IRIS
BONELLI, Mara
 Distribuzione geografica
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Continente #
NA - Nord America 3.019
EU - Europa 2.888
AS - Asia 1.245
AF - Africa 39
SA - Sud America 4
OC - Oceania 3
Totale 7.198
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Nazione #
US - Stati Uniti d'America 2.985
CN - Cina 828
IT - Italia 599
IE - Irlanda 554
FI - Finlandia 513
SE - Svezia 466
DE - Germania 278
UA - Ucraina 257
SG - Singapore 217
TR - Turchia 110
IN - India 56
BE - Belgio 49
FR - Francia 49
GB - Regno Unito 46
CI - Costa d'Avorio 38
CA - Canada 34
AT - Austria 31
NL - Olanda 13
CZ - Repubblica Ceca 10
HK - Hong Kong 10
IR - Iran 8
VN - Vietnam 8
JP - Giappone 5
PL - Polonia 4
RO - Romania 4
AR - Argentina 3
CH - Svizzera 3
HU - Ungheria 3
NZ - Nuova Zelanda 3
RU - Federazione Russa 3
ES - Italia 2
LU - Lussemburgo 2
PK - Pakistan 2
EG - Egitto 1
HR - Croazia 1
KR - Corea 1
PE - Perù 1
SI - Slovenia 1
Totale 7.198
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Città #
Dublin 554
Chandler 496
Ann Arbor 368
Jacksonville 291
Dearborn 192
Beijing 170
Parma 161
Boardman 160
Singapore 148
Ashburn 147
Nanjing 128
Izmir 110
Bremen 98
Princeton 98
Shanghai 98
San Mateo 86
New York 64
Wilmington 60
Milan 59
Woodbridge 47
Helsinki 43
Hefei 42
Nanchang 42
Shenyang 42
Chicago 39
Abidjan 38
Kunming 38
Hebei 36
Jinan 33
Brussels 31
Des Moines 31
Vienna 30
Pune 28
Los Angeles 27
Toronto 26
Marseille 25
Tianjin 23
Modena 22
Redmond 22
Jiaxing 21
Seattle 20
Dallas 18
Houston 18
Norwalk 18
Santa Clara 18
Changsha 16
Guangzhou 15
Leawood 14
Fremont 12
Munich 12
Wayne 12
Rome 11
Hangzhou 10
Hong Kong 10
Verona 9
Amsterdam 8
Ardabil 8
Augusta 8
Dong Ket 8
Fuzhou 8
Grafing 8
Taiyuan 8
Binche 7
Leuven 7
Auburn Hills 6
Chengdu 6
Follonica 6
London 6
Monmouth Junction 6
Montreal 6
Ningbo 6
Reggio Emilia 6
Salsomaggiore Terme 6
Zhengzhou 6
Bologna 5
Borås 5
Brno 5
Lanzhou 5
Mumbai 5
Redwood City 5
Casalgrande 4
Düsseldorf 4
Fairfield 4
Frankfurt am Main 4
Genoa 4
Huizen 4
Kolkata 4
Mestre 4
Mons 4
Neviano degli Arduini 4
Phoenix 4
Rockville 4
Soliera 4
Xian 4
Albano Laziale 3
Bari 3
Bergamo 3
Brescia 3
Buenos Aires 3
Castellarano 3
Totale 4.621
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Nome #
Balancing reactivity and antitumor activity: heteroarylthioacetamide derivatives as potent and time-dependent inhibitors of EGFR 206
Third generation EGFR inhibitor osimertinib combined with pemetrexed or cisplatin exerts long-lasting anti-tumor effect in EGFR-mutated pre-clinical models of NSCLC 123
Efficacy of the cdk4/6 dual inhibitor abemaciclib in egfr-mutated nsclc cell lines with different resistance mechanisms to osimertinib 122
Characterization of gefitinib uptake in NSCLC cell lines 106
Expanding the Arsenal of FGFR Inhibitors: A Novel Chloroacetamide Derivative as a New Irreversible Agent With Anti-proliferative Activity Against FGFR1-Amplified Lung Cancer Cell Lines. 106
Pemetrexed enhances membrane PD-L1 expression and potentiates T cell-mediated cytotoxicity by anti-PD-L1 antibody therapy in non-small-cell lung cancer 105
Trastuzumab emtansine is active on HER-2 overexpressing NSCLC cell lines and overcomes gefitinib resistance 102
Compatible osmolytes modulate the response of porcine endothelial cells to hypertonicity and protect them from apoptosis 101
Inhibition of PI3K Pathway Reduces Invasiveness and Epithelial-to-Mesenchymal Transition in Squamous Lung Cancer Cell Lines Harboring PIK3CA Gene Alterations. 98
