IRIS
COSTANTINO, Gabriele
 Distribuzione geografica
Salva come PNG Salva come JPEG
Continente #
NA - Nord America 6.907
AS - Asia 4.928
EU - Europa 3.999
SA - Sud America 865
AF - Africa 269
Continente sconosciuto - Info sul continente non disponibili 9
OC - Oceania 8
Totale 16.985
Salva come PNG Salva come JPEG
Nazione #
US - Stati Uniti d'America 6.743
SG - Singapore 1.990
CN - Cina 1.616
IT - Italia 708
BR - Brasile 690
IE - Irlanda 639
SE - Svezia 629
DE - Germania 478
FI - Finlandia 446
HK - Hong Kong 436
UA - Ucraina 394
VN - Vietnam 300
TR - Turchia 222
NL - Olanda 212
ZA - Sudafrica 163
CA - Canada 105
RU - Federazione Russa 104
GB - Regno Unito 82
IN - India 81
AR - Argentina 62
AT - Austria 56
FR - Francia 48
CI - Costa d'Avorio 41
EC - Ecuador 40
BD - Bangladesh 38
IQ - Iraq 37
MX - Messico 37
PL - Polonia 34
BE - Belgio 32
ID - Indonesia 31
CZ - Repubblica Ceca 30
JP - Giappone 26
ES - Italia 23
PK - Pakistan 21
KR - Corea 19
CO - Colombia 17
PY - Paraguay 16
UZ - Uzbekistan 15
EG - Egitto 13
IR - Iran 13
LT - Lituania 13
LU - Lussemburgo 13
RO - Romania 12
VE - Venezuela 11
IL - Israele 10
RS - Serbia 9
PA - Panama 8
PE - Perù 8
SA - Arabia Saudita 8
UY - Uruguay 8
AE - Emirati Arabi Uniti 7
BO - Bolivia 7
DZ - Algeria 7
KG - Kirghizistan 7
MA - Marocco 7
TN - Tunisia 7
EU - Europa 6
SN - Senegal 6
BG - Bulgaria 5
CL - Cile 5
KE - Kenya 5
NP - Nepal 5
AZ - Azerbaigian 4
HR - Croazia 4
JO - Giordania 4
KW - Kuwait 4
KZ - Kazakistan 4
MY - Malesia 4
NZ - Nuova Zelanda 4
RW - Ruanda 4
SK - Slovacchia (Repubblica Slovacca) 4
TT - Trinidad e Tobago 4
TW - Taiwan 4
AU - Australia 3
CH - Svizzera 3
CM - Camerun 3
EE - Estonia 3
JM - Giamaica 3
LB - Libano 3
OM - Oman 3
PS - Palestinian Territory 3
PT - Portogallo 3
SD - Sudan 3
SI - Slovenia 3
XK - ???statistics.table.value.countryCode.XK??? 3
AM - Armenia 2
AO - Angola 2
BA - Bosnia-Erzegovina 2
BH - Bahrain 2
BN - Brunei Darussalam 2
DO - Repubblica Dominicana 2
GH - Ghana 2
GR - Grecia 2
HN - Honduras 2
LV - Lettonia 2
NO - Norvegia 2
ZM - Zambia 2
AF - Afghanistan, Repubblica islamica di 1
BB - Barbados 1
CG - Congo 1
Totale 16.968
Salva come PNG Salva come JPEG
Città #
Dallas 1.704
Singapore 1.002
Chandler 644
Dublin 636
Ashburn 635
Jacksonville 490
Beijing 460
Hong Kong 434
Santa Clara 348
Parma 328
Ann Arbor 225
Nanjing 188
Boardman 185
Izmir 170
Princeton 154
Johannesburg 150
Dearborn 146
Munich 111
Wilmington 110
Ho Chi Minh City 107
San Mateo 100
Shanghai 100
Los Angeles 98
Helsinki 92
Hefei 87
New York 73
Hanoi 69
Nanchang 67
Toronto 67
Bremen 65
Columbus 58
Moscow 56
São Paulo 56
Shenyang 53
Hebei 44
Jinan 43
Abidjan 41
Jiaxing 41
Turku 41
Buffalo 40
Kunming 40
Chicago 39
Guangzhou 37
Vienna 37
Houston 35
Des Moines 34
The Dalles 34
Brooklyn 33
Milan 32
Warsaw 31
Tianjin 30
Changsha 29
Norwalk 25
Brussels 24
Jakarta 24
Kocaeli 24
Council Bluffs 23
Atlanta 22
Bologna 22
Frankfurt am Main 22
Seattle 22
Tokyo 22
Falls Church 20
London 19
Boston 18
Chennai 18
Haiphong 18
Rio de Janeiro 18
Belo Horizonte 17
Curitiba 17
Quito 17
Baghdad 16
Brno 16
Istanbul 16
Nuremberg 16
Seoul 16
Zhengzhou 16
Denver 15
San Francisco 15
Orem 14
Stockholm 14
Woodbridge 14
Bengaluru 13
Modena 13
Amsterdam 12
Da Nang 12
Tashkent 12
Biên Hòa 11
Dhaka 11
Hangzhou 11
Poplar 11
Borås 10
Brasília 10
Haikou 10
Manchester 10
