BACKGROUND GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation) is a prospective, global registry program describing antithrombotic treatment patterns in patients with newly diagnosed nonvalvular atrial fibrillation at risk of stroke. Phase 2 began when dabigatran, the first non-vitamin K antagonist oral anticoagulant (NOAC), became available. OBJECTIVES This study sought to describe phase 2 baseline data and compare these with the pre-NOAC era collected during phase 1. METHODS During phase 2, 15,641 consenting patients were enrolled (November 2011 to December 2014); 15,092 were eligible. This pre-specified cross-sectional analysis describes eligible patients' baseline characteristics. Atrial fibrillation disease characteristics, medical outcomes, and concomitant diseases and medications were collected. Data were analyzed using descriptive statistics. RESULTS Of the total patients, 45.5% were female; median age was 71 (interquartile range: 64, 78) years. Patients were from Europe (47.1%), North America (22.5%), Asia (20.3%), Latin America (6.0%), and the Middle East/Africa (4.0%). Most had high stroke risk (CHA(2)DS(2)-VASc [ Congestive heart failure, Hypertension, Age >= 75 years, Diabetes mellitus, previous Stroke, Vascular disease, Age 65 to 74 years, Sex category] score >= 2; 86.1%); 13.9% had moderate risk (CHA2DS2-VASc = 1). Overall, 79.9% received oral anticoagulants, of whom 47.6% received NOAC and 32.3% vitamin K antagonists (VKA); 12.1% received antiplatelet agents; 7.8% received no antithrombotic treatment. For comparison, the proportion of phase 1 patients (of N = 1,063 all eligible) prescribed VKA was 32.8%, acetylsalicylic acid 41.7%, and no therapy 20.2%. In Europe in phase 2, treatment with NOAC was more common than VKA (52.3% and 37.8%, respectively); 6.0% of patients received antiplatelet treatment; and 3.8% received no antithrombotic treatment. In North America, 52.1%, 26.2%, and 14.0% of patients received NOAC, VKA, and antiplatelet drugs, respectively; 7.5% received no antithrombotic treatment. NOAC use was less common in Asia (27.7%), where 27.5% of patients received VKA, 25.0% antiplatelet drugs, and 19.8% no antithrombotic treatment. CONCLUSIONS The baseline data from GLORIA-AF phase 2 demonstrate that in newly diagnosed nonvalvular atrial fibrillation patients, NOAC have been highly adopted into practice, becoming more frequently prescribed than VKA in Europe and North America. Worldwide, however, a large proportion of patients remain undertreated, particularly in Asia and North America. (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients With Atrial Fibrillation [ GLORIA-AF]; NCT01468701) (C) 2017 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.
The Changing Landscape for Stroke Prevention in AF Findings From the GLORIA-AF Registry Phase 2 / Huisman, Mv; Rothman, Kj; Paquette, M; Teutsch, C; Diener, Hc; Dubner, Sj; Halperin, Jl; Ma, Cs; Zint, K; Elsaesser, A; Bartels, Db; Lip, Gyh; Abban, D; Abdul, N; Abelson, M; Ackermann, A; Adams, F; Adams, L; Adragao, P; Ageno, W; Aggarwal, R; Agosti, S; Marin, Ja; Aguilar, F; Linares, Jaa; Aguinaga, L; Ahmad, Z; Ainsworth, P; Al Ghalayini, K; Al Ismail, S; Alasfar, A; Alawwa, A; Al-Dallow, R; Alderson, L; Alexopoulos, D; Ali, A; Ali, M; Aliyar, P; Al-Joundi, T; Al Mahameed, S; Almassi, H; Almuti, K; Al-Obaidi, M; Alshehri, M; Altmann, U; Alves, Ar; Al-Zoebi, A; Amara, W; Amelot, M; Amjadi, N; Ammirati, F; Andrawis, N; Angoulvant, D; Annoni, G; Ansalone, G; Antonescu, Sa; Ariani, M; Arias, Jc; Armero, S; Arora, R; Arora, C; Ashcraft, W; Aslam, Ms; Astesiano, A; Audouin, P; Augenbraun, C; Aydin, S; Azar, R; Azim, A; Aziz, S; Backes, Lm; Baig, M; Bains, S; Bakbak, A; Baker, S; Bakhtiar, K; Bala, R; Banayan, J; Bandh, S; Bando, S; Banerjee, S; Bank, A; Barbarash, O; Baron, G; Barr, C; Barrera, C; Barton, J; Kes, Vb; Baula, G; Bayeh, H; Bazargani, N; Behrens, S; Bell, A; Benezet-Mazuecos, J; Benhalima, B; Berdague, P; Van Den Berg, Bj; Van Bergen, Pfmm; Berngard, E; Bernstein, R; Berrospi, P; Berti, S; Bertomeu, V; Berz, A; Bettencourt, P; Betzu, R; Beyer-Westendorf, J; Bhagwat, R; Black, T; Ibaceta, Jhb; Bloom, S; Blumberg, E; Bo, M; Bockisch, V; Bohmer, E; Bongiorni, Mg; Boriani, G; Bosch, R; Boswijk, Dj; Bott, J; Bottacchi, E; Kalan, Mb; Brandes, A; Bratland, B; Brautigam, D; Breton, N; Brouwers, Pjam; Browne, K; Bruguera, J; Brunehaut, M; Brunschwig, C; Buathier, H; Buhl, A; Bullinga, J; Butcher, K; Honorio, Jwc; Caccavo, A; Cadinot, D; Cai, S; Calvi, V; Camm, J; Candeias, R; Capo, J; Capucci, A; Cardoso, Jn; Vera, Ycd; Carlson, B; Carvalho, P; Cary, S; Casanova, R; Casu, G; Cattan, S; Cavallini, C; Cayla, G; Cha, Tj; Cha, Ks; Chaaban, S; Chae, Jk; Challappa, K; Chand, S; Chandrashekar, H; Chang, M; Charbel, P; Chartier, L; Chatterjee, K; Cheema, A; Chen, Sa; Chevallereau, P; Chiang, Ft; Chiarella, F; Lin, Cc; Cho, Yk; Choi, Dj; Chouinard, G; Danny, Hfc; Chrysos, D; Chumakova, G; Roberto, Ejj; Valenzuela, C; Cieza-Lara, T; Nica, Vc; Ciobotaru, V; Cislowski, D; Citerne, O; Claus, M; Clay, A; Clifford, P; Cohen, S; Cohen, A; Colivicchi, F; Collins, R; Compton, S; Connors, S; Conti, A; Buenostro, Gc; Coodley, G; Cooper, M; Corbett, L; Corey, O; Coronel, J; Corrigan, J; Pereyra, Ryc; Cottin, Y; Coutu, B; Cracan, A; Crean, P; Crenshaw, J; Crijns, Hjgm; Crump, C; Cucher, F; Cudmore, D; Cui, L; Culp, J; Darius, H; Dary, P; Dascotte, O; Dauber, I; Davee, T; Davies, R; Davis, G; Davy, Jm; Dayer, M; De