Cytotoxic T cells have been suggested to be responsible for lysis of hepatitis B virus (HBV)-infected hepatocytes and control of virus infection. The frequency, kinetics, phenotype, and capacity for clonal expansion of circulating HBV-specific CD8 cells were analyzed directly in patients with acute HBV infection to clarify their pathogenetic role.
Direct ex vivo analysis of hepatitis B virus-specific CD8(+) T cells associated with the control of infection / Maini, M K; Boni, C; Ogg, G S; King, A S; Reignat, S; Lee, C K; Larrubia, J R; Webster, G J; Mcmichael, A J; Ferrari, C; Williams, R; Vergani, D; Bertoletti, A. - In: GASTROENTEROLOGY. - ISSN 0016-5085. - 117:6(1999), p. 1386-96.
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