Montreal 10
Fremont 9
Luxembourg 9
Phoenix 9
Ribeirão Preto 9
Totale 10.681
Salva come PNG Salva come JPEG
Nome #
1,4-Benzothiazine and 1,4-benzoxazine imidazole derivatives with antifungal activity: a docking study 1.564
Discovery of Substituted (2-Aminooxazol-4-yl)Isoxazole-3-carboxylic Acids as Inhibitors of Bacterial Serine Acetyltransferase in the Quest for Novel Potential Antibacterial Adjuvants 227
The in silico drug discovery toolbox: applications in lead discovery and optimization 213
Irreversible Inhibition of Epidermal Growth Factor Receptor Activity by 3-Aminopropanamides. 189
Investigational Studies on a Hit Compound Cyclopropane-Carboxylic Acid Derivative Targeting O-Acetylserine Sulfhydrylase as a Colistin Adjuvant 180
Nuovi composti antimicrobici 175
Refining the structure−activity relationships of 2-phenylcyclopropane carboxylic acids as inhibitors of O-acetylserine sulfhydrylase isoforms 169
Exploring the chemical space around N-(5-nitrothiazol-2-yl)-1,2,3-thiadiazole-4-carboxamide, a hit compound with serine acetyltransferase (SAT) inhibitory properties 155
A competitive o‐acetylserine sulfhydrylase inhibitor modulates the formation of cysteine synthase complex 155
Antifungal properties of newly designed carbonic anhydrases inhibitors selective for microbial enzymes 155
Integration of Enhanced Sampling Methods with Saturation Transfer Difference Experiments to Identify Protein Druggable Pockets 155
Inhibitors of O-Acetylserine Sulfhydrylase with a Cyclopropane-Carboxylic Acid Scaffold Are Effective Colistin Adjuvants in Gram Negative Bacteria 154
Design and synthesis of trans-2-substituted-cyclopropane-1-carboxylic acids as the first non-natural small molecule inhibitors of O-acetylserine sulfhydrylase 153
Rational Design, Synthesis and Preliminary Structure-Activity Relationships of α-Substituted-2-Phenylcyclopropane Carboxylic Acids as Inhibitors of Salmonella Typhimurium O-Acetylserine Sulfhydrylase 149
Probing the Reactivity of 2,4-Dichlorofuro[3,4-d ]pyrimidin-7-one: A Versatile and Underexploited Scaffold to Generate Substituted or Fused Pyrimidine Derivatives 145
Aspergillus fumigatus tryptophan metabolic route differently affects host immunity 143
Inhibition of Nonessential Bacterial Targets: Discovery of a Novel Serine O-Acetyltransferase Inhibitor 141
Scaffold Morphing Approach To Expand the Toolbox of Broad-Spectrum Antivirals Blocking Dengue/Zika Replication 137
Inhibitors of the sulfur assimilation pathway in bacterial pathogens as enhancers of antibiotic therapy 136
Discovering a new class of antifungal agents that selectively inhibits microbial carbonic anhydrases 135
2-Aminooxazole as a Novel Privileged Scaffold in Antitubercular Medicinal Chemistry 133
Accepting the Invitation to Open Innovation in Malaria Drug Discovery: Synthesis, Biological Evaluation, and Investigation on the Structure-Activity Relationships of Benzo[b]thiophene-2-carboxamides as Antimalarial Agents 130
Metabolite Profiling and Bioactivities of Leaves, Stems, and Flowers of Rumex usambarensis (Dammer) Dammer, a Traditional African Medicinal Plant 129
Cycloserine enantiomers are reversible inhibitors of human alanine:glyoxylate aminotransferase: Implications for Primary Hyperoxaluria type 1 129
1-Aminoindane-1,5-dicarboxylic Acid: a Novel Antagonist at Phospholipase C Linked Metabotropic Glutamate Receptors 128