La Briolle, A; De Mora, M; De Teresa, E; De Wolf, L; Decoulx, E; Deepak, S; Defaye, P; Munoz, Fdc; Brkljacic, Dd; Deluche, L; Destrac, S; Deumite, Nj; Di Legge, S; Dibon, O; Diemberger, I; Dillinger, J; Dionisio, P; Naydenov, S; Dotani, I; Dotcheva, E; D'Souza, A; Dubrey, S; Ducrocq, X; Dupljakov, D; Duthinh, V; Dutra, Op; Dutta, D; Duvilla, N; Dy, J; Dziewas, R; Eaton, C; Eaves, W; Ebinger, M; Van Eck, Jwm; Edwards, T; Egocheaga, I; Ehrlich, C; Eisenberg, S; El Hallak, A; El Jabali, A; El Mahmoud, R; El Shahawy, M; Eldadah, Z; Elghelbazouri, F; Elhag, O; El-Hamdani, M; Elias, D; Ellery, A; El-Sayed, H; Elvan, A; Erickson, B; Espaliat, E; Essandoh, L; Everington, T; Evonich, R; Ezhov, A; Facila, L; Farsad, R; Fayard, M; Fedele, F; Ferreira, Lgg; Ferreira, D; Santos, Jf; Ferrier, A; Finsen, A; First, B; Fisher, R; Floyd, J; Folk, T; Fonseca, C; Fonseca, L; Forman, S; Forsgren, M; Foster, M; Foster, N; Frais, M; Frandsen, B; Frappe, T; Freixa, R; French, W; Freydlin, M; Frickel, S; Fruntelata, Ag; Fujii, S; Fujino, Y; Fukunaga, H; Furukawa, Y; Gabelmann, M; Gabris, M; Gadsboll, N; Galin, P; Galinier, M; Ganim, R; Garcia, R; Quintana, Ag; Gartenlaub, O; Genz, C; Georger, F; Georges, Jl; Georgeson, S; Ghanbasha, A; Giedrimas, E; Gierba, M; Gillespie, E; Giniger, A; Gkotsis, A; Gmehling, J; Gniot, J; Goethals, P; Goldberg, R; Goldmann, B; Goldscher, D; Golitsyn, S; Lopez, Eag; Mesa, Jeg; Gonzalez, E; Cocina, Eg; Juanatey, Cg; Gorbunov, V; Gordon, B; Gorka, H; Gornick, C; Gorog, D; Goss, F; Gotte, A; Goube, P; Goudevenos, I; Goulden, D; Graham, B; Grande, A; Greco, C; Green, M; Greer, G; Gremmler, U; Grena, P; Grinshstein, Y; Grond, M; Gronda, E; Grondin, F; Gronefeld, G; De Groot, Jr; Guardigli, G; Guarnieri, T; Caiedo, Cg; Guignier, A; Gulizia, M; Gumbley, M; Gupta, D; Hack, T; Haerer, W; Hakas, J; Hall, C; Hampsey, J; Hananis, G; Hanbali, B; Handel, F; Hargrove, J; Hargroves, D; Harris, K; Hartley, D; Haruna, T; Hata, Y; Hayek, E; Healey, J; Hearne, S; Heggelund, G; Hemels, Mew; Hemery, Y; Henein, S; Henz, B; Her, Sh; Hermany, P; Hernandes, Me; Higashino, Y; Hill, M; Hisadome, T; Hishida, E; Hitchcock, J; Hoffer, E; Hoghton, M; Holmes, C; Hong, Sk; Nousse, Mph; Howard, V; Hsu, Lf; Huang, Ch; Huckins, D; Huehnergarth, K; Huizenga, A; Huntley, R; Hussein, G; Hwang, Gs; Igbokidi, O; Iglesias, I; Ikpoh, M; Imberti, D; Ince, H; Indolfi, C; Ionova, T; Ip, J; Irles, D; Iseki, H; Ismail, Y; Israel, N; Isserman, S; Iteld, B; Ivanchura, G; Iyer, R; Iyer, V; Villanueva, Roi; Jackson-Voyzey, E; Jaffrani, N; Jager, F; Jain, M; James, M; Jamon, Y; Jang, Sw; Jardim, Cap; Jarmukli, N; Jeanfreau, R; Jenkins, R; Jiang, X; Jiang, H; Jiang, Tm; Jiang, N; Jimenez, J; Jobe, R; Joffe, I; Johansson, B; Jones, N; Jorge, Jcm; Jouve, B; Jundi, M; Jung, W; Jung, Bc; Jung, Kt; Kabbani, S; Kabour, A; Kafkala, C; Kajiwara, K; Kalinina, L; Kampus, P; Kanda, J; Kapadia, S; Karim, A; Karolyi, L; Kashou, H; Kastrup, A; Katsivas, A; Kaufman, E; Kawai, K; Kawajiri, K; Kazmierski, J; Keeling, P; Kerfes, Ga; Saraiva, Jfk; Ketova, G; Khaira, A; Khalid, M; Khludeeva, E; Khripun, A; Kim, Di; Kim, Dk; Kim, Nh; Kim, Ks; Kim, Yh; Kim, Jb; Kim, Js; Kim, Js; Kinova, E; Klein, A; Kleinschnitz, C; Kmetzo, J; Kneller, Gl; Knezevic, A; Koch, S; Koenig, K; Koh, Sma; Kohrmann, M; Koons, J; Korabathina, R; Korennova, O; Koschutnik, M; Kosinski, E; Kovacic, D; Kowalczyk, J; Koziolova, N; Kragten, J; Krause, Lu; Kreidieh, I; Krenning, Bj; Krishnaswamy, K; Krysiak, W; Kuck, Kh; Kumar, S; Kumler, T; Kuniss, M; Kuo, Jy; Kuppers, A; Kurrelmeyer, K; Kwan, T; Kyo, E; Labovitz, A; Lacroix, A; Lam, A; Zanetti, Ftl; Landau, C; Landini, G; Lang, W; Larsen, Tb; Laske, V; Lavandier, K; Law, N; Lee, Mh; Lee, D; Leitao, A; Lejay, D; Lelonek, M; Lenarczyk, R; Leprince, P; Lequeux, B; Leschke, M; Ley, N; Li, Zc; Li, Ys; Li, Xd; Li, Zq; Li, Wh; Liang, Jq; Lieber, I; Lillestol, M; Rodriguez, Rhl; Lin, Hl; Lip, G; Litchfield, J; Liu, Zt; Liu, Xb; Liu, Yl; Liu, F; Liu, Wh; Esperon, Gal; Llisterri, Jl; Lo, T; Lo, E; Lobos, Jm; Lodde, Bp; Loiselet, P; Lopez-Sendon, J; Filho, Aml; Lori, I; Luo, M; Lupovitch, S; Lyrer, P; Zuhairy, Hm; Ma, Cs; Ma, Gs; Ma, H; Madariaga, I; Maeno, K; Magnin, D; Mahmood, S; Mahood, K; Maid, G; Mainigi, S; Makaritsis, K; Villalon, Jam; Malhotra, R; Malik, A; Mallecourt, C; Mallik, R; Manning, R; Manolis, A; Mantas, I; Jattin, Fgm; Marcionni, N; Marin, F; Santana, Am; Martinez, J; Martinez, L; Maskova, P; Hernandez, Nm; Matskeplishvili, S; Matsuda, K; Mavri, A; May, E; Mayer, N; Mazon, P; Mcclure, J; Mccormack, T; Mcgarity, W; Mcguire, M; Mcintyre, H; Mclaughlin, P; Mclaurin, B; Palomino, Fam; Mehta, P; Mehzad, R; Meinel, A; Melandri, F; Mena, A; Meno, H; Menzies, D; Metcalf, K; Meyer, B; Miarka, J; Mibach, F; Michalski, D; Michel, P; Chreih, Rm; Mikdadi, G; Mikhail, M; Mikus, M; Milicic, D; Militaru, C; Miller, G; Milonas, C; Minescu, B; Mintale, I; Miralles, A; Mirault, T; Mistry, D; Mitchell, G; Miu, Nv; Miyamoto, N; Moccetti, T; Mohammed, A; Nor, Am; De