IRIS
VACONDIO, Federica
 Distribuzione geografica
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Continente #
NA - Nord America 4.998
EU - Europa 4.086
AS - Asia 3.600
SA - Sud America 588
AF - Africa 189
Continente sconosciuto - Info sul continente non disponibili 4
AN - Antartide 1
Totale 13.466
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Nazione #
US - Stati Uniti d'America 4.865
SG - Singapore 1.504
CN - Cina 1.190
IT - Italia 1.142
FI - Finlandia 549
SE - Svezia 511
IE - Irlanda 503
BR - Brasile 481
DE - Germania 427
HK - Hong Kong 285
VN - Vietnam 231
UA - Ucraina 200
GB - Regno Unito 149
NL - Olanda 137
ZA - Sudafrica 125
RU - Federazione Russa 112
TR - Turchia 109
IN - India 92
FR - Francia 86
CA - Canada 82
AT - Austria 66
BE - Belgio 50
CI - Costa d'Avorio 40
AR - Argentina 38
MX - Messico 38
PL - Polonia 36
BD - Bangladesh 35
CZ - Repubblica Ceca 30
KR - Corea 30
JP - Giappone 28
ID - Indonesia 25
EC - Ecuador 24
ES - Italia 22
LT - Lituania 13
IQ - Iraq 12
VE - Venezuela 12
PK - Pakistan 11
CO - Colombia 10
LU - Lussemburgo 9
MA - Marocco 8
RO - Romania 8
PY - Paraguay 7
UZ - Uzbekistan 7
AE - Emirati Arabi Uniti 5
BG - Bulgaria 5
BO - Bolivia 5
BY - Bielorussia 5
JO - Giordania 5
AZ - Azerbaigian 4
CH - Svizzera 4
CL - Cile 4
EG - Egitto 4
HU - Ungheria 4
PE - Perù 4
EU - Europa 3
HN - Honduras 3
IL - Israele 3
NI - Nicaragua 3
NP - Nepal 3
PS - Palestinian Territory 3
PT - Portogallo 3
SA - Arabia Saudita 3
SN - Senegal 3
UY - Uruguay 3
AL - Albania 2
AO - Angola 2
DO - Repubblica Dominicana 2
DZ - Algeria 2
EE - Estonia 2
GH - Ghana 2
IR - Iran 2
KZ - Kazakistan 2
LB - Libano 2
LV - Lettonia 2
MD - Moldavia 2
RS - Serbia 2
SK - Slovacchia (Repubblica Slovacca) 2
TN - Tunisia 2
AM - Armenia 1
AQ - Antartide 1
BB - Barbados 1
CR - Costa Rica 1
CY - Cipro 1
DM - Dominica 1
GR - Grecia 1
HR - Croazia 1
KE - Kenya 1
KG - Kirghizistan 1
LA - Repubblica Popolare Democratica del Laos 1
MY - Malesia 1
NO - Norvegia 1
OM - Oman 1
PA - Panama 1
SV - El Salvador 1
SY - Repubblica araba siriana 1
TJ - Tagikistan 1
TW - Taiwan 1
XK - ???statistics.table.value.countryCode.XK??? 1
Totale 13.466
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Città #
Singapore 763
Ashburn 642
Dallas 619
Chandler 523
Dublin 497
Parma 375
Ann Arbor 321
Santa Clara 308
Beijing 281
Hong Kong 275
Jacksonville 210
Boardman 179
Dearborn 176
Los Angeles 129
Munich 126
Johannesburg 119
Shanghai 113
New York 111
Hefei 101
Nanjing 99
Ho Chi Minh City 98
Izmir 90
Bremen 84
Princeton 84
Milan 75
Wilmington 65
Helsinki 63
Vienna 55
Bologna 54
Moscow 53
São Paulo 50
Columbus 43
Shenyang 43
Buffalo 41
Abidjan 40
San Mateo 40
Hanoi 39
Nanchang 39
Brussels 37
Toronto 37
Modena 36
London 34
Guangzhou 32
Jinan 32
Council Bluffs 30
Hebei 30
Turku 30
Kunming 29
Warsaw 28
Seoul 27
The Dalles 27
Tokyo 27
Woodbridge 27
Chicago 26
Seattle 26
Brescia 24
Frankfurt am Main 23
Chennai 22
Nuremberg 22
Changsha 21
Jakarta 21
Pune 21
Des Moines 20
Düsseldorf 20
Tianjin 20
Montreal 19
San Jose 19
Stockholm 19
Brooklyn 18
Denver 18
Fremont 18
Orem 18
Phoenix 18
Houston 17
Belo Horizonte 16
San Francisco 16
Haiphong 15
Jiaxing 15
Manchester 15
Zhengzhou 15
Amsterdam 14
Da Nang 14
Ottawa 14
Rio de Janeiro 14
Brno 13
Mexico City 13
Norwalk 13
Atlanta 12
Florence 12
Poplar 12
Ankara 11
Boston 11
Prata Di Pordenone 11
Quito 11
Bengaluru 10
