IRIS
VACONDIO, Federica
 Distribuzione geografica
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Continente #
NA - Nord America 5.712
AS - Asia 4.676
EU - Europa 4.342
SA - Sud America 659
AF - Africa 261
Continente sconosciuto - Info sul continente non disponibili 4
AN - Antartide 1
Totale 15.655
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Nazione #
US - Stati Uniti d'America 5.559
SG - Singapore 1.643
CN - Cina 1.318
IT - Italia 1.208
VN - Vietnam 807
FI - Finlandia 553
SE - Svezia 511
BR - Brasile 510
IE - Irlanda 508
DE - Germania 439
HK - Hong Kong 335
UA - Ucraina 210
FR - Francia 184
ZA - Sudafrica 179
GB - Regno Unito 159
NL - Olanda 140
IN - India 122
RU - Federazione Russa 117
TR - Turchia 117
CA - Canada 88
AT - Austria 67
BE - Belgio 50
AR - Argentina 46
BD - Bangladesh 46
MX - Messico 46
PL - Polonia 41
CI - Costa d'Avorio 40
JP - Giappone 38
KR - Corea 38
ES - Italia 32
CZ - Repubblica Ceca 30
ID - Indonesia 28
EC - Ecuador 25
IQ - Iraq 25
PK - Pakistan 24
VE - Venezuela 24
PH - Filippine 21
CO - Colombia 20
TH - Thailandia 18
LT - Lituania 15
UZ - Uzbekistan 12
JO - Giordania 11
MA - Marocco 11
HU - Ungheria 9
LU - Lussemburgo 9
RO - Romania 9
PY - Paraguay 8
SA - Arabia Saudita 8
TW - Taiwan 8
BO - Bolivia 7
CL - Cile 7
AE - Emirati Arabi Uniti 6
AL - Albania 6
BG - Bulgaria 6
IL - Israele 6
BY - Bielorussia 5
CH - Svizzera 5
DZ - Algeria 5
MY - Malesia 5
NP - Nepal 5
PE - Perù 5
RS - Serbia 5
TN - Tunisia 5
UY - Uruguay 5
AZ - Azerbaigian 4
EG - Egitto 4
HN - Honduras 4
HR - Croazia 4
NI - Nicaragua 4
OM - Oman 4
PS - Palestinian Territory 4
SI - Slovenia 4
EU - Europa 3
KE - Kenya 3
LV - Lettonia 3
MD - Moldavia 3
PT - Portogallo 3
QA - Qatar 3
SN - Senegal 3
AM - Armenia 2
AO - Angola 2
CR - Costa Rica 2
DO - Repubblica Dominicana 2
EE - Estonia 2
GE - Georgia 2
GH - Ghana 2
GR - Grecia 2
IR - Iran 2
KZ - Kazakistan 2
LB - Libano 2
MN - Mongolia 2
PA - Panama 2
SK - Slovacchia (Repubblica Slovacca) 2
SY - Repubblica araba siriana 2
TG - Togo 2
TJ - Tagikistan 2
AQ - Antartide 1
BB - Barbados 1
BJ - Benin 1
CY - Cipro 1
Totale 15.640
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Città #
Singapore 837
Ashburn 724
Dallas 622
Chandler 523
Dublin 501
San Jose 435
Parma 388
Ann Arbor 321
Santa Clara 313
Hong Kong 310
Beijing 287
Ho Chi Minh City 260
Jacksonville 210
Boardman 179
Dearborn 176
Johannesburg 169
Hanoi 160
Los Angeles 147
Munich 129
New York 115
Shanghai 114
Hefei 101
Nanjing 99
Izmir 90
Lauterbourg 90
Bremen 84
Princeton 84
Milan 82
Helsinki 65
Wilmington 65
Vienna 55
Bologna 54
Moscow 53
São Paulo 53
Buffalo 48
Columbus 43
Da Nang 43
Shenyang 43
Council Bluffs 41
Abidjan 40
San Mateo 40
Nanchang 39
Toronto 39
Brussels 37
Haiphong 37
London 37
Modena 36
Chicago 33
Guangzhou 33
Tokyo 33
Jinan 32
Turku 32
Frankfurt am Main 30
Hebei 30
The Dalles 30
Warsaw 30
Kunming 29
Seattle 27
Seoul 27
Woodbridge 27
Chennai 26
Orem 25
Brescia 24
Nuremberg 22
Pune 22
Changsha 21
Jakarta 21
Denver 20
Des Moines 20
Düsseldorf 20
Montreal 20
Tianjin 20
Stockholm 19
Atlanta 18
Brooklyn 18
Fremont 18
Phoenix 18
Houston 17
Mexico City 17
Rio de Janeiro 17
Belo Horizonte 16
Manchester 16
San Francisco 16
Jiaxing 15
Zhengzhou 15
Amsterdam 14
Ottawa 14
Brno 13
Dhaka 13
Norwalk 13
Poplar 13
Florence 12
Lahore 12
Quito 12
Ankara 11
Boston 11
Marseille 11
Prata Di Pordenone 11
Rome 11
Amman 10
Totale 9.473
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Nome #
Balancing reactivity and antitumor activity: heteroarylthioacetamide derivatives as potent and time-dependent inhibitors of EGFR 350
Benzisothiazolinone Derivatives as Potent Allosteric Monoacylglycerol Lipase Inhibitors That Functionally Mimic Sulfenylation of Regulatory Cysteines 268
Targeting metabolic adaptive responses induced by glucose starvation inhibits cell proliferation and enhances cell death in osimertinib-resistant non-small cell lung cancer (NSCLC) cell lines 258
Targeting glucosylceramide synthase induces antiproliferative and proapoptotic effects in osimertinib-resistant NSCLC cell models 239
Discovery of a new 1-(phenylsulfonyl)-1H-indole derivative targeting the EphA2 receptor with antiproliferative activity on U251 glioblastoma cell line 231