Salazar, Dim; Molon, G; Molony, D; Mondillo, S; Mont, L; Moodley, R; Moore, R; Moreira, Dar; Mori, K; Moriarty, A; Morka, J; Moschos, N; Gomes, Mam; Mousallem, N; Moya, A; Mugge, A; Mulhearn, T; Muller, Jj; Muresan, Cm; Muse, D; Musial, W; Musumeci, F; Nadar, V; Nageh, T; Nair, P; Nakagawa, H; Nakamura, Y; Nakayama, T; Nam, Kb; Napalkov, D; Natarajan, I; Nayak, H; Nechvatal, L; Neiman, J; Nerheim, P; Neuenschwander, Fc; Nishida, K; Nizov, A; Novikova, T; Novo, S; Nowalany-Kozielska, E; Nsah, E; Fragoso, Jcn; Nyvad, O; Ibarra, Modr; O'Donnell, M; O'Donnell, P; Oh, Dj; Oh, Ys; Oh, Ctd; O'Hara, G; Oikonomou, K; Olalla, Jj; Olivari, Z; Oliver, R; Olympios, C; Osborne, J; Osca, J; Osman, R; Osunkoya, A; Padanilam, B; Panchenko, E; Pandey, As; De Paola, Aav; Paraschos, A; Pardell, H; Park, Hw; Park, Js; Parkash, R; Parker, I; Parrens, E; Parris, R; Passamonti, E; Patel, J; Patel, R; Pentz, Wh; Persic, V; Perticone, F; Peters, P; Petkar, S; Pezo, Lf; Pham, D; Phai, Gpc; Phlaum, S; Pineau, J; Pineda-Velez, A; Pini, R; Pinter, A; Pinto, F; Pirelli, S; Pivac, N; Pizzini, Am; Pocanic, D; Podoleanu, Cgc; Polanczyk, Ca; Polasek, P; Poljakovic, Z; Pollock, S; Polo, J; Poock, J; Poppert, H; Porro, Y; Pose, A; Poulain, F; Poulard, Je; Pouzar, J; Povolny, P; Pozzer, D; Pras, A; Prasad, N; Prevot, S; Protasov, K; Prunier, L; Puleo, J; Pye, M; Qaddoura, F; Quedillac, Jm; Raev, D; Rahimi, S; Raisaro, A; Rama, B; Ranadive, N; Randall, K; Ranjith, N; Raposo, N; Rashid, H; Raters, C; Rauch-Kroehnert, U; Rebane, T; Regner, S; Renzi, M; Rocha, Mar; Reza, S; Ria, L; Richter, D; Rickli, H; Rickner, K; Rieker, W; Rigo, F; Ripoll, T; Ritt, Lef; Roberts, D; Pascual, Cr; Briones, Ir; Reyes, Hr; Roelke, M; Roman, M; Romeo, F; Ronner, E; Ronziere, T; Rooyer, F; Rosenbaum, D; Roth, S; Rozkova, N; Rubacek, M; Rubalcava, F; Rubanenko, O; Rubin, A; Borret, Mr; Rybak, K; Sabbour, H; Morales, Os; Sakai, T; Salacata, A; Salecker, I; Salem, A; Salfity, M; Salguero, R; Salvioni, A; Samson, M; Sanchez, G; Sandesara, C; Saporito, Wf; Sasaoka, T; Sattar, P; Savard, D; Scala, Pj; Scemama, J; Schaupp, T; Schellinger, P; Scherr, C; Schmitz, Kh; Schmitz, B; Schmitz, L; Schnitzler, R; Schnupp, S; Schoeniger, P; Schon, N; Schuster, S; Seamark, C; Seebass, R; Seidl, Kh; Seidman, B; Sek, J; Sekaran, L; Seko, Y; Varela, Pas; Sevilla, B; Shah, V; Shah, A; Shah, N; Shah, A; Shanes, J; Sharareh, A; Sharma, Vk; Shaw, L; Shimizu, Y; Shimomura, H; Shin, Dg; Shin, Es; Shite, J; Shoukfeh, M; Shoultz, C; Silver, F; Sime, I; Simmers, T; Singal, D; Singh, N; Siostrzonek, P; Sirajuddin, M; Skeppholm, M; Smadja, D; Smith, R; Smith, D; Soda, H; Sofley, Cw; Sokal, A; Sotolongo, R; De Souza, Of; Sparby, Ja; Spinar, J; Sprigings, D; Spyropoulos, A; Stakos, D; Steinberg, A; Steinwender, C; Stergiou, G; Stites, Hw; Stoikov, A; Strasser, R; Streb, W; Styliadis, I; Su, Gh; Su, X; Suarez, Rm; Sudnik, W; Sueyoshi, A; Sukles, K; Sun, L; Suneja, R; Svensson, P; Ziekenhuis, A; Szavits-Nossan, J; Taggeselle, J; Takagi, Y; Takhar, A; Tallet, J; Tamm, A; Tanaka, S; Tanaka, K; Tang, A; Tang, S; Tassinari, T; Tayama, S; Tayebjee, M; Tebbe, U; Teixeira, J; Tesloianu, Dn; Tessier, P; The, S; Thevenin, J; Thomas, H; Timsit, S; Topkis, R; Torosoff, M; Touze, E; Traissac, T; Trendafilova, E; Troyan, B; Tsai, Wk; Tse, Hf; Tsutsui, H; Tsutsui, T; Tuininga, Y; Turakhia, M; Turk, S; Turner, W; Tveit, A; Twiddy, S; Tytus, R; Ukrainski, G; Chavez, Sbv; De Graaff, Ev; Vanacker, P; Vardas, P; Vargas, M; Vassilikos, V; Vazquez, J; Venkataraman, A; Verdecchia, P; Vester, Eg; Vial, H; Vinereanu, D; Vlastaris, A; Vogel, C; Vom Dahl, J; Von Mering, M; Vora, K; Wakefield, P; Walia, J; Walter, T; Wang, Ms; Wang, Nf; Wang, F; Wang, Xh; Wang, Zl; Wang, Ky; Watanabe, K; Wei, J; Weimar, C; Weinrich, R; Wen, Ms; Wheelan, K; Wicke, J; Wiemer, M; Wild, B; Wilke, A; Willems, S; Williams, M; Williams, D; Winkler, A; Wirtz, Jh; Witzenbichler, B; Wong, Dhk; Wong, Ksl; Wong, B; Wozakowska-Kaplon, B; Wu, Zh; Wu, Sl; Wyatt, N; Xu, Y; Xu, Xd; Yamada, A; Yamamoto, K; Yamanoue, H; Yamashita, T; Yan, Pyb; Yang, Ym; Yang, Tl; Yao, J; Yarlagadda, C; Yeh, Kh; Yotov, Y; Yvorra, S; Zahn, R; Zamorano, J; Zanini, R; Zarich, S; Zebrack, J; Zenin, S; Zeuthen, El; Zhang, Xw; Zhang, Qs; Zhang, Dd; Zhang, Dh; Zhang, Hy; Zhao, Sp; Zhao, Xw; Zheng, Y; Zheng, Qs; Zhou, J; Zhou, J; Zimmermann, Sl; Zimmermann, R; Zukerman, Ls; Van Der Zwaan, C. - In: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. - ISSN 0735-1097. - 69:7(2017), pp. 777-785. [10.1016/j.jacc.2016.11.061]
The Changing Landscape for Stroke Prevention in AF Findings From the GLORIA-AF Registry Phase 2
