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Dual Src and Abl inhibitors target wild type Abl and the AblT315I Imatinib-resistant mutant with different mechanisms 1-gen-2010 Emmanuele, Crespan; Radi, Marco; Samantha, Zanoli; Silvia, Schenone; Maurizio, Botta; Giovanni, Maga
Crystal Structure of HIV-1 Reverse Transcriptase Bound to a Non-Nucleoside Inhibitor with a Novel Mechanism of Action 1-gen-2010 Séverine, Freisz; Guillaume, Bec; Radi, Marco; Philippe, Wolff; Emmanuele, Crespan; Lucilla, Angeli; Philippe, Dumas; Giovanni, Maga; Maurizio, Botta; Eric, Ennifar
Src Kinase Inhibitors: An Update on Patented Compounds 1-gen-2011 S., Schenone; C., Brullo; F., Musumeci; Radi, Marco; D., Castagnolo
New insights into small-molecule inhibitors of Bcr-Abl 1-gen-2011 Silvia, Schenone; Olga, Bruno; Radi, Marco; Maurizio, Botta
Identification of Potent c-Src Inhibitors Strongly Affecting the Proliferation of Human Neuroblastoma Cells 1-gen-2011 Radi, Marco; Chiara, Brullo; Emmanuele, Crespan; Cristina, Tintori; Francesca, Musumeci; Mariangela, Biava; Silvia, Schenone; Elena, Dreassi; Claudio, Zamperini; Giovanni, Maga; Dafne, Pagano; Adriano, Angelucci; Mauro, Bologna; Maurizio, Botta
Design, Synthesis, Biological Activity, and ADME Properties of Pyrazolo[3,4-d]pyrimidines Active in Hypoxic Human Leukemia Cells: A Lead Optimization Study 1-gen-2011 Radi, Marco; Elena, Dreassi; Chiara, Brullo; Emmanuele, Crespan; Cristina, Tintori; Vincenzo, Bernardo; Massimo, Valoti; Claudio, Zamperini; Henry, Daigl; Francesca, Musumeci; Fabio, Carraro; Antonella, Naldini; Irene, Filippi; Giovanni, Maga; Silvia, Schenone; Maurizio, Botta
Computational techniques are valuable tools for the discovery of protein–protein interaction inhibitors: The 14-3-3σ case 1-gen-2011 Valentina, Corradi; Manuela, Mancini; Maria Alessandra, Santucci; Teresa, Carlomagno; Domenico, Sanfelice; Mattia, Mori; Giulia, Vignaroli; Federico, Falchi; Fabrizio, Manetti; Radi, Marco; Maurizio, Botta
Targeting the Human DEAD-Box Polypeptide 3 (DDX3) RNA Helicase as a Novel Strategy to Inhibit Viral Replication 1-gen-2011 Anna, Garbelli; Radi, Marco; Federico, Falchi; Sandra, Beermann; Samantha, Zanoli; Fabrizio, Manetti; Ursula, Dietrich; Maurizio, Botta; Giovanni, Maga
A Domino Microwave-Assisted Protocol for the Synthesis of 2,6-Disubstituted Pyrimidinones 1-gen-2011 Radi, Marco; Gianni, Casaluce; Maurizio, Botta
ATP-Competitive Inhibitors of mTOR: An Update 1-gen-2011 Silvia, Schenone; Chiara, Brullo; Francesca, Musumeci; Radi, Marco; Maurizio, Botta
Toward the Discovery of Novel Anti-HIV Drugs. Second-Generation Inhibitors of the Cellular ATPase DDX3 with Improved Anti-HIV Activity: Synthesis, Structure-Activity Relationship Analysis, Cytotoxicity Studies, and Target Validation 1-gen-2011 Giovanni, Maga; Federico, Falchi; Radi, Marco; Lorenzo, Botta; Gianni, Casaluce; Martina, Bernardini; Hamid, Irannejad; Fabrizio, Manetti; Anna, Garbelli; Alberta, Samuele; Samantha, Zanoli; José A., Esté; Emmanuel, Gonzalez; Elisa, Zucca; Stefania, Paolucci; Fausto, Baldanti; Jan, De rijck; Zeger, Debyser; Maurizio, Botta
Discovery of the first small molecule inhibitor of human DDX3 specifically designed to target the RNA binding site: Towards the next generation HIV-1 inhibitors 1-gen-2012 Radi, Marco; Federico, Falchi; Anna, Garbelli; Alberta, Samuele; Vincenzo, Bernardo; Stefania, Paolucci; Fausto, Baldanti; Silvia, Schenone; Fabrizio, Manetti; Giovanni, Maga; Maurizio, Botta
Synthesis, Biological Activity, and ADME Properties of Novel S-DABOs/N-DABOs as HIV Reverse Transcriptase Inhibitors 1-gen-2012 Radi, Marco; Mafalda, Pagano; Luigi, Franchi; Daniele, Castagnolo; Silvia, Schenone; Gianni, Casaluce; Claudio, Zamperini; Elena, Dreassi; Giovanni, Maga; Alberta, Samuele; Encarna, Gonzalo; Bonaventura, Clotet; Josè A., Esté; Maurizio, Botta
A combined targeted/phenotypic approach for the identification of new antiangiogenics agents active on a zebrafish model: From in silico screening to cyclodextrin formulation 1-gen-2012 Radi, Marco; Lasse, Evensen; Elena, Dreassi; Claudio, Zamperini; Marialessandra, Caporicci; Federico, Falchi; Francesca, Musumeci; Silvia, Schenone; James B., Lorens; Maurizio, Botta
Vascular Endothelial Growth Factor (VEGF) receptors: drugs and new inhibitors 1-gen-2012 Francesca, Musumeci; Radi, Marco; Chiara, Brullo; Silvia, Schenone
Allosteric Inhibitors of Bcr-Abl: Towards Novel Myristate-Pocket Binders 1-gen-2013 Radi, Marco; Silvia, Schenone; Maurizio, Botta
Unconventional plasticity of hiv-1 reverse transcriptase: How inhibitors could open a connection "gate" between allosteric and catalytic sites 1-gen-2013 Luca, Bellucci; Lucilla, Angeli; Andrea, Tafi; Radi, Marco; Maurizio, Botta
An alternative synthetic approach for the synthesis of biologically relevant 1,4-disubstituted pyrazolo[3,4-d]pyrimidines 1-gen-2013 Radi, Marco; Vincenzo, Bernardo; Giulia, Vignaroli; Annalaura, Brai; Mariangela, Biava; Silvia, Schenone; Maurizio, Botta
A Combination Strategy to Inhibit Pim-1: Synergism between Noncompetitive and ATP-Competitive Inhibitors 1-gen-2013 Mattia, Mori; Cristina, Tintori; Robert Selwyne Arul, Christopher; Radi, Marco; Silvia, Schenone; Francesca, Musumeci; Chiara, Brullo; Patrizia, Sanità; Simona, Delle monache; Adriano, Angelucci; Miroslava, Kissova; Emmanuele, Crespan; Giovanni, Maga; Maurizio, Botta
A one-pot two-step microwave-assisted synthesis of N1-substituted 5,6-ring-fused 2-pyridones 1-gen-2013 Radi, Marco; Gian Paolo, Vallerini; Alessia, Petrelli; Paolo, Vincetti; Costantino, Gabriele
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