The skin is a possible site of extramedullary localization in multiple myeloma (MM) patients; however, the mechanisms involved in this process are poorly understood. We describe the case of a refractory MM patient who developed a cutaneous localization under bortezomib treatment and we further expanded observations in other eight MM patients. We focused on the expression of genes involved in plasma cell skin homing, including CCR10, which was highly expressed. Moreover, we observed a lack of CXCR4 surface expression and the down-regulation of ICAM1/CD54 throughout the progression of the disease, suggesting a possible mechanism driving the escape of MM cells from the bone marrow into the skin.

Cutaneous localization in multiple myeloma in the context of bortezomib-based treatment: how do myeloma cells escape from the bone marrow to the skin? / Marchica, Valentina; Accardi, Fabrizio; Storti, Paola; Mancini, Cristina; Martella, Eugenia; Dalla Palma, Benedetta; Bolzoni, Marina; Todoerti, Katia; Marcatti, Magda; Schifano, Chiara; Bonomini, Sabrina; Sammarelli, Gabriella; Neri, Antonino; Ponzoni, Maurilio; Aversa, Franco; Giuliani, Nicola. - In: INTERNATIONAL JOURNAL OF HEMATOLOGY. - ISSN 0925-5710. - 105:1(2017), pp. 104-108. [10.1007/s12185-016-2104-1]

Cutaneous localization in multiple myeloma in the context of bortezomib-based treatment: how do myeloma cells escape from the bone marrow to the skin?

MARCHICA, VALENTINA;STORTI, Paola;BOLZONI, Marina;SAMMARELLI, Gabriella;AVERSA, Franco;GIULIANI, Nicola
2017

Abstract

The skin is a possible site of extramedullary localization in multiple myeloma (MM) patients; however, the mechanisms involved in this process are poorly understood. We describe the case of a refractory MM patient who developed a cutaneous localization under bortezomib treatment and we further expanded observations in other eight MM patients. We focused on the expression of genes involved in plasma cell skin homing, including CCR10, which was highly expressed. Moreover, we observed a lack of CXCR4 surface expression and the down-regulation of ICAM1/CD54 throughout the progression of the disease, suggesting a possible mechanism driving the escape of MM cells from the bone marrow into the skin.
Cutaneous localization in multiple myeloma in the context of bortezomib-based treatment: how do myeloma cells escape from the bone marrow to the skin? / Marchica, Valentina; Accardi, Fabrizio; Storti, Paola; Mancini, Cristina; Martella, Eugenia; Dalla Palma, Benedetta; Bolzoni, Marina; Todoerti, Katia; Marcatti, Magda; Schifano, Chiara; Bonomini, Sabrina; Sammarelli, Gabriella; Neri, Antonino; Ponzoni, Maurilio; Aversa, Franco; Giuliani, Nicola. - In: INTERNATIONAL JOURNAL OF HEMATOLOGY. - ISSN 0925-5710. - 105:1(2017), pp. 104-108. [10.1007/s12185-016-2104-1]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11381/2815895
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 8
  • ???jsp.display-item.citation.isi??? 9
social impact