
Adjuvant therapies against tuberculosis: discovery of a 2-aminothiazole targeting Mycobacterium tuberculosis energetics 143
The aryl hydrocarbon receptor (AhR) mediates the counter-regulatory effects of pelargonidins in models of inflammation and metabolic dysfunctions 143
Discovery of novel fragments inhibiting O-acetylserine sulphhydrylase by combining scaffold hopping and ligand–based drug design 142
A combined ligand- and structure-based approach for the identification of rilmenidine-derived compounds which synergize the antitumor effects of doxorubicin 141
A multicomponent pharmacophore fragment-decoration approach to identify selective LRRK2-targeting probes 138
Molecular dynamics simulations and docking studies on 3D models of the heterodimeric and homodimeric 5-HT(2A) receptor subtype. 137
QSAR and Molecular Modeling Studies of Baclofen Analogs as GABAB Agonists. Insights into the Role of the Aromatic Moiety in GABAB Binding and Activation. 137
alfa-Diazocarbonyl Chemistry - Target Driven Applications 135
Discovery of antitubercular 2,4-diphenyl-1H-imidazoles from chemical library repositioning and rational design 134
Inhibition of O-acetylserine sulfhydrylase by fluoroalanine derivatives 134
A microwave-assisted multicomponent protocol for the synthesis of benzofuran-2-carboxamides 133
Identification of Human Alanine-Glyoxylate Aminotransferase Ligands as Pharmacological Chaperones for Variants Associated with Primary Hyperoxaluria Type 1 132
In vitro digestion of zingiber officinale extract and evaluation of stability as a first step to determine its bioaccesibility 131
6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity. 128
Dirhodium(II)-tetraacetate-Mediated Decomposition of Ethyldiazo- acetate and Ethyldiazomalonate in the Presence of Fullerene. A New Procedure for the Selective Synthesis of [6-6]-Closed Methanofullerenes 127
Discovery of New Potential Anti-Infective Compounds Based on Carbonic Anhydrase Inhibitors by Rational Target-Focused Repurposing Approaches 126
Identification of Breast Cancer Inhibitors Specific for G Protein-Coupled Estrogen Receptor (GPER)-Expressing Cells 125
Nuova composizione 125
Discovery of Multitarget Antivirals Acting on Both the Dengue Virus NS5-NS3 Interaction and the Host Src/Fyn Kinases 123
S-(+)-2-(3'-Carboxy-bicyclo[1.1.1]pentyl)glycine, a Structurally New Group I Metabotropic Glutamate Receptor Antagonist 122
In silico approaches towards the understanding of the structure-function relationships in metabotropic glutamate receptors (mGluRs) and other family C GPRCs. 121
Predictive binding of .beta.-carboline inverse agonists and antagonists via the CoMFA/GOLPE approach 121
Antimicrobial peptides (AMPs): a patent review (2015-2020) 120
Design, Synthesis and Investigation onthe Structure–Activity Relationships of N-Substituted 2-Aminothiazole Derivatives as Antitubercular Agents 120
Homology Modeling, Validation and Dynamics of the G Protein-coupled Estrogen Receptor 1 (GPER-1) 120
Discovery of Multitarget Agents Active as Broad-Spectrum Antivirals and Correctors of Cystic Fibrosis Transmembrane Conductance Regulator for Associated Pulmonary Diseases 120
Use of Experimental Design To Optimize Docking Performance: The Case of LiGenDock, the Docking Module of Ligen, a New De Novo Design Program 119
Addressing the Conformational Flexibility of Serine Racemase by Combining Targeted Molecular Dynamics, Conformational Sampling and Docking Studies 118
Rational Design and Synthesis of Thioridazine Analogues as Enhancers of the Antituberculosis Therapy 118
Identification of Broad-Spectrum Dengue/Zika Virus Replication Inhibitors by Functionalization of Quinoline and 2,6-Diaminopurine Scaffolds 118
Synthesis and Biological Evaluation of 6-Carboxy-3,4-methanoprolines, New Rigid Glutamate Analogs 117
