IRIS
TOGNOLINI, Massimiliano
 Distribuzione geografica
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Continente #
NA - Nord America 8.759
EU - Europa 5.753
AS - Asia 4.837
SA - Sud America 817
AF - Africa 282
Continente sconosciuto - Info sul continente non disponibili 10
OC - Oceania 1
Totale 20.459
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Nazione #
US - Stati Uniti d'America 8.579
SG - Singapore 1.881
CN - Cina 1.699
IT - Italia 1.597
FI - Finlandia 826
IE - Irlanda 752
SE - Svezia 726
BR - Brasile 668
DE - Germania 632
HK - Hong Kong 372
UA - Ucraina 326
VN - Vietnam 299
NL - Olanda 181
GB - Regno Unito 180
TR - Turchia 177
ZA - Sudafrica 160
IN - India 135
FR - Francia 114
RU - Federazione Russa 112
CA - Canada 109
AR - Argentina 66
AT - Austria 62
BE - Belgio 62
CI - Costa d'Avorio 56
BD - Bangladesh 55
MX - Messico 40
JP - Giappone 39
ID - Indonesia 35
RO - Romania 35
CZ - Repubblica Ceca 34
EC - Ecuador 30
IQ - Iraq 28
KR - Corea 28
ES - Italia 22
PL - Polonia 21
CM - Camerun 17
LT - Lituania 17
PK - Pakistan 16
CO - Colombia 13
VE - Venezuela 12
MA - Marocco 11
CH - Svizzera 10
JO - Giordania 10
TN - Tunisia 10
EG - Egitto 9
EU - Europa 9
PA - Panama 9
CL - Cile 8
PY - Paraguay 8
NP - Nepal 7
AL - Albania 6
AZ - Azerbaigian 6
BG - Bulgaria 6
MY - Malesia 6
UZ - Uzbekistan 6
BO - Bolivia 5
CR - Costa Rica 5
HU - Ungheria 5
JM - Giamaica 5
KE - Kenya 5
KG - Kirghizistan 5
PE - Perù 5
AE - Emirati Arabi Uniti 4
DZ - Algeria 4
EE - Estonia 4
HN - Honduras 4
IR - Iran 4
SA - Arabia Saudita 4
SC - Seychelles 4
BY - Bielorussia 3
DK - Danimarca 3
GR - Grecia 3
RS - Serbia 3
SI - Slovenia 3
SN - Senegal 3
TW - Taiwan 3
BH - Bahrain 2
DO - Repubblica Dominicana 2
KZ - Kazakistan 2
NG - Nigeria 2
NO - Norvegia 2
OM - Oman 2
PH - Filippine 2
PT - Portogallo 2
TH - Thailandia 2
TT - Trinidad e Tobago 2
A1 - Anonimo 1
AM - Armenia 1
AU - Australia 1
BB - Barbados 1
BN - Brunei Darussalam 1
CY - Cipro 1
GA - Gabon 1
GT - Guatemala 1
HR - Croazia 1
IL - Israele 1
IM - Isola di Man 1
LK - Sri Lanka 1
LV - Lettonia 1
MC - Monaco 1
Totale 20.452
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Città #
Dallas 2.967
Singapore 976
Dublin 744
Chandler 737
Ashburn 650
Parma 478
Santa Clara 462
Ann Arbor 434
Beijing 417
Hong Kong 367
Jacksonville 359
Dearborn 309
Boardman 251
Munich 229
Nanjing 156
Johannesburg 151
Izmir 150
Shanghai 150
New York 144
Princeton 130
Hefei 128
Helsinki 125
Los Angeles 125
Ho Chi Minh City 111
Milan 110
Wilmington 110
Bremen 107
San Mateo 79
Hanoi 76
Bologna 74
São Paulo 67
Shenyang 59
Columbus 58
Kunming 57
Moscow 57
Toronto 57
Abidjan 56
Brussels 56
Vienna 50
Buffalo 49
Hebei 48
Jinan 48
Nanchang 47
Modena 45
Seattle 41
Turku 41
Guangzhou 40
Council Bluffs 36
Rome 36
Tokyo 36
Woodbridge 35
London 32
Bengaluru 30
Brescia 29
Changsha 29
Chicago 29
Des Moines 29
Rio de Janeiro 29
The Dalles 29
Jiaxing 28
Tianjin 28
Bangalore 27
Seoul 27
Brooklyn 24
Nuremberg 24
Fremont 23
Hangzhou 23
Jakarta 23
Reggio Emilia 22
Lubbock 21
Belo Horizonte 20
Düsseldorf 20
Frankfurt am Main 20
Boston 19
Houston 19
Piacenza 19
Brno 18
Ottawa 18
Phoenix 18
Stockholm 18
Grafing 17
Orem 17
Montreal 16
Pune 16
San Jose 16
Brasília 15
Amsterdam 14
Dalmine 14
Denver 14
Haiphong 14
Norwalk 14
Poplar 14
Falls Church 13
Mexico City 13
Turin 13
Warsaw 13
Acquafredda 12
Ankara 12
Atlanta 12
Curitiba 12
Totale 13.301
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Nome #
1,5-Benzodiazepines Part XIII. Substututed 4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-5-amines and 4H-imidazo-[1,2-a][ 1,5]benzodiazepin-5-amines as analgesic, anti-inflammatory and/or antipyretic agents with low acute toxicity 1.640
1,8-Naphthyridines IX. Potent anti-inflammatory and/or analgesic activity of a new group of substituted 5 amino[1,2,4]triazolo[4,3-a] [1,8]naphthyridine-6 carboxamides, of some their Mannich base derivatives and of one novel substituted 5-amino-10-oxo-10Hpyrimido[1,2-a [1,8]naphthyridine-6-carboxamide derivative 1.638
