IRIS
TOGNOLINI, Massimiliano
 Distribuzione geografica
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Continente #
EU - Europa 4.257
NA - Nord America 3.675
AS - Asia 1.496
AF - Africa 87
SA - Sud America 15
Continente sconosciuto - Info sul continente non disponibili 10
Totale 9.540
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Nazione #
US - Stati Uniti d'America 3.612
CN - Cina 1.132
IT - Italia 1.070
IE - Irlanda 748
FI - Finlandia 710
SE - Svezia 705
DE - Germania 354
UA - Ucraina 315
TR - Turchia 161
SG - Singapore 119
GB - Regno Unito 97
FR - Francia 72
CA - Canada 63
IN - India 60
CI - Costa d'Avorio 55
BE - Belgio 48
AT - Austria 44
CZ - Repubblica Ceca 25
CM - Camerun 17
RO - Romania 17
EU - Europa 9
NL - Olanda 9
ES - Italia 8
RU - Federazione Russa 7
AR - Argentina 6
BR - Brasile 6
CH - Svizzera 6
HK - Hong Kong 6
JP - Giappone 5
VN - Vietnam 5
EG - Egitto 4
PL - Polonia 4
SC - Seychelles 4
BY - Bielorussia 3
HU - Ungheria 3
SI - Slovenia 3
ZA - Sudafrica 3
DK - Danimarca 2
DZ - Algeria 2
EC - Ecuador 2
NG - Nigeria 2
PH - Filippine 2
TW - Taiwan 2
A1 - Anonimo 1
BG - Bulgaria 1
CL - Cile 1
GR - Grecia 1
HR - Croazia 1
IM - Isola di Man 1
IQ - Iraq 1
IR - Iran 1
MC - Monaco 1
MY - Malesia 1
NO - Norvegia 1
PK - Pakistan 1
RS - Serbia 1
Totale 9.540
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Città #
Dublin 740
Chandler 737
Ann Arbor 434
Parma 379
Jacksonville 359
Dearborn 309
Beijing 249
Ashburn 215
Nanjing 154
Izmir 148
Shanghai 143
Princeton 130
Wilmington 110
Bremen 107
New York 90
San Mateo 79
Boardman 69
Singapore 64
Shenyang 58
Kunming 56
Abidjan 55
Helsinki 51
Hebei 48
Jinan 48
Nanchang 47
Toronto 44
Brussels 42
Hefei 42
Vienna 41
Bologna 38
Los Angeles 36
Milan 36
Seattle 35
Woodbridge 35
Guangzhou 31
Jiaxing 28
Bangalore 27
Des Moines 27
Changsha 24
Fremont 23
Brescia 21
Modena 21
Chicago 19
Hangzhou 19
Brno 18
Düsseldorf 17
Grafing 17
Tianjin 17
Piacenza 15
Rome 15
Norwalk 14
Falls Church 13
Pune 13
West Jordan 11
Genoa 10
Munich 10
Ottawa 10
Zhengzhou 10
Houston 9
Montegaldella 9
Timisoara 9
London 8
Mestre 8
Borås 7
Fairfield 7
Fuzhou 7
Haikou 7
Hyderabad 7
Kocaeli 7
Redwood City 7
Ankara 6
Ardea 6
Ningbo 6
Nuremberg 6
Palermo 6
Rimini 6
Sant'ilario D'enza 6
Turin 6
Verona 6
Auburn Hills 5
Bergamo 5
Carpi 5
Council Bluffs 5
Matelica 5
Pesaro 5
Phoenix 5
Prata Di Pordenone 5
Rocca Canavese 5
Rockville 5
Santa Clara 5
Taizhou 5
Terni 5
Tulsa 5
Amsterdam 4
Caorso 4
Castel San Giovanni 4
Chengdu 4
Chongqing 4
Florence 4
Lanzhou 4
Totale 5.902
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Nome #
Principi di farmacognosia e fitoterapia. Seconda edizione 225
1,5-Benzodiazepines Part XIII. Substututed 4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-5-amines and 4H-imidazo-[1,2-a][ 1,5]benzodiazepin-5-amines as analgesic, anti-inflammatory and/or antipyretic agents with low acute toxicity 215
Principi di farmacognosia e fitoterapia 207
1,8-Naphthyridines IX. Potent anti-inflammatory and/or analgesic activity of a new group of substituted 5 amino[1,2,4]triazolo[4,3-a] [1,8]naphthyridine-6 carboxamides, of some their Mannich base derivatives and of one novel substituted 5-amino-10-oxo-10Hpyrimido[1,2-a [1,8]naphthyridine-6-carboxamide derivative 175
Targeting the Eph/ephrin system as anti-inflammatory strategy in IBD 155
Inhibition of Eph/ephrin interaction with the small molecule UniPR500 improves glucose tolerance in healthy and insulin-resistant mice 150
1,8-Naphthyridines V. Novel N-substituted 5-amino-N,N-diethyl-9-isopropyl [1,2,4]triazolo[4,3-a] [1,8]naphthyridine-6-carboxamides, as potent anti-inflammatory and/or analgesic agents completely devoid of acute gastrolesivity 145
Excipient-free pulmonary insulin dry powder: Pharmacokinetic and pharmacodynamics profiles in rats 134
