The enantioselective synthesis of (2S,1′S,2′S,3′R)-2-(2′-carboxy-3′-phenylcyclopropyl) glycine (PCCG-4, 3), a potent and selective mGluR2 antagonist is described.

Asymmetric Synthesis of Enantiomerically Pure (2S,1'S,2'S,3'R)-phenylcarboxycyclopropylglycine (PCCG-4): A Potent and Selective Ligand at Group II Metabotropic Glutamate Receptors / M. Marinozzi; B. Natalini; G. Costantino; P. Tijskens; C. Thomsen; R. Pellicciari. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - 6(1996), pp. 2243-2246. [10.1016/0960-894X(96)00407-6]

Asymmetric Synthesis of Enantiomerically Pure (2S,1'S,2'S,3'R)-phenylcarboxycyclopropylglycine (PCCG-4): A Potent and Selective Ligand at Group II Metabotropic Glutamate Receptors

COSTANTINO, Gabriele;
1996

Abstract

The enantioselective synthesis of (2S,1′S,2′S,3′R)-2-(2′-carboxy-3′-phenylcyclopropyl) glycine (PCCG-4, 3), a potent and selective mGluR2 antagonist is described.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11381/2437298
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