Antidepressant-like activity and cardioprotective effects of fatty acid amide hydrolase inhibitor URB694 in socially stressed Wistar Kyoto rats 228
Antidepressant-like effects of pharmacological inhibition of FAAH activity in socially isolated female rats 223
2-Aminobenzimidazoles as new potent H3-antagonists 222
Social stress-induced depressive-like symptoms and changes in gut microbial and lipidomic profiles are prevented by pharmacological inhibition of FAAH activity in male rats 216
Drug-gut microbiota metabolic interactions: the case of UniPR1331, selective antagonist of the Eph-ephrin system, in mice 215
Optimization of EphA2 antagonists based on a lithocholic acid core led to the identification of UniPR505, a new 3α-carbamoyloxy derivative with antiangiogenetic properties 214
Irreversible Inhibition of Epidermal Growth Factor Receptor Activity by 3-Aminopropanamides. 209
(2S,4R)-4-fluoroglutamine is converted into (2S,4R)-4-fluoroglutamate by glutaminase activity and may be exploited as a PET tracer in glutamine-addicted cancers 205
Dibasic biphenyl H(3) receptor antagonists: Steric tolerance for a lipophilic side chain. 204
A sulfonyl fluoride derivative inhibits EGFR L858R/T790M/C797S by covalent modification of the catalytic lysine 204
Amino acid derivatives as palmitoylethanolamide prodrugs: Synthesis, in vitro metabolism and in vivo plasma profile in rats 198
[18F](2S,4R)-4-Fluoroglutamine as a New Positron Emission Tomography Tracer in Myeloma 198
Analysis of illicit dietary supplements sold in the Italian market: Identification of a sildenafil thioderivative as adulterant using UPLC-TOF/MS and GC/MS. 197
Combining ligand- and structure-based approaches for the discovery of new inhibitors of the EPHA2-ephrin-A1 interaction 196
Aminobenzimidazoles as new potent H3-antagonists 194
5-Benzylidene-hydantoins: synthesis and antiproliferative activity on A549 lung cancer cell line 191
Synthesis, biological activity, QSAR and QSPR study of 2/aminobenzimidazole derivatives as potent H3-antagonists 190
Cell-targeted c(AmpRGD)-sunitinib molecular conjugates impair tumor growth of melanoma 187
Cardioprotective effects of fatty acid amide hydrolase inhibitor URB694, in a rodent model of trait anxiety 181
Creatine as a compatible osmolyte in muscle cells exposed to hypertonic stress 177
Novel Irreversible Epidermal Growth Factor Receptor Inhibitors by Chemical Modulation of the Cysteine-Trap Portion 176
A second generation of carbamate-based fatty acid amide hydrolase inhibitors with improved activity in vivo 176
Cognition enhancing effect in rats of a selected histamine H3 receptor antagonist with good brain penetration 174
Access to CNS of selected H3-antagonists: ex vivo binding study in rats 174
Biphenyl-3-yl alkylcarbamates as fatty acid amide hydrolase (FAAH) inhibitors: steric effects of N-alkyl chain on rat plasma and liver stability 173
Metabolic Soft Spot and Pharmacokinetics: Functionalization of C-3 Position of an Eph–Ephrin Antagonist Featuring a Bile Acid Core as an Effective Strategy to Obtain Oral Bioavailability in Mice 172
The Role of HB-Donor Groups in the Heterocyclic Polar Fragment of H3-Antagonists. I. Synthesis and Biological Assays 169
Discovery of novel FGF trap small molecules endowed with anti-myeloma activity 167
Functional modulation of the human gut microbiome by bacteria vehicled by cheese 167
Synthesis, Structural Elucidation, and Biological Evaluation of NSC12, an Orally Available Fibroblast Growth Factor (FGF) Ligand Trap for the Treatment of FGF-Dependent Lung Tumors 167
2-Aminooxazole as a Novel Privileged Scaffold in Antitubercular Medicinal Chemistry 165
Accepting the Invitation to Open Innovation in Malaria Drug Discovery: Synthesis, Biological Evaluation, and Investigation on the Structure-Activity Relationships of Benzo[b]thiophene-2-carboxamides as Antimalarial Agents 164
Discovery and development of small molecules targeting Eph-ephrin system in glioblastoma: an academic history 161
Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 7. Synthesis and Pharmacological Evaluation of 4-Quinolone-3-carboxamides and 4-Hydroxy-2-quinolone-3-carboxamides as High Affinity Cannabinoid Receptor 2 (CB2R) Ligands with Improved Aqueous Solubility 161
