IRIS
GIORGIO, Carmine
 Distribuzione geografica
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Continente #
EU - Europa 2.252
NA - Nord America 1.826
AS - Asia 705
AF - Africa 5
Continente sconosciuto - Info sul continente non disponibili 4
SA - Sud America 4
Totale 4.796
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Nazione #
US - Stati Uniti d'America 1.805
IT - Italia 702
CN - Cina 523
IE - Irlanda 421
FI - Finlandia 349
SE - Svezia 333
DE - Germania 168
TR - Turchia 80
IN - India 72
UA - Ucraina 72
FR - Francia 55
GB - Regno Unito 52
BE - Belgio 38
CA - Canada 21
SG - Singapore 14
AT - Austria 13
CZ - Repubblica Ceca 11
ES - Italia 6
RO - Romania 6
CH - Svizzera 4
JP - Giappone 4
NL - Olanda 4
EU - Europa 3
HU - Ungheria 3
KR - Corea 3
PL - Polonia 3
VN - Vietnam 3
BR - Brasile 2
DK - Danimarca 2
DZ - Algeria 2
EC - Ecuador 2
HK - Hong Kong 2
RS - Serbia 2
RU - Federazione Russa 2
SC - Seychelles 2
TW - Taiwan 2
A1 - Anonimo 1
BG - Bulgaria 1
CM - Camerun 1
HR - Croazia 1
MC - Monaco 1
MY - Malesia 1
NO - Norvegia 1
PK - Pakistan 1
SI - Slovenia 1
SK - Slovacchia (Repubblica Slovacca) 1
Totale 4.796
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Città #
Dublin 421
Chandler 393
Ann Arbor 282
Parma 256
Dearborn 143
Beijing 118
Ashburn 113
Jacksonville 87
Nanjing 75
Izmir 69
Princeton 60
Bremen 59
Shanghai 59
Wilmington 55
New York 43
Boardman 32
Brussels 31
San Mateo 30
Shenyang 30
Bologna 29
Bangalore 27
Hefei 26
Helsinki 26
Kunming 26
Jinan 19
Guangzhou 18
Los Angeles 18
Modena 18
Nanchang 18
Fremont 17
Hebei 17
Des Moines 15
Düsseldorf 15
Grafing 15
Seattle 15
Brescia 14
Jiaxing 14
Woodbridge 14
Toronto 13
Changsha 11
Piacenza 11
Vienna 11
Hangzhou 10
Milan 10
London 9
Houston 8
Brno 7
Rome 7
Ankara 6
Norwalk 6
Palermo 6
Pesaro 6
Redwood City 6
Reggio Emilia 6
Sant'ilario D'enza 6
Tianjin 6
Zhengzhou 6
Caorso 5
Faenza 5
Fairfield 5
Falls Church 5
Genoa 5
Haikou 5
Leuven 5
Prata Di Pordenone 5
Pune 5
Redmond 5
Rho 5
Rocca Canavese 5
Verona 5
West Jordan 5
Altidona 4
Aulla 4
Borås 4
Chicago 4
Council Bluffs 4
Fuzhou 4
Montegaldella 4
Ottawa 4
Pavia 4
Rimini 4
Taizhou 4
Tokyo 4
Vigevano 4
Carpi 3
Catania 3
Cesano Maderno 3
Chengdu 3
Finale Emilia 3
Florence 3
Frankfurt am Main 3
Istanbul 3
Lubbock 3
Mareo 3
Mestre 3
Munich 3
Naples 3
Neviano degli Arduini 3
Ningbo 3
Phoenix 3
Totale 3.038
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Nome #
1,8-Naphthyridines IX. Potent anti-inflammatory and/or analgesic activity of a new group of substituted 5 amino[1,2,4]triazolo[4,3-a] [1,8]naphthyridine-6 carboxamides, of some their Mannich base derivatives and of one novel substituted 5-amino-10-oxo-10Hpyrimido[1,2-a [1,8]naphthyridine-6-carboxamide derivative 157
Targeting the Eph/ephrin system as anti-inflammatory strategy in IBD 151
Inhibition of Eph/ephrin interaction with the small molecule UniPR500 improves glucose tolerance in healthy and insulin-resistant mice 142
UniPR129 is a competitive small molecule Eph-ephrin antagonist blocking in vitro angiogenesis at low micromolar concentrations. 131
Optimization of EphA2 antagonists based on a lithocholic acid core led to the identification of UniPR505, a new 3α-carbamoyloxy derivative with antiangiogenetic properties 114
Pharmacological evaluation of new bioavailable small molecules targeting Eph/ephrin interaction 110
Hypericin - apomyoglobin an enhanced photosensitizer complex for the treatment of tumor cells 104
Lithocholic acid is an Eph-ephrin ligand interfering with Eph-kinase activation 102
