The aim of this paper is to supply to the reader a complete overview of the state of the art about flexibility in drug design and discovery. Several authors show their ideas and approaches to face up the flexibility problem for biological targets using specific computational approaches.
Target flexibility: an emerging consideration in drug discovery and design / Cozzini, Pietro; Kellogg, Ge; Spyrakis, Francesca; Abraham, Dj; Costantino, Gabriele; Emerson, A; Fanelli, F; Gohlke, H; Kuhn, La; Morris, Gm; Orozco, M; Pertinhez, Thelma; Rizzi, M; Sotriffer, C.. - In: JOURNAL OF MEDICINAL CHEMISTRY. - ISSN 0022-2623. - 51:(2008), pp. 6237-6255. [10.1021/jm800562d]
Target flexibility: an emerging consideration in drug discovery and design
COZZINI, Pietro;SPYRAKIS, Francesca;COSTANTINO, Gabriele;PERTINHEZ, Thelma;
2008-01-01
Abstract
The aim of this paper is to supply to the reader a complete overview of the state of the art about flexibility in drug design and discovery. Several authors show their ideas and approaches to face up the flexibility problem for biological targets using specific computational approaches.| File | Dimensione | Formato | |
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