Induction of BGT-1 and amino acid system A transport activities in endothelial cells exposed to hyperosmolarity 98
Isolation and Characterization of Circulating Tumor Cells in Squamous Cell Carcinoma of the Lung Using a Non-EpCAM-Based Capture Method 96
Targeting PI3K somatic mutations reduces invasion and EMT in squamous cell carcinoma of the lung 94
Enhancement of the anti-tumor activity of FGFR1 inhibition in squamous cell lung cancer by targeting downstream signaling involved in glucose metabolism. 92
Anti-proliferative effect of combining Letrozole with Sorafenib in MCF-7/Arom-1 breast cancer cells 92
Osmotic regulation of ATA2 mRNA expression and amino acid transport system A activity 92
Dual inhibition of CDK4/6 and PI3K/AKT/mTOR signaling impairs energy metabolism in MPM cancer cells 90
Gefitinib inhibits invasive phenotype and epithelial-mesenchymal transition in drug-resistant NSCLC cells with MET amplification 89
Combination of Gefitinib and Pemetrexed Prevents the Acquisition of TKI Resistance in NSCLC Cell Lines Carrying EGFR-Activating Mutation 88
Metabolism of the EGFR tyrosin kinase inhibitor gefitinib by cytochrome P450 1A1 enzyme in EGFR-wild type non small cell lung cancer cell lines 87
Combined Inhibition of CDK4/6 and PI3K/AKT/mTOR Pathways Induces a Synergistic Anti-Tumor Effect in Malignant Pleural Mesothelioma Cells. 87
Everolimus restores gefitinib sensitivity in resistant non-small cell lung cancer cell lines 85
Anti-proliferative effect of letrozole and sorafenib in MCF-7/AROM-1 breast cancer cells 85
Effect of ABCG2/BCRP Expression on Efflux and Uptake of Gefitinib in NSCLC Cell Lines 85
Combined use of anti-ErbB monoclonal antibodies and erlotinib enhances antibody-dependent cellular cytotoxicity of wild-type erlotinib-sensitive NSCLC cell lines 84
Attenuated expression of 70kDa heat shock protein in WI-38 human fibroblasts during aging in vitro 83
Meccanismo d’azione di UPR 1024: un nuovo farmaco con attività antiproliferativa in cellule di carcinoma polmonare umano 83
Creatine as a compatible osmolyte in muscle cells exposed to hypertonic stress 82
Epidermal growth factor receptor tyrosine kinase inhibitors: current status and future perspectives in the development of novel irreversible inhibitors for the treatment of mutant non-small cell lung cancer 81
Roles of compatible osmolytes and heat shock protein 70 in the induction of tolerance to stresses in porcine endothelial cells 80
Overcoming acquired resistance to letrozole by targeting the PI3K/AKT/mTOR pathway in breast cancer cell clones. (Cavazzoni and Bonelli co-first authors) 79
New treatment opportunities in phosphatase and tensin homolo(PTen)-deficient tumors: Focus on PTen/focal adhesion kinase pathway 78
Anti-proliferative and pro-apoptotic effects of Sorafenib in breast cancer cells in vitro. 77
Hypertonic stress and amino acid deprivation both increase expression of mRNA for amino acid transport system A 76
5-benzylidene-hydantoin UPR 1024 acts as EGFR inhibitor and induces DNA damage in A549 NSCLC cell line 76
Enhanced efficacy of AKT and FAK kinase combined inhibition in squamous cell lung carcinomas with stable reduction in PTEN 76
The effect of heat shock on amino acid transport and cell volume in 3T3 cells 75
Effect of specific PI3K/mTOR inhibitors in squamous lung cancer cells carrying PI3K alterations 75
Stabilization of hsp70 mRNA on prolonged cell exposure to hypertonicity 73
