IRIS
VACONDIO, Federica
 Distribuzione geografica
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Continente #
NA - Nord America 6.565
AS - Asia 4.913
EU - Europa 4.596
SA - Sud America 680
AF - Africa 262
Continente sconosciuto - Info sul continente non disponibili 225
AN - Antartide 1
OC - Oceania 1
Totale 17.243
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Nazione #
US - Stati Uniti d'America 6.366
SG - Singapore 1.661
IT - Italia 1.415
CN - Cina 1.342
VN - Vietnam 811
FI - Finlandia 559
SE - Svezia 528
BR - Brasile 515
IE - Irlanda 508
DE - Germania 443
HK - Hong Kong 341
UA - Ucraina 211
BD - Bangladesh 206
FR - Francia 190
ZA - Sudafrica 179
GB - Regno Unito 163
NL - Olanda 144
IN - India 124
TR - Turchia 118
RU - Federazione Russa 117
CA - Canada 115
AT - Austria 67
MX - Messico 53
AR - Argentina 51
BE - Belgio 50
PL - Polonia 41
CI - Costa d'Avorio 40
JP - Giappone 39
KR - Corea 38
ES - Italia 35
CZ - Repubblica Ceca 30
ID - Indonesia 29
PH - Filippine 28
EC - Ecuador 27
VE - Venezuela 27
CO - Colombia 25
IQ - Iraq 25
PK - Pakistan 24
TH - Thailandia 19
LT - Lituania 16
JO - Giordania 12
UZ - Uzbekistan 12
MA - Marocco 11
MY - Malesia 10
HU - Ungheria 9
LU - Lussemburgo 9
RO - Romania 9
CL - Cile 8
PY - Paraguay 8
SA - Arabia Saudita 8
TW - Taiwan 8
BO - Bolivia 7
AE - Emirati Arabi Uniti 6
AL - Albania 6
BG - Bulgaria 6
BY - Bielorussia 6
HN - Honduras 6
IL - Israele 6
CH - Svizzera 5
CR - Costa Rica 5
DZ - Algeria 5
NI - Nicaragua 5
NP - Nepal 5
PE - Perù 5
PS - Palestinian Territory 5
RS - Serbia 5
TN - Tunisia 5
UY - Uruguay 5
AZ - Azerbaigian 4
EG - Egitto 4
HR - Croazia 4
OM - Oman 4
QA - Qatar 4
SI - Slovenia 4
EU - Europa 3
KE - Kenya 3
LB - Libano 3
LV - Lettonia 3
MD - Moldavia 3
PA - Panama 3
PT - Portogallo 3
SN - Senegal 3
AM - Armenia 2
AO - Angola 2
BB - Barbados 2
BH - Bahrain 2
DO - Repubblica Dominicana 2
EE - Estonia 2
GE - Georgia 2
GH - Ghana 2
GR - Grecia 2
GT - Guatemala 2
IR - Iran 2
KG - Kirghizistan 2
KZ - Kazakistan 2
MN - Mongolia 2
SK - Slovacchia (Repubblica Slovacca) 2
SV - El Salvador 2
SY - Repubblica araba siriana 2
TG - Togo 2
Totale 17.001
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Città #
Singapore 846
Ashburn 753
San Jose 662
Dallas 630
Chandler 523
Dublin 501
Santa Clara 425
Parma 406
Ann Arbor 321
Hong Kong 316
Beijing 295
Ho Chi Minh City 262
Jacksonville 212
Council Bluffs 196
Boardman 191
Dearborn 176
Johannesburg 169
Los Angeles 166
Hanoi 161
New York 148
Munich 129
Shanghai 114
Hefei 101
Milan 99
Nanjing 99
Izmir 90
Lauterbourg 90
Bremen 84
Princeton 84
Bologna 72
Helsinki 71
Wilmington 65
Buffalo 59
Vienna 55
Moscow 53
São Paulo 53
Columbus 45
Da Nang 43
Shenyang 43
Toronto 43
Chicago 41
Abidjan 40
San Mateo 40
Nanchang 39
London 38
Modena 38
Brussels 37
Haiphong 37
Guangzhou 33
Tokyo 33
Jinan 32
Rome 32
Turku 32
Frankfurt am Main 31
Hebei 30
Kunming 30
The Dalles 30
Warsaw 30
Orem 29
Montreal 27
Phoenix 27
Seattle 27
Seoul 27
Woodbridge 27
Brescia 26
Chennai 26
Nuremberg 22
Pune 22
Changsha 21
Jakarta 21
Mexico City 21
Denver 20
Des Moines 20
Düsseldorf 20
Tianjin 20
Atlanta 19
Brooklyn 19
Naples 19
San Francisco 19
Stockholm 19
Fremont 18
Rio de Janeiro 18
Houston 17
Manchester 17
Belo Horizonte 16
Florence 15
Jiaxing 15
Ottawa 15
Zhengzhou 15
Amsterdam 14
Dhaka 14
Brno 13
Norwalk 13
Poplar 13
Boston 12
Lahore 12
Palermo 12
Quito 12
Amman 11
Ankara 11
Totale 10.255
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Nome #
Balancing reactivity and antitumor activity: heteroarylthioacetamide derivatives as potent and time-dependent inhibitors of EGFR 357
Targeting metabolic adaptive responses induced by glucose starvation inhibits cell proliferation and enhances cell death in osimertinib-resistant non-small cell lung cancer (NSCLC) cell lines 287
Benzisothiazolinone Derivatives as Potent Allosteric Monoacylglycerol Lipase Inhibitors That Functionally Mimic Sulfenylation of Regulatory Cysteines 284
Discovery of a new 1-(phenylsulfonyl)-1H-indole derivative targeting the EphA2 receptor with antiproliferative activity on U251 glioblastoma cell line 266
Targeting glucosylceramide synthase induces antiproliferative and proapoptotic effects in osimertinib-resistant NSCLC cell models 253