Principi di farmacognosia e fitoterapia. Seconda edizione 590
A Pharmacological Investigation of Eph-Ephrin Antagonism in Prostate Cancer: UniPR1331 Efficacy Evidence 266
Principi di farmacognosia e fitoterapia 240
Targeting the Eph/ephrin system as anti-inflammatory strategy in IBD 231
Excipient-free pulmonary insulin dry powder: Pharmacokinetic and pharmacodynamics profiles in rats 222
1,8-Naphthyridines V. Novel N-substituted 5-amino-N,N-diethyl-9-isopropyl [1,2,4]triazolo[4,3-a] [1,8]naphthyridine-6-carboxamides, as potent anti-inflammatory and/or analgesic agents completely devoid of acute gastrolesivity 216
Inhibition of Eph/ephrin interaction with the small molecule UniPR500 improves glucose tolerance in healthy and insulin-resistant mice 211
Pharmacological characterization of second generation FXR agonists as effective EphA2 antagonists: A successful application of target hopping approach 208
Discovery of a new 1-(phenylsulfonyl)-1H-indole derivative targeting the EphA2 receptor with antiproliferative activity on U251 glioblastoma cell line 198
Optimization of EphA2 antagonists based on a lithocholic acid core led to the identification of UniPR505, a new 3α-carbamoyloxy derivative with antiangiogenetic properties 190
Drug-gut microbiota metabolic interactions: the case of UniPR1331, selective antagonist of the Eph-ephrin system, in mice 184
Pharmacological evaluation of new bioavailable small molecules targeting Eph/ephrin interaction 182
UniPR129 is a competitive small molecule Eph-ephrin antagonist blocking in vitro angiogenesis at low micromolar concentrations. 180
Antiplatelet and antithrombotic activities of essential oil from wild Ocotea quixos (Lam.) Kosterm. (Lauraceae) calices from Amazonian Ecuador 175
Development of an orally bioavailable small molecule targeting Eph-ephrin system: in vitro and in vivo anticancer activity. 172
Analgesic properties of benzisothiazole/ benzimidazole derivatives with acidic groups 168
Combining ligand- and structure-based approaches for the discovery of new inhibitors of the EPHA2-ephrin-A1 interaction 167
2,4-Substituted benzopyrano[4,3-d]pyrimidines and benzopyrano[4,3-d]pyrimidin-5-ones: synthesis and antiplatelet activity 162
Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor. 162
Suppression of inflammatory events associated to intestinal ischemia-reperfusion by 5-HT1A blockade in mice 160
1,8-Naphthyridines VIII. Novel 5-aminoimidazo[1,2-a] [1,8]naphthyridine-6-carboxamide and 5-amino[1,2,4]triazolo[4,3-a] [1,8]naphthyridine-6-carboxamide derivatives showing potent analgesic or anti-inflammatory activity, respectively, and completely devoid of acute gastrolesivity. 160
2-Amino-1,2-benzisothiazolin-3-one derivatives as powerful antiplatelet agents 159
Accommodation and peristalsis are functional responses to chronic obstruction in rat hypertrophic ileum 158
Polyphenol rich botanicals used as food supplements interfere with EphA2-ephrinA1 system. 157
1,8-Naphthyridines VII. New substituted 5-amino[1,2,4]triazolo[4,3-a][1,8]naphthyridine-6-carboxamides and their isosteric analogues, exhibiting notable anti-inflammatory and/or analgesic activities, but no acute gastrolesivity. 156
Metabolic Soft Spot and Pharmacokinetics: Functionalization of C-3 Position of an Eph–Ephrin Antagonist Featuring a Bile Acid Core as an Effective Strategy to Obtain Oral Bioavailability in Mice 155
inibitori eph-ephrin biodisponibili oralmente 153
Structure–Activity Relationships and Mechanism of Action of Eph–ephrin Antagonists: Interaction of Cholanic Acid with the EphA2 Receptor 153
Hypericin - apomyoglobin an enhanced photosensitizer complex for the treatment of tumor cells 152
Cognition enhancing effect in rats of a selected histamine H3 receptor antagonist with good brain penetration 151
Lithocholic acid is an Eph-ephrin ligand interfering with Eph-kinase activation 151
Discovery and development of Eph-ephrin antagonists endowed with antiangiogenic properties 151
Enhanced photosensitizing properties of protein bound curcumin 149
