IRIS
CASTELLI, Riccardo
 Distribuzione geografica
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Continente #
NA - Nord America 2.549
EU - Europa 2.178
AS - Asia 2.113
SA - Sud America 331
AF - Africa 118
OC - Oceania 2
Continente sconosciuto - Info sul continente non disponibili 1
Totale 7.292
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Nazione #
US - Stati Uniti d'America 2.476
SG - Singapore 885
IT - Italia 714
CN - Cina 605
IE - Irlanda 323
DE - Germania 282
BR - Brasile 275
FI - Finlandia 226
SE - Svezia 221
HK - Hong Kong 204
VN - Vietnam 157
NL - Olanda 80
ZA - Sudafrica 76
TR - Turchia 74
FR - Francia 73
IN - India 73
GB - Regno Unito 48
RU - Federazione Russa 46
CA - Canada 45
AR - Argentina 28
BE - Belgio 27
PL - Polonia 26
AT - Austria 24
CZ - Repubblica Ceca 22
ID - Indonesia 22
CI - Costa d'Avorio 21
MX - Messico 21
BD - Bangladesh 16
ES - Italia 13
JP - Giappone 13
KR - Corea 12
IQ - Iraq 11
LT - Lituania 10
UA - Ucraina 10
MA - Marocco 9
EC - Ecuador 8
PK - Pakistan 8
RO - Romania 6
VE - Venezuela 6
CL - Cile 5
AL - Albania 4
CH - Svizzera 4
DK - Danimarca 4
HU - Ungheria 4
IL - Israele 4
IR - Iran 4
SA - Arabia Saudita 4
TN - Tunisia 4
CO - Colombia 3
JO - Giordania 3
KE - Kenya 3
KG - Kirghizistan 3
LU - Lussemburgo 3
AE - Emirati Arabi Uniti 2
JM - Giamaica 2
MD - Moldavia 2
MY - Malesia 2
PE - Perù 2
PY - Paraguay 2
TW - Taiwan 2
UY - Uruguay 2
UZ - Uzbekistan 2
A1 - Anonimo 1
AZ - Azerbaigian 1
BB - Barbados 1
BG - Bulgaria 1
BN - Brunei Darussalam 1
CR - Costa Rica 1
DO - Repubblica Dominicana 1
EG - Egitto 1
ET - Etiopia 1
GA - Gabon 1
GT - Guatemala 1
HN - Honduras 1
HR - Croazia 1
LK - Sri Lanka 1
MC - Monaco 1
MK - Macedonia 1
NG - Nigeria 1
OM - Oman 1
PS - Palestinian Territory 1
PT - Portogallo 1
PW - Palau 1
RS - Serbia 1
SC - Seychelles 1
SY - Repubblica araba siriana 1
TM - Turkmenistan 1
WS - Samoa 1
Totale 7.292
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Città #
Singapore 438
Dublin 317
Ashburn 291
Chandler 291
Dallas 259
Parma 247
Santa Clara 223
Ann Arbor 204
Hong Kong 196
Beijing 167
Munich 156
Boardman 106
Helsinki 88
Shanghai 77
Dearborn 76
Johannesburg 72
Los Angeles 59
Ho Chi Minh City 58
Izmir 58
Princeton 52
New York 51
Wilmington 44
Nanjing 35
Hefei 34
Columbus 32
Bremen 31
Hanoi 31
Modena 30
Bangalore 27
São Paulo 26
Brescia 23
Brussels 22
London 22
Abidjan 21
Council Bluffs 20
Guangzhou 19
Milan 19
Bologna 18
Buffalo 18
Jinan 18
Nuremberg 18
The Dalles 18
Frankfurt am Main 17
Seattle 17
Warsaw 17
Des Moines 16
Jakarta 16
Moscow 16
Nanchang 16
Shenyang 16
Tianjin 16
Stockholm 15
Hebei 14
Vienna 14
Fremont 13
Rio de Janeiro 13
Turku 13
Düsseldorf 12
Houston 12
Montreal 12
Toronto 12
Ankara 11
Brno 11
Curitiba 11
Lubbock 11
Prata Di Pordenone 11
Woodbridge 11
Albany 10
Brooklyn 10
Chennai 10
Dalmine 10
Münster 10
Ottawa 10
Reggio Emilia 10
Rome 10
Amsterdam 9
Changsha 9
Kunming 9
Norwalk 9
Phoenix 9
Seoul 9
Atlanta 8
Belo Horizonte 8
Chicago 8
San Mateo 8
Tokyo 8
Zhengzhou 8
Boston 7
Denver 7
Dhaka 7
Haiphong 7
Hangzhou 7
Marseille 7
Orem 7
Pune 7
Ascoli Piceno 6
Bengaluru 6
Borås 6
Campinas 6
Fairfield 6
Totale 4.623
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Nome #
Balancing reactivity and antitumor activity: heteroarylthioacetamide derivatives as potent and time-dependent inhibitors of EGFR 308
A Pharmacological Investigation of Eph-Ephrin Antagonism in Prostate Cancer: UniPR1331 Efficacy Evidence 262
Benzisothiazolinone Derivatives as Potent Allosteric Monoacylglycerol Lipase Inhibitors That Functionally Mimic Sulfenylation of Regulatory Cysteines 236