Dhaka 10
Marseille 10
Querétaro 10
Reggio Emilia 10
Rome 10
Totale 8.243
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Nome #
Balancing reactivity and antitumor activity: heteroarylthioacetamide derivatives as potent and time-dependent inhibitors of EGFR 313
Benzisothiazolinone Derivatives as Potent Allosteric Monoacylglycerol Lipase Inhibitors That Functionally Mimic Sulfenylation of Regulatory Cysteines 239
Targeting metabolic adaptive responses induced by glucose starvation inhibits cell proliferation and enhances cell death in osimertinib-resistant non-small cell lung cancer (NSCLC) cell lines 222
Targeting glucosylceramide synthase induces antiproliferative and proapoptotic effects in osimertinib-resistant NSCLC cell models 204
Antidepressant-like activity and cardioprotective effects of fatty acid amide hydrolase inhibitor URB694 in socially stressed Wistar Kyoto rats 204
Discovery of a new 1-(phenylsulfonyl)-1H-indole derivative targeting the EphA2 receptor with antiproliferative activity on U251 glioblastoma cell line 198
2-Aminobenzimidazoles as new potent H3-antagonists 197
Irreversible Inhibition of Epidermal Growth Factor Receptor Activity by 3-Aminopropanamides. 192
Antidepressant-like effects of pharmacological inhibition of FAAH activity in socially isolated female rats 191
Social stress-induced depressive-like symptoms and changes in gut microbial and lipidomic profiles are prevented by pharmacological inhibition of FAAH activity in male rats 190
Optimization of EphA2 antagonists based on a lithocholic acid core led to the identification of UniPR505, a new 3α-carbamoyloxy derivative with antiangiogenetic properties 190
Dibasic biphenyl H(3) receptor antagonists: Steric tolerance for a lipophilic side chain. 187
Drug-gut microbiota metabolic interactions: the case of UniPR1331, selective antagonist of the Eph-ephrin system, in mice 185
Analysis of illicit dietary supplements sold in the Italian market: Identification of a sildenafil thioderivative as adulterant using UPLC-TOF/MS and GC/MS. 183
Amino acid derivatives as palmitoylethanolamide prodrugs: Synthesis, in vitro metabolism and in vivo plasma profile in rats 172
Aminobenzimidazoles as new potent H3-antagonists 172
(2S,4R)-4-fluoroglutamine is converted into (2S,4R)-4-fluoroglutamate by glutaminase activity and may be exploited as a PET tracer in glutamine-addicted cancers 171
Combining ligand- and structure-based approaches for the discovery of new inhibitors of the EPHA2-ephrin-A1 interaction 167
Cardioprotective effects of fatty acid amide hydrolase inhibitor URB694, in a rodent model of trait anxiety 164
Cell-targeted c(AmpRGD)-sunitinib molecular conjugates impair tumor growth of melanoma 164
5-Benzylidene-hydantoins: synthesis and antiproliferative activity on A549 lung cancer cell line 163
Synthesis, biological activity, QSAR and QSPR study of 2/aminobenzimidazole derivatives as potent H3-antagonists 162
[18F](2S,4R)-4-Fluoroglutamine as a New Positron Emission Tomography Tracer in Myeloma 161
A sulfonyl fluoride derivative inhibits EGFR L858R/T790M/C797S by covalent modification of the catalytic lysine 160
Novel Irreversible Epidermal Growth Factor Receptor Inhibitors by Chemical Modulation of the Cysteine-Trap Portion 159
Metabolic Soft Spot and Pharmacokinetics: Functionalization of C-3 Position of an Eph–Ephrin Antagonist Featuring a Bile Acid Core as an Effective Strategy to Obtain Oral Bioavailability in Mice 156