Preliminary structure−activity relationships analysis on N-(3,5-dichlorophenyl)-4,5-dihydronaphtho[1,2-d]thiazol-2-amine, a disruptor of mycobacterial energetics 125
Aminonicotinic acid 1-oxides are chemically stable inhibitors of quinolinic acid synthesis in the mammalian brain: a step towards new anti-excitotoxic agents 123
Cyclopropane-1,2-dicarboxylic acids as new tools for the biophysical investigation of O-acetylserine sulfhydrylases by fluorimetric methods and saturation transfer difference (STD) NMR 122
Modulation of bacterial metabolism by the microenvironment controls MAIT cell stimulation 122
Extraction and Quantification of Azelaic Acid from Different Wheat Samples (Triticum durum Desf.) and Evaluation of Their Antimicrobial and Antioxidant Activities 121
Blocking cysteine biosynthesis in Salmonella typhimurium: the moonlighting enzyme CysK as a potential antibiotic target 121
Substituted N-Phenyl-5-(2-(phenylamino)thiazol-4-yl)isoxazole-3-carboxamides Are Valuable Antitubercular Candidates that Evade Innate Efflux Machinery 121
Discovery of novel fragments inhibiting O-acetylserine sulphhydrylase by combining scaffold hopping and ligand–based drug design 120
QSAR and Molecular Modeling Studies of Baclofen Analogs as GABAB Agonists. Insights into the Role of the Aromatic Moiety in GABAB Binding and Activation. 119
Inhibition of O-acetylserine sulfhydrylase by fluoroalanine derivatives 119
Discovery of antitubercular 2,4-diphenyl-1H-imidazoles from chemical library repositioning and rational design 118
Cyclopropane derivatives as potential human serine racemase inhibitors: unveiling novel insights into a difficult target 118
Dirhodium(II)-tetraacetate-Mediated Decomposition of Ethyldiazo- acetate and Ethyldiazomalonate in the Presence of Fullerene. A New Procedure for the Selective Synthesis of [6-6]-Closed Methanofullerenes 117
Molecular dynamics simulations and docking studies on 3D models of the heterodimeric and homodimeric 5-HT(2A) receptor subtype. 116
Adjuvant therapies against tuberculosis: discovery of a 2-aminothiazole targeting Mycobacterium tuberculosis energetics 115
Antibacterial and antibiofilm activity of Eucalyptus globulus leaf extract, asiatic acid and ursolic acid against bacteria isolated from bovine mastitis 114
A High Performance Workflow for Chemistry Driven de Novo Design 113
A multicomponent pharmacophore fragment-decoration approach to identify selective LRRK2-targeting probes 113
A one-pot two-step microwave-assisted synthesis of N1-substituted 5,6-ring-fused 2-pyridones 112
alfa-Diazocarbonyl Chemistry - Target Driven Applications 112
Expanding the knowledge around antitubercular 5-(2-aminothiazol-4-yl)isoxazole-3-carboxamides: Hit–to–lead optimization and release of a novel antitubercular chemotype via scaffold derivatization 111
Further insights into the SAR of α-substituted cyclopropylamine derivatives as inhibitors of histone demethylase KDM1A 111
ANTIMICROBIAL AND ANTIBIOFILM ACTIVITY OF EUCALYPTUS GLOBULUS LEAVES EXTRACT AND ITS MAIN COMPOUNDS ON MASTITIS PATHOGENS OF DAIRY COWS. 109
The aryl hydrocarbon receptor (AhR) mediates the counter-regulatory effects of pelargonidins in models of inflammation and metabolic dysfunctions 109