Targeting the Eph/ephrin system as anti-inflammatory strategy in IBD 228
Discovery of a new 1-(phenylsulfonyl)-1H-indole derivative targeting the EphA2 receptor with antiproliferative activity on U251 glioblastoma cell line 192
Optimization of EphA2 antagonists based on a lithocholic acid core led to the identification of UniPR505, a new 3α-carbamoyloxy derivative with antiangiogenetic properties 188
Drug-gut microbiota metabolic interactions: the case of UniPR1331, selective antagonist of the Eph-ephrin system, in mice 184
Chemical modification of NSC12 leads to a specific FGF-trap with antitumor activity in multiple myeloma 184
Expanding the Arsenal of FGFR Inhibitors: A Novel Chloroacetamide Derivative as a New Irreversible Agent With Anti-proliferative Activity Against FGFR1-Amplified Lung Cancer Cell Lines. 183
Development of an orally bioavailable small molecule targeting Eph-ephrin system: in vitro and in vivo anticancer activity. 170
Amino acid derivatives as palmitoylethanolamide prodrugs: Synthesis, in vitro metabolism and in vivo plasma profile in rats 168
Combining ligand- and structure-based approaches for the discovery of new inhibitors of the EPHA2-ephrin-A1 interaction 164
A sulfonyl fluoride derivative inhibits EGFR L858R/T790M/C797S by covalent modification of the catalytic lysine 154
NEW EPH ANTAGONISTS DISCRIMINATING BETWEEN EPH-AS AND EPH-BS CLASSES 146
Synthesis, Structural Elucidation, and Biological Evaluation of NSC12, an Orally Available Fibroblast Growth Factor (FGF) Ligand Trap for the Treatment of FGF-Dependent Lung Tumors 143
Discovery of novel FGF trap small molecules endowed with anti-myeloma activity 139
Development of 3-oxo-cholenic derivatives as Eph antagonists able to block in vitro angiogenesis 137
UniPR1331: small Eph/ephrin antagonist beneficial in intestinal inflammation by interfering with type-B signaling 136
Discovery and development of small molecules targeting Eph-ephrin system in glioblastoma: an academic history 135
Protein-Protein Interaction Inhibitors Targeting the Eph-Ephrin System with a Focus on Amino Acid Conjugates of Bile Acids 133
Multiple approaches for the discovery and development of small molecules targeting Eph-ephrin protein-protein interaction 131
Δ5-Cholenoyl-amino acids as selective and orally available antagonists of the Eph-ephrin system 127
Evaluation of the anti-tumor activity of small molecules targeting eph/ephrins in apcmin j mice 124
UniPR1331, a small molecule targeting Eph/ephrin interaction, prolongs survival in glioblastoma and potentiates the effect of antiangiogenic therapy in mice 122
2-Arylmelatonin analogues: Probing the 2-phenyl binding pocket of melatonin MT1 and MT2 receptors 120
PHARMACOLOGICAL CHARACTERIZATION OF NEW COMPOUNDS AIMED AT INHIBITING EPH-EPHRIN INTERACTION IN GLIOBLASTOMA 119
Molecular Determinants of EphA2 and EphB2 Antagonism Enable the Design of Ligands with Improved Selectivity 117
Combining pharmacology, target hopping and computational medicinal chemistry to discover novel scaffold targeting EPH-ephrin interaction. 117
Eph-ephrin antagonism in tumor angiogenesis and growth: UniPR1331 preclinical evidence. 116
Metadynamics for perspective drug design: Computationally driven synthesis of new protein-protein interaction inhibitors targeting the EphA2 receptor 115
Cholenic acid derivative UniPR1331 impairs tumor angiogenesis via blockade of VEGF/VEGFR2 in addition to Eph/ephrin 114
Target Hopping as a Useful Tool for the Identification of Novel EphA2 Protein–Protein Antagonists 113
Protection by the EPH-EPHRIN System Against Mesenteric Ischemia-Reperfusion Injury 112
