IRIS
GIORGIO, Carmine
 Distribuzione geografica
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Continente #
EU - Europa 2.333
NA - Nord America 2.012
AS - Asia 917
AF - Africa 50
Continente sconosciuto - Info sul continente non disponibili 4
SA - Sud America 4
Totale 5.320
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Nazione #
US - Stati Uniti d'America 1.991
IT - Italia 737
CN - Cina 583
IE - Irlanda 422
FI - Finlandia 359
SE - Svezia 333
DE - Germania 187
SG - Singapore 143
IN - India 86
TR - Turchia 80
UA - Ucraina 72
FR - Francia 62
GB - Regno Unito 52
CI - Costa d'Avorio 43
BE - Belgio 38
CA - Canada 21
CZ - Repubblica Ceca 15
AT - Austria 14
ES - Italia 8
JP - Giappone 7
RO - Romania 6
NL - Olanda 5
CH - Svizzera 4
HK - Hong Kong 4
PK - Pakistan 4
EU - Europa 3
HU - Ungheria 3
KR - Corea 3
PL - Polonia 3
RU - Federazione Russa 3
TW - Taiwan 3
VN - Vietnam 3
BR - Brasile 2
DK - Danimarca 2
DZ - Algeria 2
EC - Ecuador 2
EG - Egitto 2
RS - Serbia 2
SC - Seychelles 2
A1 - Anonimo 1
BG - Bulgaria 1
CM - Camerun 1
HR - Croazia 1
MC - Monaco 1
MY - Malesia 1
NO - Norvegia 1
SI - Slovenia 1
SK - Slovacchia (Repubblica Slovacca) 1
Totale 5.320
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Città #
Dublin 422
Chandler 393
Ann Arbor 282
Parma 269
Dearborn 143
Ashburn 123
Beijing 118
Boardman 113
Singapore 101
Shanghai 91
Jacksonville 87
Nanjing 75
Izmir 69
Princeton 60
Bremen 59
Wilmington 55
New York 47
Abidjan 43
Helsinki 35
Brussels 31
San Mateo 30
Shenyang 30
Bologna 29
Bangalore 27
Hefei 26
Kunming 26
Chicago 25
Guangzhou 21
Jinan 19
Los Angeles 18
Modena 18
Nanchang 18
Fremont 17
Hebei 17
Des Moines 15
Düsseldorf 15
Grafing 15
Seattle 15
Brescia 14
Dallas 14
Jiaxing 14
Munich 14
Santa Clara 14
Woodbridge 14
Milan 13
Toronto 13
Brno 11
Changsha 11
Piacenza 11
Vienna 11
Hangzhou 10
London 9
Houston 8
Hyderabad 8
Lubbock 7
Marseille 7
Rome 7
Ankara 6
Norwalk 6
Palermo 6
Pesaro 6
Redwood City 6
Reggio Emilia 6
Sant'ilario D'enza 6
Tianjin 6
Zhengzhou 6
Caorso 5
Faenza 5
Fairfield 5
Falls Church 5
Genoa 5
Haikou 5
Leuven 5
Prata Di Pordenone 5
Pune 5
Redmond 5
Rho 5
Rocca Canavese 5
Rovato 5
Verona 5
West Jordan 5
Altidona 4
Assago 4
Aulla 4
Borås 4
Council Bluffs 4
Fuzhou 4
Ludhiana 4
Montegaldella 4
Ottawa 4
Pavia 4
Rimini 4
Springfield 4
Taizhou 4
Tokyo 4
Vigevano 4
Amsterdam 3
Carpi 3
Catania 3
Cesano Maderno 3
Totale 3.408
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Nome #
1,8-Naphthyridines IX. Potent anti-inflammatory and/or analgesic activity of a new group of substituted 5 amino[1,2,4]triazolo[4,3-a] [1,8]naphthyridine-6 carboxamides, of some their Mannich base derivatives and of one novel substituted 5-amino-10-oxo-10Hpyrimido[1,2-a [1,8]naphthyridine-6-carboxamide derivative 181
Targeting the Eph/ephrin system as anti-inflammatory strategy in IBD 159
Inhibition of Eph/ephrin interaction with the small molecule UniPR500 improves glucose tolerance in healthy and insulin-resistant mice 154
UniPR129 is a competitive small molecule Eph-ephrin antagonist blocking in vitro angiogenesis at low micromolar concentrations. 134
Optimization of EphA2 antagonists based on a lithocholic acid core led to the identification of UniPR505, a new 3α-carbamoyloxy derivative with antiangiogenetic properties 127
Pharmacological evaluation of new bioavailable small molecules targeting Eph/ephrin interaction 119
Development of an orally bioavailable small molecule targeting Eph-ephrin system: in vitro and in vivo anticancer activity. 108
Lithocholic acid is an Eph-ephrin ligand interfering with Eph-kinase activation 107
Multi-Target CFTR Modulators Endowed with Multiple Beneficial Side Effects for Cystic Fibrosis Patients: Toward a Simplified Therapeutic Approach 107
