Sfoglia per Autore
HIV-1 RT Inhibitors with a Novel Mechanism of Action: NNRTIs that Compete with the Nucleotide Substrate
2010-01-01 Giovanni, Maga; Radi, Marco; Marie Aline, Gerard; Maurizio, Botta; Eric, Ennifar
Design and Synthesis of Thiadiazoles and Thiazoles Targeting the Bcr-Abl T315I Mutant: from Docking False Positives to ATP-Noncompetitive Inhibitors
2010-01-01 Radi, Marco; Emmanuele, Crespan; Federico, Falchi; Vincenzo, Bernardo; Samantha, Zanoli; Fabrizio, Manetti; Silvia, Schenone; Giovanni, Maga; Maurizio, Botta
Toward the Discovery of Novel Anti-HIV Drugs. Second-Generation Inhibitors of the Cellular ATPase DDX3 with Improved Anti-HIV Activity: Synthesis, Structure-Activity Relationship Analysis, Cytotoxicity Studies, and Target Validation
2011-01-01 Giovanni, Maga; Federico, Falchi; Radi, Marco; Lorenzo, Botta; Gianni, Casaluce; Martina, Bernardini; Hamid, Irannejad; Fabrizio, Manetti; Anna, Garbelli; Alberta, Samuele; Samantha, Zanoli; José A., Esté; Emmanuel, Gonzalez; Elisa, Zucca; Stefania, Paolucci; Fausto, Baldanti; Jan, De rijck; Zeger, Debyser; Maurizio, Botta
Identification of Potent c-Src Inhibitors Strongly Affecting the Proliferation of Human Neuroblastoma Cells
2011-01-01 Radi, Marco; Chiara, Brullo; Emmanuele, Crespan; Cristina, Tintori; Francesca, Musumeci; Mariangela, Biava; Silvia, Schenone; Elena, Dreassi; Claudio, Zamperini; Giovanni, Maga; Dafne, Pagano; Adriano, Angelucci; Mauro, Bologna; Maurizio, Botta
Design, Synthesis, Biological Activity, and ADME Properties of Pyrazolo[3,4-d]pyrimidines Active in Hypoxic Human Leukemia Cells: A Lead Optimization Study
2011-01-01 Radi, Marco; Elena, Dreassi; Chiara, Brullo; Emmanuele, Crespan; Cristina, Tintori; Vincenzo, Bernardo; Massimo, Valoti; Claudio, Zamperini; Henry, Daigl; Francesca, Musumeci; Fabio, Carraro; Antonella, Naldini; Irene, Filippi; Giovanni, Maga; Silvia, Schenone; Maurizio, Botta
ATP-Competitive Inhibitors of mTOR: An Update
2011-01-01 Silvia, Schenone; Chiara, Brullo; Francesca, Musumeci; Radi, Marco; Maurizio, Botta
A Domino Microwave-Assisted Protocol for the Synthesis of 2,6-Disubstituted Pyrimidinones
2011-01-01 Radi, Marco; Gianni, Casaluce; Maurizio, Botta
Targeting the Human DEAD-Box Polypeptide 3 (DDX3) RNA Helicase as a Novel Strategy to Inhibit Viral Replication
2011-01-01 Anna, Garbelli; Radi, Marco; Federico, Falchi; Sandra, Beermann; Samantha, Zanoli; Fabrizio, Manetti; Ursula, Dietrich; Maurizio, Botta; Giovanni, Maga
New insights into small-molecule inhibitors of Bcr-Abl
2011-01-01 Silvia, Schenone; Olga, Bruno; Radi, Marco; Maurizio, Botta
Computational techniques are valuable tools for the discovery of protein–protein interaction inhibitors: The 14-3-3σ case
2011-01-01 Valentina, Corradi; Manuela, Mancini; Maria Alessandra, Santucci; Teresa, Carlomagno; Domenico, Sanfelice; Mattia, Mori; Giulia, Vignaroli; Federico, Falchi; Fabrizio, Manetti; Radi, Marco; Maurizio, Botta
Src Kinase Inhibitors: An Update on Patented Compounds
