IRIS
COSTANTINO, Gabriele
 Distribuzione geografica
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Continente #
NA - Nord America 9.518
AS - Asia 6.638
EU - Europa 4.611
SA - Sud America 1.002
AF - Africa 336
Continente sconosciuto - Info sul continente non disponibili 163
OC - Oceania 10
Totale 22.278
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Nazione #
US - Stati Uniti d'America 9.226
SG - Singapore 2.333
CN - Cina 1.805
VN - Vietnam 1.073
IT - Italia 899
BR - Brasile 766
SE - Svezia 676
IE - Irlanda 644
HK - Hong Kong 517
DE - Germania 516
FI - Finlandia 451
UA - Ucraina 403
TR - Turchia 234
FR - Francia 224
NL - Olanda 218
ZA - Sudafrica 198
CA - Canada 167
BD - Bangladesh 140
GB - Regno Unito 124
RU - Federazione Russa 120
IN - India 114
AR - Argentina 79
AT - Austria 58
IQ - Iraq 56
ES - Italia 54
MX - Messico 51
EC - Ecuador 46
PL - Polonia 45
CI - Costa d'Avorio 44
JP - Giappone 38
PH - Filippine 35
ID - Indonesia 34
BE - Belgio 33
PK - Pakistan 32
CO - Colombia 30
CZ - Repubblica Ceca 30
KR - Corea 29
TH - Thailandia 24
VE - Venezuela 24
SA - Arabia Saudita 21
MA - Marocco 19
UZ - Uzbekistan 19
PY - Paraguay 18
IL - Israele 16
EG - Egitto 15
RO - Romania 15
IR - Iran 14
LT - Lituania 14
LU - Lussemburgo 14
CR - Costa Rica 12
JM - Giamaica 12
MY - Malesia 12
TW - Taiwan 12
PE - Perù 11
AE - Emirati Arabi Uniti 10
HN - Honduras 10
KE - Kenya 10
TN - Tunisia 10
BO - Bolivia 9
DZ - Algeria 9
RS - Serbia 9
UY - Uruguay 9
EE - Estonia 8
KZ - Kazakistan 8
PA - Panama 8
TT - Trinidad e Tobago 8
CL - Cile 7
KG - Kirghizistan 7
AL - Albania 6
BG - Bulgaria 6
EU - Europa 6
GT - Guatemala 6
JO - Giordania 6
NP - Nepal 6
PT - Portogallo 6
SN - Senegal 6
AU - Australia 5
AZ - Azerbaigian 5
CH - Svizzera 5
HR - Croazia 5
LB - Libano 5
OM - Oman 5
PS - Palestinian Territory 5
KW - Kuwait 4
LV - Lettonia 4
MD - Moldavia 4
NI - Nicaragua 4
NZ - Nuova Zelanda 4
PR - Porto Rico 4
RW - Ruanda 4
SK - Slovacchia (Repubblica Slovacca) 4
XK - ???statistics.table.value.countryCode.XK??? 4
BA - Bosnia-Erzegovina 3
BN - Brunei Darussalam 3
CM - Camerun 3
DO - Repubblica Dominicana 3
GR - Grecia 3
SD - Sudan 3
SI - Slovenia 3
AM - Armenia 2
Totale 22.078
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Città #
Dallas 1.729
Singapore 1.184
Ashburn 977
San Jose 721
Chandler 644
Dublin 639
Hong Kong 492
Jacksonville 491
Beijing 479
Santa Clara 467
Parma 358
Ho Chi Minh City 307
Council Bluffs 287
Hanoi 262
Ann Arbor 225
Boardman 209
Nanjing 189
Johannesburg 180
Izmir 170
Lauterbourg 156
Princeton 155
Los Angeles 154
Washington 154
Dearborn 146
Munich 114
Wilmington 110
Shanghai 107
San Mateo 100
Hefei 96
Helsinki 94
New York 94
Toronto 75
Buffalo 70
Nanchang 67
São Paulo 66
Bremen 65
Columbus 60
Moscow 59
Haiphong 56
Da Nang 54
Shenyang 53
Frankfurt am Main 52
Milan 50
Chicago 46
Abidjan 44
Hebei 44
Turku 44
Jinan 43
Jiaxing 41
Atlanta 40
Houston 40
Kunming 40
Warsaw 40
Guangzhou 39
Vienna 37
Brooklyn 36
The Dalles 36
Bologna 35
Des Moines 35
Hillsboro 32
Tianjin 31
Changsha 29
London 27
Tokyo 27
Jakarta 26
Orem 26
Seattle 26
Baghdad 25
Brussels 25
Norwalk 25
Kocaeli 24
Chennai 23
Montreal 22
Rome 22
Falls Church 20
Boston 19
Curitiba 19
Istanbul 19
San Francisco 19
Seoul 19
Biên Hòa 18
Quito 18
Rio de Janeiro 18
Belo Horizonte 17
Denver 17
Nuremberg 17
Phoenix 17
Amsterdam 16
Bengaluru 16
Brno 16
Zhengzhou 16