Huisman MV; Rothman KJ; Paquette M; Teutsch C; Diener HC; Dubner SJ; Halperin JL; Ma CS; Zint K; Elsaesser A; Bartels DB; Lip GYH; Abban D; Abdul N; Abelson M; Ackermann A; Adams F; Adams L; Adragao P; Ageno W; Aggarwal R; Agosti S; Marin JA; Aguilar F; Linares JAA; Aguinaga L; Ahmad Z; Ainsworth P; Al Ghalayini K; Al Ismail S; Alasfar A; Alawwa A; Al-Dallow R; Alderson L; Alexopoulos D; Ali A; Ali M; Aliyar P; Al-Joundi T; Al Mahameed S; Almassi H; Almuti K; Al-Obaidi M; Alshehri M; Altmann U; Alves AR; Al-Zoebi A; Amara W; Amelot M; Amjadi N; Ammirati F; Andrawis N; Angoulvant D; Annoni G; Ansalone G; Antonescu SA; Ariani M; Arias JC; Armero S; Arora R; Arora C; Ashcraft W; Aslam MS; Astesiano A; Audouin P; Augenbraun C; Aydin S; Azar R; Azim A; Aziz S; Backes LM; Baig M; Bains S; Bakbak A; Baker S; Bakhtiar K; Bala R; Banayan J; Bandh S; Bando S; Banerjee S; Bank A; Barbarash O; Baron G; Barr C; Barrera C; Barton J; Kes VB; Baula G; Bayeh H; Bazargani N; Behrens S; Bell A; Benezet-Mazuecos J; Benhalima B; Berdague P; van den Berg BJ; van Bergen PFMM; Berngard E; Bernstein R; Berrospi P; Berti S; Bertomeu V; Berz A; Bettencourt P; Betzu R; Beyer-Westendorf J; Bhagwat R; Black T; Ibaceta JHB; Bloom S; Blumberg E; Bo M; Bockisch V; Bohmer E; Bongiorni MG; Boriani G; Bosch R; Boswijk DJ; Bott J; Bottacchi E; Kalan MB; Brandes A; Bratland B; Brautigam D; Breton N; Brouwers PJAM; Browne K; Bruguera J; Brunehaut M; Brunschwig C; Buathier H; Buhl A; Bullinga J; Butcher K; Honorio JWC; Caccavo A; Cadinot D; Cai S; Calvi V; Camm J; Candeias R; Capo J; Capucci A; Cardoso JN; Vera YCD; Carlson B; Carvalho P; Cary S; Casanova R; Casu G; Cattan S; Cavallini C; Cayla G; Cha TJ; Cha KS; Chaaban S; Chae JK; Challappa K; Chand S; Chandrashekar H; Chang M; Charbel P; Chartier L; Chatterjee K; Cheema A; Chen SA; Chevallereau P; Chiang FT; Chiarella F; Lin CC; Cho YK; Choi DJ; Chouinard G; Danny HFC; Chrysos D; Chumakova G; Roberto EJJ; Valenzuela C; Cieza-Lara T; Nica VC; Ciobotaru V; Cislowski D; Citerne O; Claus M; Clay A; Clifford P; Cohen S; Cohen A; Colivicchi F; Collins R; Compton S; Connors S; Conti A; Buenostro GC; Coodley G; Cooper M; Corbett L; Corey O; Coronel J; Corrigan J; Pereyra RYC; Cottin Y; Coutu B; Cracan A; Crean P; Crenshaw J; Crijns HJGM; Crump C; Cucher F; Cudmore D; Cui L; Culp J; Darius H; Dary P; Dascotte O; Dauber I; Davee T; Davies R; Davis G; Davy JM; Dayer M; De La Briolle A; de Mora M; De Teresa E; De Wolf L; Decoulx E; Deepak S; Defaye P; Munoz FDC; Brkljacic DD; Deluche L; Destrac S; Deumite NJ; Di Legge S; Dibon O; Diemberger I; Dillinger J; Dionisio P; Naydenov S; Dotani I; Dotcheva E; D'Souza A; Dubrey S; Ducrocq X; Dupljakov D; DuThinh V; Dutra OP; Dutta D; Duvilla N; Dy J; Dziewas R; Eaton C; Eaves W; Ebinger M; van Eck JWM; Edwards T; Egocheaga I; Ehrlich C; Eisenberg S; El Hallak A; El Jabali A; El Mahmoud R; El Shahawy M; Eldadah Z; Elghelbazouri F; Elhag O; El-Hamdani M; Elias D; Ellery A; El-Sayed H; Elvan A; Erickson B; Espaliat E; Essandoh L; Everington T; Evonich R; Ezhov A; Facila L; Farsad R; Fayard M; Fedele F; Ferreira LGG; Ferreira D; Santos JF; Ferrier A; Finsen A; First B; Fisher R; Floyd J; Folk T; Fonseca C; Fonseca L; Forman S; Forsgren M; Foster M; Foster N; Frais M; Frandsen B; Frappe T; Freixa R; French W; Freydlin M; Frickel S; Fruntelata AG; Fujii S; Fujino Y; Fukunaga H; Furukawa Y; Gabelmann M; Gabris M; Gadsboll N; Galin P; Galinier M; Ganim R; Garcia R; Quintana AG; Gartenlaub O; Genz C; Georger F; Georges JL; Georgeson S; Ghanbasha A; Giedrimas E; Gierba M; Gillespie E; Giniger A; Gkotsis A; Gmehling J; Gniot J; Goethals P; Goldberg R; Goldmann B; Goldscher D; Golitsyn S; Lopez EAG; Mesa JEG; Gonzalez E; Cocina EG; Juanatey CG; Gorbunov V; Gordon B; Gorka H; Gornick C; Gorog D; Goss F; Gotte A; Goube P; Goudevenos I; Goulden D; Graham B; Grande A; Greco C; Green M; Greer G; Gremmler U; Grena P; Grinshstein Y; Grond M; Gronda E; Grondin F; Gronefeld G; de Groot JR; Guardigli G; Guarnieri T; Caiedo CG; Guignier A; Gulizia M; Gumbley M; Gupta D; Hack T; Haerer W; Hakas J; Hall C; Hampsey J; Hananis G; Hanbali B; Handel F; Hargrove J; Hargroves D; Harris K; Hartley D; Haruna T; Hata Y; Hayek E; Healey J; Hearne S; Heggelund G; Hemels MEW; Hemery Y; Henein S; Henz B; Her SH; Hermany P; Hernandes ME; Higashino Y; Hill M; Hisadome T; Hishida E; Hitchcock J; Hoffer E; Hoghton M; Holmes C; Hong SK; Nousse MPH; Howard V; Hsu LF; Huang CH; Huckins D; Huehnergarth K; Huizenga A; Huntley R; Hussein G; Hwang GS; Igbokidi O; Iglesias I; Ikpoh M; Imberti D ;Ince H; Indolfi C; Ionova T; Ip J; Irles D; Iseki H; Ismail Y; Israel N; Isserman S; Iteld B; Ivanchura G; Iyer R; Iyer V; Villanueva ROI; Jackson-Voyzey E; Jaffrani N; Jager F; Jain M; James M; Jamon Y; Jang SW; Jardim CAP; Jarmukli N; Jeanfreau R; Jenkins R; Jiang X; Jiang H; Jiang TM; Jiang N; Jimenez J; Jobe R; Joffe I; Johansson B; Jones N; Jorge JCM; Jouve B; Jundi M; Jung W; Jung BC; Jung KT; Kabbani S; Kabour A; Kafkala C; Kajiwara K; Kalinina L; Kampus P; Kanda J; Kapadia S; Karim A; Karolyi L; Kashou H; Kastrup A; Katsivas A; Kaufman E; Kawai K; Kawajiri K; Kazmierski J; Keeling P; Kerfes GA; Saraiva JFK; Ketova G; Khaira A; Khalid M; Khludeeva E; Khripun A; Kim DI; Kim DK; Kim NH; Kim KS; Kim YH; Kim JB; Kim JS; Kim JS; Kinova E; Klein A; Kleinschnitz C; Kmetzo J; Kneller GL; Knezevic A; Koch S; Koenig K; Koh SMA; Kohrmann M; Koons J; Korabathina R; Korennova O; Koschutnik M; Kosinski E; Kovacic D; Kowalczyk J; Koziolova N; Kragten J; Krause LU; Kreidieh I; Krenning BJ; Krishnaswamy K; Krysiak W; Kuck KH; Kumar S; Kumler T; Kuniss M; Kuo