Coeliac disease is an autoimmune enteropathy that develops in genetically predisposed subjects after the ingestion of gluten or related proteins. Coeliac disease has an increasing incidence in the last years in western countries and it has been suggested that wheat breeding might have contributed to select more toxic forms of gluten. In this work, we analysed gluten peptides generated by in vitro digestion of different old and modern Triticum varieties, using LC-MS. We concluded that old varieties analysed produced a higher quantity of peptides containing immunogenic and toxic sequences than modern ones. Thus old wheat lines are not to be considered “safer” for subjects that are genetically predisposed to celiac disease.
Peptides from gluten digestion: A comparison between old and modern wheat varieties / Prandi, Barbara; Tedeschi, Tullia; Folloni, Silvia; Galaverna, Gianni; Sforza, Stefano. - In: FOOD RESEARCH INTERNATIONAL. - ISSN 0963-9969. - 91:(2017), pp. 92-102. [10.1016/j.foodres.2016.11.034]
Peptides from gluten digestion: A comparison between old and modern wheat varieties
PRANDI, Barbara
;TEDESCHI, Tullia;GALAVERNA, Gianni;SFORZA, Stefano
2017-01-01
Abstract
Coeliac disease is an autoimmune enteropathy that develops in genetically predisposed subjects after the ingestion of gluten or related proteins. Coeliac disease has an increasing incidence in the last years in western countries and it has been suggested that wheat breeding might have contributed to select more toxic forms of gluten. In this work, we analysed gluten peptides generated by in vitro digestion of different old and modern Triticum varieties, using LC-MS. We concluded that old varieties analysed produced a higher quantity of peptides containing immunogenic and toxic sequences than modern ones. Thus old wheat lines are not to be considered “safer” for subjects that are genetically predisposed to celiac disease.File | Dimensione | Formato | |
---|---|---|---|
Peptides from gluten digestion.pdf
Open Access dal 03/12/2017
Descrizione: Articolo principale
Tipologia:
Documento in Post-print
Licenza:
Creative commons
Dimensione
424.06 kB
Formato
Adobe PDF
|
424.06 kB | Adobe PDF | Visualizza/Apri |
Supplementary material S1.pdf
Open Access dal 03/12/2017
Descrizione: tabelle dei dati sperimentali
Tipologia:
Altro materiale allegato
Licenza:
Creative commons
Dimensione
518.76 kB
Formato
Adobe PDF
|
518.76 kB | Adobe PDF | Visualizza/Apri |
supplementary material S2.pdf
Open Access dal 03/12/2017
Descrizione: tabelle dei dati sperimentali
Tipologia:
Altro materiale allegato
Licenza:
Creative commons
Dimensione
201.58 kB
Formato
Adobe PDF
|
201.58 kB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.