Development of an orally bioavailable small molecule targeting Eph-ephrin system: in vitro and in vivo anticancer activity. 102
Increased Mucosal Thrombin is Associated with Crohn's Disease and Causes Inflammatory Damage through Protease-activated Receptors Activation 101
Multi-Target CFTR Modulators Endowed with Multiple Beneficial Side Effects for Cystic Fibrosis Patients: Toward a Simplified Therapeutic Approach 99
Combining ligand- and structure-based approaches for the discovery of new inhibitors of the EPHA2-ephrin-A1 interaction 96
Impact of S1P mimetics on mesenteric ischemia/reperfusion injury 96
Metabolic Soft Spot and Pharmacokinetics: Functionalization of C-3 Position of an Eph–Ephrin Antagonist Featuring a Bile Acid Core as an Effective Strategy to Obtain Oral Bioavailability in Mice 96
Drug-gut microbiota metabolic interactions: the case of UniPR1331, selective antagonist of the Eph-ephrin system, in mice 95
Polyphenol rich botanicals used as food supplements interfere with EphA2-ephrinA1 system. 92
Structure–Activity Relationships and Mechanism of Action of Eph–ephrin Antagonists: Interaction of Cholanic Acid with the EphA2 Receptor 90
Enhanced photosensitizing properties of protein bound curcumin 87
The ellagitannin colonic metabolite urolithin D selectively inhibits EphA2 phosphorylation in prostate cancer cells 83
Design and structure-activity relationship of amino acid derivatives of lithocholic acid as novel EphA2 antagonists 83
Perturbation of The EphA2-EphrinA1 System in Human Prostate Cancer Cells by Colonic (Poly)phenol Catabolites 81
1-Methyl and 1-(2-hydroxyalkyl)-5-(3-alkyl/cycloalkyl/phenyl/naphthylureido)-1H-pyrazole-4-carboxylic acid ethyl esters as potent human neutrophil chemotaxis inhibitors 80
Botanicals used as food supplements interfering with EphA2-ephrinA1 system: a screening study 79
Discovery and development of small molecules targeting Eph-ephrin system in glioblastoma: an academic history 79
Discovery of natural extracts interfering with EphA2-ephrinA1 system 78
Eph-ephrin antagonism in tumor angiogenesis and growth: UniPR1331 preclinical evidence. 77
Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor. 75
Multiple approaches for the discovery and development of small molecules targeting Eph-ephrin protein-protein interaction 74
UniPR1331, a small molecule targeting Eph/ephrin interaction, prolongs survival in glioblastoma and potentiates the effect of antiangiogenic therapy in mice 73
Metadynamics for perspective drug design: Computationally driven synthesis of new protein-protein interaction inhibitors targeting the EphA2 receptor 72
Synthesis of new 5,6-dihydrobenzo[h]quinazoline 2,4-diamino substituted and antiplatelet/antiphlogistic activities evaluation. 71
Development of 3-oxo-cholenic derivatives as Eph antagonists able to block in vitro angiogenesis 71
Discovery and development of Eph-ephrin antagonists endowed with antiangiogenic properties 70
Design and structure-activity relationships of amino acid derivatives of lithocholic acid as novel EphA2 receptor antagonists. 69
Combining pharmacology, target hopping and computational medicinal chemistry to discover novel scaffold targeting EPH-ephrin interaction. 67
UniPR1331: small Eph/ephrin antagonist beneficial in intestinal inflammation by interfering with type-B signaling 67
Protein-Protein Interaction Inhibitors Targeting the Eph-Ephrin System with a Focus on Amino Acid Conjugates of Bile Acids 66
Structure activity relationship of new EphA2 ligands 64
Target Hopping as a Useful Tool for the Identification of Novel EphA2 Protein–Protein Antagonists 64