2011-01-01 S., Schenone; C., Brullo; F., Musumeci; Radi, Marco; D., Castagnolo
A combined targeted/phenotypic approach for the identification of new antiangiogenics agents active on a zebrafish model: From in silico screening to cyclodextrin formulation
2012-01-01 Radi, Marco; Lasse, Evensen; Elena, Dreassi; Claudio, Zamperini; Marialessandra, Caporicci; Federico, Falchi; Francesca, Musumeci; Silvia, Schenone; James B., Lorens; Maurizio, Botta
Vascular Endothelial Growth Factor (VEGF) receptors: drugs and new inhibitors
2012-01-01 Francesca, Musumeci; Radi, Marco; Chiara, Brullo; Silvia, Schenone
Discovery of the first small molecule inhibitor of human DDX3 specifically designed to target the RNA binding site: Towards the next generation HIV-1 inhibitors
2012-01-01 Radi, Marco; Federico, Falchi; Anna, Garbelli; Alberta, Samuele; Vincenzo, Bernardo; Stefania, Paolucci; Fausto, Baldanti; Silvia, Schenone; Fabrizio, Manetti; Giovanni, Maga; Maurizio, Botta
Synthesis, Biological Activity, and ADME Properties of Novel S-DABOs/N-DABOs as HIV Reverse Transcriptase Inhibitors
2012-01-01 Radi, Marco; Mafalda, Pagano; Luigi, Franchi; Daniele, Castagnolo; Silvia, Schenone; Gianni, Casaluce; Claudio, Zamperini; Elena, Dreassi; Giovanni, Maga; Alberta, Samuele; Encarna, Gonzalo; Bonaventura, Clotet; Josè A., Esté; Maurizio, Botta
Design, Synthesis, and Biological Evaluation of Pyrazolo[3,4-d]pyrimidines Active in Vivo on the Bcr-Abl T315I Mutant
2013-01-01 Radi, Marco; Cristina, Tintori; Francesca, Musumeci; Chiara, Brullo; Claudio, Zamperini; Elena, Dreassi; Anna Lucia, Fallacara; Giulia, Vignaroli; Emmanuele, Crespan; Samantha, Zanoli; Ilaria, Laurenzana; Irene, Filippi; Giovanni, Maga; Silvia, Schenone; Adriano, Angelucci; Maurizio, Botta
Pyrazolo[3,4-d]pyrimidine Prodrugs: Strategic Optimization of the Aqueous Solubility of Dual Src/Abl Inhibitors
2013-01-01 Giulia, Vignaroli; Claudio, Zamperini; Elena, Dreassi; Radi, Marco; Adriano, Angelucci; Patrizia, Sanità; Emmanuele, Crespan; Miroslava, Kissova; Giovanni, Maga; Silvia, Schenone; Francesca, Musumeci; Maurizio, Botta
Allosteric Inhibitors of Bcr-Abl: Towards Novel Myristate-Pocket Binders
2013-01-01 Radi, Marco; Silvia, Schenone; Maurizio, Botta
A Combination Strategy to Inhibit Pim-1: Synergism between Noncompetitive and ATP-Competitive Inhibitors
2013-01-01 Mattia, Mori; Cristina, Tintori; Robert Selwyne Arul, Christopher; Radi, Marco; Silvia, Schenone; Francesca, Musumeci; Chiara, Brullo; Patrizia, Sanità; Simona, Delle monache; Adriano, Angelucci; Miroslava, Kissova; Emmanuele, Crespan; Giovanni, Maga; Maurizio, Botta
An alternative synthetic approach for the synthesis of biologically relevant 1,4-disubstituted pyrazolo[3,4-d]pyrimidines
2013-01-01 Radi, Marco; Vincenzo, Bernardo; Giulia, Vignaroli; Annalaura, Brai; Mariangela, Biava; Silvia, Schenone; Maurizio, Botta
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| HIV-1 RT Inhibitors with a Novel Mechanism of Action: NNRTIs that Compete with the Nucleotide Substrate | 1-gen-2010 | Giovanni, Maga; Radi, Marco; Marie Aline, Gerard; Maurizio, Botta; Eric, Ennifar | |