JY; Kuppers A; Kurrelmeyer K; Kwan T; Kyo E; Labovitz A; Lacroix A; Lam A; Zanetti FTL; Landau C; Landini G; Lang W; Larsen TB; Laske V; Lavandier K; Law N; Lee MH; Lee D; Leitao A; Lejay D; Lelonek M; Lenarczyk R; Leprince P; Lequeux B; Leschke M; Ley N; Li ZC; Li YS; Li XD; Li ZQ; Li WH; Liang JQ; Lieber I; Lillestol M; Rodriguez RHL; Lin HL; Lip G; Litchfield J; Liu ZT; Liu XB; Liu YL; Liu F; Liu WH; Esperon GAL; Llisterri JL; Lo T; Lo E; Lobos JM; Lodde BP; Loiselet P; Lopez-Sendon J; Filho AML; Lori I; Luo M; Lupovitch S; Lyrer P; Zuhairy HM; Ma CS; Ma GS; Ma H; Madariaga I; Maeno K; Magnin D; Mahmood S; Mahood K; Maid G; Mainigi S; Makaritsis K; Villalon JAM; Malhotra R; Malik A; Mallecourt C; Mallik R; Manning R; Manolis A; Mantas I; Jattin FGM; Marcionni N; Marin F; Santana AM; Martinez J; Martinez L; Maskova P; Hernandez NM; Matskeplishvili S; Matsuda K; Mavri A; May E; Mayer N; Mazon P; McClure J; McCormack T; McGarity W; McGuire M; McIntyre H; McLaughlin P; McLaurin B; Palomino FAM; Mehta P; Mehzad R; Meinel A; Melandri F; Mena A; Meno H; Menzies D; Metcalf K; Meyer B; Miarka J; Mibach F; Michalski D; Michel P; Chreih RM; Mikdadi G; Mikhail M; Mikus M; Milicic D; Militaru C; Miller G; Milonas C; Minescu B; Mintale I; Miralles A; Mirault T; Mistry D; Mitchell G; Miu NV; Miyamoto N; Moccetti T; Mohammed A; Nor AM; de Salazar DIM; Molon G; Molony D; Mondillo S; Mont L; Moodley R; Moore R; Moreira DAR; Mori K; Moriarty A; Morka J; Moschos N; Gomes MAM; Mousallem N; Moya A; Mugge A; Mulhearn T; Muller JJ; Muresan CM; Muse D; Musial W; Musumeci F; Nadar V; Nageh T; Nair P; Nakagawa H; Nakamura Y; Nakayama T; Nam KB; Napalkov D; Natarajan I; Nayak H; Nechvatal L; Neiman J; Nerheim P; Neuenschwander FC; Nishida K; Nizov A; Novikova T; Novo S; Nowalany-Kozielska E; Nsah E; Fragoso JCN; Nyvad O; Ibarra MODR; O'Donnell M; O'Donnell P; Oh DJ; Oh YS; Oh CTD; O'Hara G; Oikonomou K; Olalla JJ; Olivari Z; Oliver R; Olympios C; Osborne J; Osca J; Osman R; Osunkoya A; Padanilam B; Panchenko E; Pandey AS; de Paola AAV; Paraschos A; Pardell H; Park HW; Park JS; Parkash R; Parker I; Parrens E; Parris R; Passamonti E; Patel J; Patel R; Pentz WH; Persic V; Perticone F; Peters P; Petkar S; Pezo LF; Pham D; Phai GPC; Phlaum S; Pineau J; Pineda-Velez A; Pini R; Pinter A; Pinto F; Pirelli S; Pivac N; Pizzini AM; Pocanic D; Podoleanu CGC; Polanczyk CA; Polasek P; Poljakovic Z; Pollock S; Polo J; Poock J; Poppert H; Porro Y; Pose A; Poulain F; Poulard JE; Pouzar J; Povolny P; Pozzer D; Pras A; Prasad N; Prevot S; Protasov K; Prunier L; Puleo J; Pye M; Qaddoura F; Quedillac JM; Raev D; Rahimi S; Raisaro A; Rama B; Ranadive N; Randall K; Ranjith N; Raposo N; Rashid H; Raters C; Rauch-Kroehnert U; Rebane T; Regner S; Renzi M; Rocha MAR; Reza S; Ria L; Richter D; Rickli H; Rickner K; Rieker W; Rigo F; Ripoll T; Ritt LEF; Roberts D; Pascual CR; Briones IR; Reyes HR; Roelke M; Roman M; Romeo F; Ronner E; Ronziere T; Rooyer F; Rosenbaum D; Roth S; Rozkova N; Rubacek M; Rubalcava F; Rubanenko O; Rubin A; Borret MR; Rybak K; Sabbour H; Morales OS; Sakai T; Salacata A; Salecker I; Salem A; Salfity M; Salguero R; Salvioni A; Samson M; Sanchez G; Sandesara C; Saporito WF; Sasaoka T; Sattar P; Savard D; Scala PJ; Scemama J; Schaupp T; Schellinger P; Scherr C; Schmitz KH; Schmitz B; Schmitz L; Schnitzler R; Schnupp S; Schoeniger P; Schon N; Schuster S; Seamark C; Seebass R; Seidl KH; Seidman B; Sek J; Sekaran L; Seko Y; Varela PAS; Sevilla B; Shah V; Shah A; Shah N; Shah A; Shanes J; Sharareh A; Sharma VK; Shaw L; Shimizu Y; Shimomura H; Shin DG; Shin ES; Shite J; Shoukfeh M; Shoultz C; Silver F; Sime I; Simmers T; Singal D; Singh N; Siostrzonek P; Sirajuddin M; Skeppholm M; Smadja D; Smith R; Smith D; Soda H; Sofley CW; Sokal A; Sotolongo R; de Souza OF; Sparby JA; Spinar J; Sprigings D; Spyropoulos A; Stakos D; Steinberg A; Steinwender C; Stergiou G; Stites HW; Stoikov A; Strasser R; Streb W; Styliadis I; Su GH; Su X; Suarez RM; Sudnik W; Sueyoshi A; Sukles K; Sun L; Suneja R; Svensson P; Ziekenhuis A; Szavits-Nossan J; Taggeselle J; Takagi Y; Takhar A; Tallet J; Tamm A; Tanaka S; Tanaka K; Tang A; Tang S; Tassinari T; Tayama S; Tayebjee M; Tebbe U; Teixeira J; Tesloianu DN; Tessier P; The S; Thevenin J; Thomas H; Timsit S; Topkis R; Torosoff M; Touze E; Traissac T; Trendafilova E; Troyan B; Tsai WK; Tse HF; Tsutsui H; Tsutsui T; Tuininga Y; Turakhia M; Turk S; Turner W; Tveit A; Twiddy S; Tytus R; Ukrainski G; Chavez SBV; De Graaff EV; Vanacker P; Vardas P; Vargas M; Vassilikos V; Vazquez J; Venkataraman A; Verdecchia P; Vester EG; Vial H; Vinereanu D; Vlastaris A; Vogel C; vom Dahl J; von Mering M; Vora K; Wakefield P; Walia J; Walter T; Wang MS; Wang NF; Wang F; Wang XH; Wang ZL; Wang KY; Watanabe K; Wei J; Weimar C; Weinrich R; Wen MS; Wheelan K; Wicke J; Wiemer M; Wild B; Wilke A; Willems S; Williams M; Williams D; Winkler A; Wirtz JH; Witzenbichler B; Wong DHK; Wong KSL; Wong B; Wozakowska-Kaplon B; Wu ZH; Wu SL; Wyatt N; Xu Y; Xu XD; Yamada A; Yamamoto K; Yamanoue H; Yamashita T; Yan PYB; Yang YM; Yang TL; Yao J; Yarlagadda C; Yeh KH; Yotov Y; Yvorra S; Zahn R; Zamorano J; Zanini R; Zarich S; Zebrack J; Zenin S; Zeuthen EL; Zhang XW; Zhang QS; Zhang DD; Zhang DH; Zhang HY; Zhao SP; Zhao XW; Zheng Y; Zheng QS; Zhou J; Zhou J; Zimmermann SL; Zimmermann R; Zukerman LS; van der Zwaan C
