COSTANTINO, Gabriele
COSTANTINO, Gabriele
Dipartimento di Scienze degli Alimenti e del Farmaco
(2R,1'S,2'R,3'S)-2-(2'-Carboxy-3'-phenylcyclopropyl)glycine (PCCG-13), the first potent and selective competitive antagonist of phospholipase D-coupled metabotropic glutamate receptors: asymmetric synthesis and preliminary biological properties
1999-01-01 Pellicciari, R; Marinozzi, M; Costantino, Gabriele; Natalini, B; Moroni, F; PELLEGRINI GIAMPIETRO, D.
1,4-Benzothiazine and 1,4-benzoxazine imidazole derivatives with antifungal activity: a docking study
2002-01-01 Macchiarulo, A; Fringuelli, D; Vecchiarelli, A; Schiaffella, F; Costantino, Gabriele
1-Aminoindane-1,5-dicarboxylic Acid: a Novel Antagonist at Phospholipase C Linked Metabotropic Glutamate Receptors
1995-01-01 R., Pellicciari; R., Luneia; Costantino, Gabriele; M., Marinozzi; B., Natalini; P., Jackobsen; A., Kanstrup; G., Lombardi; F., Moroni; C., Thomsen
2-Aminooxazole as a Novel Privileged Scaffold in Antitubercular Medicinal Chemistry
2020-01-01 Azzali, E.; Girardini, M.; Annunziato, G.; Pavone, M.; Vacondio, F.; Mori, G.; Pasca, M. R.; Costantino, G.; Pieroni, M.
6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity.
2002-01-01 Pellicciari, R; Fiorucci, S; Camaioni, E; Clerici, C; Maloney, Pr; Morelli, A; Parks, Dj; Costantino, Gabriele
A combined ligand- and structure-based approach for the identification of rilmenidine-derived compounds which synergize the antitumor effects of doxorubicin
2016-01-01 Vucicevic, Jelica; Srdic Rajic, Tatjana; Pieroni, Marco; Laurila, Jonne M. M.; Perovic, Vladimir; Tassini, Sabrina; Azzali, Elisa; Costantino, Gabriele; Glisic, Sanja; Agbaba, Danica; Scheinin, Mika; Nikolic, Katarina; Radi, Marco; Veljkovic, Nevena
A competitive o‐acetylserine sulfhydrylase inhibitor modulates the formation of cysteine synthase complex
2021-01-01 Marchetti, M.; De Angelis, F. S.; Annunziato, G.; Costantino, G.; Pieroni, M.; Ronda, L.; Mozzarelli, A.; Campanini, B.; Cannistraro, S.; Bizzarri, A. R.; Bettati, S.
A High Performance Workflow for Chemistry Driven de Novo Design
2013-01-01 Beccari, Ar; Cavazzoni, C; Beato, Claudia; Costantino, Gabriele
A microwave-assisted multicomponent protocol for the synthesis of benzofuran-2-carboxamides
2016-01-01 Vincetti, Paolo; Brianza, Anna; Scalacci, Nicolò; Costantino, Gabriele; Castagnolo, Daniele; Radi, Marco
A multicomponent pharmacophore fragment-decoration approach to identify selective LRRK2-targeting probes
2016-01-01 Tassini, Sabrina; Castagnolo, Daniele; Scalacci, Nicolò; Kissova, Miroslava; Armijos Rivera, Jorge I.; Giagnorio, Federica; Maga, Giovanni; Costantino, Gabriele; Crespan, Emmanuele; Radi, Marco
A one-pot two-step microwave-assisted synthesis of N1-substituted 5,6-ring-fused 2-pyridones
2013-01-01 Radi, Marco; Gian Paolo, Vallerini; Alessia, Petrelli; Paolo, Vincetti; Costantino, Gabriele
Accepting the Invitation to Open Innovation in Malaria Drug Discovery: Synthesis, Biological Evaluation, and Investigation on the Structure-Activity Relationships of Benzo[b]thiophene-2-carboxamides as Antimalarial Agents
2017-01-01 Pieroni, Marco; Azzali, Elisa; Basilico, Nicoletta; Parapini, Silvia; Zolkiewski, Michal; Beato, Claudia; Annunziato, Giannamaria; Bruno, Agostino; Vacondio, Federica; Costantino, Gabriele
Addressing the Conformational Flexibility of Serine Racemase by Combining Targeted Molecular Dynamics, Conformational Sampling and Docking Studies
2011-01-01 A., Bruno; Amori, Laura; Costantino, Gabriele
Adjuvant therapies against tuberculosis: discovery of a 2-aminothiazole targeting Mycobacterium tuberculosis energetics
