IRIS
MOR, Marco
 Distribuzione geografica
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Continente #
EU - Europa 6.387
NA - Nord America 6.161
AS - Asia 2.171
SA - Sud America 8
Continente sconosciuto - Info sul continente non disponibili 7
AF - Africa 3
OC - Oceania 3
Totale 14.740
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Nazione #
US - Stati Uniti d'America 6.071
CN - Cina 1.761
FI - Finlandia 1.304
IE - Irlanda 1.281
SE - Svezia 1.109
IT - Italia 1.050
UA - Ucraina 625
DE - Germania 558
TR - Turchia 244
AT - Austria 143
GB - Regno Unito 107
CA - Canada 86
BE - Belgio 66
IN - India 63
FR - Francia 56
SG - Singapore 43
NL - Olanda 22
VN - Vietnam 20
HK - Hong Kong 16
CZ - Repubblica Ceca 15
ES - Italia 14
JP - Giappone 9
CL - Cile 7
EU - Europa 7
RO - Romania 7
IR - Iran 6
HR - Croazia 5
LU - Lussemburgo 4
PL - Polonia 4
RU - Federazione Russa 4
EG - Egitto 3
HU - Ungheria 3
NO - Norvegia 3
PA - Panama 3
KR - Corea 2
LT - Lituania 2
NZ - Nuova Zelanda 2
AU - Australia 1
BG - Bulgaria 1
BR - Brasile 1
EE - Estonia 1
ID - Indonesia 1
IL - Israele 1
IQ - Iraq 1
JO - Giordania 1
LI - Liechtenstein 1
MX - Messico 1
MY - Malesia 1
PK - Pakistan 1
PT - Portogallo 1
RS - Serbia 1
TH - Thailandia 1
Totale 14.740
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Città #
Chandler 1.285
Dublin 1.272
Jacksonville 752
Dearborn 456
Ann Arbor 440
Parma 403
Ashburn 399
Beijing 389
Nanjing 315
Princeton 248
Izmir 233
Wilmington 189
San Mateo 162
New York 151
Vienna 136
Shanghai 128
Bremen 113
Helsinki 107
Shenyang 107
Nanchang 92
Hebei 86
Jinan 84
Kunming 80
Toronto 79
Boardman 74
Hefei 70
Los Angeles 65
Des Moines 58
Brussels 56
Seattle 55
Düsseldorf 52
Jiaxing 49
Changsha 48
Pune 39
Woodbridge 38
Guangzhou 37
Tianjin 37
Fremont 33
Milan 31
Norwalk 30
Bologna 29
Brescia 24
Grafing 24
Zhengzhou 24
Houston 22
Fuzhou 20
Modena 20
Hangzhou 19
Dong Ket 18
Auburn Hills 15
Borås 11
Lanzhou 11
London 11
Ningbo 11
Chengdu 10
Fairfield 10
Haikou 10
Hong Kong 10
Naples 10
Palermo 10
Piacenza 10
Paris 9
Taizhou 9
Ankara 8
Ardea 8
Redmond 8
Leuven 7
Neviano degli Arduini 7
Prata Di Pordenone 7
Tokyo 7
Xian 7
Ascoli Piceno 6
Brno 6
Chongqing 6
Follonica 6
Montegaldella 6
Mordano 6
Reggio Nell'emilia 6
Tappahannock 6
Wenzhou 6
Wuhan 6
Atlanta 5
Augusta 5
Belluno 5
Canneto sull'Oglio 5
Falls Church 5
Fiorano Modenese 5
Huizen 5
Madrid 5
Redwood City 5
Reggio Emilia 5
Rome 5
Segrate 5
Soliera 5
Taiyuan 5
Washington 5
Zagreb 5
Acqui Terme 4
Ardabil 4
Baotou 4
Totale 9.036
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Nome #
Balancing reactivity and antitumor activity: heteroarylthioacetamide derivatives as potent and time-dependent inhibitors of EGFR 194
UniPR129 is a competitive small molecule Eph-ephrin antagonist blocking in vitro angiogenesis at low micromolar concentrations. 131
Benzisothiazolinone Derivatives as Potent Allosteric Monoacylglycerol Lipase Inhibitors That Functionally Mimic Sulfenylation of Regulatory Cysteines 129
Analysis of illicit dietary supplements sold in the Italian market: Identification of a sildenafil thioderivative as adulterant using UPLC-TOF/MS and GC/MS. 117
Analysis of Structure-Activity Relationships for MT2 Selective Antagonists by Melatonin MT1 and MT2 Receptor Models 112
2-Aminobenzimidazoles as new potent H3-antagonists 110
Dibasic biphenyl H(3) receptor antagonists: Steric tolerance for a lipophilic side chain. 104
Irreversible Inhibition of Epidermal Growth Factor Receptor Activity by 3-Aminopropanamides. 99
Expanding the Arsenal of FGFR Inhibitors: A Novel Chloroacetamide Derivative as a New Irreversible Agent With Anti-proliferative Activity Against FGFR1-Amplified Lung Cancer Cell Lines. 97
Combining ligand- and structure-based approaches for the discovery of new inhibitors of the EPHA2-ephrin-A1 interaction 96
