IRIS
VACONDIO, Federica
 Distribuzione geografica
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Continente #
EU - Europa 2.782
NA - Nord America 2.527
AS - Asia 817
AF - Africa 3
Continente sconosciuto - Info sul continente non disponibili 3
SA - Sud America 1
Totale 6.133
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Nazione #
US - Stati Uniti d'America 2.495
CN - Cina 648
IT - Italia 641
FI - Finlandia 497
IE - Irlanda 497
SE - Svezia 490
DE - Germania 235
UA - Ucraina 190
TR - Turchia 94
GB - Regno Unito 63
FR - Francia 44
AT - Austria 41
BE - Belgio 39
IN - India 36
CA - Canada 31
SG - Singapore 14
CZ - Repubblica Ceca 10
HK - Hong Kong 10
NL - Olanda 10
JP - Giappone 6
RO - Romania 5
VN - Vietnam 5
BG - Bulgaria 4
ES - Italia 3
EU - Europa 3
LU - Lussemburgo 3
RU - Federazione Russa 3
GH - Ghana 2
PL - Polonia 2
AE - Emirati Arabi Uniti 1
BR - Brasile 1
CH - Svizzera 1
EE - Estonia 1
EG - Egitto 1
ID - Indonesia 1
LA - Repubblica Popolare Democratica del Laos 1
LT - Lituania 1
MX - Messico 1
NO - Norvegia 1
RS - Serbia 1
TW - Taiwan 1
Totale 6.133
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Città #
Chandler 523
Dublin 491
Ann Arbor 321
Parma 241
Jacksonville 210
Dearborn 176
Ashburn 153
Beijing 132
Nanjing 96
Izmir 90
Bremen 84
Princeton 84
Wilmington 65
New York 64
Shanghai 61
Los Angeles 46
Helsinki 42
Shenyang 42
San Mateo 40
Nanchang 38
Boardman 36
Vienna 36
Jinan 32
Hebei 30
Brussels 28
Hefei 28
Kunming 28
Woodbridge 27
Guangzhou 24
Seattle 23
Toronto 22
Milan 20
Des Moines 19
Pune 19
Fremont 18
Düsseldorf 16
Brescia 15
Jiaxing 15
Changsha 14
Modena 14
Norwalk 13
Bologna 12
Prata Di Pordenone 11
Tianjin 10
Zhengzhou 10
Leuven 8
London 8
Auburn Hills 7
Hangzhou 7
Houston 7
Montegaldella 7
Redmond 7
Chengdu 6
Fairfield 6
Follonica 6
Grafing 6
Neviano degli Arduini 6
Palermo 6
Piacenza 6
Rome 6
Segrate 6
Tokyo 6
Vigevano 6
Brno 5
Falls Church 5
Haikou 5
Ottawa 5
Xian 5
Amsterdam 4
Ankara 4
Ardea 4
Dong Ket 4
Ferrara 4
Hong Kong 4
Naples 4
Paris 4
Redwood City 4
Reggio Emilia 4
Sofia 4
Soliera 4
Taizhou 4
Trento 4
Bergamo 3
Borås 3
Braunschweig 3
Caorso 3
Central 3
Diegem 3
Erba 3
Fano 3
Florence 3
Fuzhou 3
Lanzhou 3
Montreal 3
Piemonte 3
Prato 3
Rio Saliceto 3
Tappahannock 3
Washington 3
Wenzhou 3
Totale 3.771
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Nome #
Balancing reactivity and antitumor activity: heteroarylthioacetamide derivatives as potent and time-dependent inhibitors of EGFR 194
Benzisothiazolinone Derivatives as Potent Allosteric Monoacylglycerol Lipase Inhibitors That Functionally Mimic Sulfenylation of Regulatory Cysteines 129
Analysis of illicit dietary supplements sold in the Italian market: Identification of a sildenafil thioderivative as adulterant using UPLC-TOF/MS and GC/MS. 117
Optimization of EphA2 antagonists based on a lithocholic acid core led to the identification of UniPR505, a new 3α-carbamoyloxy derivative with antiangiogenetic properties 114
2-Aminobenzimidazoles as new potent H3-antagonists 110
Dibasic biphenyl H(3) receptor antagonists: Steric tolerance for a lipophilic side chain. 104
Cell-targeted c(AmpRGD)-sunitinib molecular conjugates impair tumor growth of melanoma 101
Irreversible Inhibition of Epidermal Growth Factor Receptor Activity by 3-Aminopropanamides. 99
Combining ligand- and structure-based approaches for the discovery of new inhibitors of the EPHA2-ephrin-A1 interaction 96
Metabolic Soft Spot and Pharmacokinetics: Functionalization of C-3 Position of an Eph–Ephrin Antagonist Featuring a Bile Acid Core as an Effective Strategy to Obtain Oral Bioavailability in Mice 96
Drug-gut microbiota metabolic interactions: the case of UniPR1331, selective antagonist of the Eph-ephrin system, in mice 95
Amino acid derivatives as palmitoylethanolamide prodrugs: Synthesis, in vitro metabolism and in vivo plasma profile in rats 92
