6,6-Dicarboxy-3,4-methano-L-proline (L-DCMP, 7) has been prepared by the rhodium(II)acetate dimer catalyzed decomposition of dimethyl diazomalonate in the presence of a 3,4-didehydroproline derivative. When evaluated against NMDA- and kainate-induced toxicity in cultured cortical neurons, L-DCMP (7) exhibited good neuroprotective activity

Synthesis of 6,6-Dicarboxy-3,4-methano-L-proline, a New Constrained Glutamate Analog Endowed with Neuroprotective Properties / M. Marinozzi; B. Natalini; G. Costantino; R. Pellicciari; V. Bruno; F. Nicoletti. - In: IL FARMACO. - ISSN 0014-827X. - 51:(1996), pp. 121-124.

Synthesis of 6,6-Dicarboxy-3,4-methano-L-proline, a New Constrained Glutamate Analog Endowed with Neuroprotective Properties

COSTANTINO, Gabriele;
1996

Abstract

6,6-Dicarboxy-3,4-methano-L-proline (L-DCMP, 7) has been prepared by the rhodium(II)acetate dimer catalyzed decomposition of dimethyl diazomalonate in the presence of a 3,4-didehydroproline derivative. When evaluated against NMDA- and kainate-induced toxicity in cultured cortical neurons, L-DCMP (7) exhibited good neuroprotective activity
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11381/2437270
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