| Design and Synthesis of Thiadiazoles and Thiazoles Targeting the Bcr-Abl T315I Mutant: from Docking False Positives to ATP-Noncompetitive Inhibitors | 1-gen-2010 | Radi, Marco; Emmanuele, Crespan; Federico, Falchi; Vincenzo, Bernardo; Samantha, Zanoli; Fabrizio, Manetti; Silvia, Schenone; Giovanni, Maga; Maurizio, Botta | |
| Toward the Discovery of Novel Anti-HIV Drugs. Second-Generation Inhibitors of the Cellular ATPase DDX3 with Improved Anti-HIV Activity: Synthesis, Structure-Activity Relationship Analysis, Cytotoxicity Studies, and Target Validation | 1-gen-2011 | Giovanni, Maga; Federico, Falchi; Radi, Marco; Lorenzo, Botta; Gianni, Casaluce; Martina, Bernardini; Hamid, Irannejad; Fabrizio, Manetti; Anna, Garbelli; Alberta, Samuele; Samantha, Zanoli; José A., Esté; Emmanuel, Gonzalez; Elisa, Zucca; Stefania, Paolucci; Fausto, Baldanti; Jan, De rijck; Zeger, Debyser; Maurizio, Botta | |
| Identification of Potent c-Src Inhibitors Strongly Affecting the Proliferation of Human Neuroblastoma Cells | 1-gen-2011 | Radi, Marco; Chiara, Brullo; Emmanuele, Crespan; Cristina, Tintori; Francesca, Musumeci; Mariangela, Biava; Silvia, Schenone; Elena, Dreassi; Claudio, Zamperini; Giovanni, Maga; Dafne, Pagano; Adriano, Angelucci; Mauro, Bologna; Maurizio, Botta | |
| Design, Synthesis, Biological Activity, and ADME Properties of Pyrazolo[3,4-d]pyrimidines Active in Hypoxic Human Leukemia Cells: A Lead Optimization Study | 1-gen-2011 | Radi, Marco; Elena, Dreassi; Chiara, Brullo; Emmanuele, Crespan; Cristina, Tintori; Vincenzo, Bernardo; Massimo, Valoti; Claudio, Zamperini; Henry, Daigl; Francesca, Musumeci; Fabio, Carraro; Antonella, Naldini; Irene, Filippi; Giovanni, Maga; Silvia, Schenone; Maurizio, Botta | |
| ATP-Competitive Inhibitors of mTOR: An Update | 1-gen-2011 | Silvia, Schenone; Chiara, Brullo; Francesca, Musumeci; Radi, Marco; Maurizio, Botta | |
| A Domino Microwave-Assisted Protocol for the Synthesis of 2,6-Disubstituted Pyrimidinones | 1-gen-2011 | Radi, Marco; Gianni, Casaluce; Maurizio, Botta | |
| Targeting the Human DEAD-Box Polypeptide 3 (DDX3) RNA Helicase as a Novel Strategy to Inhibit Viral Replication | 1-gen-2011 | Anna, Garbelli; Radi, Marco; Federico, Falchi; Sandra, Beermann; Samantha, Zanoli; Fabrizio, Manetti; Ursula, Dietrich; Maurizio, Botta; Giovanni, Maga | |
| New insights into small-molecule inhibitors of Bcr-Abl | 1-gen-2011 | Silvia, Schenone; Olga, Bruno; Radi, Marco; Maurizio, Botta | |
| Computational techniques are valuable tools for the discovery of protein–protein interaction inhibitors: The 14-3-3σ case | 1-gen-2011 | Valentina, Corradi; Manuela, Mancini; Maria Alessandra, Santucci; Teresa, Carlomagno; Domenico, Sanfelice; Mattia, Mori; Giulia, Vignaroli; Federico, Falchi; Fabrizio, Manetti; Radi, Marco; Maurizio, Botta | |
