IRIS
CASTELLI, Riccardo
 Distribuzione geografica
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Continente #
NA - Nord America 3.040
AS - Asia 2.834
EU - Europa 2.337
SA - Sud America 384
AF - Africa 183
OC - Oceania 3
Continente sconosciuto - Info sul continente non disponibili 1
Totale 8.782
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Nazione #
US - Stati Uniti d'America 2.950
SG - Singapore 1.009
IT - Italia 740
CN - Cina 688
VN - Vietnam 526
IE - Irlanda 325
BR - Brasile 300
DE - Germania 300
FI - Finlandia 232
HK - Hong Kong 225
SE - Svezia 222
FR - Francia 138
ZA - Sudafrica 127
IN - India 92
TR - Turchia 82
NL - Olanda 81
GB - Regno Unito 58
CA - Canada 50
RU - Federazione Russa 49
AR - Argentina 34
BD - Bangladesh 31
PL - Polonia 31
MX - Messico 29
BE - Belgio 28
AT - Austria 26
ID - Indonesia 24
CZ - Repubblica Ceca 22
CI - Costa d'Avorio 21
IQ - Iraq 19
JP - Giappone 18
ES - Italia 17
KR - Corea 15
PK - Pakistan 14
TH - Thailandia 14
PH - Filippine 13
VE - Venezuela 12
EC - Ecuador 11
LT - Lituania 11
UA - Ucraina 11
JO - Giordania 10
MA - Marocco 9
SA - Arabia Saudita 9
TN - Tunisia 8
CL - Cile 7
AL - Albania 6
RO - Romania 6
CH - Svizzera 5
ET - Etiopia 5
HU - Ungheria 5
IR - Iran 5
MY - Malesia 5
TW - Taiwan 5
BO - Bolivia 4
CO - Colombia 4
DK - Danimarca 4
IL - Israele 4
PE - Perù 4
PS - Palestinian Territory 4
PY - Paraguay 4
UZ - Uzbekistan 4
KE - Kenya 3
KG - Kirghizistan 3
LU - Lussemburgo 3
MD - Moldavia 3
RS - Serbia 3
UY - Uruguay 3
AE - Emirati Arabi Uniti 2
AZ - Azerbaigian 2
CR - Costa Rica 2
EG - Egitto 2
GT - Guatemala 2
HN - Honduras 2
HR - Croazia 2
JM - Giamaica 2
NG - Nigeria 2
OM - Oman 2
A1 - Anonimo 1
AU - Australia 1
BA - Bosnia-Erzegovina 1
BB - Barbados 1
BG - Bulgaria 1
BH - Bahrain 1
BN - Brunei Darussalam 1
BY - Bielorussia 1
DO - Repubblica Dominicana 1
DZ - Algeria 1
GA - Gabon 1
GE - Georgia 1
GF - Guiana Francese 1
GR - Grecia 1
KZ - Kazakistan 1
LK - Sri Lanka 1
LV - Lettonia 1
LY - Libia 1
MC - Monaco 1
MK - Macedonia 1
NP - Nepal 1
PT - Portogallo 1
PW - Palau 1
QA - Qatar 1
Totale 8.774
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Città #
Singapore 529
Ashburn 367
Dublin 319
Chandler 291
San Jose 263
Dallas 260
Parma 250
Santa Clara 226
Hong Kong 207
Ann Arbor 204
Beijing 170
Munich 165
Ho Chi Minh City 160
Boardman 131
Johannesburg 119
Hanoi 110
Helsinki 89
Shanghai 79
Dearborn 76
Los Angeles 70
Izmir 60
New York 56
Lauterbourg 55
Princeton 52
Wilmington 44
Nanjing 35
Hefei 34
Columbus 32
Bremen 31
Modena 30
São Paulo 30
Council Bluffs 28
Bangalore 27
Haiphong 27
Brescia 23
Frankfurt am Main 23
London 23
Bologna 22
Brussels 22
Da Nang 22
Milan 22
Abidjan 21
Buffalo 21
Guangzhou 19
Warsaw 19
Jinan 18
Nuremberg 18
The Dalles 18
Turku 18
Jakarta 17
Seattle 17
Des Moines 16
Moscow 16
Nanchang 16
Rio de Janeiro 16
Shenyang 16
Stockholm 16
Tianjin 16
Vienna 16
Orem 15
Hebei 14
Fremont 13
Montreal 13
Toronto 13
Chennai 12
Düsseldorf 12
Houston 12
Ankara 11
Brno 11
Chicago 11
Curitiba 11
Lubbock 11
Prata Di Pordenone 11
Rome 11
Woodbridge 11
Albany 10
Atlanta 10
Brooklyn 10
Dalmine 10
Dhaka 10
Mexico City 10
Münster 10
Ottawa 10
Reggio Emilia 10
Seoul 10
Tokyo 10
Amsterdam 9
Changsha 9
Hải Dương 9
Kunming 9
Norwalk 9
Phoenix 9
Belo Horizonte 8
Ninh Bình 8
San Mateo 8
Zhengzhou 8
Biên Hòa 7
Boston 7
Can Tho 7
Denver 7
Totale 5.513
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Nome #
Balancing reactivity and antitumor activity: heteroarylthioacetamide derivatives as potent and time-dependent inhibitors of EGFR 350
A Pharmacological Investigation of Eph-Ephrin Antagonism in Prostate Cancer: UniPR1331 Efficacy Evidence 298
Benzisothiazolinone Derivatives as Potent Allosteric Monoacylglycerol Lipase Inhibitors That Functionally Mimic Sulfenylation of Regulatory Cysteines 268