Attenuata induzione del gene SNAT-2 in fibroblasti umani senescenti esposti a stress iperosmolare 73
Induzione di osmotolleranza in cellule endoteliali derivate da arteria polmonare 73
Induzione di sistemi di trasporto in condizioni di stress ipertonico 73
Synergistic activity of letrozole and sorafenib on MCF7/AROM-1 breast cancer cells 73
Alterazioni della degradazione proteasoma-dipendente nel corso dell'invecchiamento ed effetti delle restrizioni caloriche 72
Dual mechanisms of action of the 5-benzylidene-hydantoin UPR1024 on lung cancer cell lines 72
CDK4/6 inhibitors improve the anti-tumor efficacy of lenvatinib in hepatocarcinoma cells 72
CDK4/6 INHIBITORS AS A NEW THERAPEUTIC APPROACH IN MESOTHELIOMA MODELS 71
Pre-treatment with the CDK4/6 inhibitor palbociclib improves the efficacy of paclitaxel in TNBC cells 71
Targeting metabolic adaptive responses induced by glucose starvation inhibits cell proliferation and enhances cell death in osimertinib-resistant non-small cell lung cancer (NSCLC) cell lines 70
Effects of osmolarity, ions and compatible osmolytes on cell-free protein synthesis 69
Damage to nuclear DNA induced by Shiga toxin 1 and ricin in human endothelial cells 69
Multiple effects of CDK4/6 inhibition in cancer: From cell cycle arrest to immunomodulation 69
CDK4/6 Inhibition Enhances the Efficacy of Standard Chemotherapy Treatment in Malignant Pleural Mesothelioma Cells 68
Alterazioni della degradazione proteasoma-dipendente nel corso dell’invecchiamento ed effetti delle restrizioni caloriche 66
Anti-proliferative and pro-apoptotic effects of soarfenib in MCF-7/AROM-1 breast cancer cells. 65
The anti-tumor efficacy of CDK4/6 inhibition is enhanced by the combination with PI3K/AKT/mTOR inhibitors through impairment of glucose metabolism in TNBC cells 64
Acquired BRAF G469A Mutation as a Resistance Mechanism to First-Line Osimertinib Treatment in NSCLC Cell Lines Harboring an EGFR Exon 19 Deletion 63
Simultaneous Combination of the CDK4/6 Inhibitor Palbociclib With Regorafenib Induces Enhanced Anti-tumor Effects in Hepatocarcinoma Cell Lines 62
Overcoming Palbociclib Resistance by Combined Treatment with PI3K/AKT/mTOR Inhibitors in Mesothelioma Cells 62
Effect of proteasome inhibition on HSP70 gene expression in human fibroblasts aging in vitro 61
Overcoming acquired resistance to letrozole by targeting the PI3K/AKT/mTOR pathway in breast cancer cell clones 61
L'inibizione dell'attività proteasomica ripristina la capacità dei fibroblasti umani senescenti di rispondere allo shock termico 61
Increased level of inducible HSP70 in cells exposed to electromagnetic fields. 60
Effects of FGFR1 inhibition on survival, proliferation, and energy metabolism in Non Small Cell Lung Cancer (NSCLC) cell lines 59
Proteasome inhibition increases HuR level, restores heat-inducible HSP72 expression and thermotolerance in WI-38 senescent human fibroblasts 59
L’inibizione dei proteasomi ripristina l’espressione del gene HSP70 in fibroblasti umani senescenti. 58
Overcoming resistance of EGFR tyrosine kinase inhibitors by new cytostatic and proapoptotic drugs in non small cell lung cancer cell lines 57
Risposta adattativa di cellule endoteliali a stress iperosmolare 56
Attenuata induzione del gene snat2 in fibroblasti umani senescenti sottoposti a stress iperosmolare 56
Synergic anti-proliferative effect of gefitinib and RAD001 in non small cell lung cancer cell lines 55