Antidepressant-like effects of pharmacological inhibition of FAAH activity in socially isolated female rats 244
Antidepressant-like activity and cardioprotective effects of fatty acid amide hydrolase inhibitor URB694 in socially stressed Wistar Kyoto rats 240
2-Aminobenzimidazoles as new potent H3-antagonists 233
Drug-gut microbiota metabolic interactions: the case of UniPR1331, selective antagonist of the Eph-ephrin system, in mice 223
Optimization of EphA2 antagonists based on a lithocholic acid core led to the identification of UniPR505, a new 3α-carbamoyloxy derivative with antiangiogenetic properties 222
Social stress-induced depressive-like symptoms and changes in gut microbial and lipidomic profiles are prevented by pharmacological inhibition of FAAH activity in male rats 221
Amino acid derivatives as palmitoylethanolamide prodrugs: Synthesis, in vitro metabolism and in vivo plasma profile in rats 221
Irreversible Inhibition of Epidermal Growth Factor Receptor Activity by 3-Aminopropanamides. 219
Metabolic Soft Spot and Pharmacokinetics: Functionalization of C-3 Position of an Eph–Ephrin Antagonist Featuring a Bile Acid Core as an Effective Strategy to Obtain Oral Bioavailability in Mice 219
Cardioprotective effects of fatty acid amide hydrolase inhibitor URB694, in a rodent model of trait anxiety 217
(2S,4R)-4-fluoroglutamine is converted into (2S,4R)-4-fluoroglutamate by glutaminase activity and may be exploited as a PET tracer in glutamine-addicted cancers 216
Dibasic biphenyl H(3) receptor antagonists: Steric tolerance for a lipophilic side chain. 214
[18F](2S,4R)-4-Fluoroglutamine as a New Positron Emission Tomography Tracer in Myeloma 214
A sulfonyl fluoride derivative inhibits EGFR L858R/T790M/C797S by covalent modification of the catalytic lysine 213
5-Benzylidene-hydantoins: synthesis and antiproliferative activity on A549 lung cancer cell line 211
Combining ligand- and structure-based approaches for the discovery of new inhibitors of the EPHA2-ephrin-A1 interaction 207
Analysis of illicit dietary supplements sold in the Italian market: Identification of a sildenafil thioderivative as adulterant using UPLC-TOF/MS and GC/MS. 201
Aminobenzimidazoles as new potent H3-antagonists 201
Synthesis, biological activity, QSAR and QSPR study of 2/aminobenzimidazole derivatives as potent H3-antagonists 200
Cell-targeted c(AmpRGD)-sunitinib molecular conjugates impair tumor growth of melanoma 199
Human colonoid-derived monolayers and Caco-2: comparative analysis of inflammatory responses 198
Novel Irreversible Epidermal Growth Factor Receptor Inhibitors by Chemical Modulation of the Cysteine-Trap Portion 197
Biphenyl-3-yl alkylcarbamates as fatty acid amide hydrolase (FAAH) inhibitors: steric effects of N-alkyl chain on rat plasma and liver stability 195
Creatine as a compatible osmolyte in muscle cells exposed to hypertonic stress 192
Discovery of novel FGF trap small molecules endowed with anti-myeloma activity 191
The Role of HB-Donor Groups in the Heterocyclic Polar Fragment of H3-Antagonists. I. Synthesis and Biological Assays 188
Functional modulation of the human gut microbiome by bacteria vehicled by cheese 187
Cognition enhancing effect in rats of a selected histamine H3 receptor antagonist with good brain penetration 183
Discovery and development of small molecules targeting Eph-ephrin system in glioblastoma: an academic history 183
A second generation of carbamate-based fatty acid amide hydrolase inhibitors with improved activity in vivo 183
Access to CNS of selected H3-antagonists: ex vivo binding study in rats 182
Steps towards sustainable solid phase peptide synthesis: use and recovery ofN-octyl pyrrolidone 178
Synthesis, Structural Elucidation, and Biological Evaluation of NSC12, an Orally Available Fibroblast Growth Factor (FGF) Ligand Trap for the Treatment of FGF-Dependent Lung Tumors 177
2-Aminooxazole as a Novel Privileged Scaffold in Antitubercular Medicinal Chemistry 173
Accepting the Invitation to Open Innovation in Malaria Drug Discovery: Synthesis, Biological Evaluation, and Investigation on the Structure-Activity Relationships of Benzo[b]thiophene-2-carboxamides as Antimalarial Agents 170
