A recent study revealed that Perillaldehyde (PAE), a natural compound from Perilla frutescens, characterized by claimed neuroprotective, antiallergic, antinflammatory, antimicrobial, antitumor, gastroprotective and antidiabetic activities, acts as a ligand of the EphA2 receptor, modulating its signaling through the inhibition of ephrin-A1-EphA2 binding. In this study, we investigated the interaction between PAE and EphA2 with binding and functional assays. Our data demonstrate that PAE neither interferes with ephrin-A1-EphA2 interaction, nor significantly affects ephrin-A1-induced EphA2 activation. PAE is just one of many instances that teaches how difficult and challenging it is to identify natural compounds characterized by selectivity and specificity towards a molecular target.
Target validation of natural compounds: Perillaldehyde case study / Blesio, A.; Giorgio, C.; Sala, S.; Cavazzoni, A.; Zanotti, I.; Tognolini, M.. - In: INTERNATIONAL IMMUNOPHARMACOLOGY. - ISSN 1567-5769. - 172:(2026). [10.1016/j.intimp.2026.116178]
Target validation of natural compounds: Perillaldehyde case study
Blesio A.Investigation
;Giorgio C.;Sala S.;Cavazzoni A.;Zanotti I.;Tognolini M.
2026-01-01
Abstract
A recent study revealed that Perillaldehyde (PAE), a natural compound from Perilla frutescens, characterized by claimed neuroprotective, antiallergic, antinflammatory, antimicrobial, antitumor, gastroprotective and antidiabetic activities, acts as a ligand of the EphA2 receptor, modulating its signaling through the inhibition of ephrin-A1-EphA2 binding. In this study, we investigated the interaction between PAE and EphA2 with binding and functional assays. Our data demonstrate that PAE neither interferes with ephrin-A1-EphA2 interaction, nor significantly affects ephrin-A1-induced EphA2 activation. PAE is just one of many instances that teaches how difficult and challenging it is to identify natural compounds characterized by selectivity and specificity towards a molecular target.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
