IRIS
VACONDIO, Federica
 Distribuzione geografica
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Continente #
NA - Nord America 6.028
AS - Asia 4.858
EU - Europa 4.468
SA - Sud America 659
AF - Africa 261
Continente sconosciuto - Info sul continente non disponibili 4
AN - Antartide 1
Totale 16.279
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Nazione #
US - Stati Uniti d'America 5.853
SG - Singapore 1.655
CN - Cina 1.334
IT - Italia 1.324
VN - Vietnam 807
FI - Finlandia 559
SE - Svezia 511
BR - Brasile 510
IE - Irlanda 508
DE - Germania 440
HK - Hong Kong 339
UA - Ucraina 210
BD - Bangladesh 193
FR - Francia 185
ZA - Sudafrica 179
GB - Regno Unito 159
NL - Olanda 141
IN - India 122
TR - Turchia 118
RU - Federazione Russa 117
CA - Canada 106
AT - Austria 67
BE - Belgio 50
MX - Messico 48
AR - Argentina 46
PL - Polonia 41
CI - Costa d'Avorio 40
JP - Giappone 39
KR - Corea 38
ES - Italia 32
CZ - Repubblica Ceca 30
ID - Indonesia 28
EC - Ecuador 25
IQ - Iraq 25
PK - Pakistan 24
VE - Venezuela 24
PH - Filippine 21
CO - Colombia 20
TH - Thailandia 18
LT - Lituania 16
UZ - Uzbekistan 12
JO - Giordania 11
MA - Marocco 11
HU - Ungheria 9
LU - Lussemburgo 9
RO - Romania 9
PY - Paraguay 8
SA - Arabia Saudita 8
TW - Taiwan 8
BO - Bolivia 7
CL - Cile 7
AE - Emirati Arabi Uniti 6
AL - Albania 6
BG - Bulgaria 6
IL - Israele 6
BY - Bielorussia 5
CH - Svizzera 5
DZ - Algeria 5
MY - Malesia 5
NP - Nepal 5
PE - Perù 5
RS - Serbia 5
TN - Tunisia 5
UY - Uruguay 5
AZ - Azerbaigian 4
EG - Egitto 4
HN - Honduras 4
HR - Croazia 4
NI - Nicaragua 4
OM - Oman 4
PS - Palestinian Territory 4
SI - Slovenia 4
CR - Costa Rica 3
EU - Europa 3
KE - Kenya 3
LB - Libano 3
LV - Lettonia 3
MD - Moldavia 3
PT - Portogallo 3
QA - Qatar 3
SN - Senegal 3
AM - Armenia 2
AO - Angola 2
DO - Repubblica Dominicana 2
EE - Estonia 2
GE - Georgia 2
GH - Ghana 2
GR - Grecia 2
IR - Iran 2
KZ - Kazakistan 2
MN - Mongolia 2
PA - Panama 2
SK - Slovacchia (Repubblica Slovacca) 2
SY - Repubblica araba siriana 2
TG - Togo 2
TJ - Tagikistan 2
AQ - Antartide 1
BB - Barbados 1
BJ - Benin 1
CY - Cipro 1
Totale 16.263
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Città #
Singapore 841
Ashburn 740
Dallas 628
Chandler 523
San Jose 513
Dublin 501
Parma 392
Santa Clara 333
Ann Arbor 321
Hong Kong 314
Beijing 293
Ho Chi Minh City 260
Jacksonville 211
Boardman 191
Dearborn 176
Johannesburg 169
Los Angeles 163
Hanoi 160
New York 145
Munich 129
Shanghai 114
Hefei 101
Nanjing 99
Izmir 90
Lauterbourg 90
Milan 89
Bremen 84
Princeton 84
Helsinki 71
Wilmington 65
Bologna 61
Buffalo 59
Vienna 55
Moscow 53
São Paulo 53
Council Bluffs 52
Columbus 45
Da Nang 43
Shenyang 43
Toronto 43
Abidjan 40
San Mateo 40
Nanchang 39
Chicago 38
Brussels 37
Haiphong 37
London 37
Modena 37
Guangzhou 33
Tokyo 33
Jinan 32
Turku 32
Frankfurt am Main 30
Hebei 30
Kunming 30
The Dalles 30
Warsaw 30
Orem 29
Seattle 27
Seoul 27
Woodbridge 27
Chennai 26
Brescia 25
Montreal 24
Nuremberg 22
Pune 22
Changsha 21
Jakarta 21
Rome 21
Denver 20
Des Moines 20
Düsseldorf 20
Tianjin 20
Atlanta 19
Mexico City 19
Stockholm 19
Brooklyn 18
Fremont 18
Phoenix 18
San Francisco 18
Houston 17
Manchester 17
Rio de Janeiro 17
Belo Horizonte 16
Naples 16
Jiaxing 15
Ottawa 15
Zhengzhou 15
Amsterdam 14
Florence 14
Brno 13
Dhaka 13
Norwalk 13
Poplar 13
Boston 12
Lahore 12
Palermo 12
Quito 12
Ankara 11
Bari 11
Totale 9.761
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Nome #
Balancing reactivity and antitumor activity: heteroarylthioacetamide derivatives as potent and time-dependent inhibitors of EGFR 350
Benzisothiazolinone Derivatives as Potent Allosteric Monoacylglycerol Lipase Inhibitors That Functionally Mimic Sulfenylation of Regulatory Cysteines 277
Targeting metabolic adaptive responses induced by glucose starvation inhibits cell proliferation and enhances cell death in osimertinib-resistant non-small cell lung cancer (NSCLC) cell lines 264
Discovery of a new 1-(phenylsulfonyl)-1H-indole derivative targeting the EphA2 receptor with antiproliferative activity on U251 glioblastoma cell line 251
Targeting glucosylceramide synthase induces antiproliferative and proapoptotic effects in osimertinib-resistant NSCLC cell models 244
