A series of 2-methoxy-5Hbenzopyrano[4,3-d]pyrimidin-5-amines were prepared and screened for their in vitro antiplatelet activity inducing the aggregation by ADP, arachidonic acid (AA) and collagen. In vivo experiments were performed in order to evaluate their antiphlogistic, analgesic and antipyretic activities. Title compounds showed antiplatelet activity in aggregation AA or collagen-induced, and a good analgesic activity without any gastric toxicity. Comparison with a number of analogue benzopyrano[4,3-d]pyrimidine derivatives and some SAR consideration were reported.
Progress in 5H  benzopyrano[4,3-d]pyrimidin-5-amine series: “-methoxy derivatives effective as antiìplatelet agents with analgesic activity / O., Bruno; C., Brullo; S., Schenone; A., Raise; F., Bondavalli; Barocelli, Elisabetta; Tognolini, Massimiliano; F., Magnanini; Ballabeni, Vigilio. - In: IL FARMACO. - ISSN 0014-827X. - 57(2002), pp. 753-758. [https://doi.org/10.1016/S0014-827X(02)01269-7]
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