Design and structure-activity relationship of amino acid derivatives of lithocholic acid as novel EphA2 antagonists 148
NEW EPH ANTAGONISTS DISCRIMINATING BETWEEN EPH-AS AND EPH-BS CLASSES 147
A simple GC-MS method for the screening of betulinic, corosolic, maslinic, oleanolic and ursolic acid contents in commercial botanicals used as food supplement ingredients 146
Perturbation of The EphA2-EphrinA1 System in Human Prostate Cancer Cells by Colonic (Poly)phenol Catabolites 143
1-Methyl and 1-(2-hydroxyalkyl)-5-(3-alkyl/cycloalkyl/phenyl/naphthylureido)-1H-pyrazole-4-carboxylic acid ethyl esters as potent human neutrophil chemotaxis inhibitors 143
Development of 3-oxo-cholenic derivatives as Eph antagonists able to block in vitro angiogenesis 141
Discovery and development of small molecules targeting Eph-ephrin system in glioblastoma: an academic history 137
UniPR1331: small Eph/ephrin antagonist beneficial in intestinal inflammation by interfering with type-B signaling 137
Influence of adenosine in the systemic and local injury caused by mesenteric ischemia-reperfusion in mice 136
A photosensitizing fusion protein with targeting capabilities 136
Multiple approaches for the discovery and development of small molecules targeting Eph-ephrin protein-protein interaction 134
Protein-Protein Interaction Inhibitors Targeting the Eph-Ephrin System with a Focus on Amino Acid Conjugates of Bile Acids 134
Eph/ephrin targeting with a small molecule improves glucose tolerance in healthy and insulin-resistant mice 133
270 Discovery, development and optimization of low molecular weight EPH–ephrin protein–protein inhibitors 132
2-Amino-1,2-benzisothiazolin-3-one Derivatives: Synthesis and Assessment of their Antiplatelet/Spasmolytic Effects 132
Botanicals used as food supplements interfering with EphA2-ephrinA1 system: a screening study 131
Design and structure-activity relationships of amino acid derivatives of lithocholic acid as novel EphA2 receptor antagonists. 131
Δ5-Cholenoyl-amino acids as selective and orally available antagonists of the Eph-ephrin system 130
The ellagitannin colonic metabolite urolithin D selectively inhibits EphA2 phosphorylation in prostate cancer cells 128
Comparative Analysis of Virtual Screening Approaches in the Search for Novel EphA2 Receptor Antagonists 127
Biochemical characterization of EphA2 antagonists with improved physico-chemical properties by cell-based assays and surface plasmon resonance analysis 127
Preventive effect of 5-HT1A receptor agonist Buspirone on mesenteric ischemia/reperfusion-induced inflammatory injuries in mice 126
Intestinal Hypoxia and reperfusion: role for Eph-ephrin system 126
Evaluation of the anti-tumor activity of small molecules targeting eph/ephrins in apcmin j mice 126
Structure activity relationship of new EphA2 ligands 125
5-Alkoxy-2-hydrazino and 5-methoxy-2-amino-5H[1]benzopyrano[4,3-d]pyrimidines: synthesis and pharmacological activity 124
Discovery of natural extracts interfering with EphA2-ephrinA1 system 123
UniPR1331, a small molecule targeting Eph/ephrin interaction, prolongs survival in glioblastoma and potentiates the effect of antiangiogenic therapy in mice 122
Discovery and development of low molecular weight Eph-ephrin protein-protein inhbi-tors endowed with antiangiogenic activity 121
PHARMACOLOGICAL CHARACTERIZATION OF NEW COMPOUNDS AIMED AT INHIBITING EPH-EPHRIN INTERACTION IN GLIOBLASTOMA 120
Exploiting Free-Energy Minima to Design Novel EphA2 Protein-Protein Antagonists: From Simulation to Experiment and Return 120
Combining pharmacology, target hopping and computational medicinal chemistry to discover novel scaffold targeting EPH-ephrin interaction. 120
High-Density Lipoproteins at the Interface between the NLRP3 Inflammasome and Myocardial Infarction 119
Analysis of adam12-mediated ephrin-a1 cleavage and its biological functions 119
Molecular Determinants of EphA2 and EphB2 Antagonism Enable the Design of Ligands with Improved Selectivity 118