N-(Anilinoethyl)amide Melatonergic Ligands with Improved Water Solubility and Metabolic Stability 168
Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 7. Synthesis and Pharmacological Evaluation of 4-Quinolone-3-carboxamides and 4-Hydroxy-2-quinolone-3-carboxamides as High Affinity Cannabinoid Receptor 2 (CB2R) Ligands with Improved Aqueous Solubility 167
Access to CNS of selected H3-antagonists: ex vivo binding study in rats 164
Multiple approaches for the discovery and development of small molecules targeting Eph-ephrin protein-protein interaction 163
QSAR study of 2-aminobenzimidazole derivatives as H3 antagonists 162
Biochemical characterization of EphA2 antagonists with improved physico-chemical properties by cell-based assays and surface plasmon resonance analysis 161
Molecular Determinants of EphA2 and EphB2 Antagonism Enable the Design of Ligands with Improved Selectivity 159
Antioxidant and cytoprotective activity of indole derivatives related to melatonin 157
Palladium Catalyst Recycling for Heck-Cassar-Sonogashira Cross-Coupling Reactions in Green Solvent/Base Blend 157
Δ5-Cholenoyl-amino acids as selective and orally available antagonists of the Eph-ephrin system 156
Brain Pharmacokinetics of Non-Imidazole Biphenyl H3 Receptor Antagonists: a Liquid Chromatography/Electrospray-Mass Spectrometry and ex vivo Binding Study in Rats 155
Mannich base derivatives as novel EGFR irreversible inhibitors 155
Development and validation of a LC-MS method with electrospray ionization for the determination of the imidazole H(3) antagonist ROS203 in rat plasma. 155
Synthesis and 3D-QSAR Analysis of H3 Receptor Antagonists Containing a Neutral Heterocyclic Polar Group 154
2,4(5)-Diarylimidazoles as Inhibitors of hNaV1.2 Sodium Channels: Pharmacological Evaluationand Structure-Property Relationships 153
Social stress contagion in rats: Behavioural, autonomic and neuroendocrine correlates 152
N-(Anilinoethyl)amides: design and synthesis of metabolically stable, selective melatonin receptor ligands 151
Epidermal Growth Factor Receptor Irreversible Inhibitors: Chemical Exploration of the Cysteine-Trap Portion 151
N-(2-Oxo-3-oxetanyl)carbamic Acid Esters as N-Acylethanolamine Acid Amidase Inhibitors: Synthesis, Structure–Activity and Structure–Property Relationships. 151
CNS access of selected H3-antagonists: ex vivo binding study in rats 150
Substituted N-Phenyl-5-(2-(phenylamino)thiazol-4-yl)isoxazole-3-carboxamides Are Valuable Antitubercular Candidates that Evade Innate Efflux Machinery 147
Expanding the knowledge around antitubercular 5-(2-aminothiazol-4-yl)isoxazole-3-carboxamides: Hit–to–lead optimization and release of a novel antitubercular chemotype via scaffold derivatization 145
Lipoprotien(a) concentration, genetic variants, apo(a) isoform size, and cellular cholesterol efflux in patients with elevated Lp(a) and coronary heart disease submitted or not to lipoprotein apheresis: An Italian case-control multicenter study on Lp(a) 144
Synthesis and biological assays of new H3-antagonists with imidazole and imidazoline polar groups 142
Metadynamics for perspective drug design: Computationally driven synthesis of new protein-protein interaction inhibitors targeting the EphA2 receptor 142
UniPR1331, a small molecule targeting Eph/ephrin interaction, prolongs survival in glioblastoma and potentiates the effect of antiangiogenic therapy in mice 142
Indole-based analogs of melatonin: in vitro antioxidant and cytoprotective activities 141
Synthesis of Novel c(AmpRGD)−Sunitinib Dual Conjugates as Molecular Tools Targeting the αvβ3 Integrin/VEGFR2 Couple and Impairing Tumor-Associated Angiogenesis 141
Disentangling the interactions between nasopharyngeal and gut microbiome and their involvement in the modulation of COVID-19 infection 140
Design, Synthesis, and Physicochemical and Pharmacological Profiling of 7-Hydroxy-5-oxopyrazolo[4,3-b]pyridine-6-carboxamide Derivatives with Antiosteoarthritic Activity in Vivo 140
Role of sphingolipid metabolism in osimertinib-resistance in EGFR-mutated NSCLC models 139
Long-lasting inhibition of EGFR autophosphorylation in A549 tumor cells by intracellular accumulation of non-covalent inhibitors 139
