To characterize acute-phase hepatitis B virus (HBV)-specific T cell responses associated with self-limited and persistent HBV infections, we compared a patient with acute HBV/HCV coinfection, who was able to control HCV but developed chronic hepatitis B, with patients who resolved acute HBV infection spontaneously. Acute-phase CD4 responses were efficient in self-limited infections but undetectable in the coinfected patient with HBV persistence. CD8 responses were multispecific irrespective of the outcome of infection, but the CD8 repertoire associated with HBV persistence lacked the most dominant specificities detectable in self-limited infections. In conclusion, insufficient CD4 help and defective CDS repertoire may play a role at the early stages of infection in influencing HBV persistence. Copyright © 2005 by the American Association for the Study of Liver Diseases.

Acute phase HBV-specific T cell responses associated with HBV persistence after HBV/HCV coinfection / Urbani, Simona; Boni, Carolina; Amadei, Barbara; Fisicaro, Paola; Cerioni, Simona; Valli, Maria Antonietta; Missale, Gabriele; Ferrari, Carlo. - In: HEPATOLOGY. - ISSN 0270-9139. - 41:4(2005), pp. 826-831. [10.1002/hep.20614]

Acute phase HBV-specific T cell responses associated with HBV persistence after HBV/HCV coinfection

Missale, Gabriele;FERRARI, Carlo
2005

Abstract

To characterize acute-phase hepatitis B virus (HBV)-specific T cell responses associated with self-limited and persistent HBV infections, we compared a patient with acute HBV/HCV coinfection, who was able to control HCV but developed chronic hepatitis B, with patients who resolved acute HBV infection spontaneously. Acute-phase CD4 responses were efficient in self-limited infections but undetectable in the coinfected patient with HBV persistence. CD8 responses were multispecific irrespective of the outcome of infection, but the CD8 repertoire associated with HBV persistence lacked the most dominant specificities detectable in self-limited infections. In conclusion, insufficient CD4 help and defective CDS repertoire may play a role at the early stages of infection in influencing HBV persistence. Copyright © 2005 by the American Association for the Study of Liver Diseases.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11381/2815054
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 54
  • ???jsp.display-item.citation.isi??? 48
social impact