IRIS
CASTELLI, Riccardo
 Distribuzione geografica
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Continente #
NA - Nord America 1.653
EU - Europa 1.550
AS - Asia 756
AF - Africa 23
Continente sconosciuto - Info sul continente non disponibili 1
SA - Sud America 1
Totale 3.984
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Nazione #
US - Stati Uniti d'America 1.631
IT - Italia 573
CN - Cina 352
IE - Irlanda 319
SG - Singapore 236
SE - Svezia 205
FI - Finlandia 167
DE - Germania 116
TR - Turchia 65
FR - Francia 51
IN - India 49
HK - Hong Kong 30
GB - Regno Unito 27
BE - Belgio 26
CA - Canada 21
CI - Costa d'Avorio 21
CZ - Repubblica Ceca 16
AT - Austria 7
NL - Olanda 7
ES - Italia 5
JP - Giappone 5
LT - Lituania 5
RO - Romania 5
UA - Ucraina 5
IR - Iran 4
PL - Polonia 4
VN - Vietnam 4
KR - Corea 3
LU - Lussemburgo 3
CH - Svizzera 2
HU - Ungheria 2
IL - Israele 2
PK - Pakistan 2
TW - Taiwan 2
A1 - Anonimo 1
BG - Bulgaria 1
BR - Brasile 1
HR - Croazia 1
JM - Giamaica 1
JO - Giordania 1
MC - Monaco 1
MY - Malesia 1
PT - Portogallo 1
RU - Federazione Russa 1
SC - Seychelles 1
ZA - Sudafrica 1
Totale 3.984
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Città #
Dublin 314
Chandler 291
Santa Clara 208
Ann Arbor 204
Singapore 198
Parma 192
Boardman 102
Ashburn 87
Dearborn 76
Shanghai 75
Beijing 61
Izmir 58
Princeton 52
Wilmington 44
Helsinki 42
Nanjing 33
New York 33
Bremen 31
Bangalore 27
Modena 23
Hong Kong 22
Abidjan 21
Brussels 21
Los Angeles 21
Munich 21
Brescia 18
Jinan 18
Des Moines 16
London 16
Nanchang 16
Seattle 16
Shenyang 15
Guangzhou 14
Hebei 14
Fremont 13
Tianjin 12
Brno 11
Düsseldorf 11
Prata Di Pordenone 11
Woodbridge 11
Albany 10
Milan 10
Münster 10
Rome 10
Bologna 9
Kunming 9
Norwalk 9
Ottawa 9
Frankfurt am Main 8
San Mateo 8
Toronto 8
Zhengzhou 8
Ankara 7
Marseille 7
Ascoli Piceno 6
Borås 6
Fairfield 6
Follonica 6
Grafing 6
Hangzhou 6
Pune 6
Acqui Terme 5
Changsha 5
Dallas 5
Hefei 5
Hyderabad 5
Jiaxing 5
Montegaldella 5
Rocca Canavese 5
Taizhou 5
Verona 5
Vienna 5
Ardea 4
Bergamo 4
Caorso 4
Dong Ket 4
Florence 4
Houston 4
Naples 4
Pavia 4
Pesaro 4
Phoenix 4
Quattro Castella 4
Redwood City 4
Rimini 4
Soliera 4
Washington 4
Amsterdam 3
Ansan-si 3
Council Bluffs 3
Ferrara 3
Fuzhou 3
Genoa 3
Jacksonville 3
Kraków 3
Leuven 3
Lubbock 3
Luxembourg 3
Mareo 3
Paris 3
Totale 2.787
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Nome #
Balancing reactivity and antitumor activity: heteroarylthioacetamide derivatives as potent and time-dependent inhibitors of EGFR 211
Targeting the Eph/ephrin system as anti-inflammatory strategy in IBD 167
Benzisothiazolinone Derivatives as Potent Allosteric Monoacylglycerol Lipase Inhibitors That Functionally Mimic Sulfenylation of Regulatory Cysteines 148
Optimization of EphA2 antagonists based on a lithocholic acid core led to the identification of UniPR505, a new 3α-carbamoyloxy derivative with antiangiogenetic properties 134
Expanding the Arsenal of FGFR Inhibitors: A Novel Chloroacetamide Derivative as a New Irreversible Agent With Anti-proliferative Activity Against FGFR1-Amplified Lung Cancer Cell Lines. 117
Development of an orally bioavailable small molecule targeting Eph-ephrin system: in vitro and in vivo anticancer activity. 115
Amino acid derivatives as palmitoylethanolamide prodrugs: Synthesis, in vitro metabolism and in vivo plasma profile in rats 112
