IRIS
TOGNOLINI, Massimiliano
 Distribuzione geografica
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Continente #
NA - Nord America 8.715
EU - Europa 5.739
AS - Asia 4.762
SA - Sud America 810
AF - Africa 282
Continente sconosciuto - Info sul continente non disponibili 10
OC - Oceania 1
Totale 20.319
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Nazione #
US - Stati Uniti d'America 8.540
SG - Singapore 1.819
CN - Cina 1.692
IT - Italia 1.590
FI - Finlandia 826
IE - Irlanda 752
SE - Svezia 724
BR - Brasile 664
DE - Germania 632
HK - Hong Kong 371
UA - Ucraina 326
VN - Vietnam 299
NL - Olanda 181
GB - Regno Unito 177
TR - Turchia 177
ZA - Sudafrica 160
IN - India 135
FR - Francia 113
RU - Federazione Russa 112
CA - Canada 107
AR - Argentina 65
AT - Austria 62
BE - Belgio 62
CI - Costa d'Avorio 56
BD - Bangladesh 55
JP - Giappone 38
MX - Messico 37
ID - Indonesia 35
RO - Romania 35
CZ - Repubblica Ceca 34
EC - Ecuador 30
KR - Corea 28
IQ - Iraq 26
ES - Italia 22
PL - Polonia 20
CM - Camerun 17
LT - Lituania 17
PK - Pakistan 16
CO - Colombia 13
VE - Venezuela 12
MA - Marocco 11
CH - Svizzera 10
TN - Tunisia 10
EG - Egitto 9
EU - Europa 9
PA - Panama 9
CL - Cile 8
JO - Giordania 8
PY - Paraguay 8
NP - Nepal 7
AL - Albania 6
AZ - Azerbaigian 6
BG - Bulgaria 6
MY - Malesia 6
UZ - Uzbekistan 6
CR - Costa Rica 5
HU - Ungheria 5
JM - Giamaica 5
KE - Kenya 5
KG - Kirghizistan 5
PE - Perù 5
AE - Emirati Arabi Uniti 4
DZ - Algeria 4
EE - Estonia 4
HN - Honduras 4
IR - Iran 4
SA - Arabia Saudita 4
SC - Seychelles 4
BO - Bolivia 3
BY - Bielorussia 3
DK - Danimarca 3
GR - Grecia 3
RS - Serbia 3
SI - Slovenia 3
SN - Senegal 3
TW - Taiwan 3
BH - Bahrain 2
DO - Repubblica Dominicana 2
KZ - Kazakistan 2
NG - Nigeria 2
NO - Norvegia 2
OM - Oman 2
PH - Filippine 2
PT - Portogallo 2
TH - Thailandia 2
TT - Trinidad e Tobago 2
A1 - Anonimo 1
AM - Armenia 1
AU - Australia 1
BB - Barbados 1
BN - Brunei Darussalam 1
CY - Cipro 1
GA - Gabon 1
GT - Guatemala 1
HR - Croazia 1
IL - Israele 1
IM - Isola di Man 1
LK - Sri Lanka 1
LV - Lettonia 1
MC - Monaco 1
Totale 20.312
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Città #
Dallas 2.967
Singapore 915
Dublin 744
Chandler 737
Ashburn 636
Parma 478
Santa Clara 462
Ann Arbor 434
Beijing 417
Hong Kong 366
Jacksonville 359
Dearborn 309
Boardman 251
Munich 229
Nanjing 156
Johannesburg 151
Izmir 150
Shanghai 150
New York 143
Princeton 130
Hefei 128
Helsinki 125
Los Angeles 123
Ho Chi Minh City 111
Wilmington 110
Bremen 107
Milan 107
San Mateo 79
Hanoi 76
Bologna 74
São Paulo 66
Shenyang 59
Columbus 58
Kunming 57
Moscow 57
Abidjan 56
Brussels 56
Toronto 56
Vienna 50
Buffalo 49
Hebei 48
Jinan 48
Nanchang 47
Modena 45
Seattle 41
Turku 41
Guangzhou 40
Council Bluffs 36
Rome 35
Tokyo 35
Woodbridge 35
London 31
Bengaluru 30
Brescia 29
Changsha 29
Chicago 29
Des Moines 29
Rio de Janeiro 29
Jiaxing 28
The Dalles 28
Tianjin 28
Bangalore 27
Seoul 27
Brooklyn 24
Nuremberg 24
Fremont 23
Hangzhou 23
Jakarta 23
Lubbock 21
Belo Horizonte 20
Düsseldorf 20
Frankfurt am Main 20
Reggio Emilia 20
Boston 19
Houston 19
Piacenza 19
Brno 18
Ottawa 18
Phoenix 18
Stockholm 18
Grafing 17
Montreal 16
Orem 16
Pune 16
Brasília 15
Amsterdam 14
Dalmine 14
Denver 14
Haiphong 14
Norwalk 14
Falls Church 13
Turin 13
Acquafredda 12
Ankara 12
Atlanta 12
Curitiba 12
Florence 12
Poplar 12
Quito 12
Redondo Beach 12
Totale 13.202
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Nome #
1,5-Benzodiazepines Part XIII. Substututed 4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-5-amines and 4H-imidazo-[1,2-a][ 1,5]benzodiazepin-5-amines as analgesic, anti-inflammatory and/or antipyretic agents with low acute toxicity 1.637
1,8-Naphthyridines IX. Potent anti-inflammatory and/or analgesic activity of a new group of substituted 5 amino[1,2,4]triazolo[4,3-a] [1,8]naphthyridine-6 carboxamides, of some their Mannich base derivatives and of one novel substituted 5-amino-10-oxo-10Hpyrimido[1,2-a [1,8]naphthyridine-6-carboxamide derivative 1.634
