IRIS
CASTELLI, Riccardo
 Distribuzione geografica
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Continente #
NA - Nord America 3.212
AS - Asia 2.887
EU - Europa 2.384
SA - Sud America 384
AF - Africa 183
OC - Oceania 4
Continente sconosciuto - Info sul continente non disponibili 1
Totale 9.055
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Nazione #
US - Stati Uniti d'America 3.115
SG - Singapore 1.018
IT - Italia 778
CN - Cina 695
VN - Vietnam 526
IE - Irlanda 325
DE - Germania 301
BR - Brasile 300
FI - Finlandia 239
HK - Hong Kong 227
SE - Svezia 222
FR - Francia 139
ZA - Sudafrica 127
IN - India 92
TR - Turchia 82
NL - Olanda 81
BD - Bangladesh 63
GB - Regno Unito 58
CA - Canada 55
RU - Federazione Russa 49
AR - Argentina 34
PL - Polonia 31
MX - Messico 30
BE - Belgio 28
AT - Austria 26
ID - Indonesia 24
CZ - Repubblica Ceca 22
CI - Costa d'Avorio 21
IQ - Iraq 19
JP - Giappone 18
ES - Italia 17
KR - Corea 15
PK - Pakistan 14
TH - Thailandia 14
PH - Filippine 13
VE - Venezuela 12
EC - Ecuador 11
LT - Lituania 11
UA - Ucraina 11
JO - Giordania 10
MA - Marocco 9
SA - Arabia Saudita 9
TN - Tunisia 8
CL - Cile 7
AL - Albania 6
RO - Romania 6
CH - Svizzera 5
ET - Etiopia 5
HU - Ungheria 5
IR - Iran 5
MY - Malesia 5
TW - Taiwan 5
BO - Bolivia 4
CO - Colombia 4
DK - Danimarca 4
IL - Israele 4
PE - Perù 4
PS - Palestinian Territory 4
PY - Paraguay 4
UZ - Uzbekistan 4
KE - Kenya 3
KG - Kirghizistan 3
LB - Libano 3
LU - Lussemburgo 3
MD - Moldavia 3
RS - Serbia 3
UY - Uruguay 3
AE - Emirati Arabi Uniti 2
AZ - Azerbaigian 2
CR - Costa Rica 2
EG - Egitto 2
GT - Guatemala 2
HN - Honduras 2
HR - Croazia 2
JM - Giamaica 2
NG - Nigeria 2
OM - Oman 2
TT - Trinidad e Tobago 2
A1 - Anonimo 1
AU - Australia 1
BA - Bosnia-Erzegovina 1
BB - Barbados 1
BG - Bulgaria 1
BH - Bahrain 1
BN - Brunei Darussalam 1
BY - Bielorussia 1
DO - Repubblica Dominicana 1
DZ - Algeria 1
GA - Gabon 1
GE - Georgia 1
GF - Guiana Francese 1
GR - Grecia 1
KZ - Kazakistan 1
LK - Sri Lanka 1
LV - Lettonia 1
LY - Libia 1
MC - Monaco 1
MK - Macedonia 1
NP - Nepal 1
NZ - Nuova Zelanda 1
Totale 9.045
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Città #
Singapore 531
Ashburn 375
Dublin 319
San Jose 307
Chandler 291
Dallas 265
Parma 251
Santa Clara 237
Hong Kong 209
Ann Arbor 204
Beijing 173
Munich 165
Ho Chi Minh City 160
Boardman 140
Johannesburg 119
Hanoi 110
Helsinki 96
Los Angeles 81
Shanghai 79
Dearborn 76
New York 73
Izmir 60
Lauterbourg 55
Princeton 52
Wilmington 44
Nanjing 35
Hefei 34
Columbus 32
Bremen 31
Modena 31
Council Bluffs 30
São Paulo 30
Bologna 28
Bangalore 27
Haiphong 27
Milan 26
Buffalo 24
Brescia 23
Frankfurt am Main 23
London 23
Brussels 22
Da Nang 22
Abidjan 21
Guangzhou 19
Warsaw 19
Jinan 18
Nuremberg 18
The Dalles 18
Turku 18
Jakarta 17
Seattle 17
Des Moines 16
Moscow 16
Nanchang 16
Rio de Janeiro 16
Shenyang 16
Stockholm 16
Tianjin 16
Vienna 16
Montreal 15
Orem 15
Hebei 14
Toronto 14
Fremont 13
Houston 13
Rome 13
Chennai 12
Chicago 12
Düsseldorf 12
Woodbridge 12
Ankara 11
Brno 11
Curitiba 11
Lubbock 11
Mexico City 11
Prata Di Pordenone 11
Albany 10
Atlanta 10
Brooklyn 10
Dalmine 10
Dhaka 10
Münster 10
Ottawa 10
Phoenix 10
Reggio Emilia 10
Seoul 10
Tokyo 10
Amsterdam 9
Changsha 9
Hải Dương 9
Kunming 9
Norwalk 9
Zhengzhou 9
Belo Horizonte 8
Denver 8
Ninh Bình 8
San Mateo 8
Biên Hòa 7
Boston 7
Can Tho 7
Totale 5.661
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Nome #
Balancing reactivity and antitumor activity: heteroarylthioacetamide derivatives as potent and time-dependent inhibitors of EGFR 350
A Pharmacological Investigation of Eph-Ephrin Antagonism in Prostate Cancer: UniPR1331 Efficacy Evidence 300
Benzisothiazolinone Derivatives as Potent Allosteric Monoacylglycerol Lipase Inhibitors That Functionally Mimic Sulfenylation of Regulatory Cysteines 278
