The design of new heterocyclic derivatives as modulatory agents at EAA receptors is described. In particular, the potent and selective activity at the NMDA receptor of trans-4-hydroxypipecolic acid-4-sulfate, as well as the neuroprotective properties of substituted thiokynurenates, a new class of competitive antagonists at the glycine site of the NMDA receptor complex, are reported.

Heterocyclic modulators of the NMDA Receptor / R. Pellicciari; B. Natalini; G. Costantino; A. Garzon; R. Luneia; M.R. Mahmoud; M. Marinozzi; M. Roberti; G.C. Rosato; S.A. Shiba. - In: IL FARMACO. - ISSN 0014-827X. - 48:(1993), pp. 151-157.

Heterocyclic modulators of the NMDA Receptor

COSTANTINO, Gabriele;
1993

Abstract

The design of new heterocyclic derivatives as modulatory agents at EAA receptors is described. In particular, the potent and selective activity at the NMDA receptor of trans-4-hydroxypipecolic acid-4-sulfate, as well as the neuroprotective properties of substituted thiokynurenates, a new class of competitive antagonists at the glycine site of the NMDA receptor complex, are reported.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11381/2437216
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