Principi di farmacognosia e fitoterapia. Seconda edizione 586
A Pharmacological Investigation of Eph-Ephrin Antagonism in Prostate Cancer: UniPR1331 Efficacy Evidence 263
Principi di farmacognosia e fitoterapia 238
Targeting the Eph/ephrin system as anti-inflammatory strategy in IBD 228
Excipient-free pulmonary insulin dry powder: Pharmacokinetic and pharmacodynamics profiles in rats 220
1,8-Naphthyridines V. Novel N-substituted 5-amino-N,N-diethyl-9-isopropyl [1,2,4]triazolo[4,3-a] [1,8]naphthyridine-6-carboxamides, as potent anti-inflammatory and/or analgesic agents completely devoid of acute gastrolesivity 215
Inhibition of Eph/ephrin interaction with the small molecule UniPR500 improves glucose tolerance in healthy and insulin-resistant mice 209
Pharmacological characterization of second generation FXR agonists as effective EphA2 antagonists: A successful application of target hopping approach 208
Discovery of a new 1-(phenylsulfonyl)-1H-indole derivative targeting the EphA2 receptor with antiproliferative activity on U251 glioblastoma cell line 196
Optimization of EphA2 antagonists based on a lithocholic acid core led to the identification of UniPR505, a new 3α-carbamoyloxy derivative with antiangiogenetic properties 188
Drug-gut microbiota metabolic interactions: the case of UniPR1331, selective antagonist of the Eph-ephrin system, in mice 184
Pharmacological evaluation of new bioavailable small molecules targeting Eph/ephrin interaction 181
UniPR129 is a competitive small molecule Eph-ephrin antagonist blocking in vitro angiogenesis at low micromolar concentrations. 178
Antiplatelet and antithrombotic activities of essential oil from wild Ocotea quixos (Lam.) Kosterm. (Lauraceae) calices from Amazonian Ecuador 174
Development of an orally bioavailable small molecule targeting Eph-ephrin system: in vitro and in vivo anticancer activity. 170
Combining ligand- and structure-based approaches for the discovery of new inhibitors of the EPHA2-ephrin-A1 interaction 166
Analgesic properties of benzisothiazole/ benzimidazole derivatives with acidic groups 166
Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor. 161
2,4-Substituted benzopyrano[4,3-d]pyrimidines and benzopyrano[4,3-d]pyrimidin-5-ones: synthesis and antiplatelet activity 160
Suppression of inflammatory events associated to intestinal ischemia-reperfusion by 5-HT1A blockade in mice 158
1,8-Naphthyridines VIII. Novel 5-aminoimidazo[1,2-a] [1,8]naphthyridine-6-carboxamide and 5-amino[1,2,4]triazolo[4,3-a] [1,8]naphthyridine-6-carboxamide derivatives showing potent analgesic or anti-inflammatory activity, respectively, and completely devoid of acute gastrolesivity. 158
Accommodation and peristalsis are functional responses to chronic obstruction in rat hypertrophic ileum 157
Polyphenol rich botanicals used as food supplements interfere with EphA2-ephrinA1 system. 156
2-Amino-1,2-benzisothiazolin-3-one derivatives as powerful antiplatelet agents 155
1,8-Naphthyridines VII. New substituted 5-amino[1,2,4]triazolo[4,3-a][1,8]naphthyridine-6-carboxamides and their isosteric analogues, exhibiting notable anti-inflammatory and/or analgesic activities, but no acute gastrolesivity. 154
Metabolic Soft Spot and Pharmacokinetics: Functionalization of C-3 Position of an Eph–Ephrin Antagonist Featuring a Bile Acid Core as an Effective Strategy to Obtain Oral Bioavailability in Mice 154
inibitori eph-ephrin biodisponibili oralmente 153
Structure–Activity Relationships and Mechanism of Action of Eph–ephrin Antagonists: Interaction of Cholanic Acid with the EphA2 Receptor 152
Hypericin - apomyoglobin an enhanced photosensitizer complex for the treatment of tumor cells 152
Lithocholic acid is an Eph-ephrin ligand interfering with Eph-kinase activation 151
Discovery and development of Eph-ephrin antagonists endowed with antiangiogenic properties 150
Cognition enhancing effect in rats of a selected histamine H3 receptor antagonist with good brain penetration 148
NEW EPH ANTAGONISTS DISCRIMINATING BETWEEN EPH-AS AND EPH-BS CLASSES 147