2017-01-01
Abstract
BACKGROUND GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation) is a prospective, global registry program describing antithrombotic treatment patterns in patients with newly diagnosed nonvalvular atrial fibrillation at risk of stroke. Phase 2 began when dabigatran, the first non-vitamin K antagonist oral anticoagulant (NOAC), became available. OBJECTIVES This study sought to describe phase 2 baseline data and compare these with the pre-NOAC era collected during phase 1. METHODS During phase 2, 15,641 consenting patients were enrolled (November 2011 to December 2014); 15,092 were eligible. This pre-specified cross-sectional analysis describes eligible patients' baseline characteristics. Atrial fibrillation disease characteristics, medical outcomes, and concomitant diseases and medications were collected. Data were analyzed using descriptive statistics. RESULTS Of the total patients, 45.5% were female; median age was 71 (interquartile range: 64, 78) years. Patients were from Europe (47.1%), North America (22.5%), Asia (20.3%), Latin America (6.0%), and the Middle East/Africa (4.0%). Most had high stroke risk (CHA(2)DS(2)-VASc [ Congestive heart failure, Hypertension, Age >= 75 years, Diabetes mellitus, previous Stroke, Vascular disease, Age 65 to 74 years, Sex category] score >= 2; 86.1%); 13.9% had moderate risk (CHA2DS2-VASc = 1). Overall, 79.9% received oral anticoagulants, of whom 47.6% received NOAC and 32.3% vitamin K antagonists (VKA); 12.1% received antiplatelet agents; 7.8% received no antithrombotic treatment. For comparison, the proportion of phase 1 patients (of N = 1,063 all eligible) prescribed VKA was 32.8%, acetylsalicylic acid 41.7%, and no therapy 20.2%. In Europe in phase 2, treatment with NOAC was more common than VKA (52.3% and 37.8%, respectively); 6.0% of patients received antiplatelet treatment; and 3.8% received no antithrombotic treatment. In North America, 52.1%, 26.2%, and 14.0% of patients received NOAC, VKA, and antiplatelet drugs, respectively; 7.5% received no antithrombotic treatment. NOAC use was less common in Asia (27.7%), where 27.5% of patients received VKA, 25.0% antiplatelet drugs, and 19.8% no antithrombotic treatment. CONCLUSIONS The baseline data from GLORIA-AF phase 2 demonstrate that in newly diagnosed nonvalvular atrial fibrillation patients, NOAC have been highly adopted into practice, becoming more frequently prescribed than VKA in Europe and North America. Worldwide, however, a large proportion of patients remain undertreated, particularly in Asia and North America. (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients With Atrial Fibrillation [ GLORIA-AF]; NCT01468701) (C) 2017 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.
Citazione
The Changing Landscape for Stroke Prevention in AF Findings From the GLORIA-AF Registry Phase 2 / Huisman, Mv; Rothman, Kj; Paquette, M; Teutsch, C; Diener, Hc; Dubner, Sj; Halperin, Jl; Ma, Cs; Zint, K; Elsaesser, A; Bartels, Db; Lip, Gyh; Abban, D; Abdul, N; Abelson, M; Ackermann, A; Adams, F; Adams, L; Adragao, P; Ageno, W; Aggarwal, R; Agosti, S; Marin, Ja; Aguilar, F; Linares, Jaa; Aguinaga, L; Ahmad, Z; Ainsworth, P; Al Ghalayini, K; Al Ismail, S; Alasfar, A; Alawwa, A; Al-Dallow, R; Alderson, L; Alexopoulos, D; Ali, A; Ali, M; Aliyar, P; Al-Joundi, T; Al Mahameed, S; Almassi, H; Almuti, K; Al-Obaidi, M; Alshehri, M; Altmann, U; Alves, Ar; Al-Zoebi, A; Amara, W; Amelot, M; Amjadi, N; Ammirati, F; Andrawis, N; Angoulvant, D; Annoni, G; Ansalone, G; Antonescu, Sa; Ariani, M; Arias, Jc; Armero, S; Arora, R; Arora, C; Ashcraft, W; Aslam, Ms; Astesiano, A; Audouin, P; Augenbraun, C; Aydin, S; Azar, R; Azim, A; Aziz, S; Backes, Lm; Baig, M; Bains, S; Bakbak, A; Baker, S; Bakhtiar, K; Bala, R; Banayan, J; Bandh, S; Bando, S; Banerjee, S; Bank, A; Barbarash, O; Baron, G; Barr, C; Barrera, C; Barton, J; Kes, Vb; Baula, G; Bayeh, H; Bazargani, N; Behrens, S; Bell, A; Benezet-Mazuecos, J; Benhalima, B; Berdague, P; Van Den Berg, Bj; Van Bergen, Pfmm; Berngard, E; Bernstein, R; Berrospi, P; Berti, S; Bertomeu, V; Berz, A; Bettencourt, P; Betzu, R; Beyer-Westendorf, J; Bhagwat, R; Black, T; Ibaceta, Jhb; Bloom, S; Blumberg, E; Bo, M; Bockisch, V; Bohmer, E; Bongiorni, Mg; Boriani, G; Bosch, R; Boswijk, Dj; Bott, J; Bottacchi, E; Kalan, Mb; Brandes, A; Bratland, B; Brautigam, D; Breton, N; Brouwers, Pjam; Browne, K; Bruguera, J; Brunehaut, M; Brunschwig, C; Buathier, H; Buhl, A; Bullinga, J; Butcher, K; Honorio, Jwc; Caccavo, A; Cadinot, D; Cai, S; Calvi, V; Camm, J; Candeias, R; Capo, J; Capucci, A; Cardoso, Jn; Vera, Ycd; Carlson, B; Carvalho, P; Cary, S; Casanova, R; Casu, G; Cattan, S; Cavallini, C; Cayla, G; Cha, Tj; Cha, Ks; Chaaban, S; Chae, Jk; Challappa, K; Chand, S; Chandrashekar, H; Chang, M; Charbel, P; Chartier, L; Chatterjee, K; Cheema, A; Chen, Sa; Chevallereau, P; Chiang, Ft; Chiarella, F; Lin, Cc; Cho, Yk; Choi, Dj; Chouinard, G; Danny, Hfc; Chrysos, D; Chumakova, G; Roberto, Ejj; Valenzuela, C; Cieza-Lara, T; Nica, Vc; Ciobotaru, V; Cislowski, D; Citerne, O; Claus, M; Clay, A; Clifford, P; Cohen, S; Cohen, A; Colivicchi, F; Collins, R; Compton, S; Connors, S; Conti, A; Buenostro, Gc; Coodley, G; Cooper, M; Corbett, L; Corey, O; Coronel, J; Corrigan, J; Pereyra, Ryc; Cottin, Y; Coutu, B; Cracan, A; Crean, P; Crenshaw, J; Crijns, Hjgm; Crump, C; Cucher, F; Cudmore, D; Cui, L; Culp, J; Darius, H; Dary, P; Dascotte, O; Dauber, I; Davee, T; Davies, R; Davis, G; Davy, Jm; Dayer, M; De