Human colonoid-derived monolayers and Caco-2: comparative analysis of inflammatory responses 160
Multiple approaches for the discovery and development of small molecules targeting Eph-ephrin protein-protein interaction 160
N-(Anilinoethyl)amide Melatonergic Ligands with Improved Water Solubility and Metabolic Stability 160
Steps towards sustainable solid phase peptide synthesis: use and recovery ofN-octyl pyrrolidone 159
QSAR study of 2-aminobenzimidazole derivatives as H3 antagonists 156
Access to CNS of selected H3-antagonists: ex vivo binding study in rats 155
Biochemical characterization of EphA2 antagonists with improved physico-chemical properties by cell-based assays and surface plasmon resonance analysis 155
Molecular Determinants of EphA2 and EphB2 Antagonism Enable the Design of Ligands with Improved Selectivity 148
Synthesis and 3D-QSAR Analysis of H3 Receptor Antagonists Containing a Neutral Heterocyclic Polar Group 148
Antioxidant and cytoprotective activity of indole derivatives related to melatonin 148
Δ5-Cholenoyl-amino acids as selective and orally available antagonists of the Eph-ephrin system 148
Palladium Catalyst Recycling for Heck-Cassar-Sonogashira Cross-Coupling Reactions in Green Solvent/Base Blend 147
Development and validation of a LC-MS method with electrospray ionization for the determination of the imidazole H(3) antagonist ROS203 in rat plasma. 146
2,4(5)-Diarylimidazoles as Inhibitors of hNaV1.2 Sodium Channels: Pharmacological Evaluationand Structure-Property Relationships 144
Epidermal Growth Factor Receptor Irreversible Inhibitors: Chemical Exploration of the Cysteine-Trap Portion 144
Mannich base derivatives as novel EGFR irreversible inhibitors 144
CNS access of selected H3-antagonists: ex vivo binding study in rats 143
Substituted N-Phenyl-5-(2-(phenylamino)thiazol-4-yl)isoxazole-3-carboxamides Are Valuable Antitubercular Candidates that Evade Innate Efflux Machinery 143
Social stress contagion in rats: Behavioural, autonomic and neuroendocrine correlates 142
Expanding the knowledge around antitubercular 5-(2-aminothiazol-4-yl)isoxazole-3-carboxamides: Hit–to–lead optimization and release of a novel antitubercular chemotype via scaffold derivatization 139
N-(Anilinoethyl)amides: design and synthesis of metabolically stable, selective melatonin receptor ligands 139
UniPR1331, a small molecule targeting Eph/ephrin interaction, prolongs survival in glioblastoma and potentiates the effect of antiangiogenic therapy in mice 139
Metadynamics for perspective drug design: Computationally driven synthesis of new protein-protein interaction inhibitors targeting the EphA2 receptor 138
Brain Pharmacokinetics of Non-Imidazole Biphenyl H3 Receptor Antagonists: a Liquid Chromatography/Electrospray-Mass Spectrometry and ex vivo Binding Study in Rats 137
N-(2-Oxo-3-oxetanyl)carbamic Acid Esters as N-Acylethanolamine Acid Amidase Inhibitors: Synthesis, Structure–Activity and Structure–Property Relationships. 137
Lipoprotien(a) concentration, genetic variants, apo(a) isoform size, and cellular cholesterol efflux in patients with elevated Lp(a) and coronary heart disease submitted or not to lipoprotein apheresis: An Italian case-control multicenter study on Lp(a) 136
Design, Synthesis, and Physicochemical and Pharmacological Profiling of 7-Hydroxy-5-oxopyrazolo[4,3-b]pyridine-6-carboxamide Derivatives with Antiosteoarthritic Activity in Vivo 134
Synthesis and biological assays of new H3-antagonists with imidazole and imidazoline polar groups 134
Indole-based analogs of melatonin: in vitro antioxidant and cytoprotective activities 132
Long-lasting inhibition of EGFR autophosphorylation in A549 tumor cells by intracellular accumulation of non-covalent inhibitors 132
Eph-ephrin antagonism in tumor angiogenesis and growth: UniPR1331 preclinical evidence. 132
Disentangling the interactions between nasopharyngeal and gut microbiome and their involvement in the modulation of COVID-19 infection 131
Free-energy studies reveal a possible mechanism for oxidation-dependent inhibition of MGL 131