UniPR129 is a competitive small molecule Eph-ephrin antagonist blocking in vitro angiogenesis at low micromolar concentrations. 132
Optimization of EphA2 antagonists based on a lithocholic acid core led to the identification of UniPR505, a new 3α-carbamoyloxy derivative with antiangiogenetic properties 123
inibitori eph-ephrin biodisponibili oralmente 119
Antiplatelet and antithrombotic activities of essential oil from wild Ocotea quixos (Lam.) Kosterm. (Lauraceae) calices from Amazonian Ecuador 119
Pharmacological evaluation of new bioavailable small molecules targeting Eph/ephrin interaction 112
Development of an orally bioavailable small molecule targeting Eph-ephrin system: in vitro and in vivo anticancer activity. 105
Hypericin - apomyoglobin an enhanced photosensitizer complex for the treatment of tumor cells 105
Lithocholic acid is an Eph-ephrin ligand interfering with Eph-kinase activation 104
Combining ligand- and structure-based approaches for the discovery of new inhibitors of the EPHA2-ephrin-A1 interaction 98
Drug-gut microbiota metabolic interactions: the case of UniPR1331, selective antagonist of the Eph-ephrin system, in mice 98
Metabolic Soft Spot and Pharmacokinetics: Functionalization of C-3 Position of an Eph–Ephrin Antagonist Featuring a Bile Acid Core as an Effective Strategy to Obtain Oral Bioavailability in Mice 98
Analgesic properties of benzisothiazole/ benzimidazole derivatives with acidic groups 96
2,4-Substituted benzopyrano[4,3-d]pyrimidines and benzopyrano[4,3-d]pyrimidin-5-ones: synthesis and antiplatelet activity 95
Polyphenol rich botanicals used as food supplements interfere with EphA2-ephrinA1 system. 95
Suppression of inflammatory events associated to intestinal ischemia-reperfusion by 5-HT1A blockade in mice 94
1,8-Naphthyridines VII. New substituted 5-amino[1,2,4]triazolo[4,3-a][1,8]naphthyridine-6-carboxamides and their isosteric analogues, exhibiting notable anti-inflammatory and/or analgesic activities, but no acute gastrolesivity. 92
Structure–Activity Relationships and Mechanism of Action of Eph–ephrin Antagonists: Interaction of Cholanic Acid with the EphA2 Receptor 92
Accommodation and peristalsis are functional responses to chronic obstruction in rat hypertrophic ileum 90
Influence of adenosine in the systemic and local injury caused by mesenteric ischemia-reperfusion in mice 88
Enhanced photosensitizing properties of protein bound curcumin 87
2-Amino-1,2-benzisothiazolin-3-one derivatives as powerful antiplatelet agents 87
1,8-Naphthyridines VIII. Novel 5-aminoimidazo[1,2-a] [1,8]naphthyridine-6-carboxamide and 5-amino[1,2,4]triazolo[4,3-a] [1,8]naphthyridine-6-carboxamide derivatives showing potent analgesic or anti-inflammatory activity, respectively, and completely devoid of acute gastrolesivity. 87
Cognition enhancing effect in rats of a selected histamine H3 receptor antagonist with good brain penetration 86
The ellagitannin colonic metabolite urolithin D selectively inhibits EphA2 phosphorylation in prostate cancer cells 86
Design and structure-activity relationship of amino acid derivatives of lithocholic acid as novel EphA2 antagonists 86
Mesenteric ischemia-reperfusion: an overview of preclinical drug strategies 85
Perturbation of The EphA2-EphrinA1 System in Human Prostate Cancer Cells by Colonic (Poly)phenol Catabolites 84
Discovery and development of small molecules targeting Eph-ephrin system in glioblastoma: an academic history 83
1-Methyl and 1-(2-hydroxyalkyl)-5-(3-alkyl/cycloalkyl/phenyl/naphthylureido)-1H-pyrazole-4-carboxylic acid ethyl esters as potent human neutrophil chemotaxis inhibitors 82
Discovery of natural extracts interfering with EphA2-ephrinA1 system 82
Botanicals used as food supplements interfering with EphA2-ephrinA1 system: a screening study 80
Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor. 79
Eph-ephrin antagonism in tumor angiogenesis and growth: UniPR1331 preclinical evidence. 78
Multiple approaches for the discovery and development of small molecules targeting Eph-ephrin protein-protein interaction 77
Novel antiplatelet and antithrombotic activities of essential oil from Lavandula hybrida Reverchon "Grosso" 75
A simple GC-MS method for the screening of betulinic, corosolic, maslinic, oleanolic and ursolic acid contents in commercial botanicals used as food supplement ingredients 75
Eph/ephrin targeting with a small molecule improves glucose tolerance in healthy and insulin-resistant mice 74
Metadynamics for perspective drug design: Computationally driven synthesis of new protein-protein interaction inhibitors targeting the EphA2 receptor 74
Disruption of Eph-ephrin B signaling pathways mitigates inflammation in a murine model of Crohn’s disease 73
Discovery and development of Eph-ephrin antagonists endowed with antiangiogenic properties 73
Development of 3-oxo-cholenic derivatives as Eph antagonists able to block in vitro angiogenesis 73
UniPR1331, a small molecule targeting Eph/ephrin interaction, prolongs survival in glioblastoma and potentiates the effect of antiangiogenic therapy in mice 73
Design and structure-activity relationships of amino acid derivatives of lithocholic acid as novel EphA2 receptor antagonists. 71
Pharmacological characterization of second generation FXR agonists as effective EphA2 antagonists: A successful application of target hopping approach 70
Comparative Analysis of Virtual Screening Approaches in the Search for Novel EphA2 Receptor Antagonists 70
Combining pharmacology, target hopping and computational medicinal chemistry to discover novel scaffold targeting EPH-ephrin interaction. 70
Protection by the EPH-EPHRIN System Against Mesenteric Ischemia-Reperfusion Injury 70
UniPR1331: small Eph/ephrin antagonist beneficial in intestinal inflammation by interfering with type-B signaling 69
Protein-Protein Interaction Inhibitors Targeting the Eph-Ephrin System with a Focus on Amino Acid Conjugates of Bile Acids 68
Target Hopping as a Useful Tool for the Identification of Novel EphA2 Protein–Protein Antagonists 67
5-Alkoxy-2-hydrazino and 5-methoxy-2-amino-5H[1]benzopyrano[4,3-d]pyrimidines: synthesis and pharmacological activity 66
270 Discovery, development and optimization of low molecular weight EPH–ephrin protein–protein inhibitors 66
Discovery and development of low molecular weight Eph-ephrin protein-protein inhbi-tors endowed with antiangiogenic activity 66
2-Amino-1,2-benzisothiazolin-3-one Derivatives: Synthesis and Assessment of their Antiplatelet/Spasmolytic Effects 66
Synthesis and pharmacological evaluation of 2,5-cycloamino-5H-[1]benzopyrano-[4,3-di]pyrimidines endowed with in vitro antiplatelet activity 65
Structure activity relationship of new EphA2 ligands 65
Evaluation of the anti-tumor activity of small molecules targeting eph/ephrins in apcmin j mice 65
A photosensitizing fusion protein with targeting capabilities 65
RESPONSIVENESS OF LONGITUDINAL AND CIRCULAR MUSCLE TO RELAXING MEDIATORS IS DIFFERENTIALLY AFFECTED IN RAT HYPERTROPHIED ILEUM 64
Comparative screening of plant essential oils: phenylpropanoid moiety as basic core for antiplatelet activity 64
Effects of subacute treatment with benzopyranopyrimidines in hemostasis and experimental thrombosis in mice 64
Biochemical characterization of EphA2 antagonists with improved physico-chemical properties by cell-based assays and surface plasmon resonance analysis 64
PHARMACOLOGICAL CHARACTERIZATION OF NEW COMPOUNDS AIMED AT INHIBITING EPH-EPHRIN INTERACTION IN GLIOBLASTOMA 63
