Understanding the fate of ingested polyphenols is crucial in elucidating the molecular mechanisms underlying the beneficial effects of a fruit and vegetable-based diet. This review focuses on the colon microbiota-mediated transformation of the flavan-3-ols and the structurally related procyanidins found in dietary plant foods and beverages, plus the flavan-3-ol-derived theaflavins of black tea, and the post-absorption phase II metabolism of the gut microbiota catabolites. Despite significant advances in the last decade major analytical challenges remain. Strategies to address them are presented.
Human colonic catabolism of dietary flavan-3-ol bioactives / Di Pede, Giuseppe; Mena, Pedro; Bresciani, Letizia; Almutairi, Tahani M; Del Rio, Daniele; Clifford, Michael N; Crozier, Alan. - In: MOLECULAR ASPECTS OF MEDICINE. - ISSN 0098-2997. - (2022), p. 101107. [10.1016/j.mam.2022.101107]
Human colonic catabolism of dietary flavan-3-ol bioactives
Di Pede, Giuseppe;Mena, Pedro;Bresciani, Letizia;Del Rio, Daniele;
2022-01-01
Abstract
Understanding the fate of ingested polyphenols is crucial in elucidating the molecular mechanisms underlying the beneficial effects of a fruit and vegetable-based diet. This review focuses on the colon microbiota-mediated transformation of the flavan-3-ols and the structurally related procyanidins found in dietary plant foods and beverages, plus the flavan-3-ol-derived theaflavins of black tea, and the post-absorption phase II metabolism of the gut microbiota catabolites. Despite significant advances in the last decade major analytical challenges remain. Strategies to address them are presented.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
