Abstract INTRODUCTION: The aim of the study was to assess 12 month changes in upper limb function in patients affected by spinal muscular atrophy type 2 and 3. METHODS: Longitudinal 12 month data was collected in 114 patients, 60 type 2 and 54 type 3, using the Revised Upper Limb Module. RESULTS: The 12 month changes ranged between -7 and 9 (mean: -0.41; SD: 2.93). The mean changes were not significantly different between the three spinal muscular atrophy groups (-0.45 in type 2, -0.23 in non-ambulant type 3 and -0.34 in ambulant type 3, p = 0.96) and the relationship between 12 month change and age classes was not significantly different among the three types of SMA patients. DISCUSSION: Our results confirm that the Module explores a wide range of functional abilities and can be used in ambulant and non-ambulant patients of different ages in conjunction with other functional scales. Muscle Nerve 59:426-430, 2019. © 2019 Wiley Periodicals, Inc. KEYWORDS: Functional assessment; Longitudinal Data; Neuromuscular disorders; Outcome measures; Spinal Muscular Atrophy; Upper limb
Revised upper limb module for spinal muscular atrophy: 12 month changes / Pera, Mc; Coratti, G; Mazzone, Es; Montes, J; Scoto, M; De Sanctis, R; Main, M; Mayhew, A; Muni Lofra, R; Dunaway Young, S; Glanzman, Am; Duong, T; Pasternak, A; Ramsey, D; Darras, B; Day, Jw; Finkel, Rs; De Vivo, Dc; Sormani, Mp; Bovis, F; Straub, V; Muntoni, F; Pane, M; Mercuri, E; iSMAC Consortium, Group. - In: MUSCLE & NERVE. - ISSN 0148-639X. - 59(2019), pp. 426-430. [10.1002/mus.26419]
Revised upper limb module for spinal muscular atrophy: 12 month changes
Pera MC;
2019-01-01
Abstract
Abstract INTRODUCTION: The aim of the study was to assess 12 month changes in upper limb function in patients affected by spinal muscular atrophy type 2 and 3. METHODS: Longitudinal 12 month data was collected in 114 patients, 60 type 2 and 54 type 3, using the Revised Upper Limb Module. RESULTS: The 12 month changes ranged between -7 and 9 (mean: -0.41; SD: 2.93). The mean changes were not significantly different between the three spinal muscular atrophy groups (-0.45 in type 2, -0.23 in non-ambulant type 3 and -0.34 in ambulant type 3, p = 0.96) and the relationship between 12 month change and age classes was not significantly different among the three types of SMA patients. DISCUSSION: Our results confirm that the Module explores a wide range of functional abilities and can be used in ambulant and non-ambulant patients of different ages in conjunction with other functional scales. Muscle Nerve 59:426-430, 2019. © 2019 Wiley Periodicals, Inc. KEYWORDS: Functional assessment; Longitudinal Data; Neuromuscular disorders; Outcome measures; Spinal Muscular Atrophy; Upper limbI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