Targeting FGFR1 pathway in non small cell lung cancer both in vitro and in vivo 111
2,2-dimethyl-4-(4-methoxy-phenoxy) butanoate and 2,2-dimethyl-4-azido butanoate: Two new pivaloate-ester-like protecting groups 110
Semisynthesis of a glycosylphosphatidylinositol-anchored prion protein 103
Synthesis and Structure-Activity Relationships of Amino Acid Conjugates of Cholanic Acid as Antagonists of the EphA2 Receptor. 98
Adlayers of dimannoside thiols on gold: Surface chemical analysis 96
Fibroblast growth factor receptor inhibitors: patent review (2015–2019) 93
A dual inhibitor of matrix metalloproteinases and a disintegrin and metalloproteinases, [18F]FB-ML5, as a molecular probe for non-invasive MMP/ADAM-targeted imaging 92
Activation of glycosyl halides by halogen bonding 88
Fighting tertiary mutations in EGFR-driven lung-cancers: Current advances and future perspectives in medicinal chemistry 87
Synthesis of the Lewis a trisaccharide based on an anomeric silyl fluorous tag 86
Critical role of amino acid position 343 of surfactant protein-D in the selective binding of glycolipids from Mycobacterium tuberculosis 85
Halting the FGF/FGFR axis leads to antitumor activity in Waldenström macroglobulinemia by silencing MYD88 84
Hierarchical Self-Assembly of Luminescent Eu(III) Complexes on Silicon 82
Fatty acid amide hydrolase inhibitors: a patent review (2009 - 2014) 79
Discrimination of Escherichia coli strains using glycan cantilever array sensors 78
Synthesis of C-Glycosyl Amino Acid Building Blocks Suitable for the Solid-Phase Synthesis of Multivalent Glycopeptide Mimics 78
MicroPET Evaluation of a Hydroxamate-Based MMP Inhibitor, [18F]FB-ML5, in a Mouse Model of Cigarette Smoke-Induced Acute Airway Inflammation 77
In vitro and in vivo efficacy of an orally bioavailable antagonist of Eph-ephrin system in tumor angiogenesis and growth 77
Cantilever array sensors detect specific carbohydrate-protein interactions with picomolar sensitivity 75
UNIPR1331: SMALL EPH/EPHRIN ANTAGONIST BENEFICIAL IN INTESTINAL INFLAMMATION BY INTERFERING WITH TYPE-B SIGNALLING 73
Novel Dual-Acting Hybrids Targeting Type-2 Cannabinoid Receptors and Cholinesterase Activity Show Neuroprotective Effects In Vitro and Amelioration of Cognitive Impairment In Vivo 63
Surface analytical characterization of carbohydrate microarrays 63
Multiple modes of binding enhance the affinity of DC-SIGN for high mannose N-linked glycans found on viral glycoproteins 60
Multimethod chemical characterization of carbohydrate-functionalized surfaces 60
Total synthesis of the triglycosyl phenolic glycolipid PGL-tb1 from mycobacterium tuberculosis 56
Protection by Eph/ephrin antagonists against TNBS-induced colitis: effects of the route of administration 53
FGF trapping inhibits multiple myeloma growth through c-Myc degradation–induced mitochondrial oxidative stress 53
Froc: A new fluorous protective group for peptide and oligosaccharide synthesis 52
Plumieribetin, a fish lectin homologous to mannose-binding B-type lectins, inhibits the collagen-binding α1β1 integrin 50
Synthesis and characterization of tetra-O-propargyl pentaerythritol 46
Totale 7.445
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Categoria #
all - tutte 26.384
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 26.384
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021205 0 0 0 0 0 38 42 22 40 16 10 37
2021/2022344 21 15 15 35 32 12 36 29 23 16 9 101
2022/20231.209 129 134 60 71 98 139 17 70 384 22 70 15
2023/2024530 36 29 23 17 37 87 63 50 24 42 46 76
2024/20251.925 56 81 127 101 194 204 148 147 247 157 164 299
2025/20262.136 357 415 455 337 544 28 0 0 0 0 0 0
Totale 7.445