Pinning down the role of the anchor: The chemical synthesis of a cysteine-modified glycosylphosphatidylinositol (GPI) anchor provides access to homogeneous GPI-anchored prion protein through expressed protein ligation (see scheme). By this method, it should be possible to investigate the influence of the complex posttranslational GPI modification on protein structure and function. (Figure Presented) © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
Semisynthesis of a glycosylphosphatidylinositol-anchored prion protein / Becker, Christian. F. W.; Liu, Xinyu.; Olschewski, Diana; Castelli, Riccardo; Seidel, Ralf; Seeberger Peter, H.. - In: ANGEWANDTE CHEMIE. INTERNATIONAL EDITION. - ISSN 1433-7851. - 47:43(2008), pp. 8215-8219. [10.1002/anie.200802161]
Semisynthesis of a glycosylphosphatidylinositol-anchored prion protein
Castelli Riccardo;
2008-01-01
Abstract
Pinning down the role of the anchor: The chemical synthesis of a cysteine-modified glycosylphosphatidylinositol (GPI) anchor provides access to homogeneous GPI-anchored prion protein through expressed protein ligation (see scheme). By this method, it should be possible to investigate the influence of the complex posttranslational GPI modification on protein structure and function. (Figure Presented) © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
