Carbohydrate-based sensors, that specifically detect sugar binding molecules or cells, are increasingly important in medical diagnostic and drug screening. Here we demonstrate that cantilever arrays functionalized with different mannosides allow the real-time detection of several Escherichia coli strains in solution. Cantilever deflection is thereby dependent on the bacterial strain studied and the glycan used as the sensing molecule. The cantilevers exhibit specific and reproducible deflection with a sensitivity range over four orders of magnitude. © 2011 American Chemical Society.
Discrimination of Escherichia coli strains using glycan cantilever array sensors / Mader, Andreas; Gruber, Kathrin; Castelli, Riccardo; Hermann, Bianca A.; Seeberger, Peter H.; Rädler, Joachim O.; Leisner, Madeleine. - In: NANO LETTERS. - ISSN 1530-6984. - 12:1(2012), pp. 420-423. [10.1021/nl203736u]
Discrimination of Escherichia coli strains using glycan cantilever array sensors
Riccardo Castelli;
2012-01-01
Abstract
Carbohydrate-based sensors, that specifically detect sugar binding molecules or cells, are increasingly important in medical diagnostic and drug screening. Here we demonstrate that cantilever arrays functionalized with different mannosides allow the real-time detection of several Escherichia coli strains in solution. Cantilever deflection is thereby dependent on the bacterial strain studied and the glycan used as the sensing molecule. The cantilevers exhibit specific and reproducible deflection with a sensitivity range over four orders of magnitude. © 2011 American Chemical Society.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