Targeting the Eph/ephrin system as anti-inflammatory strategy in IBD 253
Discovery of a new 1-(phenylsulfonyl)-1H-indole derivative targeting the EphA2 receptor with antiproliferative activity on U251 glioblastoma cell line 251
Development of an orally bioavailable small molecule targeting Eph-ephrin system: in vitro and in vivo anticancer activity. 217
Optimization of EphA2 antagonists based on a lithocholic acid core led to the identification of UniPR505, a new 3α-carbamoyloxy derivative with antiangiogenetic properties 217
Drug-gut microbiota metabolic interactions: the case of UniPR1331, selective antagonist of the Eph-ephrin system, in mice 217
Expanding the Arsenal of FGFR Inhibitors: A Novel Chloroacetamide Derivative as a New Irreversible Agent With Anti-proliferative Activity Against FGFR1-Amplified Lung Cancer Cell Lines. 215
Chemical modification of NSC12 leads to a specific FGF-trap with antitumor activity in multiple myeloma 214
A sulfonyl fluoride derivative inhibits EGFR L858R/T790M/C797S by covalent modification of the catalytic lysine 208
Amino acid derivatives as palmitoylethanolamide prodrugs: Synthesis, in vitro metabolism and in vivo plasma profile in rats 201
Combining ligand- and structure-based approaches for the discovery of new inhibitors of the EPHA2-ephrin-A1 interaction 198
Discovery of novel FGF trap small molecules endowed with anti-myeloma activity 181
NEW EPH ANTAGONISTS DISCRIMINATING BETWEEN EPH-AS AND EPH-BS CLASSES 177
Synthesis, Structural Elucidation, and Biological Evaluation of NSC12, an Orally Available Fibroblast Growth Factor (FGF) Ligand Trap for the Treatment of FGF-Dependent Lung Tumors 168
UniPR1331: small Eph/ephrin antagonist beneficial in intestinal inflammation by interfering with type-B signaling 165
Discovery and development of small molecules targeting Eph-ephrin system in glioblastoma: an academic history 163
Development of 3-oxo-cholenic derivatives as Eph antagonists able to block in vitro angiogenesis 163
Multiple approaches for the discovery and development of small molecules targeting Eph-ephrin protein-protein interaction 161
Protein-Protein Interaction Inhibitors Targeting the Eph-Ephrin System with a Focus on Amino Acid Conjugates of Bile Acids 161
2-Arylmelatonin analogues: Probing the 2-phenyl binding pocket of melatonin MT1 and MT2 receptors 161
Molecular Determinants of EphA2 and EphB2 Antagonism Enable the Design of Ligands with Improved Selectivity 151
Evaluation of the anti-tumor activity of small molecules targeting eph/ephrins in apcmin j mice 151
Δ5-Cholenoyl-amino acids as selective and orally available antagonists of the Eph-ephrin system 150
PHARMACOLOGICAL CHARACTERIZATION OF NEW COMPOUNDS AIMED AT INHIBITING EPH-EPHRIN INTERACTION IN GLIOBLASTOMA 148
Combining pharmacology, target hopping and computational medicinal chemistry to discover novel scaffold targeting EPH-ephrin interaction. 148
UniPR1331, a small molecule targeting Eph/ephrin interaction, prolongs survival in glioblastoma and potentiates the effect of antiangiogenic therapy in mice 140
Metadynamics for perspective drug design: Computationally driven synthesis of new protein-protein interaction inhibitors targeting the EphA2 receptor 138
Target Hopping as a Useful Tool for the Identification of Novel EphA2 Protein–Protein Antagonists 136
Targeting FGFR1 pathway in non small cell lung cancer both in vitro and in vivo 134
Cholenic acid derivative UniPR1331 impairs tumor angiogenesis via blockade of VEGF/VEGFR2 in addition to Eph/ephrin 134
Eph-ephrin antagonism in tumor angiogenesis and growth: UniPR1331 preclinical evidence. 134
2,2-dimethyl-4-(4-methoxy-phenoxy) butanoate and 2,2-dimethyl-4-azido butanoate: Two new pivaloate-ester-like protecting groups 132
Protection by the EPH-EPHRIN System Against Mesenteric Ischemia-Reperfusion Injury 132
