The enantioselective synthesis of (2S,1′S,2′S,3′R)-2-(2′-carboxy-3′-phenylcyclopropyl) glycine (PCCG-4, 3), a potent and selective mGluR2 antagonist is described.
Asymmetric Synthesis of Enantiomerically Pure (2S,1'S,2'S,3'R)-phenylcarboxycyclopropylglycine (PCCG-4): A Potent and Selective Ligand at Group II Metabotropic Glutamate Receptors / M., Marinozzi; B., Natalini; Costantino, Gabriele; P., Tijskens; C., Thomsen; R., Pellicciari. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - 6:(1996), pp. 2243-2246. [10.1016/0960-894X(96)00407-6]
Asymmetric Synthesis of Enantiomerically Pure (2S,1'S,2'S,3'R)-phenylcarboxycyclopropylglycine (PCCG-4): A Potent and Selective Ligand at Group II Metabotropic Glutamate Receptors
COSTANTINO, Gabriele;
1996-01-01
Abstract
The enantioselective synthesis of (2S,1′S,2′S,3′R)-2-(2′-carboxy-3′-phenylcyclopropyl) glycine (PCCG-4, 3), a potent and selective mGluR2 antagonist is described.File in questo prodotto:
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