The design of new heterocyclic derivatives as modulatory agents at EAA receptors is described. In particular, the potent and selective activity at the NMDA receptor of trans-4-hydroxypipecolic acid-4-sulfate, as well as the neuroprotective properties of substituted thiokynurenates, a new class of competitive antagonists at the glycine site of the NMDA receptor complex, are reported.
Heterocyclic modulators of the NMDA Receptor / R. Pellicciari; B. Natalini; G. Costantino; A. Garzon; R. Luneia; M.R. Mahmoud; M. Marinozzi; M. Roberti; G.C. Rosato; S.A. Shiba. - In: IL FARMACO. - ISSN 0014-827X. - 48(1993), pp. 151-157.
|Tipologia ministeriale:||Articolo su rivista|
|Appare nelle tipologie:||1.1 Articolo su rivista|