Fusarium mycotoxins are secondary metabolites produced by Fusarium spp. in cereals. Among them, deoxynivalenol (DON) and zearalenone (ZEN) are widespread worldwide contaminants of cereal commodities and are ranked as the most important chronic dietary risk factors. Their conjugates, known as masked mycotoxins, have been described but are still not accounted for in risk assessment studies. This study demonstrates for the first time that DON and ZEN are effectively deconjugated by the human colonic microbiota, releasing their toxic aglycones and generating yet unidentified catabolites. For this reason, masked mycotoxins should be considered when evaluating population exposure.

Masked Mycotoxins Are Efficiently Hydrolyzed by Human Colonic Microbiota Releasing Their Aglycones / Dall’Erta, A.; Cirlini, M.; Dall'Asta, M.; DEL RIO, D.; Galaverna, G.; Dall'Asta, C.. - In: CHEMICAL RESEARCH IN TOXICOLOGY. - ISSN 0893-228X. - 26:(2013), pp. 305-312. [10.1021/tx300438c]

Masked Mycotoxins Are Efficiently Hydrolyzed by Human Colonic Microbiota Releasing Their Aglycones

A. Dall’Erta;M. CIRLINI;M. DALL'ASTA;D. DEL RIO;G. GALAVERNA;C. DALL'ASTA
2013-01-01

Abstract

Fusarium mycotoxins are secondary metabolites produced by Fusarium spp. in cereals. Among them, deoxynivalenol (DON) and zearalenone (ZEN) are widespread worldwide contaminants of cereal commodities and are ranked as the most important chronic dietary risk factors. Their conjugates, known as masked mycotoxins, have been described but are still not accounted for in risk assessment studies. This study demonstrates for the first time that DON and ZEN are effectively deconjugated by the human colonic microbiota, releasing their toxic aglycones and generating yet unidentified catabolites. For this reason, masked mycotoxins should be considered when evaluating population exposure.
Masked Mycotoxins Are Efficiently Hydrolyzed by Human Colonic Microbiota Releasing Their Aglycones / Dall’Erta, A.; Cirlini, M.; Dall'Asta, M.; DEL RIO, D.; Galaverna, G.; Dall'Asta, C.. - In: CHEMICAL RESEARCH IN TOXICOLOGY. - ISSN 0893-228X. - 26:(2013), pp. 305-312. [10.1021/tx300438c]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2632458
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