A microwave-assisted multicomponent protocol for the synthesis of benzofuran-2-carboxamides 105
6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity. 104
A combined ligand- and structure-based approach for the identification of rilmenidine-derived compounds which synergize the antitumor effects of doxorubicin 104
Identification of Breast Cancer Inhibitors Specific for G Protein-Coupled Estrogen Receptor (GPER)-Expressing Cells 104
Chemical Markers in Italian Propolis: Chrysin, Galangin and CAPE as Indicators of Geographic Origin 104
In silico approaches towards the understanding of the structure-function relationships in metabotropic glutamate receptors (mGluRs) and other family C GPRCs. 103
Use of Experimental Design To Optimize Docking Performance: The Case of LiGenDock, the Docking Module of Ligen, a New De Novo Design Program 103
Discovery of New Potential Anti-Infective Compounds Based on Carbonic Anhydrase Inhibitors by Rational Target-Focused Repurposing Approaches 103
In vitro digestion of zingiber officinale extract and evaluation of stability as a first step to determine its bioaccesibility 103
Discovery of Multitarget Agents Active as Broad-Spectrum Antivirals and Correctors of Cystic Fibrosis Transmembrane Conductance Regulator for Associated Pulmonary Diseases 103
Discovery of Multitarget Antivirals Acting on Both the Dengue Virus NS5-NS3 Interaction and the Host Src/Fyn Kinases 103
Design, Synthesis and Investigation onthe Structure–Activity Relationships of N-Substituted 2-Aminothiazole Derivatives as Antitubercular Agents 101
Identification of Human Alanine-Glyoxylate Aminotransferase Ligands as Pharmacological Chaperones for Variants Associated with Primary Hyperoxaluria Type 1 100
Asymmetric Synthesis of Enantiomerically Pure (2S,1'S,2'S,3'R)-phenylcarboxycyclopropylglycine (PCCG-4): A Potent and Selective Ligand at Group II Metabotropic Glutamate Receptors 100
Autocorrelation as a tool for a congruent description of molecules in 3D-QSAR studies 99
Computational Insights into the mechanism of inhibition of OASS-A by a small molecule inhibitor 98
Identification of Broad-Spectrum Dengue/Zika Virus Replication Inhibitors by Functionalization of Quinoline and 2,6-Diaminopurine Scaffolds 98
Nuova composizione 98
Discovery and characterization of novel potent PARP-1 inhibitors endowed with neuroprotective properties: From TIQ-A to HYDAMTIQ 97
S-(+)-2-(3'-Carboxy-bicyclo[1.1.1]pentyl)glycine, a Structurally New Group I Metabotropic Glutamate Receptor Antagonist 94
Synthesis and biological evaluation of (2S)- and (2R)-2-(3'-phosphonobicyclo[1.1.1]pentyl)glycines as novel group III selective metabotropic glutamate receptor ligands. 93
Synthesis and Biological Evaluation of 6-Carboxy-3,4-methanoprolines, New Rigid Glutamate Analogs 93
Predictive binding of .beta.-carboline inverse agonists and antagonists via the CoMFA/GOLPE approach 93
Derivatives of Nicotinic Acid N-Oxide, their preparation and their use as inhibitors of enzyme 3-hydroxyanthranilate-3,4-dioxygenase 92
Synthesis of 6,6-Dicarboxy-3,4-methano-L-proline, a New Constrained Glutamate Analog Endowed with Neuroprotective Properties 91
Design, Synthesis and Preliminary Evaluation of Novel 3’-Substituted Carboxycyclopropylglycines as Antagonists at Group 2 Metabotropic Glutamate Receptors 91
