: The timely introduction of non-invasive ventilation (NIV) is extremely relevant in the multidisciplinary management of patients affected by amyotrophic lateral sclerosis (ALS) and is based on the proper identification of red flags for early diaphragmatic exhaustion. Polygraphic sleep recording may provide insightful information on the ongoing respiratory impairment; in particular, atypical breathing patterns need to be recognized, as the application of current guidelines for sleep-related hypoxemia or sleep apnea may be insufficient for detecting early signs of diaphragmatic fatigue. We report the case of a 51-year-old man affected by ALS who was asymptomatic for breathing impairment, but whose nocturnal polysomnographic recording, despite not significant for obstructive sleep apnea nor for conventional hypoventilatory patterns, strongly suggested initial respiratory failure, as lately confirmed by the pulmonary follow-up. We discuss the advantages of including sleep recording in the clinical work-up of patients affected by ALS.

Unraveling sleep respiratory dysfunction in amyotrophic lateral sclerosis: Beyond the apnea-hypopnea index and sleep-related hypoxia / Nuredini, Andi; Bottignole, Dario; Stragliati, Filippo; Anceschi, Pietro; Romano, Sonia; Pollara, Irene; Abramo, Anna; Rausa, Francesco; Parrino, Liborio; Zinno, Lucia; Mutti, Carlotta. - In: HELIYON. - ISSN 2405-8440. - 10:11(2024). [10.1016/j.heliyon.2024.e32250]

Unraveling sleep respiratory dysfunction in amyotrophic lateral sclerosis: Beyond the apnea-hypopnea index and sleep-related hypoxia

Nuredini, Andi
;
Bottignole, Dario;Stragliati, Filippo;Anceschi, Pietro;Romano, Sonia;Pollara, Irene;Rausa, Francesco;Parrino, Liborio;Zinno, Lucia;Mutti, Carlotta
2024-01-01

Abstract

: The timely introduction of non-invasive ventilation (NIV) is extremely relevant in the multidisciplinary management of patients affected by amyotrophic lateral sclerosis (ALS) and is based on the proper identification of red flags for early diaphragmatic exhaustion. Polygraphic sleep recording may provide insightful information on the ongoing respiratory impairment; in particular, atypical breathing patterns need to be recognized, as the application of current guidelines for sleep-related hypoxemia or sleep apnea may be insufficient for detecting early signs of diaphragmatic fatigue. We report the case of a 51-year-old man affected by ALS who was asymptomatic for breathing impairment, but whose nocturnal polysomnographic recording, despite not significant for obstructive sleep apnea nor for conventional hypoventilatory patterns, strongly suggested initial respiratory failure, as lately confirmed by the pulmonary follow-up. We discuss the advantages of including sleep recording in the clinical work-up of patients affected by ALS.
2024
Unraveling sleep respiratory dysfunction in amyotrophic lateral sclerosis: Beyond the apnea-hypopnea index and sleep-related hypoxia / Nuredini, Andi; Bottignole, Dario; Stragliati, Filippo; Anceschi, Pietro; Romano, Sonia; Pollara, Irene; Abramo, Anna; Rausa, Francesco; Parrino, Liborio; Zinno, Lucia; Mutti, Carlotta. - In: HELIYON. - ISSN 2405-8440. - 10:11(2024). [10.1016/j.heliyon.2024.e32250]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2994054
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