Drug-gut microbiota metabolic interactions: the case of UniPR1331, selective antagonist of the Eph-ephrin system, in mice 111
Combining ligand- and structure-based approaches for the discovery of new inhibitors of the EPHA2-ephrin-A1 interaction 107
Discovery and development of small molecules targeting Eph-ephrin system in glioblastoma: an academic history 92
Synthesis, Structural Elucidation, and Biological Evaluation of NSC12, an Orally Available Fibroblast Growth Factor (FGF) Ligand Trap for the Treatment of FGF-Dependent Lung Tumors 90
Development of 3-oxo-cholenic derivatives as Eph antagonists able to block in vitro angiogenesis 89
Eph-ephrin antagonism in tumor angiogenesis and growth: UniPR1331 preclinical evidence. 86
Multiple approaches for the discovery and development of small molecules targeting Eph-ephrin protein-protein interaction 85
Metadynamics for perspective drug design: Computationally driven synthesis of new protein-protein interaction inhibitors targeting the EphA2 receptor 81
UniPR1331, a small molecule targeting Eph/ephrin interaction, prolongs survival in glioblastoma and potentiates the effect of antiangiogenic therapy in mice 81
A sulfonyl fluoride derivative inhibits EGFR L858R/T790M/C797S by covalent modification of the catalytic lysine 81
Protein-Protein Interaction Inhibitors Targeting the Eph-Ephrin System with a Focus on Amino Acid Conjugates of Bile Acids 81
Combining pharmacology, target hopping and computational medicinal chemistry to discover novel scaffold targeting EPH-ephrin interaction. 80
Protection by the EPH-EPHRIN System Against Mesenteric Ischemia-Reperfusion Injury 80
NEW EPH ANTAGONISTS DISCRIMINATING BETWEEN EPH-AS AND EPH-BS CLASSES 78
Target Hopping as a Useful Tool for the Identification of Novel EphA2 Protein–Protein Antagonists 78
UniPR1331: small Eph/ephrin antagonist beneficial in intestinal inflammation by interfering with type-B signaling 78
PHARMACOLOGICAL CHARACTERIZATION OF NEW COMPOUNDS AIMED AT INHIBITING EPH-EPHRIN INTERACTION IN GLIOBLASTOMA 76
Evaluation of the anti-tumor activity of small molecules targeting eph/ephrins in apcmin j mice 75
Δ5-Cholenoyl-amino acids as selective and orally available antagonists of the Eph-ephrin system 70
Chemical modification of NSC12 leads to a specific FGF-trap with antitumor activity in multiple myeloma 69
Semisynthesis of a glycosylphosphatidylinositol-anchored prion protein 63
Synthesis and Structure-Activity Relationships of Amino Acid Conjugates of Cholanic Acid as Antagonists of the EphA2 Receptor. 61
In vitro and in vivo efficacy of an orally bioavailable antagonist of Eph-ephrin system in tumor angiogenesis and growth 59
2,2-dimethyl-4-(4-methoxy-phenoxy) butanoate and 2,2-dimethyl-4-azido butanoate: Two new pivaloate-ester-like protecting groups 58
Synthesis of the Lewis a trisaccharide based on an anomeric silyl fluorous tag 56
Fibroblast growth factor receptor inhibitors: patent review (2015–2019) 55
A Pharmacological Investigation of Eph-Ephrin Antagonism in Prostate Cancer: UniPR1331 Efficacy Evidence 53
Hierarchical Self-Assembly of Luminescent Eu(III) Complexes on Silicon 53
MicroPET Evaluation of a Hydroxamate-Based MMP Inhibitor, [18F]FB-ML5, in a Mouse Model of Cigarette Smoke-Induced Acute Airway Inflammation 53