Manchester 15
Stockholm 15
Brasília 14
Dhaka 14
Modena 14
Tashkent 14
Woodbridge 14
Hải Dương 13
Poplar 12
Totale 13.673
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Nome #
1,4-Benzothiazine and 1,4-benzoxazine imidazole derivatives with antifungal activity: a docking study 1.633
Antibacterial and antibiofilm activity of Eucalyptus globulus leaf extract, asiatic acid and ursolic acid against bacteria isolated from bovine mastitis 291
Discovery of Substituted (2-Aminooxazol-4-yl)Isoxazole-3-carboxylic Acids as Inhibitors of Bacterial Serine Acetyltransferase in the Quest for Novel Potential Antibacterial Adjuvants 281
The in silico drug discovery toolbox: applications in lead discovery and optimization 245
Investigational Studies on a Hit Compound Cyclopropane-Carboxylic Acid Derivative Targeting O-Acetylserine Sulfhydrylase as a Colistin Adjuvant 228
Irreversible Inhibition of Epidermal Growth Factor Receptor Activity by 3-Aminopropanamides. 221
Chemical Probes to Investigate Central Nervous System Disorders: Design, Synthesis and Mechanism of Action of a Potent Human Serine Racemase Inhibitor 216
Exploring the chemical space around N-(5-nitrothiazol-2-yl)-1,2,3-thiadiazole-4-carboxamide, a hit compound with serine acetyltransferase (SAT) inhibitory properties 212
Antifungal properties of newly designed carbonic anhydrases inhibitors selective for microbial enzymes 209
Inhibitors of O-Acetylserine Sulfhydrylase with a Cyclopropane-Carboxylic Acid Scaffold Are Effective Colistin Adjuvants in Gram Negative Bacteria 205
ANTIMICROBIAL AND ANTIBIOFILM ACTIVITY OF EUCALYPTUS GLOBULUS LEAVES EXTRACT AND ITS MAIN COMPOUNDS ON MASTITIS PATHOGENS OF DAIRY COWS. 204
Refining the structure−activity relationships of 2-phenylcyclopropane carboxylic acids as inhibitors of O-acetylserine sulfhydrylase isoforms 203
A competitive o‐acetylserine sulfhydrylase inhibitor modulates the formation of cysteine synthase complex 202
Nuovi composti antimicrobici 200
Design and synthesis of trans-2-substituted-cyclopropane-1-carboxylic acids as the first non-natural small molecule inhibitors of O-acetylserine sulfhydrylase 198
Aspergillus fumigatus tryptophan metabolic route differently affects host immunity 195
Extraction and Quantification of Azelaic Acid from Different Wheat Samples (Triticum durum Desf.) and Evaluation of Their Antimicrobial and Antioxidant Activities 190
Rational Design, Synthesis and Preliminary Structure-Activity Relationships of α-Substituted-2-Phenylcyclopropane Carboxylic Acids as Inhibitors of Salmonella Typhimurium O-Acetylserine Sulfhydrylase 189
Preliminary structure−activity relationships analysis on N-(3,5-dichlorophenyl)-4,5-dihydronaphtho[1,2-d]thiazol-2-amine, a disruptor of mycobacterial energetics 186
Inhibition of Nonessential Bacterial Targets: Discovery of a Novel Serine O-Acetyltransferase Inhibitor 185
Integration of Enhanced Sampling Methods with Saturation Transfer Difference Experiments to Identify Protein Druggable Pockets 184
Metabolite Profiling and Bioactivities of Leaves, Stems, and Flowers of Rumex usambarensis (Dammer) Dammer, a Traditional African Medicinal Plant 183
Accepting the Invitation to Open Innovation in Malaria Drug Discovery: Synthesis, Biological Evaluation, and Investigation on the Structure-Activity Relationships of Benzo[b]thiophene-2-carboxamides as Antimalarial Agents 181