Metabolic Soft Spot and Pharmacokinetics: Functionalization of C-3 Position of an Eph–Ephrin Antagonist Featuring a Bile Acid Core as an Effective Strategy to Obtain Oral Bioavailability in Mice 96
Application of 3D-QSAR in the Rational Design of Receptor Ligands and Enzyme Inhibitors 95
Drug-gut microbiota metabolic interactions: the case of UniPR1331, selective antagonist of the Eph-ephrin system, in mice 95
Amino acid derivatives as palmitoylethanolamide prodrugs: Synthesis, in vitro metabolism and in vivo plasma profile in rats 92
Antidepressant-like activity and cardioprotective effects of fatty acid amide hydrolase inhibitor URB694 in socially stressed Wistar Kyoto rats 91
Synthesis and 3D-QSAR Analysis of H3 Receptor Antagonists Containing a Neutral Heterocyclic Polar Group 90
2-N-Acylaminoalkylindoles: Design and Quantitative Structure-Activity Relationship Studies Leading to MT2-Selective Melatonin Antagonists 90
Structure–Activity Relationships and Mechanism of Action of Eph–ephrin Antagonists: Interaction of Cholanic Acid with the EphA2 Receptor 90
Antidepressant-like effects of pharmacological inhibition of FAAH activity in socially isolated female rats 90
QSAR study of 2-aminobenzimidazole derivatives as H3 antagonists 88
5-Benzylidene-hydantoins as new EGFR inhibitors with antiproliferative activity 85
Novel Irreversible Epidermal Growth Factor Receptor Inhibitors by Chemical Modulation of the Cysteine-Trap Portion 85
Cardioprotective effects of fatty acid amide hydrolase inhibitor URB694, in a rodent model of trait anxiety 85
Biphenyl-3-yl alkylcarbamates as fatty acid amide hydrolase (FAAH) inhibitors: steric effects of N-alkyl chain on rat plasma and liver stability 84
Aminobenzimidazoles as new potent H3-antagonists 84
Application of a SCC-DFTB QM/MM approach to the investigation of the catalytic mechanism of fatty acid amide hydrolase. 84
The Hippo Pathway and YAP/TAZ-TEAD Protein-Protein Interaction as Targets for Regenerative Medicine and Cancer Treatment 84
Chiral Recognition of Flexible Melatonin Receptor Ligands Induced by Conformational Equilibria 83
N-Acylethanolamine Acid Amidase (NAAA): Structure, Function, and Inhibition 83
Synthesis and biological assays of new H3-antagonists with imidazole and imidazoline polar groups 83
Design and structure-activity relationship of amino acid derivatives of lithocholic acid as novel EphA2 antagonists 83
Metabolism of the EGFR tyrosin kinase inhibitor gefitinib by cytochrome P450 1A1 enzyme in EGFR-wild type non small cell lung cancer cell lines 82
5-Benzylidene-hydantoins: synthesis and antiproliferative activity on A549 lung cancer cell line 81
Free-Energy Simulations Support a Lipophilic Binding Route for Melatonin Receptors 80
Validation of a histamine H3 receptor model through structure–activity relationships for classical H3 antagonists 80
A New Potent and Selective Histamine H3-Receptor Antagonist, 4(5)-{2-[4(5)-cyclohexylimidazol-2-ylthio]ethyl}imidazole 79
Meccanismo d’azione di UPR 1024: un nuovo farmaco con attività antiproliferativa in cellule di carcinoma polmonare umano 78
Antiproliferative and proapototic effects of a new combi-molecule on non small cell lung cancer cell lines 78
Alchilammidi tricicliche: ligandi selettivi dei recettori melatoninergici MT1 e MT2 77
Epidermal growth factor receptor tyrosine kinase inhibitors: current status and future perspectives in the development of novel irreversible inhibitors for the treatment of mutant non-small cell lung cancer 76
Plasma concentration and brain penetration of the H3-receptor antagonist Thioperamide in rats 75
4-(1,2-benzisothiazol-3-)alkanoic and phenylalkanoic acids: synthesis and anti-inflammatory, analgesic and antipyretic activities 75
