The Eph-ephrin system comprises emerging proteins involved in many pathophysiological processes. The pharmacological activity of the main metabolites derived from the intake of some classes of (poly)phenolic compounds, such as caffeoylquinic acids, flavan-3-ols, and ellagitannins, on the Eph-ephrin interaction was evaluated at physiological concentrations. Functional studies to elucidate their role in prostate cancer were also performed.
The ellagitannin colonic metabolite urolithin D selectively inhibits EphA2 phosphorylation in prostate cancer cells / Giorgio, Carmine; MENA PARRENO, Pedro Miguel; DEL RIO, Daniele; Brighenti, Furio; Barocelli, Elisabetta; HASSAN MOHAMED, Iftiin; Callegari, Donatella; Lodola, Alessio; Tognolini, Massimiliano. - In: MOLECULAR NUTRITION & FOOD RESEARCH. - ISSN 1613-4125. - 59:11(2015), pp. 2155-2167. [10.1002/mnfr.201500470]
The ellagitannin colonic metabolite urolithin D selectively inhibits EphA2 phosphorylation in prostate cancer cells
GIORGIO, Carmine;MENA PARRENO, Pedro Miguel;DEL RIO, Daniele;BRIGHENTI, Furio;BAROCELLI, Elisabetta;HASSAN MOHAMED, Iftiin;CALLEGARI, DONATELLA;LODOLA, Alessio;TOGNOLINI, Massimiliano
2015-01-01
Abstract
The Eph-ephrin system comprises emerging proteins involved in many pathophysiological processes. The pharmacological activity of the main metabolites derived from the intake of some classes of (poly)phenolic compounds, such as caffeoylquinic acids, flavan-3-ols, and ellagitannins, on the Eph-ephrin interaction was evaluated at physiological concentrations. Functional studies to elucidate their role in prostate cancer were also performed.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