Hypericin - apomyoglobin an enhanced photosensitizer complex for the treatment of tumor cells 107
Increased Mucosal Thrombin is Associated with Crohn's Disease and Causes Inflammatory Damage through Protease-activated Receptors Activation 105
Impact of S1P mimetics on mesenteric ischemia/reperfusion injury 102
Combining ligand- and structure-based approaches for the discovery of new inhibitors of the EPHA2-ephrin-A1 interaction 101
Drug-gut microbiota metabolic interactions: the case of UniPR1331, selective antagonist of the Eph-ephrin system, in mice 101
Metabolic Soft Spot and Pharmacokinetics: Functionalization of C-3 Position of an Eph–Ephrin Antagonist Featuring a Bile Acid Core as an Effective Strategy to Obtain Oral Bioavailability in Mice 100
Polyphenol rich botanicals used as food supplements interfere with EphA2-ephrinA1 system. 99
Structure–Activity Relationships and Mechanism of Action of Eph–ephrin Antagonists: Interaction of Cholanic Acid with the EphA2 Receptor 93
Design and structure-activity relationship of amino acid derivatives of lithocholic acid as novel EphA2 antagonists 92
Enhanced photosensitizing properties of protein bound curcumin 91
Discovery and development of small molecules targeting Eph-ephrin system in glioblastoma: an academic history 88
The ellagitannin colonic metabolite urolithin D selectively inhibits EphA2 phosphorylation in prostate cancer cells 88
Perturbation of The EphA2-EphrinA1 System in Human Prostate Cancer Cells by Colonic (Poly)phenol Catabolites 87
1-Methyl and 1-(2-hydroxyalkyl)-5-(3-alkyl/cycloalkyl/phenyl/naphthylureido)-1H-pyrazole-4-carboxylic acid ethyl esters as potent human neutrophil chemotaxis inhibitors 86
Discovery of natural extracts interfering with EphA2-ephrinA1 system 86
Botanicals used as food supplements interfering with EphA2-ephrinA1 system: a screening study 83
Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor. 83
Discovery and development of Eph-ephrin antagonists endowed with antiangiogenic properties 83
Eph-ephrin antagonism in tumor angiogenesis and growth: UniPR1331 preclinical evidence. 80
Multiple approaches for the discovery and development of small molecules targeting Eph-ephrin protein-protein interaction 79
Pharmacological characterization of second generation FXR agonists as effective EphA2 antagonists: A successful application of target hopping approach 78
Development of 3-oxo-cholenic derivatives as Eph antagonists able to block in vitro angiogenesis 77
Metadynamics for perspective drug design: Computationally driven synthesis of new protein-protein interaction inhibitors targeting the EphA2 receptor 77
UniPR1331, a small molecule targeting Eph/ephrin interaction, prolongs survival in glioblastoma and potentiates the effect of antiangiogenic therapy in mice 77
Eph/ephrin targeting with a small molecule improves glucose tolerance in healthy and insulin-resistant mice 76
Design and structure-activity relationships of amino acid derivatives of lithocholic acid as novel EphA2 receptor antagonists. 75
Synthesis of new 5,6-dihydrobenzo[h]quinazoline 2,4-diamino substituted and antiplatelet/antiphlogistic activities evaluation. 75
Combining pharmacology, target hopping and computational medicinal chemistry to discover novel scaffold targeting EPH-ephrin interaction. 74
UniPR1331: small Eph/ephrin antagonist beneficial in intestinal inflammation by interfering with type-B signaling 72
Protein-Protein Interaction Inhibitors Targeting the Eph-Ephrin System with a Focus on Amino Acid Conjugates of Bile Acids 72
Target Hopping as a Useful Tool for the Identification of Novel EphA2 Protein–Protein Antagonists 71
Discovery and development of low molecular weight Eph-ephrin protein-protein inhbi-tors endowed with antiangiogenic activity 70