Derivatives of Nicotinic Acid N-Oxide, their preparation and their use as inhibitors of enzyme 3-hydroxyanthranilate-3,4-dioxygenase 117
Autocorrelation as a tool for a congruent description of molecules in 3D-QSAR studies 116
Asymmetric Synthesis of Enantiomerically Pure (2S,1'S,2'S,3'R)-phenylcarboxycyclopropylglycine (PCCG-4): A Potent and Selective Ligand at Group II Metabotropic Glutamate Receptors 116
Design, Synthesis and Preliminary Evaluation of Novel 3’-Substituted Carboxycyclopropylglycines as Antagonists at Group 2 Metabotropic Glutamate Receptors 116
Formulazione topica a base di estratto di Eucalyptus Globus L. e antibiotici convenzionali per il trattamento dell'uomo e nell'animale delle infezioni della pelle e del cavo orale 115
Computational Insights into the mechanism of inhibition of OASS-A by a small molecule inhibitor 115
Discovery and characterization of novel potent PARP-1 inhibitors endowed with neuroprotective properties: From TIQ-A to HYDAMTIQ 115
(2R,1'S,2'R,3'S)-2-(2'-Carboxy-3'-phenylcyclopropyl)glycine (PCCG-13), the first potent and selective competitive antagonist of phospholipase D-coupled metabotropic glutamate receptors: asymmetric synthesis and preliminary biological properties 114
Heterocyclic modulators of the NMDA Receptor 112
Modulation of bacterial metabolism by the microenvironment controls MAIT cell stimulation article 112
Generating optimal linear PLS estimation (GOLPE). An advanced chemometric tool for handling 3D-QSAR problems 110
Sodium channel blockers for neuropathic pain. 108
Kynurenine-3-hydroxylase and its Selective Inhibitors: Molecular Modelling Studies 106
Synthesis and biological evaluation of (2S)- and (2R)-2-(3'-phosphonobicyclo[1.1.1]pentyl)glycines as novel group III selective metabotropic glutamate receptor ligands. 105
Predictive ability of regression models. Part II: Selection of the best predictive PLS model 104
Synthesis of 6,6-Dicarboxy-3,4-methano-L-proline, a New Constrained Glutamate Analog Endowed with Neuroprotective Properties 104
Life or death decisions: the cast of poly(ADP-ribose)polymerase (PARP) as a therapeutic target for brain ischaemia. 103
Membrane-Sensitive Conformational States of Helix 8 in the Metabotropic Glu2 Receptor, a Class C GPCR 103
Back door modulation of the farnesoid X receptor: design, synthesis, and biological evaluation of a series of side chain modified chenodeoxycholic acid derivatives. 103
Series Design 103
Homology model of the closed, functionally active, form of the amino terminal domain of mGlur1. 101
Molecular dynamics simulation of the heterodimeric mGluR2/5HT(2A) complex. An atomistic resolution study of a potential new target in psychiatric conditions. 101
Homology Modeling of Metabotropic Glutamate Receptors (mGluRs). Structural Motifs Affecting Binding Modes and Pharmacological Profile of mGluR1 Agonists and Competitive Antagonists 100
Predictive ability of regression models. Part I: Standard Deviation of Prediction Errors (SDEP) 99
Unveiling hidden features of orphan nuclear receptors: the case of the small heterodimer partner (SHP). 98
Metabotropic glutamate receptors: new ligads and molecular modelling studies 97
Conformational requirements for interaction of L-Glutamic acid with metabotropic EEA receptors 96
Target flexibility: an emerging consideration in drug discovery and design 94
Totale 15.703
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Categoria #
all - tutte 75.549
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 75.549
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022777 0 35 20 41 28 37 88 111 47 50 67 253
2022/20232.630 338 289 143 177 248 309 34 161 791 20 79 41
2023/2024940 59 79 27 48 96 148 87 68 31 57 100 140
2024/20253.544 96 205 292 172 316 352 151 151 378 320 377 734
2025/20268.904 749 1.056 1.924 727 1.056 396 898 265 921 504 218 190
2026/2027482 166 316 0 0 0 0 0 0 0 0 0 0
Totale 21.086