Biphenyl-3-yl alkylcarbamates as fatty acid amide hydrolase (FAAH) inhibitors: steric effects of N-alkyl chain on rat plasma and liver stability 154
Cognition enhancing effect in rats of a selected histamine H3 receptor antagonist with good brain penetration 151
The Role of HB-Donor Groups in the Heterocyclic Polar Fragment of H3-Antagonists. I. Synthesis and Biological Assays 151
A second generation of carbamate-based fatty acid amide hydrolase inhibitors with improved activity in vivo 151
Creatine as a compatible osmolyte in muscle cells exposed to hypertonic stress 150
Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 7. Synthesis and Pharmacological Evaluation of 4-Quinolone-3-carboxamides and 4-Hydroxy-2-quinolone-3-carboxamides as High Affinity Cannabinoid Receptor 2 (CB2R) Ligands with Improved Aqueous Solubility 150
Synthesis, Structural Elucidation, and Biological Evaluation of NSC12, an Orally Available Fibroblast Growth Factor (FGF) Ligand Trap for the Treatment of FGF-Dependent Lung Tumors 145
Access to CNS of selected H3-antagonists: ex vivo binding study in rats 144
Discovery of novel FGF trap small molecules endowed with anti-myeloma activity 141
Discovery and development of small molecules targeting Eph-ephrin system in glioblastoma: an academic history 137
QSAR study of 2-aminobenzimidazole derivatives as H3 antagonists 137
2-Aminooxazole as a Novel Privileged Scaffold in Antitubercular Medicinal Chemistry 136
Synthesis and 3D-QSAR Analysis of H3 Receptor Antagonists Containing a Neutral Heterocyclic Polar Group 135
Multiple approaches for the discovery and development of small molecules targeting Eph-ephrin protein-protein interaction 134
Access to CNS of selected H3-antagonists: ex vivo binding study in rats 133
Accepting the Invitation to Open Innovation in Malaria Drug Discovery: Synthesis, Biological Evaluation, and Investigation on the Structure-Activity Relationships of Benzo[b]thiophene-2-carboxamides as Antimalarial Agents 133
N-(Anilinoethyl)amide Melatonergic Ligands with Improved Water Solubility and Metabolic Stability 132
Steps towards sustainable solid phase peptide synthesis: use and recovery ofN-octyl pyrrolidone 132
Functional modulation of the human gut microbiome by bacteria vehicled by cheese 131
Δ5-Cholenoyl-amino acids as selective and orally available antagonists of the Eph-ephrin system 130
Palladium Catalyst Recycling for Heck-Cassar-Sonogashira Cross-Coupling Reactions in Green Solvent/Base Blend 130
Epidermal Growth Factor Receptor Irreversible Inhibitors: Chemical Exploration of the Cysteine-Trap Portion 129
Development and validation of a LC-MS method with electrospray ionization for the determination of the imidazole H(3) antagonist ROS203 in rat plasma. 128
CNS access of selected H3-antagonists: ex vivo binding study in rats 127
Mannich base derivatives as novel EGFR irreversible inhibitors 127
Antioxidant and cytoprotective activity of indole derivatives related to melatonin 127
Biochemical characterization of EphA2 antagonists with improved physico-chemical properties by cell-based assays and surface plasmon resonance analysis 127
Substituted N-Phenyl-5-(2-(phenylamino)thiazol-4-yl)isoxazole-3-carboxamides Are Valuable Antitubercular Candidates that Evade Innate Efflux Machinery 125