Toward the Definition of Stereochemical Requirements for MT(2)-Selective Antagonists and Partial Agonists by Studying 4-Phenyl-2-propionamidotetralin Derivatives. 75
A critical cysteine residue in monoacylglycerol lipase is targeted by a new class of isothiazolinone-based enzyme inhibitors. 75
Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor. 75
Chapter 9: Natural and Synthetic Agents That Target Intracellular Monoacylglycerol Lipase (MGL) Activity 74
Tricyclic Alkylamides as Melatonin Receptor Ligands with Antagonist or Inverse Agonist Activity 74
Multiple approaches for the discovery and development of small molecules targeting Eph-ephrin protein-protein interaction 74
Cyclohexylcarbamic Acid 3'- or 4'-Substituted Biphenyl-3-yl Esters of as Fatty Acid Amide Hydrolase Inhibitors: Synthesis, Quantitative Structure-Activity Relationships and Molecular Modelling Studies 73
Dibasic non-imidazole histamine H3 receptor antagonists with a rigid byphenyl scaffold. 73
A catalytic mechanism for cysteine N-terminal nucleophile hydrolases, as revealed by free energy simulations 73
HPLC detection ofthioperamide from biological samples and its determination in rat blood and brainafter systemic administration 72
QM/MM modelling of oleamide hydrolysis in fatty acid amide hydrolase (FAAH) reveals a new mechanism of nucleophile activation 72
Synthesis, biological activity, QSAR and QSPR study of 2/aminobenzimidazole derivatives as potent H3-antagonists 72
Clinical perspective for irreversible tyrosine kinase inhibitors in cancer 72
Modulation of Anxiety Through Blockade of Anandamide Hydrolysis 71
ACID CERAMIDASE INHIBITORS AND THEIR USE AS MEDICAMENTS 71
Antioxidant and cytoprotective activity of indole derivatives related to melatonin 71
Synthesis and structure-activity relationships for biphenyl H3 receptor antagonists with moderate anti-cholinesterase activity. 71
Development of 3-oxo-cholenic derivatives as Eph antagonists able to block in vitro angiogenesis 71
Pushing the Boundaries of Vinylogous Reactivity: Catalytic Enantioselective Mukaiyama Aldol Reactions of Highly Unsaturated 2-Silyloxyindoles 71
Chiral NMR discrimination of the diastereoisomeric salts of the H(3)-antagonist 2-[3-(1H-imidazol-4-ylmethyl)piperidin-1-yl]-1H-benzimidazole. 70
Development of a GPCR model for SAR interpretation of classical and new H3 antagonists 70
N-(Anilinoethyl)amides: design and synthesis of metabolically stable, selective melatonin receptor ligands 69
Design and structure-activity relationships of amino acid derivatives of lithocholic acid as novel EphA2 receptor antagonists. 69
Dual mechanisms of action of the 5-benzylidene-hydantoin UPR1024 on lung cancer cell lines 68
5-benzylidene-hydantoin UPR 1024 acts as EGFR inhibitor and induces DNA damage in A549 NSCLC cell line 68
N-(2-Oxo-3-oxetanyl)carbamic Acid Esters as N-Acylethanolamine Acid Amidase Inhibitors: Synthesis, Structure–Activity and Structure–Property Relationships. 68
A sulfonyl fluoride derivative inhibits EGFR L858R/T790M/C797S by covalent modification of the catalytic lysine 68
Comparative Analysis of Virtual Screening Approaches in the Search for Novel EphA2 Receptor Antagonists 67
Predicting the reactivity of nitrile-carrying compounds with cysteine: a combined computational and experimental study. 67
Combining pharmacology, target hopping and computational medicinal chemistry to discover novel scaffold targeting EPH-ephrin interaction. 67
Synthesis, Structural Elucidation, and Biological Evaluation of NSC12, an Orally Available Fibroblast Growth Factor (FGF) Ligand Trap for the Treatment of FGF-Dependent Lung Tumors 67
Indole-based analogs of melatonin: in vitro antioxidant and cytoprotective activities 66
Synthesis, Pharmacological Evaluation and Structure-Activity Relationships of Benzopyran Derivatives with Potent SERM Activity 66
