Collated observations from several epidemiological studies have demonstrated that dietary intake of (poly)phenols from nuts, coffee, cocoa, grapes, and berries may protect against the development of atherosclerosis. Whereas this beneficial activity has previously been linked mainly to antioxidant or anti-inflammatory properties, recently emerging data suggest mechanisms by which (poly)phenolic substances can modulate cellular lipid metabolism, thereby mitigating atherosclerotic plaque formation. In this review, both experimental studies and clinical trials investigating the atheroprotective effects of the most relevant dietary (poly)phenols are critically discussed.
Atheroprotective effects of (poly)phenols: focus on cell cholesterol metabolism / Zanotti, Ilaria; Dall'Asta, Margherita; MENA PARRENO, Pedro Miguel; Mele, Laura; Bruni, Renato; Sumantra, Ray; DEL RIO, Daniele. - In: FOOD & FUNCTION. - ISSN 2042-6496. - 6:1(2015), pp. 13-31. [10.1039/C4FO00670D]
Atheroprotective effects of (poly)phenols: focus on cell cholesterol metabolism
ZANOTTI, Ilaria;DALL'ASTA, Margherita;MENA PARRENO, Pedro Miguel;MELE, Laura;BRUNI, Renato;DEL RIO, Daniele
2015-01-01
Abstract
Collated observations from several epidemiological studies have demonstrated that dietary intake of (poly)phenols from nuts, coffee, cocoa, grapes, and berries may protect against the development of atherosclerosis. Whereas this beneficial activity has previously been linked mainly to antioxidant or anti-inflammatory properties, recently emerging data suggest mechanisms by which (poly)phenolic substances can modulate cellular lipid metabolism, thereby mitigating atherosclerotic plaque formation. In this review, both experimental studies and clinical trials investigating the atheroprotective effects of the most relevant dietary (poly)phenols are critically discussed.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