Antidepressant-like effects of pharmacological inhibition of FAAH activity in socially isolated female rats 239
Antidepressant-like activity and cardioprotective effects of fatty acid amide hydrolase inhibitor URB694 in socially stressed Wistar Kyoto rats 234
2-Aminobenzimidazoles as new potent H3-antagonists 224
Social stress-induced depressive-like symptoms and changes in gut microbial and lipidomic profiles are prevented by pharmacological inhibition of FAAH activity in male rats 218
Optimization of EphA2 antagonists based on a lithocholic acid core led to the identification of UniPR505, a new 3α-carbamoyloxy derivative with antiangiogenetic properties 217
Drug-gut microbiota metabolic interactions: the case of UniPR1331, selective antagonist of the Eph-ephrin system, in mice 217
Irreversible Inhibition of Epidermal Growth Factor Receptor Activity by 3-Aminopropanamides. 214
(2S,4R)-4-fluoroglutamine is converted into (2S,4R)-4-fluoroglutamate by glutaminase activity and may be exploited as a PET tracer in glutamine-addicted cancers 211
Metabolic Soft Spot and Pharmacokinetics: Functionalization of C-3 Position of an Eph–Ephrin Antagonist Featuring a Bile Acid Core as an Effective Strategy to Obtain Oral Bioavailability in Mice 210
Dibasic biphenyl H(3) receptor antagonists: Steric tolerance for a lipophilic side chain. 208
A sulfonyl fluoride derivative inhibits EGFR L858R/T790M/C797S by covalent modification of the catalytic lysine 208
[18F](2S,4R)-4-Fluoroglutamine as a New Positron Emission Tomography Tracer in Myeloma 205
5-Benzylidene-hydantoins: synthesis and antiproliferative activity on A549 lung cancer cell line 203
Amino acid derivatives as palmitoylethanolamide prodrugs: Synthesis, in vitro metabolism and in vivo plasma profile in rats 201
Combining ligand- and structure-based approaches for the discovery of new inhibitors of the EPHA2-ephrin-A1 interaction 198
Synthesis, biological activity, QSAR and QSPR study of 2/aminobenzimidazole derivatives as potent H3-antagonists 198
Analysis of illicit dietary supplements sold in the Italian market: Identification of a sildenafil thioderivative as adulterant using UPLC-TOF/MS and GC/MS. 198
Aminobenzimidazoles as new potent H3-antagonists 196
Cardioprotective effects of fatty acid amide hydrolase inhibitor URB694, in a rodent model of trait anxiety 195
Cell-targeted c(AmpRGD)-sunitinib molecular conjugates impair tumor growth of melanoma 194
Novel Irreversible Epidermal Growth Factor Receptor Inhibitors by Chemical Modulation of the Cysteine-Trap Portion 191
Biphenyl-3-yl alkylcarbamates as fatty acid amide hydrolase (FAAH) inhibitors: steric effects of N-alkyl chain on rat plasma and liver stability 188
Human colonoid-derived monolayers and Caco-2: comparative analysis of inflammatory responses 185
The Role of HB-Donor Groups in the Heterocyclic Polar Fragment of H3-Antagonists. I. Synthesis and Biological Assays 183
Creatine as a compatible osmolyte in muscle cells exposed to hypertonic stress 182
Discovery of novel FGF trap small molecules endowed with anti-myeloma activity 181
Cognition enhancing effect in rats of a selected histamine H3 receptor antagonist with good brain penetration 178
A second generation of carbamate-based fatty acid amide hydrolase inhibitors with improved activity in vivo 178
Access to CNS of selected H3-antagonists: ex vivo binding study in rats 177
Functional modulation of the human gut microbiome by bacteria vehicled by cheese 171
Synthesis, Structural Elucidation, and Biological Evaluation of NSC12, an Orally Available Fibroblast Growth Factor (FGF) Ligand Trap for the Treatment of FGF-Dependent Lung Tumors 168
2-Aminooxazole as a Novel Privileged Scaffold in Antitubercular Medicinal Chemistry 166
Accepting the Invitation to Open Innovation in Malaria Drug Discovery: Synthesis, Biological Evaluation, and Investigation on the Structure-Activity Relationships of Benzo[b]thiophene-2-carboxamides as Antimalarial Agents 165
Discovery and development of small molecules targeting Eph-ephrin system in glioblastoma: an academic history 163
Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 7. Synthesis and Pharmacological Evaluation of 4-Quinolone-3-carboxamides and 4-Hydroxy-2-quinolone-3-carboxamides as High Affinity Cannabinoid Receptor 2 (CB2R) Ligands with Improved Aqueous Solubility 162
N-(Anilinoethyl)amide Melatonergic Ligands with Improved Water Solubility and Metabolic Stability 162
Steps towards sustainable solid phase peptide synthesis: use and recovery ofN-octyl pyrrolidone 162
Multiple approaches for the discovery and development of small molecules targeting Eph-ephrin protein-protein interaction 161
QSAR study of 2-aminobenzimidazole derivatives as H3 antagonists 159
Access to CNS of selected H3-antagonists: ex vivo binding study in rats 156
Biochemical characterization of EphA2 antagonists with improved physico-chemical properties by cell-based assays and surface plasmon resonance analysis 156
Antioxidant and cytoprotective activity of indole derivatives related to melatonin 153
Palladium Catalyst Recycling for Heck-Cassar-Sonogashira Cross-Coupling Reactions in Green Solvent/Base Blend 153
Molecular Determinants of EphA2 and EphB2 Antagonism Enable the Design of Ligands with Improved Selectivity 151
Development and validation of a LC-MS method with electrospray ionization for the determination of the imidazole H(3) antagonist ROS203 in rat plasma. 151
Δ5-Cholenoyl-amino acids as selective and orally available antagonists of the Eph-ephrin system 150
Synthesis and 3D-QSAR Analysis of H3 Receptor Antagonists Containing a Neutral Heterocyclic Polar Group 149
Brain Pharmacokinetics of Non-Imidazole Biphenyl H3 Receptor Antagonists: a Liquid Chromatography/Electrospray-Mass Spectrometry and ex vivo Binding Study in Rats 148
Mannich base derivatives as novel EGFR irreversible inhibitors 148
2,4(5)-Diarylimidazoles as Inhibitors of hNaV1.2 Sodium Channels: Pharmacological Evaluationand Structure-Property Relationships 147
Social stress contagion in rats: Behavioural, autonomic and neuroendocrine correlates 147
Epidermal Growth Factor Receptor Irreversible Inhibitors: Chemical Exploration of the Cysteine-Trap Portion 146
N-(2-Oxo-3-oxetanyl)carbamic Acid Esters as N-Acylethanolamine Acid Amidase Inhibitors: Synthesis, Structure–Activity and Structure–Property Relationships. 146
CNS access of selected H3-antagonists: ex vivo binding study in rats 144
Substituted N-Phenyl-5-(2-(phenylamino)thiazol-4-yl)isoxazole-3-carboxamides Are Valuable Antitubercular Candidates that Evade Innate Efflux Machinery 143
Expanding the knowledge around antitubercular 5-(2-aminothiazol-4-yl)isoxazole-3-carboxamides: Hit–to–lead optimization and release of a novel antitubercular chemotype via scaffold derivatization 142
N-(Anilinoethyl)amides: design and synthesis of metabolically stable, selective melatonin receptor ligands 142
UniPR1331, a small molecule targeting Eph/ephrin interaction, prolongs survival in glioblastoma and potentiates the effect of antiangiogenic therapy in mice 140
Metadynamics for perspective drug design: Computationally driven synthesis of new protein-protein interaction inhibitors targeting the EphA2 receptor 138
Lipoprotien(a) concentration, genetic variants, apo(a) isoform size, and cellular cholesterol efflux in patients with elevated Lp(a) and coronary heart disease submitted or not to lipoprotein apheresis: An Italian case-control multicenter study on Lp(a) 138
Synthesis and biological assays of new H3-antagonists with imidazole and imidazoline polar groups 137
Indole-based analogs of melatonin: in vitro antioxidant and cytoprotective activities 136
Synthesis of Novel c(AmpRGD)−Sunitinib Dual Conjugates as Molecular Tools Targeting the αvβ3 Integrin/VEGFR2 Couple and Impairing Tumor-Associated Angiogenesis 136
Design, Synthesis, and Physicochemical and Pharmacological Profiling of 7-Hydroxy-5-oxopyrazolo[4,3-b]pyridine-6-carboxamide Derivatives with Antiosteoarthritic Activity in Vivo 136
Long-lasting inhibition of EGFR autophosphorylation in A549 tumor cells by intracellular accumulation of non-covalent inhibitors 134
Eph-ephrin antagonism in tumor angiogenesis and growth: UniPR1331 preclinical evidence. 134
Free-energy studies reveal a possible mechanism for oxidation-dependent inhibition of MGL 133