Human colonoid-derived monolayers and Caco-2: comparative analysis of inflammatory responses 123
N-(Anilinoethyl)amides: design and synthesis of metabolically stable, selective melatonin receptor ligands 122
UniPR1331, a small molecule targeting Eph/ephrin interaction, prolongs survival in glioblastoma and potentiates the effect of antiangiogenic therapy in mice 122
Design, Synthesis, and Physicochemical and Pharmacological Profiling of 7-Hydroxy-5-oxopyrazolo[4,3-b]pyridine-6-carboxamide Derivatives with Antiosteoarthritic Activity in Vivo 120
Synthesis and biological assays of new H3-antagonists with imidazole and imidazoline polar groups 120
Molecular Determinants of EphA2 and EphB2 Antagonism Enable the Design of Ligands with Improved Selectivity 119
Brain Pharmacokinetics of Non-Imidazole Biphenyl H3 Receptor Antagonists: a Liquid Chromatography/Electrospray-Mass Spectrometry and ex vivo Binding Study in Rats 119
Metadynamics for perspective drug design: Computationally driven synthesis of new protein-protein interaction inhibitors targeting the EphA2 receptor 118
Eph-ephrin antagonism in tumor angiogenesis and growth: UniPR1331 preclinical evidence. 118
Role of sphingolipid metabolism in osimertinib-resistance in EGFR-mutated NSCLC models 116
2,4(5)-Diarylimidazoles as Inhibitors of hNaV1.2 Sodium Channels: Pharmacological Evaluationand Structure-Property Relationships 116
N-(2-Oxo-3-oxetanyl)carbamic Acid Esters as N-Acylethanolamine Acid Amidase Inhibitors: Synthesis, Structure–Activity and Structure–Property Relationships. 116
Predicting the reactivity of nitrile-carrying compounds with cysteine: a combined computational and experimental study. 116
Lipoprotien(a) concentration, genetic variants, apo(a) isoform size, and cellular cholesterol efflux in patients with elevated Lp(a) and coronary heart disease submitted or not to lipoprotein apheresis: An Italian case-control multicenter study on Lp(a) 116
Indole-based analogs of melatonin: in vitro antioxidant and cytoprotective activities 114
Long-lasting inhibition of EGFR autophosphorylation in A549 tumor cells by intracellular accumulation of non-covalent inhibitors 114
Synthesis and preclinical evaluation of a novel, selective 111-In-labelled aminoproline-RGD-peptide for non-invasive melanoma tumor imaging 114
Expanding the knowledge around antitubercular 5-(2-aminothiazol-4-yl)isoxazole-3-carboxamides: Hit–to–lead optimization and release of a novel antitubercular chemotype via scaffold derivatization 113
Social stress contagion in rats: Behavioural, autonomic and neuroendocrine correlates 113
Free-energy studies reveal a possible mechanism for oxidation-dependent inhibition of MGL 111
Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism. 110
Synthesis of Novel c(AmpRGD)−Sunitinib Dual Conjugates as Molecular Tools Targeting the αvβ3 Integrin/VEGFR2 Couple and Impairing Tumor-Associated Angiogenesis 108
Synthesis, antioxidant activity and structure-activity relationships for a new series of 2-(N-acylaminoethyl)indoles with melatonin-like cytoprotective activity 108
Anti-αVβ3 integrin peptidomimetic-Sunitinib dual conjugates as therapeutic tool for the inhibition of integrin/growth factor cross-talk in human melanoma cells. 108
