Non-small cell lung cancer is possibly the solid tumor with more potential drugable molecular targets, but the smallest tumor specimens. An optimization of tumor tissue handling is then mandatory. In this landscape, the precise definition of non-small cell lung cancer histologic type had a renewal role in selecting different therapeutic strategies, also leading to a large use of immunohistochemistry even in malignancies showing an overt morphologic differentiation. We suggest here 4 different clinicopathologic scenarios with some helpful rules aimed at preventing unnecessary and expensive immunostains, then underlining the ageless value of morphology and preserving tumor tissues for molecular investigations. © 2013 by Lippincott Williams & Wilkins.

Is immunohistochemistry always required to diagnose lung cancer? / Rossi, G.; Tiseo, M.; Cavazza, A.; Colby, T. V.. - In: ADVANCES IN ANATOMIC PATHOLOGY. - ISSN 1072-4109. - 20:5(2013), pp. 327-333. [10.1097/PAP.0b013e3182a28a24]

Is immunohistochemistry always required to diagnose lung cancer?

Tiseo M.;Cavazza A.;
2013-01-01

Abstract

Non-small cell lung cancer is possibly the solid tumor with more potential drugable molecular targets, but the smallest tumor specimens. An optimization of tumor tissue handling is then mandatory. In this landscape, the precise definition of non-small cell lung cancer histologic type had a renewal role in selecting different therapeutic strategies, also leading to a large use of immunohistochemistry even in malignancies showing an overt morphologic differentiation. We suggest here 4 different clinicopathologic scenarios with some helpful rules aimed at preventing unnecessary and expensive immunostains, then underlining the ageless value of morphology and preserving tumor tissues for molecular investigations. © 2013 by Lippincott Williams & Wilkins.
2013
Is immunohistochemistry always required to diagnose lung cancer? / Rossi, G.; Tiseo, M.; Cavazza, A.; Colby, T. V.. - In: ADVANCES IN ANATOMIC PATHOLOGY. - ISSN 1072-4109. - 20:5(2013), pp. 327-333. [10.1097/PAP.0b013e3182a28a24]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2862175
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