The Eph-ephrin system comprises emerging proteins involved in many pathophysiological processes. The pharmacological activity of the main metabolites derived from the intake of some classes of (poly)phenolic compounds, such as caffeoylquinic acids, flavan-3-ols, and ellagitannins, on the Eph-ephrin interaction was evaluated at physiological concentrations. Functional studies to elucidate their role in prostate cancer were also performed.

The ellagitannin colonic metabolite urolithin D selectively inhibits EphA2 phosphorylation in prostate cancer cells / Giorgio, Carmine; Mena, Pedro; Del Rio, Daniele; Brighenti, Furio; Barocelli, Elisabetta; Hassan-Mohamed, Iftiin; Callegari, Donatella; Lodola, Alessio; Tognolini, Massimiliano. - In: MOLECULAR NUTRITION & FOOD RESEARCH. - ISSN 1613-4125. - 59:11(2015), pp. 2155-2167. [10.1002/mnfr.201500470]

The ellagitannin colonic metabolite urolithin D selectively inhibits EphA2 phosphorylation in prostate cancer cells

GIORGIO, Carmine;MENA PARRENO, Pedro Miguel;DEL RIO, Daniele;BRIGHENTI, Furio;BAROCELLI, Elisabetta;HASSAN MOHAMED, Iftiin;CALLEGARI, DONATELLA;LODOLA, Alessio;TOGNOLINI, Massimiliano
2015

Abstract

The Eph-ephrin system comprises emerging proteins involved in many pathophysiological processes. The pharmacological activity of the main metabolites derived from the intake of some classes of (poly)phenolic compounds, such as caffeoylquinic acids, flavan-3-ols, and ellagitannins, on the Eph-ephrin interaction was evaluated at physiological concentrations. Functional studies to elucidate their role in prostate cancer were also performed.
The ellagitannin colonic metabolite urolithin D selectively inhibits EphA2 phosphorylation in prostate cancer cells / Giorgio, Carmine; Mena, Pedro; Del Rio, Daniele; Brighenti, Furio; Barocelli, Elisabetta; Hassan-Mohamed, Iftiin; Callegari, Donatella; Lodola, Alessio; Tognolini, Massimiliano. - In: MOLECULAR NUTRITION & FOOD RESEARCH. - ISSN 1613-4125. - 59:11(2015), pp. 2155-2167. [10.1002/mnfr.201500470]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11381/2795734
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