La Briolle, A; De Mora, M; De Teresa, E; De Wolf, L; Decoulx, E; Deepak, S; Defaye, P; Munoz, Fdc; Brkljacic, Dd; Deluche, L; Destrac, S; Deumite, Nj; Di Legge, S; Dibon, O; Diemberger, I; Dillinger, J; Dionisio, P; Naydenov, S; Dotani, I; Dotcheva, E; D'Souza, A; Dubrey, S; Ducrocq, X; Dupljakov, D; Duthinh, V; Dutra, Op; Dutta, D; Duvilla, N; Dy, J; Dziewas, R; Eaton, C; Eaves, W; Ebinger, M; Van Eck, Jwm; Edwards, T; Egocheaga, I; Ehrlich, C; Eisenberg, S; El Hallak, A; El Jabali, A; El Mahmoud, R; El Shahawy, M; Eldadah, Z; Elghelbazouri, F; Elhag, O; El-Hamdani, M; Elias, D; Ellery, A; El-Sayed, H; Elvan, A; Erickson, B; Espaliat, E; Essandoh, L; Everington, T; Evonich, R; Ezhov, A; Facila, L; Farsad, R; Fayard, M; Fedele, F; Ferreira, Lgg; Ferreira, D; Santos, Jf; Ferrier, A; Finsen, A; First, B; Fisher, R; Floyd, J; Folk, T; Fonseca, C; Fonseca, L; Forman, S; Forsgren, M; Foster, M; Foster, N; Frais, M; Frandsen, B; Frappe, T; Freixa, R; French, W; Freydlin, M; Frickel, S; Fruntelata, Ag; Fujii, S; Fujino, Y; Fukunaga, H; Furukawa, Y; Gabelmann, M; Gabris, M; Gadsboll, N; Galin, P; Galinier, M; Ganim, R; Garcia, R; Quintana, Ag; Gartenlaub, O; Genz, C; Georger, F; Georges, Jl; Georgeson, S; Ghanbasha, A; Giedrimas, E; Gierba, M; Gillespie, E; Giniger, A; Gkotsis, A; Gmehling, J; Gniot, J; Goethals, P; Goldberg, R; Goldmann, B; Goldscher, D; Golitsyn, S; Lopez, Eag; Mesa, Jeg; Gonzalez, E; Cocina, Eg; Juanatey, Cg; Gorbunov, V; Gordon, B; Gorka, H; Gornick, C; Gorog, D; Goss, F; Gotte, A; Goube, P; Goudevenos, I; Goulden, D; Graham, B; Grande, A; Greco, C; Green, M; Greer, G; Gremmler, U; Grena, P; Grinshstein, Y; Grond, M; Gronda, E; Grondin, F; Gronefeld, G; De Groot, Jr; Guardigli, G; Guarnieri, T; Caiedo, Cg; Guignier, A; Gulizia, M; Gumbley, M; Gupta, D; Hack, T; Haerer, W; Hakas, J; Hall, C; Hampsey, J; Hananis, G; Hanbali, B; Handel, F; Hargrove, J; Hargroves, D; Harris, K; Hartley, D; Haruna, T; Hata, Y; Hayek, E; Healey, J; Hearne, S; Heggelund, G; Hemels, Mew; Hemery, Y; Henein, S; Henz, B; Her, Sh; Hermany, P; Hernandes, Me; Higashino, Y; Hill, M; Hisadome, T; Hishida, E; Hitchcock, J; Hoffer, E; Hoghton, M; Holmes, C; Hong, Sk; Nousse, Mph; Howard, V; Hsu, Lf; Huang, Ch; Huckins, D; Huehnergarth, K; Huizenga, A; Huntley, R; Hussein, G; Hwang, Gs; Igbokidi, O; Iglesias, I; Ikpoh, M; Imberti, D; Ince, H; Indolfi, C; Ionova, T; Ip, J; Irles, D; Iseki, H; Ismail, Y; Israel, N; Isserman, S; Iteld, B; Ivanchura, G; Iyer, R; Iyer, V; Villanueva, Roi; Jackson-Voyzey, E; Jaffrani, N; Jager, F; Jain, M; James, M; Jamon, Y; Jang, Sw; Jardim, Cap; Jarmukli, N; Jeanfreau, R; Jenkins, R; Jiang, X; Jiang, H; Jiang, Tm; Jiang, N; Jimenez, J; Jobe, R; Joffe, I; Johansson, B; Jones, N; Jorge, Jcm; Jouve, B; Jundi, M; Jung, W; Jung, Bc; Jung, Kt; Kabbani, S; Kabour, A; Kafkala, C; Kajiwara, K; Kalinina, L; Kampus, P; Kanda, J; Kapadia, S; Karim, A; Karolyi, L; Kashou, H; Kastrup, A; Katsivas, A; Kaufman, E; Kawai, K; Kawajiri, K; Kazmierski, J; Keeling, P; Kerfes, Ga; Saraiva, Jfk; Ketova, G; Khaira, A; Khalid, M; Khludeeva, E; Khripun, A; Kim, Di; Kim, Dk; Kim, Nh; Kim, Ks; Kim, Yh; Kim, Jb; Kim, Js; Kim, Js; Kinova, E; Klein, A; Kleinschnitz, C; Kmetzo, J; Kneller, Gl; Knezevic, A; Koch, S; Koenig, K; Koh, Sma; Kohrmann, M; Koons, J; Korabathina, R; Korennova, O; Koschutnik, M; Kosinski, E; Kovacic, D; Kowalczyk, J; Koziolova, N; Kragten, J; Krause, Lu; Kreidieh, I; Krenning, Bj; Krishnaswamy, K; Krysiak, W; Kuck, Kh; Kumar, S; Kumler, T; Kuniss, M; Kuo, Jy; Kuppers, A; Kurrelmeyer, K; Kwan, T; Kyo, E; Labovitz, A; Lacroix, A; Lam, A; Zanetti, Ftl; Landau, C; Landini, G; Lang, W; Larsen, Tb; Laske, V; Lavandier, K; Law, N; Lee, Mh; Lee, D; Leitao, A; Lejay, D; Lelonek, M; Lenarczyk, R; Leprince, P; Lequeux, B; Leschke, M; Ley, N; Li, Zc; Li, Ys; Li, Xd; Li, Zq; Li, Wh; Liang, Jq; Lieber, I; Lillestol, M; Rodriguez, Rhl; Lin, Hl; Lip, G; Litchfield, J; Liu, Zt; Liu, Xb; Liu, Yl; Liu, F; Liu, Wh; Esperon, Gal; Llisterri, Jl; Lo, T; Lo, E; Lobos, Jm; Lodde, Bp; Loiselet, P; Lopez-Sendon, J; Filho, Aml; Lori, I; Luo, M; Lupovitch, S; Lyrer, P; Zuhairy, Hm; Ma, Cs; Ma, Gs; Ma, H; Madariaga, I; Maeno, K; Magnin, D; Mahmood, S; Mahood, K; Maid, G; Mainigi, S; Makaritsis, K; Villalon, Jam; Malhotra, R; Malik, A; Mallecourt, C; Mallik, R; Manning, R; Manolis, A; Mantas, I; Jattin, Fgm; Marcionni, N; Marin, F; Santana, Am; Martinez, J; Martinez, L; Maskova, P; Hernandez, Nm; Matskeplishvili, S; Matsuda, K; Mavri, A; May, E; Mayer, N; Mazon, P; Mcclure, J; Mccormack, T; Mcgarity, W; Mcguire, M; Mcintyre, H; Mclaughlin, P; Mclaurin, B; Palomino, Fam; Mehta, P; Mehzad, R; Meinel, A; Melandri, F; Mena, A; Meno, H; Menzies, D; Metcalf, K; Meyer, B; Miarka, J; Mibach, F; Michalski, D; Michel, P; Chreih, Rm; Mikdadi, G; Mikhail, M; Mikus, M; Milicic, D; Militaru, C; Miller, G; Milonas, C; Minescu, B; Mintale, I; Miralles, A; Mirault, T; Mistry, D; Mitchell, G; Miu, Nv; Miyamoto, N; Moccetti, T; Mohammed, A; Nor, Am; De