Mammalians use the kynurenine pathway for tryptophan degradation inducing tolerogenic immune responses. Zelante et al. report that similarly, the fungus Aspergillus fumigatus uses the kynurenine pathway. Pathogenic immune response occurs when the fungus catabolizes tryptophan via the indolepyruvate pathway, which targets host AhR. Administration of Ido inducers ameliorates infection outcome.
Aspergillus fumigatus tryptophan metabolic route differently affects host immunity / Zelante, T.; Choera, T.; Beauvais, A.; Fallarino, F.; Paolicelli, G.; Pieraccini, G.; Pieroni, M.; Galosi, C.; Beato, C.; De Luca, A.; Boscaro, F.; Romoli, R.; Liu, X.; Warris, A.; Verweij, P. E.; Ballard, E.; Borghi, M.; Pariano, M.; Costantino, G.; Calvitti, M.; Vacca, C.; Oikonomou, V.; Gargaro, M.; Wong, A. Y. W.; Boon, L.; den Hartog, M.; Spacil, Z.; Puccetti, P.; Latge, J. -P.; Keller, N. P.; Romani, L.. - In: CELL REPORTS. - ISSN 2211-1247. - 34:4(2021), p. 108673. [10.1016/j.celrep.2020.108673]
Aspergillus fumigatus tryptophan metabolic route differently affects host immunity
Pieroni M.;Beato C.;Costantino G.;Vacca C.;
2021-01-01
Abstract
Mammalians use the kynurenine pathway for tryptophan degradation inducing tolerogenic immune responses. Zelante et al. report that similarly, the fungus Aspergillus fumigatus uses the kynurenine pathway. Pathogenic immune response occurs when the fungus catabolizes tryptophan via the indolepyruvate pathway, which targets host AhR. Administration of Ido inducers ameliorates infection outcome.| File | Dimensione | Formato | |
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