Three-Dimensional Quantitative Structure-Activity Relationship Studies on Selected MT1 and MT2 Melatonin Receptor Ligands: Requirements for Subtype Selectivity and Intrinsic Activity Modulation 106
Relationship between structure and ex-vivo binding of imidazole H3 antagonists to rat brain H3 receptors 104
Structure-property relationships of a class of carbamate-based fatty acid amide hydrolase (FAAH) inhibitors: chemical and biological stability 104
Disentangling the interactions between nasopharyngeal and gut microbiome and their involvement in the modulation of COVID-19 infection 103
Potent, Metabolically Stable 2-Alkyl-8-(2H-1,2,3-triazol-2-yl)-9H-adenines as Adenosine A2A Receptor Ligands 103
Structure-Property Relationships on Histamine H3-Antagonists: Binding of Phenyl-substituted Alkylthioimidazole Derivatives to Rat Plasma Proteins 98
Liquid chromatography-mass spectrometric method for determination of the non-imidazole H(3) -receptor antagonist UPR1056 in rat plasma. 96
Imidazole H3-antagonists: Relationship between Structure and Ex-vivo binding to Rat Brain H3-Receptors 95
Pharmacological inhibition of FAAH activity in rodents: A promising pharmacological approach for psychological-cardiac comorbidity? 93
The 1,2-dichloroethane/water versus the n-octanol/water system: more about intra- or intermolecular H-bond interactions 87
Synthesis and stability in biological media of 1H-imidazole-1-carboxylates of ROS203, an antagonist of the histamine H3 receptor. 87
Enhancement of peripheral fatty acyl ethanolamide signaling prevents stress‑induced social avoidance and anxiety‑like behaviors in male rats 86
Investigating drug-gut microbiota interactions: reductive and hydrolytic metabolism of oral glucocorticoids by in vitro artificial gut microbiota 84
Quantitative structure-property relationships of a class of carbamate-based fatty acid amide hydrolase (FAAH) inhibitors. 84
The GABAB receptor positive allosteric modulator COR659: In vitro metabolism, in vivo pharmacokinetics in rats, synthesis and pharmacological characterization of metabolically protected derivatives 84
Qualitative structure-metabolism relationships in the hydrolysis of carbamates 81
Synthesis and Quantitative Structure-Activity Relationship of Fatty Acid Amide Hydrolase Inhibitors: Modulation at the N-Portion of Biphenyl-3-yl Alkylcarbamates. 81
Novel cycloAmpRGD-Sunitinib Dual Conjugates as Potent Targeted Anti-angiogenic Tools 81
In vitro and in vivo efficacy of an orally bioavailable antagonist of Eph-ephrin system in tumor angiogenesis and growth 78
On the selection of an opioid for local skin analgesia: Structure-skin permeability relationships 74
Peroxide-Dependent MGL Sulfenylation Regulates 2-AG-Mediated Endocannabinoid Signaling in Brain Neurons 71
Synthesis and structure-activity relationships of N-(2-oxo-3-oxetanyl)amides as N-acylethanolamine-hydrolyzing acid amidase inhibitors. 69
Totale 13.416
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Categoria #
all - tutte 46.624
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 46.624
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021422 0 0 0 0 0 38 94 36 113 31 74 36
2021/2022602 20 28 20 78 40 14 72 65 42 35 49 139
2022/20232.142 228 223 137 161 239 250 35 121 602 45 75 26
2023/2024959 33 48 20 31 78 197 84 66 44 84 126 148
2024/20252.919 102 146 201 219 235 291 187 159 334 292 277 476
2025/20264.176 605 729 990 673 845 334 0 0 0 0 0 0
Totale 13.684