Synthesis and Structure-Activity Relationships of Amino Acid Conjugates of Cholanic Acid as Antagonists of the EphA2 Receptor. 126
Semisynthesis of a glycosylphosphatidylinositol-anchored prion protein 126
Adlayers of dimannoside thiols on gold: Surface chemical analysis 122
Fibroblast growth factor receptor inhibitors: patent review (2015–2019) 114
Fighting tertiary mutations in EGFR-driven lung-cancers: Current advances and future perspectives in medicinal chemistry 113
Activation of glycosyl halides by halogen bonding 113
A dual inhibitor of matrix metalloproteinases and a disintegrin and metalloproteinases, [18F]FB-ML5, as a molecular probe for non-invasive MMP/ADAM-targeted imaging 112
Critical role of amino acid position 343 of surfactant protein-D in the selective binding of glycolipids from Mycobacterium tuberculosis 107
Halting the FGF/FGFR axis leads to antitumor activity in Waldenström macroglobulinemia by silencing MYD88 107
UNIPR1331: SMALL EPH/EPHRIN ANTAGONIST BENEFICIAL IN INTESTINAL INFLAMMATION BY INTERFERING WITH TYPE-B SIGNALLING 104
Synthesis of the Lewis a trisaccharide based on an anomeric silyl fluorous tag 98
Hierarchical Self-Assembly of Luminescent Eu(III) Complexes on Silicon 96
Novel Dual-Acting Hybrids Targeting Type-2 Cannabinoid Receptors and Cholinesterase Activity Show Neuroprotective Effects In Vitro and Amelioration of Cognitive Impairment In Vivo 95
Cantilever array sensors detect specific carbohydrate-protein interactions with picomolar sensitivity 93
MicroPET Evaluation of a Hydroxamate-Based MMP Inhibitor, [18F]FB-ML5, in a Mouse Model of Cigarette Smoke-Induced Acute Airway Inflammation 89
Discrimination of Escherichia coli strains using glycan cantilever array sensors 89
In vitro and in vivo efficacy of an orally bioavailable antagonist of Eph-ephrin system in tumor angiogenesis and growth 89
Synthesis of C-Glycosyl Amino Acid Building Blocks Suitable for the Solid-Phase Synthesis of Multivalent Glycopeptide Mimics 88
Fatty acid amide hydrolase inhibitors: a patent review (2009 - 2014) 88
Multimethod chemical characterization of carbohydrate-functionalized surfaces 78
Surface analytical characterization of carbohydrate microarrays 78
Multiple modes of binding enhance the affinity of DC-SIGN for high mannose N-linked glycans found on viral glycoproteins 77
Protection by Eph/ephrin antagonists against TNBS-induced colitis: effects of the route of administration 73
Froc: A new fluorous protective group for peptide and oligosaccharide synthesis 69
The rare bile acid isoallolithocholic acid (IALCA) is an EphA2 antagonist sparing FXR and TGR5 receptors 67
Total synthesis of the triglycosyl phenolic glycolipid PGL-tb1 from mycobacterium tuberculosis 65
FGF trapping inhibits multiple myeloma growth through c-Myc degradation–induced mitochondrial oxidative stress 65
Plumieribetin, a fish lectin homologous to mannose-binding B-type lectins, inhibits the collagen-binding α1β1 integrin 64
Dual targeting of EphAs and KDR axis hampers VEGF-induced angiogenesis and glioma stem cell replication 60
Synthesis and characterization of tetra-O-propargyl pentaerythritol 56
FGF/FGFR inhibitors downmodulates c-Myc oncoprotein and hampers the growth of adrenocortical carcinoma 43
Totale 9.211
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Categoria #
all - tutte 30.713
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 30.713
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/202137 0 0 0 0 0 0 0 0 0 0 0 37
2021/2022344 21 15 15 35 32 12 36 29 23 16 9 101
2022/20231.209 129 134 60 71 98 139 17 70 384 22 70 15
2023/2024530 36 29 23 17 37 87 63 50 24 42 46 76
2024/20251.925 56 81 127 101 194 204 148 147 247 157 164 299
2025/20263.902 357 415 455 337 544 223 364 145 496 333 156 77
Totale 9.211