Experimental and Theoretical Analysis of the Interaction of (±)-cis-Ketoconazole with b-Cyclodextrin in the presence of (+)-L-Tartaric Acid 66
Structure-Property Relationships on Histamine H3-Antagonists: Binding of Phenyl-substituted Alkylthioimidazole Derivatives to Rat Plasma Proteins 66
MT2 selective melatonin receptor antagonists: design and structure-activity relationships 66
Sviluppo e caratterizzazione farmacologica di un nuovo potente e selettivo H3-bloccante istaminico non-tioureico 66
Heteroarylaminoethyl and heteroarylthioethylimidazoles. Synthesis and H3-receptor affinity 66
New strategies to overcome resistance to EGFR tyrosine kinase inhibitors in non small cell lung cancer 66
L718Q Mutation as New Mechanism of Acquired Resistance to AZD9291 in EGFR-Mutated NSCLC 66
Tetrahydroquinoline Ring as a Versatile Bioisostere of Tetralin for Melatonin Receptor Ligands 66
5-benzylidene-hydantoins as new inhibitors of cell proliferation 65
A second generation of carbamate-based fatty acid amide hydrolase inhibitors with improved activity in vivo 65
Imidazole H3-antagonists: Relationship between Structure and Ex-vivo binding to Rat Brain H3-Receptors 65
Relationship between structure and ex-vivo binding of imidazole H3 antagonists to rat brain H3 receptors 64
Catalytic, Asymmetric Hypervinylogous Mukaiyama Aldol Reactions of Extended Furan-Based Silyl Enolates 64
Irreversible EGFR inhibitor compounds with antiproliferative activity 64
Discovery and development of low molecular weight Eph-ephrin protein-protein inhbi-tors endowed with antiangiogenic activity 64
Atropisomerism and Conformational Equilibria: Impact on PI3Kδ Inhibition of 2-((6-Amino-9H-purin-9-yl)methyl)-5-methyl-3-(o-tolyl)quinazolin-4(3H)-one (IC87114) and Its Conformationally Restricted Analogs 64
Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 7. Synthesis and Pharmacological Evaluation of 4-Quinolone-3-carboxamides and 4-Hydroxy-2-quinolone-3-carboxamides as High Affinity Cannabinoid Receptor 2 (CB2R) Ligands with Improved Aqueous Solubility 64
Ligands for the histamine H3-receptor: new potent antagonists of the 2-thioimidazole type 63
Modular Approach toward the Construction of the Core Motifs of Annonaceous Acetogenins and Variants Thereof 63
Brain Pharmacokinetics of Non-Imidazole Biphenyl H3 Receptor Antagonists: a Liquid Chromatography/Electrospray-Mass Spectrometry and ex vivo Binding Study in Rats 63
Molecular mechanisms underlying the antitumor activity of 3-aminopropanamide irreversible inhibitors of the epidermal growth factor receptor in non-small cell lung cancer 63
Development and validation of a LC-MS method with electrospray ionization for the determination of the imidazole H(3) antagonist ROS203 in rat plasma. 63
Biological studies on 1,2-benzisothiazole derivatives. V. Antimicrobial properties of N-alkanoic, N-arylalkanoic and N-aryloxyalkanoic derivatives of 1,2-benzisothiazolin-3-one: QSAR study and genotoxicity evaluation 63
Biochemical characterization of EphA2 antagonists with improved physico-chemical properties by cell-based assays and surface plasmon resonance analysis 63
N-Acylethanolamine Acid Amidase (NAAA): Mechanism of Palmitoylethanolamide Hydrolysis Revealed by Mechanistic Simulations 63
Totale 7.831
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Categoria #
all - tutte 50.512
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 50.512
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/2019318 0 0 0 0 0 0 0 0 0 0 308 10
2019/20202.997 508 450 178 43 250 345 391 63 314 172 89 194
2020/20211.559 19 179 155 61 192 51 206 40 341 45 213 57
2021/20221.311 24 37 14 121 85 40 149 175 91 102 90 383
2022/20235.095 551 503 311 392 486 607 46 313 1.575 60 188 63
2023/20241.514 109 148 56 68 145 457 166 159 78 124 4 0
Totale 15.080