2018-01-01 Machado, Diana; Azzali, Elisa; Couto, Isabel; Costantino, Gabriele; Pieroni, Marco; Viveiros, Miguel
alfa-Diazocarbonyl Chemistry - Target Driven Applications
1998-01-01 R., Pellicciari; Costantino, Gabriele; M., Marinozzi; L., Mattoli; B., Natalini
Aminonicotinic acid 1-oxides are chemically stable inhibitors of quinolinic acid synthesis in the mammalian brain: a step towards new anti-excitotoxic agents
2013-01-01 Vallerini, Gp; Amori, Laura; Beato, Claudia; Tararina, M; Wang, Xd; Schwarcz, R; Costantino, Gabriele
Antifungal properties of newly designed carbonic anhydrases inhibitors selective for microbial enzymes
2018-01-01 Giovati, Laura; Annunziato, Giannamaria; Ciociola, Tecla; Magliani, Valter; Polonelli, Luciano; Conti, Stefania; Supuran, Claudiu T.; Costantino, Gabriele
Antimicrobial peptides (AMPs): a patent review (2015-2020)
2020-01-01 Annunziato, Giannamaria; Costantino, Gabriele
Aspergillus fumigatus tryptophan metabolic route differently affects host immunity
2021-01-01 Zelante, T.; Choera, T.; Beauvais, A.; Fallarino, F.; Paolicelli, G.; Pieraccini, G.; Pieroni, M.; Galosi, C.; Beato, C.; De Luca, A.; Boscaro, F.; Romoli, R.; Liu, X.; Warris, A.; Verweij, P. E.; Ballard, E.; Borghi, M.; Pariano, M.; Costantino, G.; Calvitti, M.; Vacca, C.; Oikonomou, V.; Gargaro, M.; Wong, A. Y. W.; Boon, L.; den Hartog, M.; Spacil, Z.; Puccetti, P.; Latge, J. -P.; Keller, N. P.; Romani, L.
Asymmetric Synthesis of Enantiomerically Pure (2S,1'S,2'S,3'R)-phenylcarboxycyclopropylglycine (PCCG-4): A Potent and Selective Ligand at Group II Metabotropic Glutamate Receptors
1996-01-01 M., Marinozzi; B., Natalini; Costantino, Gabriele; P., Tijskens; C., Thomsen; R., Pellicciari
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| (2R,1'S,2'R,3'S)-2-(2'-Carboxy-3'-phenylcyclopropyl)glycine (PCCG-13), the first potent and selective competitive antagonist of phospholipase D-coupled metabotropic glutamate receptors: asymmetric synthesis and preliminary biological properties | 1-gen-1999 | Pellicciari, R; Marinozzi, M; Costantino, Gabriele; Natalini, B; Moroni, F; PELLEGRINI GIAMPIETRO, D. | |
| 1,4-Benzothiazine and 1,4-benzoxazine imidazole derivatives with antifungal activity: a docking study | 1-gen-2002 | Macchiarulo, A; Fringuelli, D; Vecchiarelli, A; Schiaffella, F; Costantino, Gabriele | |
| 1-Aminoindane-1,5-dicarboxylic Acid: a Novel Antagonist at Phospholipase C Linked Metabotropic Glutamate Receptors | 1-gen-1995 | R., Pellicciari; R., Luneia; Costantino, Gabriele; M., Marinozzi; B., Natalini; P., Jackobsen; A., Kanstrup; G., Lombardi; F., Moroni; C., Thomsen | |
| 2-Aminooxazole as a Novel Privileged Scaffold in Antitubercular Medicinal Chemistry | 1-gen-2020 | Azzali, E.; Girardini, M.; Annunziato, G.; Pavone, M.; Vacondio, F.; Mori, G.; Pasca, M. R.; Costantino, G.; Pieroni, M. | |
| 6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity. | 1-gen-2002 | Pellicciari, R; Fiorucci, S; Camaioni, E; Clerici, C; Maloney, Pr; Morelli, A; Parks, Dj; Costantino, Gabriele | |
| A combined ligand- and structure-based approach for the identification of rilmenidine-derived compounds which synergize the antitumor effects of doxorubicin | 1-gen-2016 | Vucicevic, Jelica; Srdic Rajic, Tatjana; Pieroni, Marco; Laurila, Jonne M. M.; Perovic, Vladimir; Tassini, Sabrina; Azzali, Elisa; Costantino, Gabriele; Glisic, Sanja; Agbaba, Danica; Scheinin, Mika; Nikolic, Katarina; Radi, Marco; Veljkovic, Nevena | |