Targeting the Eph/ephrin system as anti-inflammatory strategy in IBD 250
Discovery of a new 1-(phenylsulfonyl)-1H-indole derivative targeting the EphA2 receptor with antiproliferative activity on U251 glioblastoma cell line 232
Drug-gut microbiota metabolic interactions: the case of UniPR1331, selective antagonist of the Eph-ephrin system, in mice 215
Optimization of EphA2 antagonists based on a lithocholic acid core led to the identification of UniPR505, a new 3α-carbamoyloxy derivative with antiangiogenetic properties 214
Chemical modification of NSC12 leads to a specific FGF-trap with antitumor activity in multiple myeloma 213
Expanding the Arsenal of FGFR Inhibitors: A Novel Chloroacetamide Derivative as a New Irreversible Agent With Anti-proliferative Activity Against FGFR1-Amplified Lung Cancer Cell Lines. 210
A sulfonyl fluoride derivative inhibits EGFR L858R/T790M/C797S by covalent modification of the catalytic lysine 204
Development of an orally bioavailable small molecule targeting Eph-ephrin system: in vitro and in vivo anticancer activity. 202
Amino acid derivatives as palmitoylethanolamide prodrugs: Synthesis, in vitro metabolism and in vivo plasma profile in rats 198
Combining ligand- and structure-based approaches for the discovery of new inhibitors of the EPHA2-ephrin-A1 interaction 196
NEW EPH ANTAGONISTS DISCRIMINATING BETWEEN EPH-AS AND EPH-BS CLASSES 176
Discovery of novel FGF trap small molecules endowed with anti-myeloma activity 167
Synthesis, Structural Elucidation, and Biological Evaluation of NSC12, an Orally Available Fibroblast Growth Factor (FGF) Ligand Trap for the Treatment of FGF-Dependent Lung Tumors 167
Discovery and development of small molecules targeting Eph-ephrin system in glioblastoma: an academic history 161
Development of 3-oxo-cholenic derivatives as Eph antagonists able to block in vitro angiogenesis 161
UniPR1331: small Eph/ephrin antagonist beneficial in intestinal inflammation by interfering with type-B signaling 161
Multiple approaches for the discovery and development of small molecules targeting Eph-ephrin protein-protein interaction 160
Protein-Protein Interaction Inhibitors Targeting the Eph-Ephrin System with a Focus on Amino Acid Conjugates of Bile Acids 153
Evaluation of the anti-tumor activity of small molecules targeting eph/ephrins in apcmin j mice 150
2-Arylmelatonin analogues: Probing the 2-phenyl binding pocket of melatonin MT1 and MT2 receptors 149
Molecular Determinants of EphA2 and EphB2 Antagonism Enable the Design of Ligands with Improved Selectivity 148
Δ5-Cholenoyl-amino acids as selective and orally available antagonists of the Eph-ephrin system 148
PHARMACOLOGICAL CHARACTERIZATION OF NEW COMPOUNDS AIMED AT INHIBITING EPH-EPHRIN INTERACTION IN GLIOBLASTOMA 145
Combining pharmacology, target hopping and computational medicinal chemistry to discover novel scaffold targeting EPH-ephrin interaction. 142
UniPR1331, a small molecule targeting Eph/ephrin interaction, prolongs survival in glioblastoma and potentiates the effect of antiangiogenic therapy in mice 139
Metadynamics for perspective drug design: Computationally driven synthesis of new protein-protein interaction inhibitors targeting the EphA2 receptor 138
Target Hopping as a Useful Tool for the Identification of Novel EphA2 Protein–Protein Antagonists 133
Targeting FGFR1 pathway in non small cell lung cancer both in vitro and in vivo 132
Cholenic acid derivative UniPR1331 impairs tumor angiogenesis via blockade of VEGF/VEGFR2 in addition to Eph/ephrin 132
Eph-ephrin antagonism in tumor angiogenesis and growth: UniPR1331 preclinical evidence. 132
2,2-dimethyl-4-(4-methoxy-phenoxy) butanoate and 2,2-dimethyl-4-azido butanoate: Two new pivaloate-ester-like protecting groups 130
Protection by the EPH-EPHRIN System Against Mesenteric Ischemia-Reperfusion Injury 127