Fighting tertiary mutations in EGFR-driven lung-cancers: Current advances and future perspectives in medicinal chemistry 53
Adlayers of dimannoside thiols on gold: Surface chemical analysis 53
2-Arylmelatonin analogues: Probing the 2-phenyl binding pocket of melatonin MT1 and MT2 receptors 52
Targeting FGFR1 pathway in non small cell lung cancer both in vitro and in vivo 50
Fatty acid amide hydrolase inhibitors: a patent review (2009 - 2014) 50
Cholenic acid derivative UniPR1331 impairs tumor angiogenesis via blockade of VEGF/VEGFR2 in addition to Eph/ephrin 47
Activation of glycosyl halides by halogen bonding 46
Discrimination of Escherichia coli strains using glycan cantilever array sensors 45
Synthesis of C-Glycosyl Amino Acid Building Blocks Suitable for the Solid-Phase Synthesis of Multivalent Glycopeptide Mimics 42
Molecular Determinants of EphA2 and EphB2 Antagonism Enable the Design of Ligands with Improved Selectivity 41
A dual inhibitor of matrix metalloproteinases and a disintegrin and metalloproteinases, [18F]FB-ML5, as a molecular probe for non-invasive MMP/ADAM-targeted imaging 41
Critical role of amino acid position 343 of surfactant protein-D in the selective binding of glycolipids from Mycobacterium tuberculosis 40
Discovery of a new 1-(phenylsulfonyl)-1H-indole derivative targeting the EphA2 receptor with antiproliferative activity on U251 glioblastoma cell line 38
Cantilever array sensors detect specific carbohydrate-protein interactions with picomolar sensitivity 37
Surface analytical characterization of carbohydrate microarrays 36
Halting the FGF/FGFR axis leads to antitumor activity in Waldenström macroglobulinemia by silencing MYD88 34
Total synthesis of the triglycosyl phenolic glycolipid PGL-tb1 from mycobacterium tuberculosis 32
Multiple modes of binding enhance the affinity of DC-SIGN for high mannose N-linked glycans found on viral glycoproteins 30
FGF trapping inhibits multiple myeloma growth through c-Myc degradation–induced mitochondrial oxidative stress 30
Discovery of novel FGF trap small molecules endowed with anti-myeloma activity 29
Multimethod chemical characterization of carbohydrate-functionalized surfaces 28
Plumieribetin, a fish lectin homologous to mannose-binding B-type lectins, inhibits the collagen-binding α1β1 integrin 24
Froc: A new fluorous protective group for peptide and oligosaccharide synthesis 21
Novel Dual-Acting Hybrids Targeting Type-2 Cannabinoid Receptors and Cholinesterase Activity Show Neuroprotective Effects In Vitro and Amelioration of Cognitive Impairment In Vivo 17
UNIPR1331: SMALL EPH/EPHRIN ANTAGONIST BENEFICIAL IN INTESTINAL INFLAMMATION BY INTERFERING WITH TYPE-B SIGNALLING 13
Protection by Eph/ephrin antagonists against TNBS-induced colitis: effects of the route of administration 12
Synthesis and characterization of tetra-O-propargyl pentaerythritol 4
Totale 4.128
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Categoria #
all - tutte 16.934
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 16.934
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020369 0 0 0 0 0 79 72 20 47 100 33 18
2020/2021350 9 11 33 36 56 38 42 22 40 16 10 37
2021/2022344 21 15 15 35 32 12 36 29 23 16 9 101
2022/20231.209 129 134 60 71 98 139 17 70 384 22 70 15
2023/2024530 36 29 23 17 37 87 63 50 24 42 46 76
2024/2025744 56 81 127 101 194 185 0 0 0 0 0 0
Totale 4.128