Modulation of bacterial metabolism by the microenvironment controls MAIT cell stimulation article 91
Unveiling hidden features of orphan nuclear receptors: the case of the small heterodimer partner (SHP). 90
Generating optimal linear PLS estimation (GOLPE). An advanced chemometric tool for handling 3D-QSAR problems 90
Rational Design and Synthesis of Thioridazine Analogues as Enhancers of the Antituberculosis Therapy 90
Life or death decisions: the cast of poly(ADP-ribose)polymerase (PARP) as a therapeutic target for brain ischaemia. 89
Antimicrobial peptides (AMPs): a patent review (2015-2020) 88
Heterocyclic modulators of the NMDA Receptor 88
Homology model of the closed, functionally active, form of the amino terminal domain of mGlur1. 87
Membrane-Sensitive Conformational States of Helix 8 in the Metabotropic Glu2 Receptor, a Class C GPCR 87
(2R,1'S,2'R,3'S)-2-(2'-Carboxy-3'-phenylcyclopropyl)glycine (PCCG-13), the first potent and selective competitive antagonist of phospholipase D-coupled metabotropic glutamate receptors: asymmetric synthesis and preliminary biological properties 87
Back door modulation of the farnesoid X receptor: design, synthesis, and biological evaluation of a series of side chain modified chenodeoxycholic acid derivatives. 86
Addressing the Conformational Flexibility of Serine Racemase by Combining Targeted Molecular Dynamics, Conformational Sampling and Docking Studies 86
Series Design 85
Homology Modeling, Validation and Dynamics of the G Protein-coupled Estrogen Receptor 1 (GPER-1) 84
Homology Modeling of Metabotropic Glutamate Receptors (mGluRs). Structural Motifs Affecting Binding Modes and Pharmacological Profile of mGluR1 Agonists and Competitive Antagonists 83
Sodium channel blockers for neuropathic pain. 82
Bile acid derivatives as ligands of the farnesoid X receptor. Synthesis, evaluation, and structure-activity relationship of a series of body and side chain modified analogues of chenodeoxycholic acid. 80
Predictive ability of regression models. Part II: Selection of the best predictive PLS model 80
Binding modes of noncompetitive AMPA antagonists: a computational approach 79
Molecular dynamics simulation of the heterodimeric mGluR2/5HT(2A) complex. An atomistic resolution study of a potential new target in psychiatric conditions. 79
Predictive ability of regression models. Part I: Standard Deviation of Prediction Errors (SDEP) 79
Modulation of glutamate receptor pathways in the search for new neuroprotective agents. 78
Bulky 1,4-benzoxazine derivatives with antifungal activity. 78
Kynurenine-3-hydroxylase and its Selective Inhibitors: Molecular Modelling Studies 78
Insights into phenylalanine derivatives recognition of VLA-4 integrin: from a pharmacophoric study to 3D-QSAR and molecular docking analyses 77
Totale 12.758
Salva come PNG Salva come JPEG
Categoria #
all - tutte 63.011
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 63.011
Salva come PNG Salva come JPEG


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021596 0 0 0 0 0 24 97 50 219 48 137 21
2021/2022796 19 35 20 41 28 37 88 111 47 50 67 253
2022/20232.630 338 289 143 177 248 309 34 161 791 20 79 41
2023/2024940 59 79 27 48 96 148 87 68 31 57 100 140
2024/20253.477 96 203 278 169 315 343 145 149 374 315 370 720
2025/20265.499 739 1.043 1.900 716 1.046 55 0 0 0 0 0 0
Totale 17.132