Probing the Reactivity of 2,4-Dichlorofuro[3,4-d ]pyrimidin-7-one: A Versatile and Underexploited Scaffold to Generate Substituted or Fused Pyrimidine Derivatives 180
2-Aminooxazole as a Novel Privileged Scaffold in Antitubercular Medicinal Chemistry 178
Cyclopropane-1,2-dicarboxylic acids as new tools for the biophysical investigation of O-acetylserine sulfhydrylases by fluorimetric methods and saturation transfer difference (STD) NMR 173
Inhibitors of the sulfur assimilation pathway in bacterial pathogens as enhancers of antibiotic therapy 172
Cycloserine enantiomers are reversible inhibitors of human alanine:glyoxylate aminotransferase: Implications for Primary Hyperoxaluria type 1 172
Discovering a new class of antifungal agents that selectively inhibits microbial carbonic anhydrases 170
Blocking cysteine biosynthesis in Salmonella typhimurium: the moonlighting enzyme CysK as a potential antibiotic target 165
1-Aminoindane-1,5-dicarboxylic Acid: a Novel Antagonist at Phospholipase C Linked Metabotropic Glutamate Receptors 164
Aminonicotinic acid 1-oxides are chemically stable inhibitors of quinolinic acid synthesis in the mammalian brain: a step towards new anti-excitotoxic agents 159
Scaffold Morphing Approach To Expand the Toolbox of Broad-Spectrum Antivirals Blocking Dengue/Zika Replication 159
Chemical Markers in Italian Propolis: Chrysin, Galangin and CAPE as Indicators of Geographic Origin 159
Expanding the knowledge around antitubercular 5-(2-aminothiazol-4-yl)isoxazole-3-carboxamides: Hit–to–lead optimization and release of a novel antitubercular chemotype via scaffold derivatization 157
The aryl hydrocarbon receptor (AhR) mediates the counter-regulatory effects of pelargonidins in models of inflammation and metabolic dysfunctions 157
A one-pot two-step microwave-assisted synthesis of N1-substituted 5,6-ring-fused 2-pyridones 154
Further insights into the SAR of α-substituted cyclopropylamine derivatives as inhibitors of histone demethylase KDM1A 153
Discovery of novel fragments inhibiting O-acetylserine sulphhydrylase by combining scaffold hopping and ligand–based drug design 152
Modulation of bacterial metabolism by the microenvironment controls MAIT cell stimulation 152
A combined ligand- and structure-based approach for the identification of rilmenidine-derived compounds which synergize the antitumor effects of doxorubicin 150
Cyclopropane derivatives as potential human serine racemase inhibitors: unveiling novel insights into a difficult target 150
A High Performance Workflow for Chemistry Driven de Novo Design 149
Substituted N-Phenyl-5-(2-(phenylamino)thiazol-4-yl)isoxazole-3-carboxamides Are Valuable Antitubercular Candidates that Evade Innate Efflux Machinery 149
Adjuvant therapies against tuberculosis: discovery of a 2-aminothiazole targeting Mycobacterium tuberculosis energetics 147
A multicomponent pharmacophore fragment-decoration approach to identify selective LRRK2-targeting probes 147
QSAR and Molecular Modeling Studies of Baclofen Analogs as GABAB Agonists. Insights into the Role of the Aromatic Moiety in GABAB Binding and Activation. 145
A microwave-assisted multicomponent protocol for the synthesis of benzofuran-2-carboxamides 145
Dirhodium(II)-tetraacetate-Mediated Decomposition of Ethyldiazo- acetate and Ethyldiazomalonate in the Presence of Fullerene. A New Procedure for the Selective Synthesis of [6-6]-Closed Methanofullerenes 143
