HBV-specific T cells play a key role in antiviral protection and failure to control HBV is associated with severely dysfunctional T cell responses. Therefore, functional T cell reconstitution represents a potential way to treat chronically infected patients. The growing understanding of the dysregulated transcriptional/epigenetic and metabolic programs underlying T cell exhaustion allows to envisage functional T cell reconstitution strategies based on the combined/sequential use of compounds able to induce decline of antigen load, checkpoint modulation, metabolic and epigenetic reprogramming with possible boosting of functionally restored responses by specific vaccines.
Strategies to overcome HBV-specific T cell exhaustion: checkpoint inhibitors and metabolic re-programming / Fisicaro, Paola; Boni, Carolina; Barili, Valeria; Laccabue, Diletta; Ferrari, Carlo. - In: CURRENT OPINION IN VIROLOGY. - ISSN 1879-6257. - 30(2018), pp. 1-8. [10.1016/j.coviro.2018.01.003]
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