Here we investigated the anti-inflammatory properties of Ocotea quixos essential oil and of its main components, trans-cinnamaldehyde and methyl cinnamate, in in vitro and in vivo models. Ocotea essential oil and trans-cinnamaldehyde but not methyl cinnamate significantly reduced LPS-induced NO release from J774 macrophages at non-toxic concentrations, inhibited LPS- induced COX-2 expression and increased forskolin-induced cAMP production. The essential oil (30–100 mg/kg os) and trans-cinnamaldehyde (10 mg/kg os) in carrageenan-induced rat paw edema showed anti-inflammatory effect without damaging gastric mucosa. In conclusion we provide the first evidence of a significant anti-inflammatory gastro-sparing activity of O. quixos essential oil.

Ocotea quixos Lam. essential oil: In vitro and in vivo investigation on its anti-inflammatory properties / Ballabeni, Vigilio; Tognolini, Massimiliano; Giorgio, Carmine; Bertoni, Simona; Bruni, Renato; Barocelli, Elisabetta. - In: FITOTERAPIA. - ISSN 1971-551X. - 81:(2010), pp. 289-295. [10.1016/j.fitote.2009.10.002]

Ocotea quixos Lam. essential oil: In vitro and in vivo investigation on its anti-inflammatory properties.

BALLABENI, Vigilio;TOGNOLINI, Massimiliano;GIORGIO, Carmine;BERTONI, Simona;BRUNI, Renato;BAROCELLI, Elisabetta
2010-01-01

Abstract

Here we investigated the anti-inflammatory properties of Ocotea quixos essential oil and of its main components, trans-cinnamaldehyde and methyl cinnamate, in in vitro and in vivo models. Ocotea essential oil and trans-cinnamaldehyde but not methyl cinnamate significantly reduced LPS-induced NO release from J774 macrophages at non-toxic concentrations, inhibited LPS- induced COX-2 expression and increased forskolin-induced cAMP production. The essential oil (30–100 mg/kg os) and trans-cinnamaldehyde (10 mg/kg os) in carrageenan-induced rat paw edema showed anti-inflammatory effect without damaging gastric mucosa. In conclusion we provide the first evidence of a significant anti-inflammatory gastro-sparing activity of O. quixos essential oil.
2010
Ocotea quixos Lam. essential oil: In vitro and in vivo investigation on its anti-inflammatory properties / Ballabeni, Vigilio; Tognolini, Massimiliano; Giorgio, Carmine; Bertoni, Simona; Bruni, Renato; Barocelli, Elisabetta. - In: FITOTERAPIA. - ISSN 1971-551X. - 81:(2010), pp. 289-295. [10.1016/j.fitote.2009.10.002]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2293934
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