IRIS
CASTELLI, Riccardo
 Distribuzione geografica
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Continente #
NA - Nord America 3.530
AS - Asia 2.916
EU - Europa 2.449
SA - Sud America 403
AF - Africa 185
Continente sconosciuto - Info sul continente non disponibili 160
OC - Oceania 4
Totale 9.647
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Nazione #
US - Stati Uniti d'America 3.421
SG - Singapore 1.019
IT - Italia 831
CN - Cina 701
VN - Vietnam 528
IE - Irlanda 325
BR - Brasile 307
DE - Germania 301
FI - Finlandia 239
SE - Svezia 230
HK - Hong Kong 229
FR - Francia 139
ZA - Sudafrica 127
IN - India 96
NL - Olanda 83
TR - Turchia 82
BD - Bangladesh 69
GB - Regno Unito 60
CA - Canada 59
RU - Federazione Russa 49
AR - Argentina 37
MX - Messico 32
PL - Polonia 31
BE - Belgio 28
AT - Austria 26
ID - Indonesia 25
CZ - Repubblica Ceca 22
CI - Costa d'Avorio 21
IQ - Iraq 19
JP - Giappone 18
ES - Italia 17
KR - Corea 15
PH - Filippine 14
PK - Pakistan 14
TH - Thailandia 14
VE - Venezuela 14
EC - Ecuador 13
JO - Giordania 11
LT - Lituania 11
SA - Arabia Saudita 11
UA - Ucraina 11
MA - Marocco 9
CL - Cile 8
CO - Colombia 8
TN - Tunisia 8
AL - Albania 6
MY - Malesia 6
RO - Romania 6
CH - Svizzera 5
ET - Etiopia 5
HU - Ungheria 5
IR - Iran 5
TW - Taiwan 5
BO - Bolivia 4
DK - Danimarca 4
IL - Israele 4
KE - Kenya 4
PE - Perù 4
PS - Palestinian Territory 4
PY - Paraguay 4
UZ - Uzbekistan 4
BH - Bahrain 3
GT - Guatemala 3
HN - Honduras 3
KG - Kirghizistan 3
LB - Libano 3
LU - Lussemburgo 3
MD - Moldavia 3
RS - Serbia 3
TT - Trinidad e Tobago 3
UY - Uruguay 3
AE - Emirati Arabi Uniti 2
AZ - Azerbaigian 2
BB - Barbados 2
CR - Costa Rica 2
EG - Egitto 2
HR - Croazia 2
JM - Giamaica 2
NG - Nigeria 2
OM - Oman 2
A1 - Anonimo 1
AU - Australia 1
BA - Bosnia-Erzegovina 1
BG - Bulgaria 1
BN - Brunei Darussalam 1
BY - Bielorussia 1
CG - Congo 1
CW - ???statistics.table.value.countryCode.CW??? 1
DO - Repubblica Dominicana 1
DZ - Algeria 1
GA - Gabon 1
GE - Georgia 1
GF - Guiana Francese 1
GR - Grecia 1
KZ - Kazakistan 1
LK - Sri Lanka 1
LV - Lettonia 1
LY - Libia 1
MC - Monaco 1
MK - Macedonia 1
Totale 9.475
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Città #
Singapore 531
San Jose 392
Ashburn 383
Dublin 319
Santa Clara 297
Chandler 291
Dallas 266
Parma 261
Hong Kong 211
Ann Arbor 204
Beijing 175
Munich 165
Ho Chi Minh City 161
Boardman 140
Johannesburg 119
Hanoi 111
Council Bluffs 103
Helsinki 96
Los Angeles 82
Shanghai 80
Dearborn 76
New York 76
Izmir 60
Lauterbourg 55
Princeton 52
Wilmington 44
Milan 35
Nanjing 35
Hefei 34
Bologna 32
Columbus 32
Bremen 31
Modena 31
São Paulo 30
Bangalore 27
Haiphong 27
Buffalo 24
Rome 24
Brescia 23
Frankfurt am Main 23
London 23
Brussels 22
Da Nang 22
Abidjan 21
Guangzhou 19
Warsaw 19
Jinan 18
Nuremberg 18
The Dalles 18
Turku 18
Jakarta 17
Seattle 17
Chicago 16
Des Moines 16
Moscow 16
Nanchang 16
Rio de Janeiro 16
Shenyang 16
Stockholm 16
Tianjin 16
Vienna 16
Montreal 15
Orem 15
Phoenix 15
Toronto 15
Hebei 14
Fremont 13
Houston 13
Brooklyn 12
Chennai 12
Curitiba 12
Dhaka 12
Düsseldorf 12
Woodbridge 12
Ankara 11
Brno 11
Lubbock 11
Mexico City 11
Prata Di Pordenone 11
Albany 10
Atlanta 10
Bengaluru 10
Dalmine 10
Münster 10
Ottawa 10
Reggio Emilia 10
Seoul 10
Tokyo 10
Amsterdam 9
Changsha 9
Hải Dương 9
Kunming 9
Norwalk 9
Zhengzhou 9
Belo Horizonte 8
Denver 8
Ninh Bình 8
San Mateo 8
Amman 7
Biên Hòa 7
Totale 5.951
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Nome #
Balancing reactivity and antitumor activity: heteroarylthioacetamide derivatives as potent and time-dependent inhibitors of EGFR 357
A Pharmacological Investigation of Eph-Ephrin Antagonism in Prostate Cancer: UniPR1331 Efficacy Evidence 304
Benzisothiazolinone Derivatives as Potent Allosteric Monoacylglycerol Lipase Inhibitors That Functionally Mimic Sulfenylation of Regulatory Cysteines 284