| A competitive o‐acetylserine sulfhydrylase inhibitor modulates the formation of cysteine synthase complex | 1-gen-2021 | Marchetti, M.; De Angelis, F. S.; Annunziato, G.; Costantino, G.; Pieroni, M.; Ronda, L.; Mozzarelli, A.; Campanini, B.; Cannistraro, S.; Bizzarri, A. R.; Bettati, S. | |
| A High Performance Workflow for Chemistry Driven de Novo Design | 1-gen-2013 | Beccari, Ar; Cavazzoni, C; Beato, Claudia; Costantino, Gabriele | |
| A microwave-assisted multicomponent protocol for the synthesis of benzofuran-2-carboxamides | 1-gen-2016 | Vincetti, Paolo; Brianza, Anna; Scalacci, Nicolò; Costantino, Gabriele; Castagnolo, Daniele; Radi, Marco | |
| A multicomponent pharmacophore fragment-decoration approach to identify selective LRRK2-targeting probes | 1-gen-2016 | Tassini, Sabrina; Castagnolo, Daniele; Scalacci, Nicolò; Kissova, Miroslava; Armijos Rivera, Jorge I.; Giagnorio, Federica; Maga, Giovanni; Costantino, Gabriele; Crespan, Emmanuele; Radi, Marco | |
| A one-pot two-step microwave-assisted synthesis of N1-substituted 5,6-ring-fused 2-pyridones | 1-gen-2013 | Radi, Marco; Gian Paolo, Vallerini; Alessia, Petrelli; Paolo, Vincetti; Costantino, Gabriele | |
| Accepting the Invitation to Open Innovation in Malaria Drug Discovery: Synthesis, Biological Evaluation, and Investigation on the Structure-Activity Relationships of Benzo[b]thiophene-2-carboxamides as Antimalarial Agents | 1-gen-2017 | Pieroni, Marco; Azzali, Elisa; Basilico, Nicoletta; Parapini, Silvia; Zolkiewski, Michal; Beato, Claudia; Annunziato, Giannamaria; Bruno, Agostino; Vacondio, Federica; Costantino, Gabriele | |
| Addressing the Conformational Flexibility of Serine Racemase by Combining Targeted Molecular Dynamics, Conformational Sampling and Docking Studies | 1-gen-2011 | A., Bruno; Amori, Laura; Costantino, Gabriele | |
| Adjuvant therapies against tuberculosis: discovery of a 2-aminothiazole targeting Mycobacterium tuberculosis energetics | 1-gen-2018 | Machado, Diana; Azzali, Elisa; Couto, Isabel; Costantino, Gabriele; Pieroni, Marco; Viveiros, Miguel | |
| alfa-Diazocarbonyl Chemistry - Target Driven Applications | 1-gen-1998 | R., Pellicciari; Costantino, Gabriele; M., Marinozzi; L., Mattoli; B., Natalini | |
| Aminonicotinic acid 1-oxides are chemically stable inhibitors of quinolinic acid synthesis in the mammalian brain: a step towards new anti-excitotoxic agents | 1-gen-2013 | Vallerini, Gp; Amori, Laura; Beato, Claudia; Tararina, M; Wang, Xd; Schwarcz, R; Costantino, Gabriele | |
| Antifungal properties of newly designed carbonic anhydrases inhibitors selective for microbial enzymes | 1-gen-2018 | Giovati, Laura; Annunziato, Giannamaria; Ciociola, Tecla; Magliani, Valter; Polonelli, Luciano; Conti, Stefania; Supuran, Claudiu T.; Costantino, Gabriele | |
| Antimicrobial peptides (AMPs): a patent review (2015-2020) | 1-gen-2020 | Annunziato, Giannamaria; Costantino, Gabriele | |
| Aspergillus fumigatus tryptophan metabolic route differently affects host immunity | 1-gen-2021 | Zelante, T.; Choera, T.; Beauvais, A.; Fallarino, F.; Paolicelli, G.; Pieraccini, G.; Pieroni, M.; Galosi, C.; Beato, C.; De Luca, A.; Boscaro, F.; Romoli, R.; Liu, X.; Warris, A.; Verweij, P. E.; Ballard, E.; Borghi, M.; Pariano, M.; Costantino, G.; Calvitti, M.; Vacca, C.; Oikonomou, V.; Gargaro, M.; Wong, A. Y. W.; Boon, L.; den Hartog, M.; Spacil, Z.; Puccetti, P.; Latge, J. -P.; Keller, N. P.; Romani, L. | |
| Asymmetric Synthesis of Enantiomerically Pure (2S,1'S,2'S,3'R)-phenylcarboxycyclopropylglycine (PCCG-4): A Potent and Selective Ligand at Group II Metabotropic Glutamate Receptors | 1-gen-1996 | M., Marinozzi; B., Natalini; Costantino, Gabriele; P., Tijskens; C., Thomsen; R., Pellicciari |