Predicting the reactivity of nitrile-carrying compounds with cysteine: a combined computational and experimental study. 129
Synthesis and preclinical evaluation of a novel, selective 111-In-labelled aminoproline-RGD-peptide for non-invasive melanoma tumor imaging 129
Role of sphingolipid metabolism in osimertinib-resistance in EGFR-mutated NSCLC models 128
Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism. 128
Anti-αVβ3 integrin peptidomimetic-Sunitinib dual conjugates as therapeutic tool for the inhibition of integrin/growth factor cross-talk in human melanoma cells. 126
Synthesis of Novel c(AmpRGD)−Sunitinib Dual Conjugates as Molecular Tools Targeting the αvβ3 Integrin/VEGFR2 Couple and Impairing Tumor-Associated Angiogenesis 119
Synthesis, antioxidant activity and structure-activity relationships for a new series of 2-(N-acylaminoethyl)indoles with melatonin-like cytoprotective activity 119
Three-Dimensional Quantitative Structure-Activity Relationship Studies on Selected MT1 and MT2 Melatonin Receptor Ligands: Requirements for Subtype Selectivity and Intrinsic Activity Modulation 115
Structure-property relationships of a class of carbamate-based fatty acid amide hydrolase (FAAH) inhibitors: chemical and biological stability 114
Potent, Metabolically Stable 2-Alkyl-8-(2H-1,2,3-triazol-2-yl)-9H-adenines as Adenosine A2A Receptor Ligands 114
Enhancement of peripheral fatty acyl ethanolamide signaling prevents stress‑induced social avoidance and anxiety‑like behaviors in male rats 113
Relationship between structure and ex-vivo binding of imidazole H3 antagonists to rat brain H3 receptors 113
Investigating drug-gut microbiota interactions: reductive and hydrolytic metabolism of oral glucocorticoids by in vitro artificial gut microbiota 109
Imidazole H3-antagonists: Relationship between Structure and Ex-vivo binding to Rat Brain H3-Receptors 107
Liquid chromatography-mass spectrometric method for determination of the non-imidazole H(3) -receptor antagonist UPR1056 in rat plasma. 107
Structure-Property Relationships on Histamine H3-Antagonists: Binding of Phenyl-substituted Alkylthioimidazole Derivatives to Rat Plasma Proteins 106
Pharmacological inhibition of FAAH activity in rodents: A promising pharmacological approach for psychological-cardiac comorbidity? 104
The GABAB receptor positive allosteric modulator COR659: In vitro metabolism, in vivo pharmacokinetics in rats, synthesis and pharmacological characterization of metabolically protected derivatives 102
Quantitative structure-property relationships of a class of carbamate-based fatty acid amide hydrolase (FAAH) inhibitors. 99
The 1,2-dichloroethane/water versus the n-octanol/water system: more about intra- or intermolecular H-bond interactions 98
Synthesis and stability in biological media of 1H-imidazole-1-carboxylates of ROS203, an antagonist of the histamine H3 receptor. 98
Qualitative structure-metabolism relationships in the hydrolysis of carbamates 92
Synthesis and Quantitative Structure-Activity Relationship of Fatty Acid Amide Hydrolase Inhibitors: Modulation at the N-Portion of Biphenyl-3-yl Alkylcarbamates. 92
Novel cycloAmpRGD-Sunitinib Dual Conjugates as Potent Targeted Anti-angiogenic Tools 91
In vitro and in vivo efficacy of an orally bioavailable antagonist of Eph-ephrin system in tumor angiogenesis and growth 89
On the selection of an opioid for local skin analgesia: Structure-skin permeability relationships 84
Peroxide-Dependent MGL Sulfenylation Regulates 2-AG-Mediated Endocannabinoid Signaling in Brain Neurons 81
Combined targeting of fatty acid amide hydrolase and melatonin receptors promotes neuroprotection and stimulates inflammation resolution in rats 78
Totale 15.486
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Categoria #
all - tutte 49.965
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 49.965
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021141 0 0 0 0 0 0 0 0 0 31 74 36
2021/2022602 20 28 20 78 40 14 72 65 42 35 49 139
2022/20232.142 228 223 137 161 239 250 35 121 602 45 75 26
2023/2024959 33 48 20 31 78 197 84 66 44 84 126 148
2024/20252.919 102 146 201 219 235 291 187 159 334 292 277 476
2025/20266.366 605 729 990 673 845 407 658 225 786 448 0 0
Totale 15.874