Eph-ephrin antagonism in tumor angiogenesis and growth: UniPR1331 preclinical evidence. 139
Synthesis and preclinical evaluation of a novel, selective 111-In-labelled aminoproline-RGD-peptide for non-invasive melanoma tumor imaging 138
Functional and morphological characterisation of human colonoid-derived monolayers under inflammatory conditions 137
Free-energy studies reveal a possible mechanism for oxidation-dependent inhibition of MGL 137
Predicting the reactivity of nitrile-carrying compounds with cysteine: a combined computational and experimental study. 134
Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism. 132
Three-Dimensional Quantitative Structure-Activity Relationship Studies on Selected MT1 and MT2 Melatonin Receptor Ligands: Requirements for Subtype Selectivity and Intrinsic Activity Modulation 132
Anti-αVβ3 integrin peptidomimetic-Sunitinib dual conjugates as therapeutic tool for the inhibition of integrin/growth factor cross-talk in human melanoma cells. 130
Protective Activity of Melatonin Combinations and Melatonin-Based Hybrid Molecules in Neurodegenerative Diseases 126
Synthesis, antioxidant activity and structure-activity relationships for a new series of 2-(N-acylaminoethyl)indoles with melatonin-like cytoprotective activity 123
Enhancement of peripheral fatty acyl ethanolamide signaling prevents stress‑induced social avoidance and anxiety‑like behaviors in male rats 122
Investigating drug-gut microbiota interactions: reductive and hydrolytic metabolism of oral glucocorticoids by in vitro artificial gut microbiota 121
Relationship between structure and ex-vivo binding of imidazole H3 antagonists to rat brain H3 receptors 121
Structure-property relationships of a class of carbamate-based fatty acid amide hydrolase (FAAH) inhibitors: chemical and biological stability 120
Potent, Metabolically Stable 2-Alkyl-8-(2H-1,2,3-triazol-2-yl)-9H-adenines as Adenosine A2A Receptor Ligands 119
Structure-Property Relationships on Histamine H3-Antagonists: Binding of Phenyl-substituted Alkylthioimidazole Derivatives to Rat Plasma Proteins 114
The rare bile acid isoallolithocholic acid (IALCA) is an EphA2 antagonist sparing FXR and TGR5 receptors 113
Pharmacological inhibition of FAAH activity in rodents: A promising pharmacological approach for psychological-cardiac comorbidity? 113
Imidazole H3-antagonists: Relationship between Structure and Ex-vivo binding to Rat Brain H3-Receptors 113
Liquid chromatography-mass spectrometric method for determination of the non-imidazole H(3) -receptor antagonist UPR1056 in rat plasma. 111
Synthesis and Quantitative Structure-Activity Relationship of Fatty Acid Amide Hydrolase Inhibitors: Modulation at the N-Portion of Biphenyl-3-yl Alkylcarbamates. 110
The GABAB receptor positive allosteric modulator COR659: In vitro metabolism, in vivo pharmacokinetics in rats, synthesis and pharmacological characterization of metabolically protected derivatives 110
The 1,2-dichloroethane/water versus the n-octanol/water system: more about intra- or intermolecular H-bond interactions 103
Quantitative structure-property relationships of a class of carbamate-based fatty acid amide hydrolase (FAAH) inhibitors. 103
Synthesis and stability in biological media of 1H-imidazole-1-carboxylates of ROS203, an antagonist of the histamine H3 receptor. 101
Qualitative structure-metabolism relationships in the hydrolysis of carbamates 100
Synthesis and structure-activity relationships of N-(2-oxo-3-oxetanyl)amides as N-acylethanolamine-hydrolyzing acid amidase inhibitors. 98
Novel cycloAmpRGD-Sunitinib Dual Conjugates as Potent Targeted Anti-angiogenic Tools 98
Totale 16.720
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Categoria #
all - tutte 56.808
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 56.808
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022554 0 0 20 78 40 14 72 65 42 35 49 139
2022/20232.142 228 223 137 161 239 250 35 121 602 45 75 26
2023/2024959 33 48 20 31 78 197 84 66 44 84 126 148
2024/20252.919 102 146 201 219 235 291 187 159 334 292 277 476
2025/20267.033 605 729 990 673 845 407 658 225 786 537 355 223
2026/2027702 180 341 181 0 0 0 0 0 0 0 0 0
Totale 17.243