Inhibition of O-acetylserine sulfhydrylase by fluoroalanine derivatives 142
Discovery of antitubercular 2,4-diphenyl-1H-imidazoles from chemical library repositioning and rational design 141
Identification of Human Alanine-Glyoxylate Aminotransferase Ligands as Pharmacological Chaperones for Variants Associated with Primary Hyperoxaluria Type 1 140
Molecular dynamics simulations and docking studies on 3D models of the heterodimeric and homodimeric 5-HT(2A) receptor subtype. 140
In vitro digestion of zingiber officinale extract and evaluation of stability as a first step to determine its bioaccesibility 140
Identification of Breast Cancer Inhibitors Specific for G Protein-Coupled Estrogen Receptor (GPER)-Expressing Cells 140
alfa-Diazocarbonyl Chemistry - Target Driven Applications 139
Discovery of New Potential Anti-Infective Compounds Based on Carbonic Anhydrase Inhibitors by Rational Target-Focused Repurposing Approaches 135
6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity. 133
Nuova composizione 131
Design, Synthesis and Preliminary Evaluation of Novel 3’-Substituted Carboxycyclopropylglycines as Antagonists at Group 2 Metabotropic Glutamate Receptors 130
Rational Design and Synthesis of Thioridazine Analogues as Enhancers of the Antituberculosis Therapy 129
Discovery of Multitarget Agents Active as Broad-Spectrum Antivirals and Correctors of Cystic Fibrosis Transmembrane Conductance Regulator for Associated Pulmonary Diseases 128
Discovery of Multitarget Antivirals Acting on Both the Dengue Virus NS5-NS3 Interaction and the Host Src/Fyn Kinases 128
Predictive binding of .beta.-carboline inverse agonists and antagonists via the CoMFA/GOLPE approach 127
Design, Synthesis and Investigation onthe Structure–Activity Relationships of N-Substituted 2-Aminothiazole Derivatives as Antitubercular Agents 127
Antimicrobial peptides (AMPs): a patent review (2015-2020) 126
Formulazione topica a base di estratto di Eucalyptus Globus L. e antibiotici convenzionali per il trattamento dell'uomo e nell'animale delle infezioni della pelle e del cavo orale 125
S-(+)-2-(3'-Carboxy-bicyclo[1.1.1]pentyl)glycine, a Structurally New Group I Metabotropic Glutamate Receptor Antagonist 125
Asymmetric Synthesis of Enantiomerically Pure (2S,1'S,2'S,3'R)-phenylcarboxycyclopropylglycine (PCCG-4): A Potent and Selective Ligand at Group II Metabotropic Glutamate Receptors 125
Homology Modeling, Validation and Dynamics of the G Protein-coupled Estrogen Receptor 1 (GPER-1) 125
In silico approaches towards the understanding of the structure-function relationships in metabotropic glutamate receptors (mGluRs) and other family C GPRCs. 124
Addressing the Conformational Flexibility of Serine Racemase by Combining Targeted Molecular Dynamics, Conformational Sampling and Docking Studies 124
Synthesis and Biological Evaluation of 6-Carboxy-3,4-methanoprolines, New Rigid Glutamate Analogs 123
Use of Experimental Design To Optimize Docking Performance: The Case of LiGenDock, the Docking Module of Ligen, a New De Novo Design Program 122
Identification of Broad-Spectrum Dengue/Zika Virus Replication Inhibitors by Functionalization of Quinoline and 2,6-Diaminopurine Scaffolds 122
