A computational reference for human genomics analysis in (poly)phenol research

: (Poly)phenols are bioactive compounds found in plant-based food. They have been associated with numerous health-promoting features. To date, several research studies are investigating their contribution to human health and disease by applying different omics techniques. However, a standard reference for human genomics investigation is missing, limiting the current understanding and knowledge on the impact of (poly)phenols on humans when using omics approaches. In this study, we present a computational functional investigation of 121 candidate human genes involved in (poly)phenol absorption, distribution, metabolism, and excretion to propose a standard reference for genomics analyses in personalised nutrition and health research. Starting from genomics information, this reference framework includes gene networks, exploring their functional consequences and favouring the understanding of protein-protein interactions, thus paving the way for future multi-omics approaches.