Enhanced photosensitizing properties of protein bound curcumin 147
Design and structure-activity relationship of amino acid derivatives of lithocholic acid as novel EphA2 antagonists 146
A simple GC-MS method for the screening of betulinic, corosolic, maslinic, oleanolic and ursolic acid contents in commercial botanicals used as food supplement ingredients 145
Perturbation of The EphA2-EphrinA1 System in Human Prostate Cancer Cells by Colonic (Poly)phenol Catabolites 142
1-Methyl and 1-(2-hydroxyalkyl)-5-(3-alkyl/cycloalkyl/phenyl/naphthylureido)-1H-pyrazole-4-carboxylic acid ethyl esters as potent human neutrophil chemotaxis inhibitors 141
Development of 3-oxo-cholenic derivatives as Eph antagonists able to block in vitro angiogenesis 139
UniPR1331: small Eph/ephrin antagonist beneficial in intestinal inflammation by interfering with type-B signaling 137
Influence of adenosine in the systemic and local injury caused by mesenteric ischemia-reperfusion in mice 136
Discovery and development of small molecules targeting Eph-ephrin system in glioblastoma: an academic history 135
A photosensitizing fusion protein with targeting capabilities 135
Protein-Protein Interaction Inhibitors Targeting the Eph-Ephrin System with a Focus on Amino Acid Conjugates of Bile Acids 134
Multiple approaches for the discovery and development of small molecules targeting Eph-ephrin protein-protein interaction 133
Eph/ephrin targeting with a small molecule improves glucose tolerance in healthy and insulin-resistant mice 132
270 Discovery, development and optimization of low molecular weight EPH–ephrin protein–protein inhibitors 131
2-Amino-1,2-benzisothiazolin-3-one Derivatives: Synthesis and Assessment of their Antiplatelet/Spasmolytic Effects 131
Botanicals used as food supplements interfering with EphA2-ephrinA1 system: a screening study 130
Design and structure-activity relationships of amino acid derivatives of lithocholic acid as novel EphA2 receptor antagonists. 130
Δ5-Cholenoyl-amino acids as selective and orally available antagonists of the Eph-ephrin system 128
The ellagitannin colonic metabolite urolithin D selectively inhibits EphA2 phosphorylation in prostate cancer cells 127
Biochemical characterization of EphA2 antagonists with improved physico-chemical properties by cell-based assays and surface plasmon resonance analysis 127
Comparative Analysis of Virtual Screening Approaches in the Search for Novel EphA2 Receptor Antagonists 126
Evaluation of the anti-tumor activity of small molecules targeting eph/ephrins in apcmin j mice 126
Preventive effect of 5-HT1A receptor agonist Buspirone on mesenteric ischemia/reperfusion-induced inflammatory injuries in mice 124
Structure activity relationship of new EphA2 ligands 123
Intestinal Hypoxia and reperfusion: role for Eph-ephrin system 123
5-Alkoxy-2-hydrazino and 5-methoxy-2-amino-5H[1]benzopyrano[4,3-d]pyrimidines: synthesis and pharmacological activity 122
Discovery of natural extracts interfering with EphA2-ephrinA1 system 122
UniPR1331, a small molecule targeting Eph/ephrin interaction, prolongs survival in glioblastoma and potentiates the effect of antiangiogenic therapy in mice 122
Discovery and development of low molecular weight Eph-ephrin protein-protein inhbi-tors endowed with antiangiogenic activity 121
PHARMACOLOGICAL CHARACTERIZATION OF NEW COMPOUNDS AIMED AT INHIBITING EPH-EPHRIN INTERACTION IN GLIOBLASTOMA 120
Combining pharmacology, target hopping and computational medicinal chemistry to discover novel scaffold targeting EPH-ephrin interaction. 119
Molecular Determinants of EphA2 and EphB2 Antagonism Enable the Design of Ligands with Improved Selectivity 118
High-Density Lipoproteins at the Interface between the NLRP3 Inflammasome and Myocardial Infarction 118
Exploiting Free-Energy Minima to Design Novel EphA2 Protein-Protein Antagonists: From Simulation to Experiment and Return 118
Mesenteric ischemia-reperfusion: an overview of preclinical drug strategies 117