270 Discovery, development and optimization of low molecular weight EPH–ephrin protein–protein inhibitors 69
Evaluation of the anti-tumor activity of small molecules targeting eph/ephrins in apcmin j mice 69
PHARMACOLOGICAL CHARACTERIZATION OF NEW COMPOUNDS AIMED AT INHIBITING EPH-EPHRIN INTERACTION IN GLIOBLASTOMA 67
NEW EPH ANTAGONISTS DISCRIMINATING BETWEEN EPH-AS AND EPH-BS CLASSES 67
Structure activity relationship of new EphA2 ligands 67
Biochemical characterization of EphA2 antagonists with improved physico-chemical properties by cell-based assays and surface plasmon resonance analysis 67
Probing the effects of MR120 in preclinical chronic colitis: A first-in-class anti-IBD agent targeting the CCL20/CCR6 axis 66
Δ5-Cholenoyl-amino acids as selective and orally available antagonists of the Eph-ephrin system 66
Investigation on the anti-inflammatory properties of Ocotea quixos Lam. essential oil. 64
Lithocholic acid competitively inhibits EphA2-ephrinA1 binding: pharmacological and structural considerations. 64
Exploiting Free-Energy Minima to Design Novel EphA2 Protein-Protein Antagonists: From Simulation to Experiment and Return 64
Lithocholic acid competitively inhibitis EphA2-ephrinA1 binding: pharmacological and structural considerations. 63
Therapeutic perspectives of Eph–ephrin system modulation 63
Lithocholic Acid Is an Eph-ephrin Ligand Interfering with Eph-kinase Activation. 63
Antinflammatory properties of novel 5-amino[1,2,4]-triazolo[4,3-a][1,8]naphthyridines-caroboxamides derivatives 62
Discovery of small-molecule targeting the CCL20/CCR6 axis as first-in-class inhibitors for inflammatory bowel diseases 58
Ocotea quixos Lam. essential oil: In vitro and in vivo investigation on its anti-inflammatory properties. 57
Synthesis and Structure-Activity Relationships of Amino Acid Conjugates of Cholanic Acid as Antagonists of the EphA2 Receptor. 57
In vitro and in vivo efficacy of an orally bioavailable antagonist of Eph-ephrin system in tumor angiogenesis and growth 55
Target-hopping: a useful approach to identify novel Eph receptor antagonists 53
Ephrin or not? Six tough questions on Eph targeting 49
Targeting Eph/ephrin system in cancer therapy 45
Recombinant Alpha-1 Antitrypsin as Dry Powder for Pulmonary Administration: A Formulative Proof of Concept 35
Studies on the antiplatelet and antithrombotic profile of anti-inflammatory coumarin derivatives 34
A Pharmacological Investigation of Eph-Ephrin Antagonism in Prostate Cancer: UniPR1331 Efficacy Evidence 33
Molecular Determinants of EphA2 and EphB2 Antagonism Enable the Design of Ligands with Improved Selectivity 31
Su1816–Protection by Ccr6 Blockade in a Murine Model of Crohn’s Disease 23
Drug discovery: In silico dry data can bypass biological wet data? 21
Benzofuran-2-Carboxamide Derivatives as Immunomodulatory Agents Blocking the CCL20-Induced Chemotaxis and Colon Cancer Growth 11
Discovery of a new 1-(phenylsulfonyl)-1H-indole derivative targeting the EphA2 receptor with antiproliferative activity on U251 glioblastoma cell line 10
UNIPR1331: SMALL EPH/EPHRIN ANTAGONIST BENEFICIAL IN INTESTINAL INFLAMMATION BY INTERFERING WITH TYPE-B SIGNALLING 4
Protection by Eph/ephrin antagonists against TNBS-induced colitis: effects of the route of administration 3
Totale 5.484
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Categoria #
all - tutte 19.241
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 19.241
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020587 0 0 0 22 55 135 116 31 77 85 37 29
2020/2021541 16 29 41 54 76 48 65 36 79 36 33 28
2021/2022539 24 23 27 108 36 27 45 44 36 40 18 111
2022/20231.650 161 172 77 133 185 175 42 89 505 27 56 28
2023/2024693 44 41 36 35 47 129 67 53 27 47 75 92
2024/2025367 98 115 132 22 0 0 0 0 0 0 0 0
Totale 5.484