Semisynthesis of a glycosylphosphatidylinositol-anchored prion protein 124
Adlayers of dimannoside thiols on gold: Surface chemical analysis 120
Synthesis and Structure-Activity Relationships of Amino Acid Conjugates of Cholanic Acid as Antagonists of the EphA2 Receptor. 118
Fibroblast growth factor receptor inhibitors: patent review (2015–2019) 113
Activation of glycosyl halides by halogen bonding 110
Fighting tertiary mutations in EGFR-driven lung-cancers: Current advances and future perspectives in medicinal chemistry 108
A dual inhibitor of matrix metalloproteinases and a disintegrin and metalloproteinases, [18F]FB-ML5, as a molecular probe for non-invasive MMP/ADAM-targeted imaging 108
Halting the FGF/FGFR axis leads to antitumor activity in Waldenström macroglobulinemia by silencing MYD88 107
Critical role of amino acid position 343 of surfactant protein-D in the selective binding of glycolipids from Mycobacterium tuberculosis 104
UNIPR1331: SMALL EPH/EPHRIN ANTAGONIST BENEFICIAL IN INTESTINAL INFLAMMATION BY INTERFERING WITH TYPE-B SIGNALLING 100
Synthesis of the Lewis a trisaccharide based on an anomeric silyl fluorous tag 98
Hierarchical Self-Assembly of Luminescent Eu(III) Complexes on Silicon 91
Cantilever array sensors detect specific carbohydrate-protein interactions with picomolar sensitivity 91
Discrimination of Escherichia coli strains using glycan cantilever array sensors 89
In vitro and in vivo efficacy of an orally bioavailable antagonist of Eph-ephrin system in tumor angiogenesis and growth 89
Synthesis of C-Glycosyl Amino Acid Building Blocks Suitable for the Solid-Phase Synthesis of Multivalent Glycopeptide Mimics 88
Novel Dual-Acting Hybrids Targeting Type-2 Cannabinoid Receptors and Cholinesterase Activity Show Neuroprotective Effects In Vitro and Amelioration of Cognitive Impairment In Vivo 87
Fatty acid amide hydrolase inhibitors: a patent review (2009 - 2014) 85
MicroPET Evaluation of a Hydroxamate-Based MMP Inhibitor, [18F]FB-ML5, in a Mouse Model of Cigarette Smoke-Induced Acute Airway Inflammation 84
Surface analytical characterization of carbohydrate microarrays 76
Multiple modes of binding enhance the affinity of DC-SIGN for high mannose N-linked glycans found on viral glycoproteins 75
Multimethod chemical characterization of carbohydrate-functionalized surfaces 75
Protection by Eph/ephrin antagonists against TNBS-induced colitis: effects of the route of administration 69
Froc: A new fluorous protective group for peptide and oligosaccharide synthesis 67
Total synthesis of the triglycosyl phenolic glycolipid PGL-tb1 from mycobacterium tuberculosis 65
Plumieribetin, a fish lectin homologous to mannose-binding B-type lectins, inhibits the collagen-binding α1β1 integrin 63
FGF trapping inhibits multiple myeloma growth through c-Myc degradation–induced mitochondrial oxidative stress 63
Synthesis and characterization of tetra-O-propargyl pentaerythritol 56
Dual targeting of EphAs and KDR axis hampers VEGF-induced angiogenesis and glioma stem cell replication 47
FGF/FGFR inhibitors downmodulates c-Myc oncoprotein and hampers the growth of adrenocortical carcinoma 39
The rare bile acid isoallolithocholic acid (IALCA) is an EphA2 antagonist sparing FXR and TGR5 receptors 28
Totale 8.938
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Categoria #
all - tutte 28.989
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 28.989
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/202163 0 0 0 0 0 0 0 0 0 16 10 37
2021/2022344 21 15 15 35 32 12 36 29 23 16 9 101
2022/20231.209 129 134 60 71 98 139 17 70 384 22 70 15
2023/2024530 36 29 23 17 37 87 63 50 24 42 46 76
2024/20251.925 56 81 127 101 194 204 148 147 247 157 164 299
2025/20263.629 357 415 455 337 544 223 364 145 496 293 0 0
Totale 8.938