Analysis of adam12-mediated ephrin-a1 cleavage and its biological functions 117
Novel antiplatelet and antithrombotic activities of essential oil from Lavandula hybrida Reverchon "Grosso" 116
RESPONSIVENESS OF LONGITUDINAL AND CIRCULAR MUSCLE TO RELAXING MEDIATORS IS DIFFERENTIALLY AFFECTED IN RAT HYPERTROPHIED ILEUM 116
Comparative screening of plant essential oils: phenylpropanoid moiety as basic core for antiplatelet activity 116
Eph-ephrin antagonism in tumor angiogenesis and growth: UniPR1331 preclinical evidence. 116
Evidence for the involvement of 5-HT(2A) receptors in mild mesenteric ischemia/reperfusion dysfunctions in mice 115
Disruption of Eph-ephrin B signaling pathways mitigates inflammation in a murine model of Crohn’s disease 115
Metadynamics for perspective drug design: Computationally driven synthesis of new protein-protein interaction inhibitors targeting the EphA2 receptor 115
Target Hopping as a Useful Tool for the Identification of Novel EphA2 Protein–Protein Antagonists 114
Cholenic acid derivative UniPR1331 impairs tumor angiogenesis via blockade of VEGF/VEGFR2 in addition to Eph/ephrin 114
Protection by the EPH-EPHRIN System Against Mesenteric Ischemia-Reperfusion Injury 112
Are we using the right pharmacological tools to target EphA4? 110
Lithocholic acid competitively inhibits EphA2-ephrinA1 binding: pharmacological and structural considerations. 108
Lithocholic acid competitively inhibitis EphA2-ephrinA1 binding: pharmacological and structural considerations. 108
PHENYLPROPANOID RICH ESSENTIAL OILS AS POTENTIAL ANTITHROMBOTICS ENDOWED WITH GASTROPROTECTIVE EFFECTS 107
2-Amino/azido/hydrazino-5-alkoxy-5H-[1]benzopyrano[4,3-d]pyrimidines: synthesis and pharmacological evaluation 106
Effects of subacute treatment with benzopyranopyrimidines in hemostasis and experimental thrombosis in mice 106
Progress in 5H [1] benzopyrano[4,3-d]pyrimidin-5-amine series: “-methoxy derivatives effective as antiìplatelet agents with analgesic activity 105
Pharmacological screening of novel antiplatelet agents with analgesic activity 105
Inhibitors of blood platelet aggregation: synthesis and in vitro characterization of 2-amino-1,2-benzisothiazolin-3-one derivatives 102
Signaling by ephrinB1 and Eph kinases in platelets promotes Rap1 activation, platelet adhesion, and aggregation via effector pathways that do not require phosphorylation of ephrinB1 102
Synthesis and Biological Evaluation of N-Pyrazolyl-N'-alkyl/benzyl/phenylureas: a New Class of Potent Inhibitors of Interleukin 8-Induced Neutrophil Chemotaxis 101
Investigation on the anti-inflammatory properties of Ocotea quixos Lam. essential oil. 101
New insights into the pharmacological properties of potent antiplatelet 2-amino-benzo|d|isothiazol-3-one derivatives 101
Ocotea quixos Lam. essential oil: In vitro and in vivo investigation on its anti-inflammatory properties. 101
6-amino-4-oxo-1,3-diphenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonyl derivatives as a new class of potent inhibitors of Interleukin-8-induced neutrophil chemotaxis. 101
5-substituted derivatives of 6-amino-1,3-diphenyl-2-thioxo-2.3-dihydropyrimidin-4(1H9-one as a new class of potent inhibitors of interleukin 8-induced chemotaxis 101
Synthesis and pharmacological properties of benzisothiazole/benzimidazole derivatives with acidic groups 101
Computer-Aided Design of Novel Antagonists of the EphA2 Receptor 100
Ephrin receptor type-A2 (EphA2) targeting in cancer: a patent review (2018-present) 99
Totale 17.263
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Categoria #
all - tutte 62.230
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 62.230
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021662 0 0 0 0 0 75 140 38 185 62 118 44
2021/2022844 35 31 32 100 41 35 81 87 59 74 57 212
2022/20232.958 330 302 157 237 320 333 64 162 876 43 96 38
2023/20241.195 68 75 32 45 91 229 117 82 60 111 118 167
2024/20254.051 127 197 275 214 398 429 232 242 539 373 360 665
2025/20266.850 730 1.326 2.863 736 1.003 192 0 0 0 0 0 0
Totale 20.549