Discovery of a new 1-(phenylsulfonyl)-1H-indole derivative targeting the EphA2 receptor with antiproliferative activity on U251 glioblastoma cell line 266
Targeting the Eph/ephrin system as anti-inflammatory strategy in IBD 258
Development of an orally bioavailable small molecule targeting Eph-ephrin system: in vitro and in vivo anticancer activity. 227
Drug-gut microbiota metabolic interactions: the case of UniPR1331, selective antagonist of the Eph-ephrin system, in mice 223
Chemical modification of NSC12 leads to a specific FGF-trap with antitumor activity in multiple myeloma 223
Expanding the Arsenal of FGFR Inhibitors: A Novel Chloroacetamide Derivative as a New Irreversible Agent With Anti-proliferative Activity Against FGFR1-Amplified Lung Cancer Cell Lines. 222
Optimization of EphA2 antagonists based on a lithocholic acid core led to the identification of UniPR505, a new 3α-carbamoyloxy derivative with antiangiogenetic properties 222
Amino acid derivatives as palmitoylethanolamide prodrugs: Synthesis, in vitro metabolism and in vivo plasma profile in rats 221
A sulfonyl fluoride derivative inhibits EGFR L858R/T790M/C797S by covalent modification of the catalytic lysine 213
Combining ligand- and structure-based approaches for the discovery of new inhibitors of the EPHA2-ephrin-A1 interaction 207
Discovery of novel FGF trap small molecules endowed with anti-myeloma activity 191
NEW EPH ANTAGONISTS DISCRIMINATING BETWEEN EPH-AS AND EPH-BS CLASSES 185
Discovery and development of small molecules targeting Eph-ephrin system in glioblastoma: an academic history 183
Synthesis, Structural Elucidation, and Biological Evaluation of NSC12, an Orally Available Fibroblast Growth Factor (FGF) Ligand Trap for the Treatment of FGF-Dependent Lung Tumors 178
UniPR1331: small Eph/ephrin antagonist beneficial in intestinal inflammation by interfering with type-B signaling 171
Protein-Protein Interaction Inhibitors Targeting the Eph-Ephrin System with a Focus on Amino Acid Conjugates of Bile Acids 170
2-Arylmelatonin analogues: Probing the 2-phenyl binding pocket of melatonin MT1 and MT2 receptors 167
Development of 3-oxo-cholenic derivatives as Eph antagonists able to block in vitro angiogenesis 166
Multiple approaches for the discovery and development of small molecules targeting Eph-ephrin protein-protein interaction 163
Molecular Determinants of EphA2 and EphB2 Antagonism Enable the Design of Ligands with Improved Selectivity 159
Δ5-Cholenoyl-amino acids as selective and orally available antagonists of the Eph-ephrin system 156
PHARMACOLOGICAL CHARACTERIZATION OF NEW COMPOUNDS AIMED AT INHIBITING EPH-EPHRIN INTERACTION IN GLIOBLASTOMA 155
Evaluation of the anti-tumor activity of small molecules targeting eph/ephrins in apcmin j mice 154
Combining pharmacology, target hopping and computational medicinal chemistry to discover novel scaffold targeting EPH-ephrin interaction. 152
Metadynamics for perspective drug design: Computationally driven synthesis of new protein-protein interaction inhibitors targeting the EphA2 receptor 142
UniPR1331, a small molecule targeting Eph/ephrin interaction, prolongs survival in glioblastoma and potentiates the effect of antiangiogenic therapy in mice 142
Cholenic acid derivative UniPR1331 impairs tumor angiogenesis via blockade of VEGF/VEGFR2 in addition to Eph/ephrin 140
Target Hopping as a Useful Tool for the Identification of Novel EphA2 Protein–Protein Antagonists 139
Eph-ephrin antagonism in tumor angiogenesis and growth: UniPR1331 preclinical evidence. 139
Targeting FGFR1 pathway in non small cell lung cancer both in vitro and in vivo 138
2,2-dimethyl-4-(4-methoxy-phenoxy) butanoate and 2,2-dimethyl-4-azido butanoate: Two new pivaloate-ester-like protecting groups 136
Protection by the EPH-EPHRIN System Against Mesenteric Ischemia-Reperfusion Injury 136
