Background & Aims: The cytokine pattern secreted by T cells at the site of viral replication may influence the final outcome of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections, The aim of this study was to assess whether a cytokine imbalance oriented toward T helper (Th) 1 or Th2-type responses may play a role in chronic hepatitis B or C. Methods: Production of interferon (IFN)-gamma, interleukin (IL)-4, and IL-5 by wide series of T-cell clones derived from the liver of 6 patients with chronic hepatitis B (291 clones) and 9 patients with chronic hepatitis 6 (260 clones) was studied, T-cell clones were generated by limiting dilution from freshly isolated mononuclear cells derived from liver tissue to give a reliable representation of the intrahepatic inflammatory infiltrates, Results: The majority of liver-infiltrating T cells in chronic hepatitis C were Th1 cells able to secrete IFN-gamma but unable to secrete IL-4 or IL-5, whereas in hepatitis B, most CD4(+) and CD8(+) liver T cells were ThO-like cells able to produce not only IFN-gamma but also IL-4 and IL-5, Conclusions: The different cytokine profiles of T cells within the liver in chronic HBV and HCV infections illustrate a different behavior of the local immune response in these two infections that may have pathogenetic implications.
Different cytokine profiles of intrahepatic T cells in chronic hepatitis B and hepatitis C virus infections / Bertoletti, A; Delios, Mm; Boni, C; Decarli, M; Zignego, Al; Durazzo, M; Missale, G; Penna, A; Fiaccadori, F; Delprete, G; Ferrari, C. - In: GASTROENTEROLOGY. - ISSN 0016-5085. - 112:1(1997), pp. 193-199. [10.1016/S0016-5085(97)70235-X]
Different cytokine profiles of intrahepatic T cells in chronic hepatitis B and hepatitis C virus infections
Boni C;Missale G;Ferrari C
1997-01-01
Abstract
Background & Aims: The cytokine pattern secreted by T cells at the site of viral replication may influence the final outcome of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections, The aim of this study was to assess whether a cytokine imbalance oriented toward T helper (Th) 1 or Th2-type responses may play a role in chronic hepatitis B or C. Methods: Production of interferon (IFN)-gamma, interleukin (IL)-4, and IL-5 by wide series of T-cell clones derived from the liver of 6 patients with chronic hepatitis B (291 clones) and 9 patients with chronic hepatitis 6 (260 clones) was studied, T-cell clones were generated by limiting dilution from freshly isolated mononuclear cells derived from liver tissue to give a reliable representation of the intrahepatic inflammatory infiltrates, Results: The majority of liver-infiltrating T cells in chronic hepatitis C were Th1 cells able to secrete IFN-gamma but unable to secrete IL-4 or IL-5, whereas in hepatitis B, most CD4(+) and CD8(+) liver T cells were ThO-like cells able to produce not only IFN-gamma but also IL-4 and IL-5, Conclusions: The different cytokine profiles of T cells within the liver in chronic HBV and HCV infections illustrate a different behavior of the local immune response in these two infections that may have pathogenetic implications.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
