Amino acid transport system A (SNAT2) in Chinese hamster ovary (CHO-K1) cells was stimulated when the cells were depleted of amino acids or subjected to hypertonic stress. Each of these stresses also caused increases in the abundance of SNAT2 mRNA in these cells. Similar results were obtained with Madin-Darby canine kidney (MDCK) cells, porcine pulmonary artery endothelial cells and human WI-38 fibroblasts. We conclude that the cellular signal transduction pathways for hypertonic stress and amino acid starvation must converge at or before transcription of the message for SNAT2.
Hypertonic stress and amino acid deprivation both increase expression of mRNA for amino acid transport system A / Alfieri, Roberta; Bonelli, Mara; Petronini, Pier Giorgio; Desenzani, Silvia; Cavazzoni, Andrea; Borghetti, A. F; Wheeler, K. P.. - In: JOURNAL OF GENERAL PHYSIOLOGY. - ISSN 0022-1295. - 125:(2005), pp. 37-39. [10.1085/jgp.200409195]
Hypertonic stress and amino acid deprivation both increase expression of mRNA for amino acid transport system A
ALFIERI, Roberta;BONELLI, Mara;PETRONINI, Pier Giorgio;DESENZANI, Silvia;CAVAZZONI, Andrea;
2005-01-01
Abstract
Amino acid transport system A (SNAT2) in Chinese hamster ovary (CHO-K1) cells was stimulated when the cells were depleted of amino acids or subjected to hypertonic stress. Each of these stresses also caused increases in the abundance of SNAT2 mRNA in these cells. Similar results were obtained with Madin-Darby canine kidney (MDCK) cells, porcine pulmonary artery endothelial cells and human WI-38 fibroblasts. We conclude that the cellular signal transduction pathways for hypertonic stress and amino acid starvation must converge at or before transcription of the message for SNAT2.File | Dimensione | Formato | |
---|---|---|---|
J Gen Physiol 2005.pdf
non disponibili
Tipologia:
Documento in Post-print
Licenza:
NON PUBBLICO - Accesso privato/ristretto
Dimensione
190.03 kB
Formato
Adobe PDF
|
190.03 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.