Metadynamics for perspective drug design: Computationally driven synthesis of new protein-protein interaction inhibitors targeting the EphA2 receptor 118
Eph-ephrin antagonism in tumor angiogenesis and growth: UniPR1331 preclinical evidence. 118
Novel antiplatelet and antithrombotic activities of essential oil from Lavandula hybrida Reverchon "Grosso" 117
Mesenteric ischemia-reperfusion: an overview of preclinical drug strategies 117
RESPONSIVENESS OF LONGITUDINAL AND CIRCULAR MUSCLE TO RELAXING MEDIATORS IS DIFFERENTIALLY AFFECTED IN RAT HYPERTROPHIED ILEUM 116
Disruption of Eph-ephrin B signaling pathways mitigates inflammation in a murine model of Crohn’s disease 116
Comparative screening of plant essential oils: phenylpropanoid moiety as basic core for antiplatelet activity 116
Evidence for the involvement of 5-HT(2A) receptors in mild mesenteric ischemia/reperfusion dysfunctions in mice 115
Cholenic acid derivative UniPR1331 impairs tumor angiogenesis via blockade of VEGF/VEGFR2 in addition to Eph/ephrin 115
Target Hopping as a Useful Tool for the Identification of Novel EphA2 Protein–Protein Antagonists 114
Protection by the EPH-EPHRIN System Against Mesenteric Ischemia-Reperfusion Injury 114
Are we using the right pharmacological tools to target EphA4? 112
Lithocholic acid competitively inhibitis EphA2-ephrinA1 binding: pharmacological and structural considerations. 109
PHENYLPROPANOID RICH ESSENTIAL OILS AS POTENTIAL ANTITHROMBOTICS ENDOWED WITH GASTROPROTECTIVE EFFECTS 108
Lithocholic acid competitively inhibits EphA2-ephrinA1 binding: pharmacological and structural considerations. 108
2-Amino/azido/hydrazino-5-alkoxy-5H-[1]benzopyrano[4,3-d]pyrimidines: synthesis and pharmacological evaluation 107
Effects of subacute treatment with benzopyranopyrimidines in hemostasis and experimental thrombosis in mice 107
Progress in 5H [1] benzopyrano[4,3-d]pyrimidin-5-amine series: “-methoxy derivatives effective as antiìplatelet agents with analgesic activity 106
Pharmacological screening of novel antiplatelet agents with analgesic activity 106
Inhibitors of blood platelet aggregation: synthesis and in vitro characterization of 2-amino-1,2-benzisothiazolin-3-one derivatives 104
Synthesis and Biological Evaluation of N-Pyrazolyl-N'-alkyl/benzyl/phenylureas: a New Class of Potent Inhibitors of Interleukin 8-Induced Neutrophil Chemotaxis 103
6-amino-4-oxo-1,3-diphenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonyl derivatives as a new class of potent inhibitors of Interleukin-8-induced neutrophil chemotaxis. 103
Investigation on the anti-inflammatory properties of Ocotea quixos Lam. essential oil. 102
5-substituted derivatives of 6-amino-1,3-diphenyl-2-thioxo-2.3-dihydropyrimidin-4(1H9-one as a new class of potent inhibitors of interleukin 8-induced chemotaxis 102
Signaling by ephrinB1 and Eph kinases in platelets promotes Rap1 activation, platelet adhesion, and aggregation via effector pathways that do not require phosphorylation of ephrinB1 102
Synthesis and pharmacological properties of benzisothiazole/benzimidazole derivatives with acidic groups 102
Antinflammatory properties of novel 5-amino[1,2,4]-triazolo[4,3-a][1,8]naphthyridines-caroboxamides derivatives 101
New insights into the pharmacological properties of potent antiplatelet 2-amino-benzo|d|isothiazol-3-one derivatives 101
Ocotea quixos Lam. essential oil: In vitro and in vivo investigation on its anti-inflammatory properties. 101
Computer-Aided Design of Novel Antagonists of the EphA2 Receptor 101
Totale 17.390
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Categoria #
all - tutte 63.240
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 63.240
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021662 0 0 0 0 0 75 140 38 185 62 118 44
2021/2022844 35 31 32 100 41 35 81 87 59 74 57 212
2022/20232.958 330 302 157 237 320 333 64 162 876 43 96 38
2023/20241.195 68 75 32 45 91 229 117 82 60 111 118 167
2024/20254.051 127 197 275 214 398 429 232 242 539 373 360 665
2025/20266.990 730 1.326 2.863 736 1.003 332 0 0 0 0 0 0
Totale 20.689