Erlotinib potentiates Cetuximab-dependent call citotoxicity in EGFR wild type NSCLC cell lines 55
Targeting glucosylceramide synthase induces antiproliferative and proapoptotic effects in osimertinib-resistant NSCLC cell models 54
Effetto dell’inibizione proteasomica sull’espressione del gene HSP70 in cellule senescenti. 54
Effect of letrozole and sorafenib on cell proliferation and apoptosis of MCF-7/AROM-1 breast cancer cell line 54
Synergistic activity of letrozole and sorafenib on breast cancer cells 54
Effects of sorafenib on energy metabolism in breast cancer cells: role of AMPK-mTORC1 signaling 54
Evaluation of gefitinib maintenance in an EGFR-mutant NSCLC cell line with acquired resistance 53
Targeting oncogenic PI3K/Akt/mTOR pathway in squamous cell lung carcinoma 53
Functional characterization of gefitinib uptake in non-small cell lung cancer cell lines 53
Espressione Inducibile del gene FHIT in cellule di carcinoma polmonare 52
PD-L1 overexpression induces STAT signaling and promotes the secretion of pro-angiogenic cytokines in non-small cell lung cancer (NSCLC) 52
Heat-induced proteasomic degradation of HSF1 in serum-starved human fibroblasts aging in vitro 51
L’inibizione proteasomica ripristina in cellule senescenti l’espressione di HSP70 50
L’inibizione dei proteasomi ripristina l’espressione del gene HSP70 in fibroblasti umani senescenti 50
Trastuzumab emtansine delays and overcomes resistance to the third-generation EGFR-TKI osimertinib in NSCLC EGFR mutated cell lines 50
Targeting PI3K/AKT/mTOR pathway in non small cell lung cancer 49
Hyperosmotic stress response 49
Effect of protesasome inhibition on HSP70 gene expression in human fibroblasts aging in vitro 48
Shiga toxin 1 and ricin inhibit thr repair of H2O2-induced DNA single strand breks in cultured mammalian cells 48
Immunotherapeutic approaches in malignant pleural mesothelioma 48
Increased level of 70-kDa Heat Shock Protein in human cells exposed to electromagnetic fields. 47
Induzione differenziale da ipertonicità delle attività di trasporto dei sistemi A e BGT-1 in cellule endoteliali 47
Low-level caloric restriction rescues proteasome activity and hsc70 level in liver of aged rats 47
Hyperosmotic stress response 47
Proteasome inhibition restores accumulation of HSP72 and HuR proteins in human fibroblasts aged in vitro 47
Erlotinib potentiates Cetuximab-dependent cell citotoxicity in EGFR wild-type NSCLC cell lines 47
Pure anti-tumor effect of zoledronic acid in naive bone-only metastatic and locally advanced breast cancer: proof from the "biological window therapy" 44
Synergic anti-proliferative effect of letrozole and sorafenib in MCF-7/AROM breast cancer cells 44
Proteasome inhibition during heat shock restores synthesis and accumulation of HSP72 protein in human fibroblasts aged in vitro. 43
Evaluation of gefitinib maintenance in an EGFR-mutant NSCL cell line with acquired resistance 43
New therapeutic strategies for malignant pleural mesothelioma 43
Totale 7.057
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Categoria #
all - tutte 26.476
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 26.476
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020900 0 0 0 19 95 152 201 55 119 112 53 94
2020/2021752 13 77 62 37 88 14 74 31 133 24 162 37
2021/2022560 30 19 27 47 19 10 86 61 31 38 37 155
2022/20232.100 222 205 136 141 236 233 17 115 671 7 91 26
2023/2024892 38 64 31 39 67 187 65 70 36 51 95 149
2024/2025458 93 148 175 42 0 0 0 0 0 0 0 0
Totale 7.363