| Src Kinase Inhibitors: An Update on Patented Compounds | 1-gen-2011 | S., Schenone; C., Brullo; F., Musumeci; Radi, Marco; D., Castagnolo | |
| A combined targeted/phenotypic approach for the identification of new antiangiogenics agents active on a zebrafish model: From in silico screening to cyclodextrin formulation | 1-gen-2012 | Radi, Marco; Lasse, Evensen; Elena, Dreassi; Claudio, Zamperini; Marialessandra, Caporicci; Federico, Falchi; Francesca, Musumeci; Silvia, Schenone; James B., Lorens; Maurizio, Botta | |
| Vascular Endothelial Growth Factor (VEGF) receptors: drugs and new inhibitors | 1-gen-2012 | Francesca, Musumeci; Radi, Marco; Chiara, Brullo; Silvia, Schenone | |
| Discovery of the first small molecule inhibitor of human DDX3 specifically designed to target the RNA binding site: Towards the next generation HIV-1 inhibitors | 1-gen-2012 | Radi, Marco; Federico, Falchi; Anna, Garbelli; Alberta, Samuele; Vincenzo, Bernardo; Stefania, Paolucci; Fausto, Baldanti; Silvia, Schenone; Fabrizio, Manetti; Giovanni, Maga; Maurizio, Botta | |
| Synthesis, Biological Activity, and ADME Properties of Novel S-DABOs/N-DABOs as HIV Reverse Transcriptase Inhibitors | 1-gen-2012 | Radi, Marco; Mafalda, Pagano; Luigi, Franchi; Daniele, Castagnolo; Silvia, Schenone; Gianni, Casaluce; Claudio, Zamperini; Elena, Dreassi; Giovanni, Maga; Alberta, Samuele; Encarna, Gonzalo; Bonaventura, Clotet; Josè A., Esté; Maurizio, Botta | |
| Design, Synthesis, and Biological Evaluation of Pyrazolo[3,4-d]pyrimidines Active in Vivo on the Bcr-Abl T315I Mutant | 1-gen-2013 | Radi, Marco; Cristina, Tintori; Francesca, Musumeci; Chiara, Brullo; Claudio, Zamperini; Elena, Dreassi; Anna Lucia, Fallacara; Giulia, Vignaroli; Emmanuele, Crespan; Samantha, Zanoli; Ilaria, Laurenzana; Irene, Filippi; Giovanni, Maga; Silvia, Schenone; Adriano, Angelucci; Maurizio, Botta | |
| Pyrazolo[3,4-d]pyrimidine Prodrugs: Strategic Optimization of the Aqueous Solubility of Dual Src/Abl Inhibitors | 1-gen-2013 | Giulia, Vignaroli; Claudio, Zamperini; Elena, Dreassi; Radi, Marco; Adriano, Angelucci; Patrizia, Sanità; Emmanuele, Crespan; Miroslava, Kissova; Giovanni, Maga; Silvia, Schenone; Francesca, Musumeci; Maurizio, Botta | |
| Allosteric Inhibitors of Bcr-Abl: Towards Novel Myristate-Pocket Binders | 1-gen-2013 | Radi, Marco; Silvia, Schenone; Maurizio, Botta | |
| A Combination Strategy to Inhibit Pim-1: Synergism between Noncompetitive and ATP-Competitive Inhibitors | 1-gen-2013 | Mattia, Mori; Cristina, Tintori; Robert Selwyne Arul, Christopher; Radi, Marco; Silvia, Schenone; Francesca, Musumeci; Chiara, Brullo; Patrizia, Sanità; Simona, Delle monache; Adriano, Angelucci; Miroslava, Kissova; Emmanuele, Crespan; Giovanni, Maga; Maurizio, Botta | |
| An alternative synthetic approach for the synthesis of biologically relevant 1,4-disubstituted pyrazolo[3,4-d]pyrimidines | 1-gen-2013 | Radi, Marco; Vincenzo, Bernardo; Giulia, Vignaroli; Annalaura, Brai; Mariangela, Biava; Silvia, Schenone; Maurizio, Botta |
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