Semisynthesis of a glycosylphosphatidylinositol-anchored prion protein 130
Synthesis and Structure-Activity Relationships of Amino Acid Conjugates of Cholanic Acid as Antagonists of the EphA2 Receptor. 129
Adlayers of dimannoside thiols on gold: Surface chemical analysis 127
Fighting tertiary mutations in EGFR-driven lung-cancers: Current advances and future perspectives in medicinal chemistry 120
Fibroblast growth factor receptor inhibitors: patent review (2015–2019) 117
A dual inhibitor of matrix metalloproteinases and a disintegrin and metalloproteinases, [18F]FB-ML5, as a molecular probe for non-invasive MMP/ADAM-targeted imaging 117
Activation of glycosyl halides by halogen bonding 116
The rare bile acid isoallolithocholic acid (IALCA) is an EphA2 antagonist sparing FXR and TGR5 receptors 114
Critical role of amino acid position 343 of surfactant protein-D in the selective binding of glycolipids from Mycobacterium tuberculosis 113
Halting the FGF/FGFR axis leads to antitumor activity in Waldenström macroglobulinemia by silencing MYD88 113
UNIPR1331: SMALL EPH/EPHRIN ANTAGONIST BENEFICIAL IN INTESTINAL INFLAMMATION BY INTERFERING WITH TYPE-B SIGNALLING 106
Hierarchical Self-Assembly of Luminescent Eu(III) Complexes on Silicon 102
Synthesis of the Lewis a trisaccharide based on an anomeric silyl fluorous tag 102
Novel Dual-Acting Hybrids Targeting Type-2 Cannabinoid Receptors and Cholinesterase Activity Show Neuroprotective Effects In Vitro and Amelioration of Cognitive Impairment In Vivo 99
Cantilever array sensors detect specific carbohydrate-protein interactions with picomolar sensitivity 96
MicroPET Evaluation of a Hydroxamate-Based MMP Inhibitor, [18F]FB-ML5, in a Mouse Model of Cigarette Smoke-Induced Acute Airway Inflammation 92
Fatty acid amide hydrolase inhibitors: a patent review (2009 - 2014) 92
In vitro and in vivo efficacy of an orally bioavailable antagonist of Eph-ephrin system in tumor angiogenesis and growth 92
Discrimination of Escherichia coli strains using glycan cantilever array sensors 91
Synthesis of C-Glycosyl Amino Acid Building Blocks Suitable for the Solid-Phase Synthesis of Multivalent Glycopeptide Mimics 91
Dual targeting of EphAs and KDR axis hampers VEGF-induced angiogenesis and glioma stem cell replication 81
Surface analytical characterization of carbohydrate microarrays 81
Multimethod chemical characterization of carbohydrate-functionalized surfaces 80
Multiple modes of binding enhance the affinity of DC-SIGN for high mannose N-linked glycans found on viral glycoproteins 79
Protection by Eph/ephrin antagonists against TNBS-induced colitis: effects of the route of administration 75
Froc: A new fluorous protective group for peptide and oligosaccharide synthesis 71
Total synthesis of the triglycosyl phenolic glycolipid PGL-tb1 from mycobacterium tuberculosis 69
FGF trapping inhibits multiple myeloma growth through c-Myc degradation–induced mitochondrial oxidative stress 68
Plumieribetin, a fish lectin homologous to mannose-binding B-type lectins, inhibits the collagen-binding α1β1 integrin 66
Synthesis and characterization of tetra-O-propargyl pentaerythritol 61
FGF/FGFR inhibitors downmodulates c-Myc oncoprotein and hampers the growth of adrenocortical carcinoma 50
FGF/FGFR inhibitors downmodulates c-Myc oncoprotein and hampers the growth of adrenocortical carcinoma 18
Totale 9.647
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Categoria #
all - tutte 33.107
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 33.107
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022308 0 0 15 35 32 12 36 29 23 16 9 101
2022/20231.209 129 134 60 71 98 139 17 70 384 22 70 15
2023/2024530 36 29 23 17 37 87 63 50 24 42 46 76
2024/20251.925 56 81 127 101 194 204 148 147 247 157 164 299
2025/20263.926 357 415 455 337 544 223 364 145 496 333 156 101
2026/2027412 97 207 108 0 0 0 0 0 0 0 0 0
Totale 9.647