A growing body of research on nutrition omics has led to recent advances in cardiovascular disease epidemiology and prevention. Within the PREDIMED trial, significant associations between diet-related metabolites and cardiovascular disease were identified, which were subsequently replicated in independent cohorts. Some notable metabolites identified include plasma levels of ceramides, acyl-carnitines, branched-chain amino acids, tryptophan, urea cycle pathways, and the lipidome. These metabolites and their related pathways have been associated with incidence of both cardiovascular disease and type 2 diabetes. Future directions in precision nutrition research include: a) developing more robust multimetabolomic scores to predict long-term risk of cardiovascular disease and mortality; b) incorporating more diverse populations and a broader range of dietary patterns; and c) conducting more translational research to bridge the gap between precision nutrition studies and clinical applications.
Recent advances in precision nutrition and cardiometabolic diseases / Martinez-Gonzalez, M. A.; Planes, F. J.; Ruiz-Canela, M.; Toledo, E.; Estruch, R.; Salas-Salvado, J.; Valdes-Mas, R.; Mena, P.; Castaner, O.; Fito, M.; Clish, C.; Landberg, R.; Wittenbecher, C.; Liang, L.; Guasch-Ferre, M.; Lamuela-Raventos, R. M.; Wang, D. D.; Forouhi, N.; Razquin, C.; F. B., Hu. - In: REVISTA ESPAÑOLA DE CARDIOLOGÍA. - ISSN 0300-8932. - (2024). [10.1016/j.recesp.2024.09.005]
Recent advances in precision nutrition and cardiometabolic diseases
Mena P.;
2024-01-01
Abstract
A growing body of research on nutrition omics has led to recent advances in cardiovascular disease epidemiology and prevention. Within the PREDIMED trial, significant associations between diet-related metabolites and cardiovascular disease were identified, which were subsequently replicated in independent cohorts. Some notable metabolites identified include plasma levels of ceramides, acyl-carnitines, branched-chain amino acids, tryptophan, urea cycle pathways, and the lipidome. These metabolites and their related pathways have been associated with incidence of both cardiovascular disease and type 2 diabetes. Future directions in precision nutrition research include: a) developing more robust multimetabolomic scores to predict long-term risk of cardiovascular disease and mortality; b) incorporating more diverse populations and a broader range of dietary patterns; and c) conducting more translational research to bridge the gap between precision nutrition studies and clinical applications.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.