The Role of HB-Donor Groups in the Heterocyclic Polar Fragment of H3-Antagonists. I. Synthesis and Biological Assays 92
Antidepressant-like activity and cardioprotective effects of fatty acid amide hydrolase inhibitor URB694 in socially stressed Wistar Kyoto rats 91
Synthesis and 3D-QSAR Analysis of H3 Receptor Antagonists Containing a Neutral Heterocyclic Polar Group 90
Antidepressant-like effects of pharmacological inhibition of FAAH activity in socially isolated female rats 90
QSAR study of 2-aminobenzimidazole derivatives as H3 antagonists 88
Access to CNS of selected H3-antagonists: ex vivo binding study in rats 87
Novel Irreversible Epidermal Growth Factor Receptor Inhibitors by Chemical Modulation of the Cysteine-Trap Portion 85
Cardioprotective effects of fatty acid amide hydrolase inhibitor URB694, in a rodent model of trait anxiety 85
Biphenyl-3-yl alkylcarbamates as fatty acid amide hydrolase (FAAH) inhibitors: steric effects of N-alkyl chain on rat plasma and liver stability 84
Aminobenzimidazoles as new potent H3-antagonists 84
Cognition enhancing effect in rats of a selected histamine H3 receptor antagonist with good brain penetration 83
Synthesis and biological assays of new H3-antagonists with imidazole and imidazoline polar groups 83
5-Benzylidene-hydantoins: synthesis and antiproliferative activity on A549 lung cancer cell line 81
Discovery and development of small molecules targeting Eph-ephrin system in glioblastoma: an academic history 79
CNS access of selected H3-antagonists: ex vivo binding study in rats 77
Eph-ephrin antagonism in tumor angiogenesis and growth: UniPR1331 preclinical evidence. 77
Multiple approaches for the discovery and development of small molecules targeting Eph-ephrin protein-protein interaction 74
Creatine as a compatible osmolyte in muscle cells exposed to hypertonic stress 73
UniPR1331, a small molecule targeting Eph/ephrin interaction, prolongs survival in glioblastoma and potentiates the effect of antiangiogenic therapy in mice 73
Synthesis, biological activity, QSAR and QSPR study of 2/aminobenzimidazole derivatives as potent H3-antagonists 72
Metadynamics for perspective drug design: Computationally driven synthesis of new protein-protein interaction inhibitors targeting the EphA2 receptor 72
Antioxidant and cytoprotective activity of indole derivatives related to melatonin 71
Access to CNS of selected H3-antagonists: ex vivo binding study in rats 71
N-(Anilinoethyl)amides: design and synthesis of metabolically stable, selective melatonin receptor ligands 69
(2S,4R)-4-fluoroglutamine is converted into (2S,4R)-4-fluoroglutamate by glutaminase activity and may be exploited as a PET tracer in glutamine-addicted cancers 69
N-(2-Oxo-3-oxetanyl)carbamic Acid Esters as N-Acylethanolamine Acid Amidase Inhibitors: Synthesis, Structure–Activity and Structure–Property Relationships. 68
A sulfonyl fluoride derivative inhibits EGFR L858R/T790M/C797S by covalent modification of the catalytic lysine 68
Predicting the reactivity of nitrile-carrying compounds with cysteine: a combined computational and experimental study. 67
Synthesis, Structural Elucidation, and Biological Evaluation of NSC12, an Orally Available Fibroblast Growth Factor (FGF) Ligand Trap for the Treatment of FGF-Dependent Lung Tumors 67
Indole-based analogs of melatonin: in vitro antioxidant and cytoprotective activities 66
Structure-Property Relationships on Histamine H3-Antagonists: Binding of Phenyl-substituted Alkylthioimidazole Derivatives to Rat Plasma Proteins 66
A second generation of carbamate-based fatty acid amide hydrolase inhibitors with improved activity in vivo 65
Imidazole H3-antagonists: Relationship between Structure and Ex-vivo binding to Rat Brain H3-Receptors 65
Relationship between structure and ex-vivo binding of imidazole H3 antagonists to rat brain H3 receptors 64
Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 7. Synthesis and Pharmacological Evaluation of 4-Quinolone-3-carboxamides and 4-Hydroxy-2-quinolone-3-carboxamides as High Affinity Cannabinoid Receptor 2 (CB2R) Ligands with Improved Aqueous Solubility 64
Brain Pharmacokinetics of Non-Imidazole Biphenyl H3 Receptor Antagonists: a Liquid Chromatography/Electrospray-Mass Spectrometry and ex vivo Binding Study in Rats 63
Development and validation of a LC-MS method with electrospray ionization for the determination of the imidazole H(3) antagonist ROS203 in rat plasma. 63
Biochemical characterization of EphA2 antagonists with improved physico-chemical properties by cell-based assays and surface plasmon resonance analysis 63
Epidermal Growth Factor Receptor Irreversible Inhibitors: Chemical Exploration of the Cysteine-Trap Portion 62
Synthesis and preclinical evaluation of a novel, selective 111-In-labelled aminoproline-RGD-peptide for non-invasive melanoma tumor imaging 62
Three-Dimensional Quantitative Structure-Activity Relationship Studies on Selected MT1 and MT2 Melatonin Receptor Ligands: Requirements for Subtype Selectivity and Intrinsic Activity Modulation 61
Δ5-Cholenoyl-amino acids as selective and orally available antagonists of the Eph-ephrin system 61
Lipoprotien(a) concentration, genetic variants, apo(a) isoform size, and cellular cholesterol efflux in patients with elevated Lp(a) and coronary heart disease submitted or not to lipoprotein apheresis: An Italian case-control multicenter study on Lp(a) 61
Palladium Catalyst Recycling for Heck-Cassar-Sonogashira Cross-Coupling Reactions in Green Solvent/Base Blend 61
Synthesis, antioxidant activity and structure-activity relationships for a new series of 2-(N-acylaminoethyl)indoles with melatonin-like cytoprotective activity 60
N-(Anilinoethyl)amide Melatonergic Ligands with Improved Water Solubility and Metabolic Stability 60
[18F](2S,4R)-4-Fluoroglutamine as a New Positron Emission Tomography Tracer in Myeloma 59
Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism. 58
Liquid chromatography-mass spectrometric method for determination of the non-imidazole H(3) -receptor antagonist UPR1056 in rat plasma. 58
Accepting the Invitation to Open Innovation in Malaria Drug Discovery: Synthesis, Biological Evaluation, and Investigation on the Structure-Activity Relationships of Benzo[b]thiophene-2-carboxamides as Antimalarial Agents 55
Anti-αVβ3 integrin peptidomimetic-Sunitinib dual conjugates as therapeutic tool for the inhibition of integrin/growth factor cross-talk in human melanoma cells. 55
Steps towards sustainable solid phase peptide synthesis: use and recovery ofN-octyl pyrrolidone 54
2,4(5)-Diarylimidazoles as Inhibitors of hNaV1.2 Sodium Channels: Pharmacological Evaluationand Structure-Property Relationships 53
Quantitative structure-property relationships of a class of carbamate-based fatty acid amide hydrolase (FAAH) inhibitors. 53
Substituted N-Phenyl-5-(2-(phenylamino)thiazol-4-yl)isoxazole-3-carboxamides Are Valuable Antitubercular Candidates that Evade Innate Efflux Machinery 52
Synthesis and stability in biological media of 1H-imidazole-1-carboxylates of ROS203, an antagonist of the histamine H3 receptor. 51
Design, Synthesis, and Physicochemical and Pharmacological Profiling of 7-Hydroxy-5-oxopyrazolo[4,3-b]pyridine-6-carboxamide Derivatives with Antiosteoarthritic Activity in Vivo 50
Structure-property relationships of a class of carbamate-based fatty acid amide hydrolase (FAAH) inhibitors: chemical and biological stability 49
Mannich base derivatives as novel EGFR irreversible inhibitors 49
Synthesis of Novel c(AmpRGD)−Sunitinib Dual Conjugates as Molecular Tools Targeting the αvβ3 Integrin/VEGFR2 Couple and Impairing Tumor-Associated Angiogenesis 49
The 1,2-dichloroethane/water versus the n-octanol/water system: more about intra- or intermolecular H-bond interactions 49