Role of sphingolipid metabolism in osimertinib-resistance in EGFR-mutated NSCLC models 132
Disentangling the interactions between nasopharyngeal and gut microbiome and their involvement in the modulation of COVID-19 infection 132
Synthesis and preclinical evaluation of a novel, selective 111-In-labelled aminoproline-RGD-peptide for non-invasive melanoma tumor imaging 132
Predicting the reactivity of nitrile-carrying compounds with cysteine: a combined computational and experimental study. 131
Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism. 129
Three-Dimensional Quantitative Structure-Activity Relationship Studies on Selected MT1 and MT2 Melatonin Receptor Ligands: Requirements for Subtype Selectivity and Intrinsic Activity Modulation 128
Anti-αVβ3 integrin peptidomimetic-Sunitinib dual conjugates as therapeutic tool for the inhibition of integrin/growth factor cross-talk in human melanoma cells. 127
Synthesis, antioxidant activity and structure-activity relationships for a new series of 2-(N-acylaminoethyl)indoles with melatonin-like cytoprotective activity 119
Relationship between structure and ex-vivo binding of imidazole H3 antagonists to rat brain H3 receptors 117
Potent, Metabolically Stable 2-Alkyl-8-(2H-1,2,3-triazol-2-yl)-9H-adenines as Adenosine A2A Receptor Ligands 116
Enhancement of peripheral fatty acyl ethanolamide signaling prevents stress‑induced social avoidance and anxiety‑like behaviors in male rats 115
Structure-property relationships of a class of carbamate-based fatty acid amide hydrolase (FAAH) inhibitors: chemical and biological stability 114
Investigating drug-gut microbiota interactions: reductive and hydrolytic metabolism of oral glucocorticoids by in vitro artificial gut microbiota 113
Functional and morphological characterisation of human colonoid-derived monolayers under inflammatory conditions 112
Pharmacological inhibition of FAAH activity in rodents: A promising pharmacological approach for psychological-cardiac comorbidity? 109
Structure-Property Relationships on Histamine H3-Antagonists: Binding of Phenyl-substituted Alkylthioimidazole Derivatives to Rat Plasma Proteins 108
Imidazole H3-antagonists: Relationship between Structure and Ex-vivo binding to Rat Brain H3-Receptors 108
Liquid chromatography-mass spectrometric method for determination of the non-imidazole H(3) -receptor antagonist UPR1056 in rat plasma. 108
Synthesis and Quantitative Structure-Activity Relationship of Fatty Acid Amide Hydrolase Inhibitors: Modulation at the N-Portion of Biphenyl-3-yl Alkylcarbamates. 106
The GABAB receptor positive allosteric modulator COR659: In vitro metabolism, in vivo pharmacokinetics in rats, synthesis and pharmacological characterization of metabolically protected derivatives 104
Protective Activity of Melatonin Combinations and Melatonin-Based Hybrid Molecules in Neurodegenerative Diseases 102
The 1,2-dichloroethane/water versus the n-octanol/water system: more about intra- or intermolecular H-bond interactions 100
Quantitative structure-property relationships of a class of carbamate-based fatty acid amide hydrolase (FAAH) inhibitors. 100
Synthesis and stability in biological media of 1H-imidazole-1-carboxylates of ROS203, an antagonist of the histamine H3 receptor. 98
Qualitative structure-metabolism relationships in the hydrolysis of carbamates 96
Synthesis and structure-activity relationships of N-(2-oxo-3-oxetanyl)amides as N-acylethanolamine-hydrolyzing acid amidase inhibitors. 95
Novel cycloAmpRGD-Sunitinib Dual Conjugates as Potent Targeted Anti-angiogenic Tools 94
In vitro and in vivo efficacy of an orally bioavailable antagonist of Eph-ephrin system in tumor angiogenesis and growth 89
Totale 16.024
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Categoria #
all - tutte 53.013
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 53.013
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/202136 0 0 0 0 0 0 0 0 0 0 0 36
2021/2022602 20 28 20 78 40 14 72 65 42 35 49 139
2022/20232.142 228 223 137 161 239 250 35 121 602 45 75 26
2023/2024959 33 48 20 31 78 197 84 66 44 84 126 148
2024/20252.919 102 146 201 219 235 291 187 159 334 292 277 476
2025/20266.990 605 729 990 673 845 407 658 225 786 537 355 180
Totale 16.498