Salazar, Dim; Molon, G; Molony, D; Mondillo, S; Mont, L; Moodley, R; Moore, R; Moreira, Dar; Mori, K; Moriarty, A; Morka, J; Moschos, N; Gomes, Mam; Mousallem, N; Moya, A; Mugge, A; Mulhearn, T; Muller, Jj; Muresan, Cm; Muse, D; Musial, W; Musumeci, F; Nadar, V; Nageh, T; Nair, P; Nakagawa, H; Nakamura, Y; Nakayama, T; Nam, Kb; Napalkov, D; Natarajan, I; Nayak, H; Nechvatal, L; Neiman, J; Nerheim, P; Neuenschwander, Fc; Nishida, K; Nizov, A; Novikova, T; Novo, S; Nowalany-Kozielska, E; Nsah, E; Fragoso, Jcn; Nyvad, O; Ibarra, Modr; O'Donnell, M; O'Donnell, P; Oh, Dj; Oh, Ys; Oh, Ctd; O'Hara, G; Oikonomou, K; Olalla, Jj; Olivari, Z; Oliver, R; Olympios, C; Osborne, J; Osca, J; Osman, R; Osunkoya, A; Padanilam, B; Panchenko, E; Pandey, As; De Paola, Aav; Paraschos, A; Pardell, H; Park, Hw; Park, Js; Parkash, R; Parker, I; Parrens, E; Parris, R; Passamonti, E; Patel, J; Patel, R; Pentz, Wh; Persic, V; Perticone, F; Peters, P; Petkar, S; Pezo, Lf; Pham, D; Phai, Gpc; Phlaum, S; Pineau, J; Pineda-Velez, A; Pini, R; Pinter, A; Pinto, F; Pirelli, S; Pivac, N; Pizzini, Am; Pocanic, D; Podoleanu, Cgc; Polanczyk, Ca; Polasek, P; Poljakovic, Z; Pollock, S; Polo, J; Poock, J; Poppert, H; Porro, Y; Pose, A; Poulain, F; Poulard, Je; Pouzar, J; Povolny, P; Pozzer, D; Pras, A; Prasad, N; Prevot, S; Protasov, K; Prunier, L; Puleo, J; Pye, M; Qaddoura, F; Quedillac, Jm; Raev, D; Rahimi, S; Raisaro, A; Rama, B; Ranadive, N; Randall, K; Ranjith, N; Raposo, N; Rashid, H; Raters, C; Rauch-Kroehnert, U; Rebane, T; Regner, S; Renzi, M; Rocha, Mar; Reza, S; Ria, L; Richter, D; Rickli, H; Rickner, K; Rieker, W; Rigo, F; Ripoll, T; Ritt, Lef; Roberts, D; Pascual, Cr; Briones, Ir; Reyes, Hr; Roelke, M; Roman, M; Romeo, F; Ronner, E; Ronziere, T; Rooyer, F; Rosenbaum, D; Roth, S; Rozkova, N; Rubacek, M; Rubalcava, F; Rubanenko, O; Rubin, A; Borret, Mr; Rybak, K; Sabbour, H; Morales, Os; Sakai, T; Salacata, A; Salecker, I; Salem, A; Salfity, M; Salguero, R; Salvioni, A; Samson, M; Sanchez, G; Sandesara, C; Saporito, Wf; Sasaoka, T; Sattar, P; Savard, D; Scala, Pj; Scemama, J; Schaupp, T; Schellinger, P; Scherr, C; Schmitz, Kh; Schmitz, B; Schmitz, L; Schnitzler, R; Schnupp, S; Schoeniger, P; Schon, N; Schuster, S; Seamark, C; Seebass, R; Seidl, Kh; Seidman, B; Sek, J; Sekaran, L; Seko, Y; Varela, Pas; Sevilla, B; Shah, V; Shah, A; Shah, N; Shah, A; Shanes, J; Sharareh, A; Sharma, Vk; Shaw, L; Shimizu, Y; Shimomura, H; Shin, Dg; Shin, Es; Shite, J; Shoukfeh, M; Shoultz, C; Silver, F; Sime, I; Simmers, T; Singal, D; Singh, N; Siostrzonek, P; Sirajuddin, M; Skeppholm, M; Smadja, D; Smith, R; Smith, D; Soda, H; Sofley, Cw; Sokal, A; Sotolongo, R; De Souza, Of; Sparby, Ja; Spinar, J; Sprigings, D; Spyropoulos, A; Stakos, D; Steinberg, A; Steinwender, C; Stergiou, G; Stites, Hw; Stoikov, A; Strasser, R; Streb, W; Styliadis, I; Su, Gh; Su, X; Suarez, Rm; Sudnik, W; Sueyoshi, A; Sukles, K; Sun, L; Suneja, R; Svensson, P; Ziekenhuis, A; Szavits-Nossan, J; Taggeselle, J; Takagi, Y; Takhar, A; Tallet, J; Tamm, A; Tanaka, S; Tanaka, K; Tang, A; Tang, S; Tassinari, T; Tayama, S; Tayebjee, M; Tebbe, U; Teixeira, J; Tesloianu, Dn; Tessier, P; The, S; Thevenin, J; Thomas, H; Timsit, S; Topkis, R; Torosoff, M; Touze, E; Traissac, T; Trendafilova, E; Troyan, B; Tsai, Wk; Tse, Hf; Tsutsui, H; Tsutsui, T; Tuininga, Y; Turakhia, M; Turk, S; Turner, W; Tveit, A; Twiddy, S; Tytus, R; Ukrainski, G; Chavez, Sbv; De Graaff, Ev; Vanacker, P; Vardas, P; Vargas, M; Vassilikos, V; Vazquez, J; Venkataraman, A; Verdecchia, P; Vester, Eg; Vial, H; Vinereanu, D; Vlastaris, A; Vogel, C; Vom Dahl, J; Von Mering, M; Vora, K; Wakefield, P; Walia, J; Walter, T; Wang, Ms; Wang, Nf; Wang, F; Wang, Xh; Wang, Zl; Wang, Ky; Watanabe, K; Wei, J; Weimar, C; Weinrich, R; Wen, Ms; Wheelan, K; Wicke, J; Wiemer, M; Wild, B; Wilke, A; Willems, S; Williams, M; Williams, D; Winkler, A; Wirtz, Jh; Witzenbichler, B; Wong, Dhk; Wong, Ksl; Wong, B; Wozakowska-Kaplon, B; Wu, Zh; Wu, Sl; Wyatt, N; Xu, Y; Xu, Xd; Yamada, A; Yamamoto, K; Yamanoue, H; Yamashita, T; Yan, Pyb; Yang, Ym; Yang, Tl; Yao, J; Yarlagadda, C; Yeh, Kh; Yotov, Y; Yvorra, S; Zahn, R; Zamorano, J; Zanini, R; Zarich, S; Zebrack, J; Zenin, S; Zeuthen, El; Zhang, Xw; Zhang, Qs; Zhang, Dd; Zhang, Dh; Zhang, Hy; Zhao, Sp; Zhao, Xw; Zheng, Y; Zheng, Qs; Zhou, J; Zhou, J; Zimmermann, Sl; Zimmermann, R; Zukerman, Ls; Van Der Zwaan, C. - In: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. - ISSN 0735-1097. - 69:7(2017), pp. 777-785. [10.1016/j.jacc.2016.11.061]
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Il report seguente simula gli indicatori relativi alla propria produzione scientifica in relazione alle soglie ASN 2023-2025 del proprio SC/SSD. Si ricorda che il superamento dei valori soglia (almeno 2 su 3) è requisito necessario ma non sufficiente al conseguimento dell'abilitazione.