Δ5-Cholenoyl-amino acids as selective and orally available antagonists of the Eph-ephrin system 63
Inhibitors of blood platelet aggregation: synthesis and in vitro characterization of 2-amino-1,2-benzisothiazolin-3-one derivatives 62
On the Use of 2,5-Dimethyl-Pyrrol-1-yl-Benzoic Acid Derivatives as EPH-Ephrin Antagonists. 62
NEW EPH ANTAGONISTS DISCRIMINATING BETWEEN EPH-AS AND EPH-BS CLASSES 61
Investigation on the anti-inflammatory properties of Ocotea quixos Lam. essential oil. 61
Lithocholic acid competitively inhibits EphA2-ephrinA1 binding: pharmacological and structural considerations. 61
Lithocholic acid competitively inhibitis EphA2-ephrinA1 binding: pharmacological and structural considerations. 61
Therapeutic perspectives of Eph–ephrin system modulation 61
Synthesis and pharmacological properties of benzisothiazole/benzimidazole derivatives with acidic groups 61
Preventive effect of 5-HT1A receptor agonist Buspirone on mesenteric ischemia/reperfusion-induced inflammatory injuries in mice 61
Lithocholic Acid Is an Eph-ephrin Ligand Interfering with Eph-kinase Activation. 60
Exploiting Free-Energy Minima to Design Novel EphA2 Protein-Protein Antagonists: From Simulation to Experiment and Return 60
Pharmacological characterization of new antiplatelet benzopyrano[4,3-d]pyrimidines 59
Progress in 5H [1] benzopyrano[4,3-d]pyrimidin-5-amine series: “-methoxy derivatives effective as antiìplatelet agents with analgesic activity 58
Synthesis and Biological Evaluation of N-Pyrazolyl-N'-alkyl/benzyl/phenylureas: a New Class of Potent Inhibitors of Interleukin 8-Induced Neutrophil Chemotaxis 58
Antinflammatory properties of novel 5-amino[1,2,4]-triazolo[4,3-a][1,8]naphthyridines-caroboxamides derivatives 58
New insights into the pharmacological properties of potent antiplatelet 2-amino-benzo|d|isothiazol-3-one derivatives 57
Synthesis and pharmacological evaluation of 5H-[1]benzopyrano[4,3-d]pyrimidines effective as antiplatelet/analgesic agents 56
In vitro and in vivo antiplatelet/antithrombotic properties of Lavandula hybrida Reverchon essential oil 56
Intestinal Hypoxia and reperfusion: role for Eph-ephrin system 56
Evidence for the involvement of 5-HT(2A) receptors in mild mesenteric ischemia/reperfusion dysfunctions in mice 55
Ocotea quixos Lam. essential oil: In vitro and in vivo investigation on its anti-inflammatory properties. 55
Are we using the right pharmacological tools to target EphA4? 55
Synthesis and Structure-Activity Relationships of Amino Acid Conjugates of Cholanic Acid as Antagonists of the EphA2 Receptor. 54
5-substituted derivatives of 6-amino-1,3-diphenyl-2-thioxo-2.3-dihydropyrimidin-4(1H9-one as a new class of potent inhibitors of interleukin 8-induced chemotaxis 54
2-Amino/azido/hydrazino-5-alkoxy-5H-[1]benzopyrano[4,3-d]pyrimidines: synthesis and pharmacological evaluation 54
PHENYLPROPANOID RICH ESSENTIAL OILS AS POTENTIAL ANTITHROMBOTICS ENDOWED WITH GASTROPROTECTIVE EFFECTS 53
6-amino-4-oxo-1,3-diphenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonyl derivatives as a new class of potent inhibitors of Interleukin-8-induced neutrophil chemotaxis. 53
New polycyclic pyrimidine derivatives with antiplatelet in vitro activity: synthesis and pharmacological screening 53
Totale 8.276
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Categoria #
all - tutte 31.294
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 31.294
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20201.843 283 259 87 59 149 227 249 56 178 139 70 87
2020/20211.070 21 90 108 60 129 75 140 38 185 62 118 44
2021/2022844 35 31 32 100 41 35 81 87 59 74 57 212
2022/20232.958 330 302 157 237 320 333 64 162 876 43 96 38
2023/20241.195 68 75 32 45 91 229 117 82 60 111 118 167
2024/2025107 107 0 0 0 0 0 0 0 0 0 0 0
Totale 9.755