Long-lasting inhibition of EGFR autophosphorylation in A549 tumor cells by intracellular accumulation of non-covalent inhibitors 49
In vitro and in vivo efficacy of an orally bioavailable antagonist of Eph-ephrin system in tumor angiogenesis and growth 49
Role of sphingolipid metabolism in osimertinib-resistance in EGFR-mutated NSCLC models 48
Free-energy studies reveal a possible mechanism for oxidation-dependent inhibition of MGL 48
Synthesis and Quantitative Structure-Activity Relationship of Fatty Acid Amide Hydrolase Inhibitors: Modulation at the N-Portion of Biphenyl-3-yl Alkylcarbamates. 48
Qualitative structure-metabolism relationships in the hydrolysis of carbamates 47
Social stress contagion in rats: Behavioural, autonomic and neuroendocrine correlates 45
Pharmacological inhibition of FAAH activity in rodents: A promising pharmacological approach for psychological-cardiac comorbidity? 44
Potent, Metabolically Stable 2-Alkyl-8-(2H-1,2,3-triazol-2-yl)-9H-adenines as Adenosine A2A Receptor Ligands 43
Peroxide-Dependent MGL Sulfenylation Regulates 2-AG-Mediated Endocannabinoid Signaling in Brain Neurons 42
2-Aminooxazole as a Novel Privileged Scaffold in Antitubercular Medicinal Chemistry 39
The GABAB receptor positive allosteric modulator COR659: In vitro metabolism, in vivo pharmacokinetics in rats, synthesis and pharmacological characterization of metabolically protected derivatives 37
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Novel cycloAmpRGD-Sunitinib Dual Conjugates as Potent Targeted Anti-angiogenic Tools 36
On the selection of an opioid for local skin analgesia: Structure-skin permeability relationships 35
Synthesis and structure-activity relationships of N-(2-oxo-3-oxetanyl)amides as N-acylethanolamine-hydrolyzing acid amidase inhibitors. 35
Social stress-induced depressive-like symptoms and changes in gut microbial and lipidomic profiles are prevented by pharmacological inhibition of FAAH activity in male rats 31
Combined targeting of fatty acid amide hydrolase and melatonin receptors promotes neuroprotection and stimulates inflammation resolution in rats 28
pH-partition profiles of 4-(3-oxo-1,2-benzisothiazolin-2-yl)phenyl and phenoxyalkanoic acids 24
Disentangling the interactions between nasopharyngeal and gut microbiome and their involvement in the modulation of COVID-19 infection 18
Expanding the knowledge around antitubercular 5-(2-aminothiazol-4-yl)isoxazole-3-carboxamides: Hit–to–lead optimization and release of a novel antitubercular chemotype via scaffold derivatization 17
Enhancement of peripheral fatty acyl ethanolamide signaling prevents stress‑induced social avoidance and anxiety‑like behaviors in male rats 17
Molecular Determinants of EphA2 and EphB2 Antagonism Enable the Design of Ligands with Improved Selectivity 16
Targeting metabolic adaptive responses induced by glucose starvation inhibits cell proliferation and enhances cell death in osimertinib-resistant non-small cell lung cancer (NSCLC) cell lines 8
Targeting glucosylceramide synthase induces antiproliferative and proapoptotic effects in osimertinib-resistant NSCLC cell models 5
Systematic Modification of the Substitution Pattern of the 7-Hydroxy-5-oxopyrazolo[4,3-b]pyridine-6-carboxamide Scaffold Enabled the Discovery of New Ligands with High Affinity and Selectivity for the Cannabinoid Type 2 Receptor 2
Totale 6.325
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Categoria #
all - tutte 20.142
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 20.142
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/2019119 0 0 0 0 0 0 0 0 0 0 115 4
2019/20201.126 182 166 57 24 83 140 148 25 101 94 38 68
2020/2021680 13 57 65 47 76 38 94 36 113 31 74 36
2021/2022602 20 28 20 78 40 14 72 65 42 35 49 139
2022/20232.142 228 223 137 161 239 250 35 121 602 45 75 26
2023/2024695 33 48 20 31 78 197 84 66 44 84 10 0
Totale 6.325