(2R,1'S,2'R,3'S)-2-(2'-Carboxy-3'-phenylcyclopropyl)glycine (PCCG-13), the first potent and selective competitive antagonist of phospholipase D-coupled metabotropic glutamate receptors: asymmetric synthesis and preliminary biological properties 121
Derivatives of Nicotinic Acid N-Oxide, their preparation and their use as inhibitors of enzyme 3-hydroxyanthranilate-3,4-dioxygenase 121
Modulation of bacterial metabolism by the microenvironment controls MAIT cell stimulation article 120
Computational Insights into the mechanism of inhibition of OASS-A by a small molecule inhibitor 119
Sodium channel blockers for neuropathic pain. 118
Autocorrelation as a tool for a congruent description of molecules in 3D-QSAR studies 118
Discovery and characterization of novel potent PARP-1 inhibitors endowed with neuroprotective properties: From TIQ-A to HYDAMTIQ 118
Synthesis and biological evaluation of (2S)- and (2R)-2-(3'-phosphonobicyclo[1.1.1]pentyl)glycines as novel group III selective metabotropic glutamate receptor ligands. 117
Heterocyclic modulators of the NMDA Receptor 117
Generating optimal linear PLS estimation (GOLPE). An advanced chemometric tool for handling 3D-QSAR problems 116
Synthesis of 6,6-Dicarboxy-3,4-methano-L-proline, a New Constrained Glutamate Analog Endowed with Neuroprotective Properties 114
Predictive ability of regression models. Part II: Selection of the best predictive PLS model 112
Benzotriazole derivatives as alternate O-acetylserine sulfhydrylase substrates to impair cysteine biosynthesis in Gram-negative bacteria 111
Life or death decisions: the cast of poly(ADP-ribose)polymerase (PARP) as a therapeutic target for brain ischaemia. 109
Back door modulation of the farnesoid X receptor: design, synthesis, and biological evaluation of a series of side chain modified chenodeoxycholic acid derivatives. 108
Predictive ability of regression models. Part I: Standard Deviation of Prediction Errors (SDEP) 108
Kynurenine-3-hydroxylase and its Selective Inhibitors: Molecular Modelling Studies 107
Membrane-Sensitive Conformational States of Helix 8 in the Metabotropic Glu2 Receptor, a Class C GPCR 107
Series Design 107
Molecular dynamics simulation of the heterodimeric mGluR2/5HT(2A) complex. An atomistic resolution study of a potential new target in psychiatric conditions. 106
Homology Modeling of Metabotropic Glutamate Receptors (mGluRs). Structural Motifs Affecting Binding Modes and Pharmacological Profile of mGluR1 Agonists and Competitive Antagonists 105
Target flexibility: an emerging consideration in drug discovery and design 104
Homology model of the closed, functionally active, form of the amino terminal domain of mGlur1. 102
Unveiling hidden features of orphan nuclear receptors: the case of the small heterodimer partner (SHP). 100
Metabotropic glutamate receptors: new ligads and molecular modelling studies 100
Totale 16.518
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Categoria #
all - tutte 79.977
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 79.977
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022722 0 0 0 41 28 37 88 111 47 50 67 253
2022/20232.630 338 289 143 177 248 309 34 161 791 20 79 41
2023/2024940 59 79 27 48 96 148 87 68 31 57 100 140
2024/20253.544 96 205 292 172 316 352 151 151 378 320 377 734
2025/20268.922 749 1.056 1.924 727 1.056 396 905 267 926 506 220 190
2026/20271.656 167 410 395 684 0 0 0 0 0 0 0 0
Totale 22.278