Discovery and development of low molecular weight Eph-ephrin protein-protein inhbi-tors endowed with antiangiogenic activity 64
Eph/ephrin targeting with a small molecule improves glucose tolerance in healthy and insulin-resistant mice 64
Biochemical characterization of EphA2 antagonists with improved physico-chemical properties by cell-based assays and surface plasmon resonance analysis 63
Evaluation of the anti-tumor activity of small molecules targeting eph/ephrins in apcmin j mice 63
270 Discovery, development and optimization of low molecular weight EPH–ephrin protein–protein inhibitors 62
Pharmacological characterization of second generation FXR agonists as effective EphA2 antagonists: A successful application of target hopping approach 61
Δ5-Cholenoyl-amino acids as selective and orally available antagonists of the Eph-ephrin system 61
Investigation on the anti-inflammatory properties of Ocotea quixos Lam. essential oil. 60
Therapeutic perspectives of Eph–ephrin system modulation 60
PHARMACOLOGICAL CHARACTERIZATION OF NEW COMPOUNDS AIMED AT INHIBITING EPH-EPHRIN INTERACTION IN GLIOBLASTOMA 59
Lithocholic acid competitively inhibits EphA2-ephrinA1 binding: pharmacological and structural considerations. 59
Lithocholic Acid Is an Eph-ephrin Ligand Interfering with Eph-kinase Activation. 59
Lithocholic acid competitively inhibitis EphA2-ephrinA1 binding: pharmacological and structural considerations. 58
Antinflammatory properties of novel 5-amino[1,2,4]-triazolo[4,3-a][1,8]naphthyridines-caroboxamides derivatives 57
Exploiting Free-Energy Minima to Design Novel EphA2 Protein-Protein Antagonists: From Simulation to Experiment and Return 57
Ocotea quixos Lam. essential oil: In vitro and in vivo investigation on its anti-inflammatory properties. 55
NEW EPH ANTAGONISTS DISCRIMINATING BETWEEN EPH-AS AND EPH-BS CLASSES 53
Synthesis and Structure-Activity Relationships of Amino Acid Conjugates of Cholanic Acid as Antagonists of the EphA2 Receptor. 51
In vitro and in vivo efficacy of an orally bioavailable antagonist of Eph-ephrin system in tumor angiogenesis and growth 49
Target-hopping: a useful approach to identify novel Eph receptor antagonists 47
Ephrin or not? Six tough questions on Eph targeting 47
Probing the effects of MR120 in preclinical chronic colitis: A first-in-class anti-IBD agent targeting the CCL20/CCR6 axis 44
Targeting Eph/ephrin system in cancer therapy 42
Discovery of small-molecule targeting the CCL20/CCR6 axis as first-in-class inhibitors for inflammatory bowel diseases 37
Studies on the antiplatelet and antithrombotic profile of anti-inflammatory coumarin derivatives 31
Recombinant Alpha-1 Antitrypsin as Dry Powder for Pulmonary Administration: A Formulative Proof of Concept 30
Molecular Determinants of EphA2 and EphB2 Antagonism Enable the Design of Ligands with Improved Selectivity 16
Su1816–Protection by Ccr6 Blockade in a Murine Model of Crohn’s Disease 16
A Pharmacological Investigation of Eph-Ephrin Antagonism in Prostate Cancer: UniPR1331 Efficacy Evidence 14
Drug discovery: In silico dry data can bypass biological wet data? 7
Totale 4.954
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Categoria #
all - tutte 15.048
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 15.048
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/201982 0 0 0 0 0 0 0 0 0 0 80 2
2019/2020872 124 132 29 22 55 135 116 31 77 85 37 29
2020/2021541 16 29 41 54 76 48 65 36 79 36 33 28
2021/2022539 24 23 27 108 36 27 45 44 36 40 18 111
2022/20231.650 161 172 77 133 185 175 42 89 505 27 56 28
2023/2024530 44 41 36 35 47 129 67 53 27 47 4 0
Totale 4.954